Difference between the resistance mechanisms of aclacinomycin- and adriamycin-resistant P388 cell lines.

abstract：:Human skin fibroblasts were exposed to global system for mobile communication (GSM) cellular phone radiofrequency for 1 h. GSM exposure induced alterations in cell morphology and increased the expression of mitogenic signal transduction genes (e.g., MAP kinase kinase 3, G2/mitotic-specific cyclin G1), cell growth inhi...

journal_title：Oncology research

authors： Pacini S,Ruggiero M,Sardi I,Aterini S,Gulisano F,Gulisano M

更新日期：2002-01-01 00:00:00

abstract：:We evaluated the effects of ultrasound-mediated microbubble transfection of VEGF-C siRNA on breast cancer cells in vitro and in vivo. MCF-7 cells were transfected with VEGF-C siRNA and the protein and mRNA expression of VEGF-C was tested using Western blot and qRT-PCR. Twenty nude mice tumors were established by injec...

journal_title：Oncology research

authors： Xu Q,Sun T,Tian H,Wang C,Zhou H

更新日期：2013-01-01 00:00:00

abstract：:Laryngeal cancer, one of the most common head and neck malignancies, is an aggressive neoplasm. Increasing evidence has demonstrated that microRNAs (miRNAs) exert important roles in oncogenesis and progression of diverse types of human cancers. miR-632, a tumor-related miRNA, has been reported to be dysregulated and i...

journal_title：Oncology research

authors： Zhou ZX,Zhang ZP,Tao ZZ,Tan TZ

更新日期：2020-02-07 00:00:00

abstract：:Lung cancer is a lethal solid tumor with poor prognosis because of its high metastasis and resistance to current therapies. Recently, cancer stem cells (CSCs) were suggested to be major contributors to tumorigenicity and cancer relapse. However, therapeutic targets for lung cancer-related CSCs remain undetermined. The...

journal_title：Oncology research

authors： Huang Y,Zeng F,Xu L,Zhou J,Liu X,Le H

更新日期：2013-01-01 00:00:00

abstract：:EO9 [3-hydroxy-5-aziridinyl-1-methyl-2-(1H-indole-4,7-indione)-prop-be ta- en-alpha-ol] is a new bioreductive alkylating indoloquinone with a distinct antitumor activity against solid tumors, excellent activity under hypoxic conditions, and lack of bone marrow toxicity in preclinical models. Clinical phase I studies w...

journal_title：Oncology research

authors： Verweij J,Aamdal S,Schellens J,Koier I,Lund B

更新日期：1994-01-01 00:00:00

abstract：:The present study aimed to investigate the effect of miR-186 on proliferation, migration, invasion, and epithelialmesenchymal transition (EMT) of hepatocellular carcinoma (HCC). In this work, miR-186 was downregulated in HCC tissues and cells, and low miR-186 level helped predict the occurrence of vascular invasion an...

journal_title：Oncology research

authors： Lu J,Zhao Z,Ma Y

更新日期：2020-12-10 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is an uncommon and highly aggressive tumor of the neuroendocrine system, which derives from the neuroendocrine C cells of the thyroid gland. Except for surgical resection, there are not very many effective systemic treatment options for MTC. N-Myc downstream-regulated gene 2 (NDRG2) h...

journal_title：Oncology research

authors： Yin A,Wang C,Sun J,Gao J,Tao L,Du X,Zhao H,Yang J,Li Y

更新日期：2016-01-21 00:00:00

abstract：:Signal peptide CUB EGF-like domain-containing protein 2 (SCUBE2), a member of the SCUBE family of proteins, was recently found to play an important role in cancer development. However, little is known regarding its biological function in glioma. In the present study, we investigated the effect of SCUBE2 on glioma and ...

journal_title：Oncology research

authors： Guo E,Liu H,Liu X

更新日期：2017-03-13 00:00:00

abstract：:Lung cancer is the leading cause of deaths due to cancer. Studies suggest an important role of microRNAs (miRNAs) in a variety of cancers, including lung cancer. In the present study, we evaluated the role of miR-641 in human lung cancer A549 cells. Quantitative RT-PCR and Western blot were used to measure mRNA and pr...

journal_title：Oncology research

authors： Kong Q,Shu N,Li J,Xu N

更新日期：2018-06-11 00:00:00

abstract：:Kiss-1 has been identified as a putative metastasis suppressor gene in various human malignancies. However, there is little information about its possible role in gastric carcinoma. In this study, we determined whether the Kiss-1 gene negatively regulates MMP-9 expression. cDNA microarray technology was used to identi...

journal_title：Oncology research

authors： Lee KH,Kim JR

更新日期：2009-01-01 00:00:00

abstract：:To elucidate the proteins related to the development and progress of esophageal squamous cell carcinoma (ESCC), we performed gene expression profile analysis of 14 ESCC tissues. We identified 182 genes that were commonly upregulated (p < 10(-5)) and 54 genes that were downregulated in ESCC tissues (p < 10(-6)). In ord...

journal_title：Oncology research

authors： Kwon YJ,Lee SJ,Koh JS,Kim SH,Kim YJ,Park JH

更新日期：2009-01-01 00:00:00

abstract：:Aberrantly expressed microRNAs (miRNAs/miRs) and their role in cancer development have recently gained more attention. However, the potential role of miRNAs in hepatocellular carcinoma (HCC) remains largely unknown. In this study, we demonstrated that miR-377 was markedly downregulated in HCC cell lines and primary hu...

journal_title：Oncology research

authors： Ge H,Zou D,Wang Y,Jiang H,Wang L

更新日期：2017-01-02 00:00:00

abstract：:Colorectal carcinoma is one of the leading causes of cancer-related deaths and has a high tendency for metastasis, which makes it a priority to find novel methods to diagnose and treat colorectal carcinoma at a very early stage. We studied the role of the regulator of G-protein signaling (RGS) family of proteins RGS17...

journal_title：Oncology research

authors： Li L,Luo HS

更新日期：2018-01-19 00:00:00

abstract：:Treatment of female SKH-1 hairless mice with ultraviolet B light twice a week for 20 weeks resulted in a population of tumor-free mice with a high risk of developing skin tumors during the next several months in the absence of additional UVB treatment (high-risk mice). Topical applications of nondenatured soymilk but ...

journal_title：Oncology research

authors： Huang MT,Xie JG,Lin CB,Kizoulis M,Seiberg M,Shapiro S,Conney AH

更新日期：2004-01-01 00:00:00

abstract：:The clinical study of compounds that modulate multidrug resistance has been hindered by both the toxicities of these agents and the inability to monitor their effectiveness at the level of the tumor cell. Previously, toremifene has been shown to be well tolerated clinically and to sensitize multidrug resistant cells t...

journal_title：Oncology research

authors： Baker WJ,Maenpaa JU,Wurz GT,Koester SK,Seymour RC,Emshoff VD,Wiebe VJ,DeGregorio MW

更新日期：1993-01-01 00:00:00

abstract：:Spinal osteosarcoma (OS) is a malignant tumor that has a poor outcome. MicroRNA-520b (miR-520b) acts as a cancer suppressor in various types of cancer. Because of the limited amount of literature on OS, we aimed to identify the role of miR-520b in OS. The miR-520b level in clinical spinal OS tissues and adjacent nontu...

journal_title：Oncology research

authors： Wang J,Pang W,Zuo Z,Zhang W,He W

更新日期：2017-09-21 00:00:00

abstract：:Numerous data indicate that cellular oxidoreductases may be responsible for the cardiotoxic effects of antitumor anthracycline drugs as a consequence of the mediation by these agents of one-electron transfer from reduced nucleotides to atmospheric oxygen. This process is catalyzed primarily by NADH dehydrogenase, NADP...

journal_title：Oncology research

authors： Pawłowska J,Priebe W,Paine MJ,Wolf CR,Borowski E,Tarasiuk J

更新日期：2004-01-01 00:00:00

abstract：:Ahead of Print article withdrawn by publisher. ...

journal_title：Oncology research

authors： Maimaitiming A,Wusiman A,Aimudula A,Tudahong T,Aisimutula D

更新日期：2017-06-15 00:00:00

abstract：:Oncogene Bmi-1 (B-cell-specific Moloney murine leukemia virus integration site 1) has attracted much attention for its involvement in the initiation of a variety of tumors. Our previous study showed that Bmi-1 was highly expressed in gastric cancer and correlated with patient prognosis. However, whether aberrant Bmi-1...

journal_title：Oncology research

authors： Chen Y,Lian G,Zhang Q,Zeng L,Qian C,Chen S,Huang K

更新日期：2013-01-01 00:00:00

abstract：:A Wnt agonist, 2-amino-4-[3,4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl) pyrimidine, is a cell-permeable pyrimidine compound that has been shown to mimic the effect of Wnt. In this study, leukemic mouse cell lines, RAW 264.7 and J774.1, were incubated with the Wnt agonist. The Wnt agonist showed cell death in th...

journal_title：Oncology research

authors： Kato Y,Naiki Y,Komatsu T,Takahashi K,Nakamura J,Koide N

更新日期：2017-04-14 00:00:00

abstract：:N-Butyl-N-(4-hydroxybutyl)-nitrosamine (BBN), which induces bladder carcinoma in female Wistar rats and female C3H/HeJ mice, was given as 0.025% (w/v) solution to rats and 0.05% to mice in the drinking water. Thymosin fraction 5 (TF5) or thymosin alpha 1 (T alpha 1) dissolved in normal saline, and normal saline (contr...

journal_title：Oncology research

authors： Wada S,Kinoshita Y,Kamizuru M,Asai Y,Iwata H,Ikemoto S,Hato F,Kishimoto T,Fukushima S

更新日期：1996-01-01 00:00:00

abstract：:Accumulated studies have strongly implicated aberrantly expressed microRNAs (miRNAs) in carcinogenesis and cancer progression of various cancers, including colorectal cancer (CRC). Hence, a comprehensive study of miRNAs and their association with CRC may be a promising therapeutic method for patients with this maligna...

journal_title：Oncology research

authors： Shen J,Li M

更新日期：2018-10-17 00:00:00

abstract：:Chemoresistance is a major impediment to the successful treatment of cancer. It involves various mechanisms, including defects in the apoptosis program that is induced by anticancer drugs. To further explore the mechanisms underlying the development of chemoresistance in ovarian carcinoma after cisplatin (CDDP) treatm...

journal_title：Oncology research

authors： Mansouri A,Zhang Q,Ridgway LD,Tian L,Claret FX

更新日期：2003-01-01 00:00:00

abstract：:Lung cancer remains a critical health concern worldwide. Long noncoding RNAs with ultraconserved elements have recently been implicated in human tumorigenesis. The present study investigated the role of ultraconserved element 338 (uc.338) in the regulation of cell proliferation and metastasis in human lung cancer. Our...

journal_title：Oncology research

authors： Gao X,Gao X,Li C,Zhang Y,Gao L

更新日期：2016-01-01 00:00:00

abstract：:A novel hydroquinone and NADH oxidase with protein disulfide-thiol interchange activity (designated ENOX2 or tNOX), associated exclusively with the outer leaflet of the plasma membrane at the surface of cancer cells and in sera of cancer patients, is absent from the surface of noncancer cells and from sera from health...

journal_title：Oncology research

authors： Tang X,Morré DJ,Morré DM

更新日期：2007-01-01 00:00:00

abstract：:The beta-adrenergic receptors transduce catecholamine signals to the G protein, which through a cascade of chemical reactions in cells generates highly specific parallel signals. The beta2-adrenergic receptor (ADRB2) is the most involved in the carcinogenic processes. Previous studies have determined the relationship ...

journal_title：Oncology research

authors： Pérez-Sayáns M,Somoza-Martín JM,Barros-Angueira F,Diz PG,Gándara Rey JM,García-García A

更新日期：2010-01-01 00:00:00

abstract：:Tamoxifen causes a mitochondrial transmembrane potential dysfunction and ATP depletion, which may play a role in tamoxifen cytotoxicity. Administration of oligomycin-2 deoxy glucose (2DG) enhanced tamoxifen antiproliferative effects, which may be due to exacerbated ATP depletion following tamoxifen and oligomycin-2DG ...

journal_title：Oncology research

authors： Seyedabadi M,Ghahremani MH,Ostad SN

更新日期：2009-01-01 00:00:00

abstract：:The patterns of DNA fragmentation were evaluated following a brief exposure (2 h) of the human ileocecal adenocarcinoma cell line, HCT-8, to several specific thymidylate synthase inhibitors, a quinazoline (ZD1694) and benz[cd]indole-containing molecule (AG-331). The magnitude and size of DNA fragmentation induced by t...

journal_title：Oncology research

authors： Panadero A,Yin MB,Voigt W,Rustum YM

更新日期：1995-01-01 00:00:00

abstract：:It has been demonstrated that microRNAs (miRNAs) act as oncogenes or tumor suppressors in a variety of cancers. Our previous work suggested that miR-10a/b functioned as a tumor suppressor in gastric cancer, and miR-10b was also reported to be significantly downregulated in advanced stage cervical cancer tissues. Howev...

journal_title：Oncology research

authors： Zou D,Zhou Q,Wang D,Guan L,Yuan L,Li S

更新日期：2016-01-01 00:00:00

abstract：:Accumulation of beta-catenin in cytoplasm and nuclei is frequently observed in a wide variety of tumors arising, for example, in the colon, liver, uterus, or brain. In association with Tcf/LEF transcription factors, beta-catenin regulates expression of genes involved in the Wnt/wingless signaling pathway, but the prec...

journal_title：Oncology research

authors： Miwa N,Furuse M,Tsukita S,Niikawa N,Nakamura Y,Furukawa Y

更新日期：2001-01-01 00:00:00