Abstract:
:To elucidate the proteins related to the development and progress of esophageal squamous cell carcinoma (ESCC), we performed gene expression profile analysis of 14 ESCC tissues. We identified 182 genes that were commonly upregulated (p < 10(-5)) and 54 genes that were downregulated in ESCC tissues (p < 10(-6)). In order to validate the gene expression profiles, we did semiquantitative RT-PCR analysis and found 11 genes upregulated in greater than 70% of 19 tissue samples. We further examined the protein expression level and the distribution patterns of four genes: aurora kinase B (AURKB), periostin (POSTN), heat shock protein 47 (HSP47), and matrix metalloprotease 1 (MMP1). Ultimately, three genes (AURKB, HSP47, POSTN) were verified to be increased at both the mRNA and protein levels. Among them, AURKB and HSP47 were found to increase in the early development stage of ESCC and POSTN might be considered to function in the cell-cell interactions between cancer cell and adjacent stromal cells. Accordingly, these studies may provide valuable information for the identification of the genes that are necessary to study further their functions. Moreover, these genes might be used as potential diagnostic or therapeutic target molecules for ESCC patients.
journal_name
Oncol Resjournal_title
Oncology researchauthors
Kwon YJ,Lee SJ,Koh JS,Kim SH,Kim YJ,Park JHdoi
10.3727/096504009790217407subject
Has Abstractpub_date
2009-01-01 00:00:00pages
141-51issue
4eissn
0965-0407issn
1555-3906journal_volume
18pub_type
杂志文章abstract::Colorectal cancer is an aggressive malignancy for which there are limited treatment options. Oncolytic vaccinia virus isbeing developed as a novel strategy for cancer therapy. Arming vaccinia virus with immunostimulatory cytokines can enhance the tumor cell-specific replication and antitumor efficacy. Interleukin-24 (...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504020X15942028641011
更新日期:2020-07-08 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504017X14974834436195
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journal_title:Oncology research
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the most common malignancies, with a poor prognosis and high recurrence rate. In the present study, we identified CD133, one of the markers of cancer stem cells, as a novel molecular target of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). In four human HCC ce...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504016X14685034103950
更新日期:2016-10-27 00:00:00
abstract::DNA topoisomerase II alpha is a nuclear enzyme essential for DNA metabolism and cell cycle progression. Previous studies have shown that human tumor cell lines can express more than one topoisomerase II alpha isoform through alternative splicing. A 160-kDa isoform of topoisomerase II alpha has been described in severa...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::It has been demonstrated that microRNAs (miRNAs) act as oncogenes or tumor suppressors in a variety of cancers. Our previous work suggested that miR-10a/b functioned as a tumor suppressor in gastric cancer, and miR-10b was also reported to be significantly downregulated in advanced stage cervical cancer tissues. Howev...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504016X14611963142173
更新日期:2016-01-01 00:00:00
abstract::We previously reported that 9-methylstreptimidone, a piperidine compound isolated from a culture filtrate of Streptomyces, induces apoptosis selectively in adult T-cell leukemia cells. It was screened for a compound that inhibits LPS-induced NF-kappaB and NO production in mouse macrophages. However, 9-methystreptimido...
journal_title:Oncology research
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doi:10.3727/096504012x13425470196056
更新日期:2012-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Grb2-associated binder 1 (Gab1) is often aberrant in cancerous cells and tissues, whose alteration is responsible for aggressive phenotypes. In this study, we examined the Gab1 expression in human oral squamous cell carcinoma (OSCC) tissues and investigated the cellular and molecular effect of Gab1 on migration, invas...
journal_title:Oncology research
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doi:10.3727/096504017X15043589260618
更新日期:2018-05-07 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504016X14772395226335
更新日期:2017-05-24 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504017X14965111926391
更新日期:2018-03-05 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504019X15561873320465
更新日期:2019-09-23 00:00:00
abstract::Genistein is an inhibitor of the enzymes protein tyrosine kinase and topoisomerase-II. It induces G2-phase arrest in human Jurkat and murine P388 leukemia cells at concentrations at which it is also cytotoxic. The effects of genistein have been investigated on Jurkat and P388 leukemia sublines that manifest multidrug ...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504016X14756640150695
更新日期:2017-04-14 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:
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abstract::Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the initiation and development of many solid tumors, including osteosarcoma (OS). In this study, we showed that MALAT1 was increased in human OS tissues and cell lines. MALAT1 knockdown suppressed OS ce...
journal_title:Oncology research
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doi:10.3727/096504017X14957939026111
更新日期:2018-04-27 00:00:00
abstract::ErbB4 is a member of the ErbB family of receptor tyrosine kinases. Because of a paucity of appropriate pharmacologic tools, little is known about ErbB4 functions in vivo. In response to this need, we hypothesized that a recombinant form of the extracellular domain of ErbB4 would antagonize ligand-induced receptor tyro...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/0965040042707907
更新日期:2004-01-01 00:00:00
abstract::Dysregulation of SUMO-specific protease 1 (SENP1) expression has been reported in several kinds of cancer, including human colorectal and prostate cancers, proposing SENP1 as an oncogene with a critical role in cancer progression. miR-133a-3p has been reported as a tumor suppressor in several malignant neoplasias. How...
journal_title:Oncology research
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doi:10.3727/096504017X15004613574679
更新日期:2018-06-11 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504015X14452563486093
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abstract::The regular RIN1 gene is a molecule located on chromosome 1lq13.2, and contains a coding region of 2352 bp with a 3' domain that binds to H-Ras protein, suggesting that it is an important molecule in the intracellular signaling pathway. In this study, we confirmed the existence of a novel form of the RIN1 gene with a ...
journal_title:Oncology research
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doi:10.3727/096504009789745566
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abstract::Drug resistance is the major obstacle for the successful therapy of lung adenocarcinoma. It was suggested that ß-elemene, a major isoform of elemene, could reverse the drug resistance in lung cancer cells. However, the underlying mechanisms remains poorly known. Here, we aimed to investigate whether elemene is involve...
journal_title:Oncology research
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doi:10.3727/096504014X13907540404833
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journal_title:Oncology research
pub_type: 杂志文章,评审
doi:10.3727/096504008786111383
更新日期:2008-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are emerging as pivotal regulators in the development and progression of various cancers, including renal cell carcinoma (RCC). MicroRNA-384 (miR-384) has been found to be an important cancer-related miRNA in several types of cancers. However, the role of miR-384 in RCC remains unclear. In this stud...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X15035025554553
更新日期:2018-04-10 00:00:00
abstract::Solid tumors involving glandular organs express mucin glycoprotein that is eventually shed into the circulation. As a result, these proteins can easily be measured in the serum and be used as potential tumor markers. The most commonly used tumor markers for breast cancer are CA27-29 and CA15-3, which both measure the ...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X15128550060375
更新日期:2018-04-10 00:00:00
abstract::The sequence of biochemical and molecular events that mediate growth arrest and cell death in tumor cells exposed to agents that induce DNA damage is poorly defined. This commentary exploits the recent explosion of information regarding oncogenes, tumor suppressor genes, and cell-cycle regulatory genes to develop a mo...
journal_title:Oncology research
pub_type: 杂志文章,评审
doi:
更新日期:1993-01-01 00:00:00
abstract::Ovarian cancer is highly malignant with a gradually increasing incidence and a high mortality rate. Immunosuppression is induced in ovarian cancer, although the mechanism detail is not clear. It has been indicated that HVEM (herpesvirus entry mediator) B- and T-lymphocyte attenuator (BTLA) negatively regulates the imm...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504016X14641336229602
更新日期:2016-01-01 00:00:00
abstract::Recently, microRNA (miR)-33b has been demonstrated to act as a tumor suppressor in osteosarcoma. However, the regulatory mechanism of miR-33b in osteosarcoma cell proliferation and migration remains largely unknown. In this study, real-time PCR showed that miR-33b was significantly downregulated in osteosarcoma tissue...
journal_title:Oncology research
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doi:10.3727/096504016X14743337535446
更新日期:2017-03-13 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504009788428424
更新日期:2009-01-01 00:00:00
abstract::We have compared the effects of a number of inhibitors including aphidicolin, 2,4-dinitrophenol (DNP) and novobiocin on the in vitro cytotoxicity of several topoisomerase II (topo II)-directed agents, using cultured murine Lewis lung carcinoma cells. These agents comprised amsacrine, CI-921 (9-[(2-methoxy-4-methylsulf...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00