miR-133a-3p Targets SUMO-Specific Protease 1 to Inhibit Cell Proliferation and Cell Cycle Progress in Colorectal Cancer.

abstract：:Glioma is a common type of malignant brain tumor characterized by aggressive metastasis capability. Recent evidence has suggested that noncoding RNAs, including microRNAs, have important functions in the pathophysiology of glioma development. In this study, we investigated the biological function of miR-422a in human ...

journal_title：Oncology research

authors： Wang H,Tang C,Na M,Ma W,Jiang Z,Gu Y,Ma G,Ge H,Shen H,Lin Z

更新日期：2017-01-26 00:00:00

abstract：:Colorectal carcinoma is one of the leading causes of cancer-related deaths and has a high tendency for metastasis, which makes it a priority to find novel methods to diagnose and treat colorectal carcinoma at a very early stage. We studied the role of the regulator of G-protein signaling (RGS) family of proteins RGS17...

journal_title：Oncology research

authors： Li L,Luo HS

更新日期：2018-01-19 00:00:00

abstract：:To elucidate the proteins related to the development and progress of esophageal squamous cell carcinoma (ESCC), we performed gene expression profile analysis of 14 ESCC tissues. We identified 182 genes that were commonly upregulated (p < 10(-5)) and 54 genes that were downregulated in ESCC tissues (p < 10(-6)). In ord...

journal_title：Oncology research

authors： Kwon YJ,Lee SJ,Koh JS,Kim SH,Kim YJ,Park JH

更新日期：2009-01-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) of non-small cell lung cancer (NSCLC) may contribute to tumor metastasis. TGF-β1-induced EMT in H1975 cells (a human NSCLC cell line) resulted in the adoption of mesenchymal responses that were predominantly mediated via the TGF-β1-...

journal_title：Oncology research

authors： Ruan JS,Zhou H,Yang L,Wang L,Jiang ZS,Sun H,Wang SM

更新日期：2019-05-07 00:00:00

abstract：:Phytochemicals present in tea, particularly polyphenols, have anticancer properties against several cancer types. However, studies elucidating the role and the mechanism(s) of action of tea polyphenols in cervical cancer are sparse. In this study, we investigated the mechanism of antiproliferative and apoptotic action...

journal_title：Oncology research

authors： Singh M,Singh R,Bhui K,Tyagi S,Mahmood Z,Shukla Y

更新日期：2011-01-01 00:00:00

abstract：:Lung cancer is the leading cause of deaths due to cancer. Studies suggest an important role of microRNAs (miRNAs) in a variety of cancers, including lung cancer. In the present study, we evaluated the role of miR-641 in human lung cancer A549 cells. Quantitative RT-PCR and Western blot were used to measure mRNA and pr...

journal_title：Oncology research

authors： Kong Q,Shu N,Li J,Xu N

更新日期：2018-06-11 00:00:00

abstract：:Empty spiracles homeobox 2 (EMX2) is a homeodomain-containing transcription factor that plays an essential role in tumorigenesis. However, to the best of our knowledge, the role of EMX2 in human colorectal cancer (CRC) is still unclear. Thus, the aim of this study was to investigate the expression and role of EMX2 in ...

journal_title：Oncology research

authors： Zhang Y,Cao G,Yuan QG,Li JH,Yang WB

更新日期：2017-04-14 00:00:00

abstract：:A novel hydroquinone and NADH oxidase with protein disulfide-thiol interchange activity (designated ENOX2 or tNOX), associated exclusively with the outer leaflet of the plasma membrane at the surface of cancer cells and in sera of cancer patients, is absent from the surface of noncancer cells and from sera from health...

journal_title：Oncology research

authors： Tang X,Morré DJ,Morré DM

更新日期：2007-01-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most frequent cancer worldwide. HNSCC cell lines are typically refractory to transforming growth factor-beta (TGF-beta)-mediated cell cycle arrest. A number of these cell lines carry inactivating mutations of the TGF-beta type II (TbetaR-II) receptor, an...

journal_title：Oncology research

authors： Xie W,Bharathy S,Kim D,Haffty BG,Rimm DL,Reiss M

更新日期：2003-01-01 00:00:00

abstract：:There is growing evidence on the clinical significance of Tumor Microenvironment (TME) cells in predicting prognosis and therapeutic effects. However, cell interactionsin tumor microenvironments have not been thoroughly studied or systematicallyanalyzed so far. In this study, 22 immune cell components in the lung aden...

journal_title：Oncology research

authors： Ling B,Huang Z,Huang S,Qian L,Li G,Tang Q

更新日期：2020-05-29 00:00:00

abstract：:The human nucleolar protein p120 is highly expressed in human cancers. Its high expression in breast cancer correlates with a poor prognosis, and its overexpression in 3T3 mouse fibroblasts causes malignant transformation. This study reports that a combination of monoclonal anti-p 120 antibody (MAbp120), liposomes (Li...

journal_title：Oncology research

authors： Perlaky L,Busch RK,Busch H

更新日期：1996-01-01 00:00:00

abstract：:Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the initiation and development of many solid tumors, including osteosarcoma (OS). In this study, we showed that MALAT1 was increased in human OS tissues and cell lines. MALAT1 knockdown suppressed OS ce...

journal_title：Oncology research

authors： Zhang Y,Dai Q,Zeng F,Liu H

更新日期：2018-04-27 00:00:00

abstract：:Pancreatic cancer is characterized as a type of gastrointestinal tumor with a poor prognosis and high degree of malignancy. CIITA gene was found highly methylated in pancreatic carcinoma cell line PANC-1 and responsible for the low expression of major histocompatability complex II (MHC-II) that may lead to immune evas...

journal_title：Oncology research

authors： Tao Y,Lin F,Li T,Xie J,Shen C,Zhu Z

更新日期：2013-01-01 00:00:00

abstract：:Aberrant expression of microRNA-92a (miR-92a) has been investigated in various cancers. However, the function and mechanism of miR-92a in acute myeloid leukemia (AML) remain to be elucidated. Our data showed that miR-92a was evidently downregulated and methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) was remarkably ...

journal_title：Oncology research

authors： Gu Y,Si J,Xiao X,Tian Y,Yang S

更新日期：2017-08-07 00:00:00

abstract：:Lung cancer remains a critical health concern worldwide. Long noncoding RNAs with ultraconserved elements have recently been implicated in human tumorigenesis. The present study investigated the role of ultraconserved element 338 (uc.338) in the regulation of cell proliferation and metastasis in human lung cancer. Our...

journal_title：Oncology research

authors： Gao X,Gao X,Li C,Zhang Y,Gao L

更新日期：2016-01-01 00:00:00

abstract：:We have compared the effects of a number of inhibitors including aphidicolin, 2,4-dinitrophenol (DNP) and novobiocin on the in vitro cytotoxicity of several topoisomerase II (topo II)-directed agents, using cultured murine Lewis lung carcinoma cells. These agents comprised amsacrine, CI-921 (9-[(2-methoxy-4-methylsulf...

journal_title：Oncology research

authors： Haldane A,Finlay GJ,Baguley BC

更新日期：1993-01-01 00:00:00

abstract：:The aim of this study was to assess serum levels of vascular endothelial growth factor C and D (VEGF-C, VEGF-D) and soluble VEGF receptor 2 (sVEGFR-2) in patients with lung cancer during chemotherapy. The study included 80 patients (64 men and 16 women; mean age 61.1) diagnosed histologically with lung cancer. Forty-f...

journal_title：Oncology research

authors： Naumnik W,Izycki T,Swidzińska E,Ossolińiska M,Chyczewska E

更新日期：2007-01-01 00:00:00

abstract：:The mechanism of action of the anthraquinone antileukemic drug mitoxantrone (MIT) was investigated and compared with that of daunorubicin (DNR) with emphasis on the interaction with DNA to clarify the more potent cytotoxic activity of MIT than DNR in human leukemia cells. MIT showed similar characteristics to those of...

journal_title：Oncology research

authors： Fukushima T,Kawai Y,Nakayama T,Yamauchi T,Yoshida A,Urasaki Y,Imamura S,Kamiya K,Tsutani H,Ueda T,Nakamura T

更新日期：1996-01-01 00:00:00

abstract：:A novel keto-diepoxide Sch 49209 and its derivative Sch 50672, produced by the fungus Nattrassia mangiferae, inhibited tumor cell invasion through an artificial basement membrane. These compounds, at nontoxic concentrations, inhibited invasion of HT-1080 cells in a dose-dependent manner. The IC50 values for Sch 49209 ...

journal_title：Oncology research

authors： King I,Blood C,Chu M,Patel M,Liu M,Li Z,Robertson N,Maxwell E,Catino JJ

更新日期：1995-01-01 00:00:00

abstract：:The regular RIN1 gene is a molecule located on chromosome 1lq13.2, and contains a coding region of 2352 bp with a 3' domain that binds to H-Ras protein, suggesting that it is an important molecule in the intracellular signaling pathway. In this study, we confirmed the existence of a novel form of the RIN1 gene with a ...

journal_title：Oncology research

authors： Fujioka M,Goi T,Hirono Y,Katayama K,Yamaguchi A

更新日期：2009-01-01 00:00:00

abstract：:Cervical cancer is one of the most common neoplastic diseases affecting women, with a combined worldwide incidence of almost half a million new cases. Considering the fact that IL-18 plays an important role in the interactions among T cells, NK cells, and macrophages and induces IFN-gamma production, efforts should be...

journal_title：Oncology research

authors： Sobti RC,Shekari M,Tamandani DM,Malekzadeh K,Suri V

更新日期：2008-01-01 00:00:00

abstract：:Angiogenesis, the formation of new vessels, is essential for tumor growth and metastasis. Mutations of p53 tumor suppressor gene are frequent and play an important role in colorectal oncogenesis. A role of p53 as an angiogenesis inhibitor has also been proposed. We evaluated angiogenesis and p53 expression in 16 hyper...

journal_title：Oncology research

authors： Kakolyris SA,Kaklamanis LG,Koukourakis MJ,Giatromanolaki A,Rousomoustakaki M,Souglakos JC,Reppa DK,Georgoulias VA,Gatter KC,Harris AL

更新日期：2000-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are emerging as pivotal regulators in the development and progression of various cancers, including renal cell carcinoma (RCC). MicroRNA-384 (miR-384) has been found to be an important cancer-related miRNA in several types of cancers. However, the role of miR-384 in RCC remains unclear. In this stud...

journal_title：Oncology research

authors： Song H,Rao Y,Zhang G,Kong X

更新日期：2018-04-10 00:00:00

abstract：:Tripartite motif-containing protein 37 (TRIM37), a new member of the RING-B-box-coiled-coil (RBCC) subfamily of zinc finger proteins, was found to be involved in the development and progression of several cancers. However, the expression pattern and biological functions of TRIM37 in colorectal cancer (CRC) remain unkn...

journal_title：Oncology research

authors： Zhao P,Guan HT,Dai ZJ,Ma YG,Liu XX,Wang XJ

更新日期：2017-01-02 00:00:00

abstract：:Gastric cancer (GC) is the most common epithelial malignancy worldwide. Basic transcription factor 3 (BTF3) plays a crucial role in the regulation of various biological processes. We designed experiments to investigate the molecular mechanism underlying the role of BTF3 in GC cell proliferation and metastasis. We conf...

journal_title：Oncology research

authors： Zhang DZ,Chen BH,Zhang LF,Cheng MK,Fang XJ,Wu XJ

更新日期：2017-11-02 00:00:00

abstract：:The clinical study of compounds that modulate multidrug resistance has been hindered by both the toxicities of these agents and the inability to monitor their effectiveness at the level of the tumor cell. Previously, toremifene has been shown to be well tolerated clinically and to sensitize multidrug resistant cells t...

journal_title：Oncology research

authors： Baker WJ,Maenpaa JU,Wurz GT,Koester SK,Seymour RC,Emshoff VD,Wiebe VJ,DeGregorio MW

更新日期：1993-01-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) are at the foundation of the hematopoietic hierarchy and give rise to all blood lineages in the adult organism. A thorough understanding of the molecular, cellular, and developmental biology of HSCs is of fundamental importance, but is also clinically relevant for the advancement of cel...

journal_title：Oncology research

authors： Robin C,Ottersbach K,de Bruijn M,Ma X,van der Horn K,Dzierzak E

更新日期：2003-01-01 00:00:00

abstract：:Solid tumors involving glandular organs express mucin glycoprotein that is eventually shed into the circulation. As a result, these proteins can easily be measured in the serum and be used as potential tumor markers. The most commonly used tumor markers for breast cancer are CA27-29 and CA15-3, which both measure the ...

journal_title：Oncology research

authors： Copur MS,Wurdeman JM,Nelson D,Ramaekers R,Gauchan D,Crockett D

更新日期：2018-04-10 00:00:00

abstract：:In colorectal cancers, the local cytokine network and the levels of nitric oxide (NO) and reactive oxygen species (ROS) are known to be closely related to cancer progression and metastasis, but the influence of the currently administered therapies on the cancer microenvironment is not completely understood. We analyze...

journal_title：Oncology research

authors： Paduch R,Kandefer-Szerszeń M,Piersiak T

更新日期：2010-01-01 00:00:00

abstract：:Ameloblastoma is the most frequently encountered odontogenic tumor, characterized by a locally invasive behavior, frequent recurrences, and, although rare, metastatic capacity. Loss or inactivation of tumor suppressor genes (TSGs) allows cells to acquire neoplastic growth. The ING family proteins are tumor suppressors...

journal_title：Oncology research

authors： Borkosky SS,Gunduz M,Beder L,Tsujigiwa H,Tamamura R,Gunduz E,Katase N,Rodriguez AP,Sasaki A,Nagai N,Nagatsuka H

更新日期：2010-01-01 00:00:00