Follicle stimulating hormone receptor in ovarian surface epithelium and epithelial ovarian cancer.

Abstract:

:Epithelial ovarian cancer (EOC) has remained an enigmatic disease, the etiology of which is mostly unknown. Considering the age incidence around menopause, a "gonadotrophin theory" has been proposed, and considering the association with infertility, an "incessant ovulation" theory has been proposed. EOC originates from ovarian surface epithelium (OSE), which not only secretes cytokines/growth factors and steroids but expresses gonadotrophin and steroid hormone receptors as well. The most important gonadotrophin receptor is the follicle stimulating hormone receptor (FSHR), which has definite oncogenic potential and is a probable candidate for oncogenesis. In this article, we review existing knowledge of FSHR in ovary, in OSE, and in epithelial ovarian cancer and try to establish relative importance of this receptor over its ligand. A systematic review through PubMed was done on the subject of FSHR and its metabolism. For the obvious difficulty of meager amounts of tissue available, most of studies so far see it in granulosa cells and cell lines rather than in OSE. Thus, effort was made to deduce workable knowledge that can establish its role and can then be applied in OSE and EOC. There is great deal of information regarding metabolism of FSHR, including regulation of its gene expression, isoforms, and pathways of desensitization and degradation with which ovarian cancer etiology researchers have to be familiar with, and there are a number of steps where manipulation may stop carcinogenesis. Hormone therapy of such cancer has so far been only mildly active, probably because we do not understand the role and mechanism of action of FSH and FSHR in the hypothalamo-pituitary-ovarian axis in development of such cancer.

journal_name

Oncol Res

journal_title

Oncology research

authors

Bose CK

doi

10.3727/096504008786111383

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

231-8

issue

5

eissn

0965-0407

issn

1555-3906

journal_volume

17

pub_type

杂志文章,评审
  • miR-133a-3p Targets SUMO-Specific Protease 1 to Inhibit Cell Proliferation and Cell Cycle Progress in Colorectal Cancer.

    abstract::Dysregulation of SUMO-specific protease 1 (SENP1) expression has been reported in several kinds of cancer, including human colorectal and prostate cancers, proposing SENP1 as an oncogene with a critical role in cancer progression. miR-133a-3p has been reported as a tumor suppressor in several malignant neoplasias. How...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X15004613574679

    authors: Zhou GQ,Han F,Shi ZL,Yu L,Li XF,Yu C,Shen CL,Wan DW,Zhu XG,Li R,He SB

    更新日期:2018-06-11 00:00:00

  • Exposure to global system for mobile communication (GSM) cellular phone radiofrequency alters gene expression, proliferation, and morphology of human skin fibroblasts.

    abstract::Human skin fibroblasts were exposed to global system for mobile communication (GSM) cellular phone radiofrequency for 1 h. GSM exposure induced alterations in cell morphology and increased the expression of mitogenic signal transduction genes (e.g., MAP kinase kinase 3, G2/mitotic-specific cyclin G1), cell growth inhi...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504002108747926

    authors: Pacini S,Ruggiero M,Sardi I,Aterini S,Gulisano F,Gulisano M

    更新日期:2002-01-01 00:00:00

  • Tea polyphenols induce apoptosis through mitochondrial pathway and by inhibiting nuclear factor-kappaB and Akt activation in human cervical cancer cells.

    abstract::Phytochemicals present in tea, particularly polyphenols, have anticancer properties against several cancer types. However, studies elucidating the role and the mechanism(s) of action of tea polyphenols in cervical cancer are sparse. In this study, we investigated the mechanism of antiproliferative and apoptotic action...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504011x13021877989711

    authors: Singh M,Singh R,Bhui K,Tyagi S,Mahmood Z,Shukla Y

    更新日期:2011-01-01 00:00:00

  • Heterogeneous expression of DNA topoisomerase II alpha isoforms in tumor cell lines.

    abstract::DNA topoisomerase II alpha is a nuclear enzyme essential for DNA metabolism and cell cycle progression. Previous studies have shown that human tumor cell lines can express more than one topoisomerase II alpha isoform through alternative splicing. A 160-kDa isoform of topoisomerase II alpha has been described in severa...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Mo YY,Beck WT

    更新日期:1997-01-01 00:00:00

  • miR-422a Inhibits Glioma Proliferation and Invasion by Targeting IGF1 and IGF1R.

    abstract::Glioma is a common type of malignant brain tumor characterized by aggressive metastasis capability. Recent evidence has suggested that noncoding RNAs, including microRNAs, have important functions in the pathophysiology of glioma development. In this study, we investigated the biological function of miR-422a in human ...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504016X14732772150389

    authors: Wang H,Tang C,Na M,Ma W,Jiang Z,Gu Y,Ma G,Ge H,Shen H,Lin Z

    更新日期:2017-01-26 00:00:00

  • Piceatannol Enhances the Antitumor Efficacy of Gemcitabine in Human A549 Non-Small Cell Lung Cancer Cells.

    abstract::To enhance the anticancer efficacy of gemcitabine in the treatment of non-small cell lung cancer (NSCLC), the potential synergistic effect of piceatannol on gemcitabine cytotoxicity was investigated in the human NSCLC A459 cell line. The MTT cell viability assay showed that piceatannol significantly enhanced the cytot...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504015X14386062091398

    authors: Xu B,Tao ZZ

    更新日期:2014-01-01 00:00:00

  • Synthesis and biological evaluation of novel bis-aziridinylnaphthoquinone derivatives.

    abstract::A series of bis-aziridinylnaphthoquinone derivatives has been prepared. The cytotoxic activities and DNA alkylation abilities of these synthetic bis-aziridinylnaphthoquinone derivatives were investigated. They displayed significant cytotoxicity against human carcinomna cell lines and weak cytotoxic activities against ...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Huang ST,Kuo HS,Lin CM,Tsai HD,Peng YC,Chen CT,Lin YL

    更新日期:2003-01-01 00:00:00

  • Compassionate use of everolimus in a patient with a neuroendocrine tumor: a case report and discussion of the literature.

    abstract::Neuroendocrine tumors (NETs) represent a relatively rare form of neoplasias for which, in advanced unresectable stages, palliative treatment options remain limited largely to the use of somatostatin analogues or chemotherapy. Several newer targeted therapeutic options, alone or in combination with somatostatin analogu...

    journal_title:Oncology research

    pub_type: 杂志文章,评审

    doi:10.3727/096504011x13123323849799

    authors: Pusceddu S,Milione M,Procopio G

    更新日期:2011-01-01 00:00:00

  • Ursolic Acid Attenuates TGF-β1-Induced Epithelial-Mesenchymal Transition in NSCLC by Targeting Integrin αVβ5/MMPs Signaling.

    abstract::Transforming growth factor-β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) of non-small cell lung cancer (NSCLC) may contribute to tumor metastasis. TGF-β1-induced EMT in H1975 cells (a human NSCLC cell line) resulted in the adoption of mesenchymal responses that were predominantly mediated via the TGF-β1-...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X15051723858706

    authors: Ruan JS,Zhou H,Yang L,Wang L,Jiang ZS,Sun H,Wang SM

    更新日期:2019-05-07 00:00:00

  • Targeted Silencing of Kim-1 Inhibits the Growth of Clear Cell Renal Cell Carcinoma Cell Line 786-0 In Vitro and In Vivo.

    abstract::To investigate the effect of Kim-1 on 786-0 cells in vivo and in vitro, several experiments such as quantitative real-time PCR, Western blot, MTT, colony formation, and flow cytometry were performed to evaluate the biological behavior of 786-0 cells treated with Kim-1 siRNA. Furthermore, the tumor xenograft model was ...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X15140544654946

    authors: Xu J,Sun L,Sun W,Tian J,Guo H

    更新日期:2018-08-23 00:00:00

  • Cellular pharmacology of p120 antisense oligodeoxynucleotide phosphorothioate ISIS 3466.

    abstract::Previous studies demonstrated that an antisense phosphorothioate oligodeoxynucleotide, ISIS 3466, to the human nucleolar p120 protein, markedly inhibited the growth of human tumor cell lines in vitro and inhibited the growth of the human LOX tumor in vivo in an i.p./i.p. model, in the presence of DOTMA (Perlaky et al....

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Saijo Y,Perlaky L,Valdez BC,Wang H,Henning D,Busch H

    更新日期:1993-01-01 00:00:00

  • Detection of Necroptosis in Ligand-Mediated and Hypoxia-Induced Injury of Hepatocytes Using a Novel Optic Probe-Detecting Receptor-Interacting Protein (RIP)1/RIP3 Binding.

    abstract::Liver injury is often observed in various pathological conditions including posthepatectomy state and cancer chemotherapy. It occurs mainly as a consequence of the combined necrotic and apoptotic types of cell death. In order to study liver/hepatocyte injury by the necrotic type of cell death, we studied signal-regula...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X15005102445191

    authors: Haga S,Kanno A,Ozawa T,Morita N,Asano M,Ozaki M

    更新日期:2018-04-10 00:00:00

  • Efficacy and Safety of Drug-Eluting Beads Transarterial Chemoembolization by CalliSpheres® in 275 Hepatocellular Carcinoma Patients: Results From the Chinese CalliSpheres® Transarterial Chemoembolization in Liver Cancer (CTILC) Study.

    abstract::The purpose of this study was to investigate the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) treatment in Chinese hepatocellular carcinoma (HCC) patients and the prognostic factors for treatment response as well as survival. A total of 275 HCC patients were included in this pro...

    journal_title:Oncology research

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.3727/096504019X15662966719585

    authors: Sun J,Zhou G,Xie X,Gu W,Huang J,Zhu D,Hu W,Hou Q,Shi C,Li T,Zhang X,Ji W,Ying S,Peng Z,Zhou J,Yu Z,Ji J,Du H,Guo X,Fang J,Han J,Xu H,Sun Z,Yu W,Shao G,Wu X,Hu H,Li L,Zheng J,Luo J,Chen Y,Cao

    更新日期:2020-02-07 00:00:00

  • CCR5-Delta32 polymorphism and susceptibility to cervical cancer: association with early stage of cervical cancer.

    abstract::Inflammation plays a major role in the pathogenesis of cervical cancer. Chemokines are involved in inflammation, cancer, and infectious diseases. Therefore, we evaluated the association of the chemokine receptor gene polymorphism CCR5 Delta32 with risk of cervical cancer. A total of 150 histopathologically confirmed p...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504008784523667

    authors: Singh H,Sachan R,Jain M,Mittal B

    更新日期:2008-01-01 00:00:00

  • secErbB4-26/549 antagonizes ligand-induced ErbB4 tyrosine phosphorylation.

    abstract::ErbB4 is a member of the ErbB family of receptor tyrosine kinases. Because of a paucity of appropriate pharmacologic tools, little is known about ErbB4 functions in vivo. In response to this need, we hypothesized that a recombinant form of the extracellular domain of ErbB4 would antagonize ligand-induced receptor tyro...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/0965040042707907

    authors: Gilmore JL,Riese DJ 2nd

    更新日期:2004-01-01 00:00:00

  • Comparison of flow cytometry and RT-PCR for the detection of ovarian cancer cells in peripheral blood.

    abstract::Recently, there has been significant effort in developing techniques designed to detect disseminated tumor cells in the peripheral blood (PB). These techniques include immunocytochemical staining of cytocentrifuge slides, flow cytometry, and RT-PCR. Several authors reported various results concerning the sensitivity o...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Stimpfl M,Schmid BC,Obermair A,Tong D,Schiebel I,Gitsch G,Leodolter S,Zeillinger R

    更新日期:1999-01-01 00:00:00

  • miR-186 Represses Proliferation, Migration, Invasion, and EMT of Hepatocellular Carcinoma via Directly Targeting CDK6.

    abstract::The present study aimed to investigate the effect of miR-186 on proliferation, migration, invasion, and epithelialmesenchymal transition (EMT) of hepatocellular carcinoma (HCC). In this work, miR-186 was downregulated in HCC tissues and cells, and low miR-186 level helped predict the occurrence of vascular invasion an...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504020X15954139263808

    authors: Lu J,Zhao Z,Ma Y

    更新日期:2020-12-10 00:00:00

  • miR-767-3p Inhibits Growth and Migration of Lung Adenocarcinoma Cells by Regulating CLDN18.

    abstract::Claudin18 (CLDN18) is necessary for intercellular junctions and is reported to be involved in cell migration and metastasis, making it like an oncogene in various cancer types. However, the biological function and regulatory mechanisms of CLDN18 in lung adenocarcinoma are not yet clear. In this study, we found downreg...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X15112639918174

    authors: Wan YL,Dai HJ,Liu W,Ma HT

    更新日期:2018-05-07 00:00:00

  • UCA1 Regulates the Growth and Metastasis of Pancreatic Cancer by Sponging miR-135a.

    abstract::Pancreatic cancer (PC) is a devastating malignant disease with a poor prognosis. This study aimed to investigate the role of urothelial carcinoma associated 1 (UCA1) in the progression of PC. Our results revealed that long noncoding RNA (lncRNA) UCA1 was overexpressed in PC tissues compared with adjacent histologicall...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X14888987683152

    authors: Zhang X,Gao F,Zhou L,Wang H,Shi G,Tan X

    更新日期:2017-11-02 00:00:00

  • Superior cytotoxic potency of mitoxantrone in interaction with DNA: comparison with that of daunorubicin.

    abstract::The mechanism of action of the anthraquinone antileukemic drug mitoxantrone (MIT) was investigated and compared with that of daunorubicin (DNR) with emphasis on the interaction with DNA to clarify the more potent cytotoxic activity of MIT than DNR in human leukemia cells. MIT showed similar characteristics to those of...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Fukushima T,Kawai Y,Nakayama T,Yamauchi T,Yoshida A,Urasaki Y,Imamura S,Kamiya K,Tsutani H,Ueda T,Nakamura T

    更新日期:1996-01-01 00:00:00

  • Three Combined Treatments, a Novel HDAC Inhibitor OBP-801/YM753, 5-Fluorouracil, and Paclitaxel, Induce G₂ Phase Arrest Through the p38 Pathway in Human Ovarian Cancer Cells.

    abstract::Ovarian cancer is the most lethal disease among gynecological malignancies. More effective therapy is required to counter high recurrence rates and chemotherapy resistance. We investigated the efficacy and molecular mechanisms of three combined treatments (TCTs)-a novel histone deacetylase (HDAC) inhibitor OBP-801/YM7...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X14850164661097

    authors: Akiyama M,Sowa Y,Taniguchi T,Watanabe M,Yogosawa S,Kitawaki J,Sakai T

    更新日期:2017-09-21 00:00:00

  • miR-183 Modulates Cell Apoptosis and Proliferation in Tongue Squamous Cell Carcinoma SCC25 Cell Line.

    abstract::This study was designed to investigate the role of miR-183 in modulating cell growth and apoptosis of tongue squamous cell carcinoma SCC25 cell line. Human squamous epithelial cell and squamous cell carcinoma cell line SCC25 was used, and miR-183 was inhibited. Cell growth, colony formation, and apoptotic rate, as wel...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504016X14685034103239

    authors: Yan D,Cai X,Feng Y

    更新日期:2016-10-27 00:00:00

  • miR-205 Inhibits Neuroblastoma Growth by Targeting cAMP-Responsive Element-Binding Protein 1.

    abstract::Accumulating evidence indicates that microRNA-205 (miR-205) is involved in tumor initiation, development, and metastasis in various cancers. However, its functions in neuroblastoma (NB) remain largely unclear. Here we found that miR-205 was significantly downregulated in human NB tissue samples and cell lines. miR-205...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X14974834436195

    authors: Chen S,Jin L,Nie S,Han L,Lu N,Zhou Y

    更新日期:2018-04-10 00:00:00

  • The Inhibitory Effect of PDIA6 Downregulation on Bladder Cancer Cell Proliferation and Invasion.

    abstract::Protein disulfide isomerases A6 (PDIA6) belongs to the PDI family. Recently, PDIA6 was found to have a close association with various cancers. However, there has been little investigation into the biological functions of PDIA6 in bladder cancer (BC). In this study, we explored the expression pattern and functional sig...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504016X14761811155298

    authors: Cheng HP,Liu Q,Li Y,Li XD,Zhu CY

    更新日期:2017-04-14 00:00:00

  • TNF-alpha induction of A1 expression in human cancer cells.

    abstract::A1, a member of the Bcl-2 gene family, was originally identified as a hemopoietic-specific early response gene. Later it was found that A1 was overexpressed in human stomach cancer tissues and was induced by tumor necrosis factor-alpha (TNF-alpha) in human vascular endothelial cells. However, its expression in human c...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Pang XP,Hershman JM,Karsan A

    更新日期:1997-01-01 00:00:00

  • Influence of pH on the cytotoxicity of cisplatin in EMT6 mouse mammary tumor cells.

    abstract::Pathophysiological factors exist within solid tumors that lead to a low pH environment. Therefore, pH-sensitive cancer chemotherapeutic agents may selectively target and kill tumor cells while sparing the normal tissue from toxicity. Using colony forming assays to assess cell survival, we found that EMT6 mouse mammary...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Laurencot CM,Kennedy KA

    更新日期:1995-01-01 00:00:00

  • O6-Alkylguanine-DNA alkyltransferase in normal colon tissue and colon cancer.

    abstract::O6-Alkylguanine-DNA alkyltransferase (AGT) is a DNA repair protein that reverses alkylation damage produced by chloroethylnitrosoureas and is a major determinant of cellular resistance to adjuvant chemotherapy with these drugs. AGT activity was measured in 119 samples from 69 patients, including normal, tumor, and dis...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: White A,Kibitel J,Garcia Y,Belanich M,Yarosh D,Wideroff J,Levin L,Held D,Fuchs A,Citron M

    更新日期:1997-01-01 00:00:00

  • Therapeutic efficacy of curcumin/TRAIL combination regimen for hormone-refractory prostate cancer.

    abstract::Because of lack of effective treatment options for hormone-refractory prostate cancer at the present time, the need for developing novel therapeutic strategies and targets to treat and prevent the progression of hormone-sensitive prostate cancer to the hormone-refractory stage is paramount. Our previous in vitro studi...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504008786991611

    authors: Andrzejewski T,Deeb D,Gao X,Danyluk A,Arbab AS,Dulchavsky SA,Gautam SC

    更新日期:2008-01-01 00:00:00

  • MicroRNA-21 Inhibits the Apoptosis of Osteosarcoma Cell Line SAOS-2 via Targeting Caspase 8.

    abstract::Currently, multiple microRNAs (miRNAs) have been found to play vital roles in the pathogenesis of osteosarcoma. This study aimed to investigate the role of miR-21 in osteosarcoma. The level of miR-21 in 20 pairs of osteosarcoma and corresponding adjacent tissues was monitored by qPCR. Human osteosarcoma cell line SAOS...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X14841698396829

    authors: Xu B,Xia H,Cao J,Wang Z,Yang Y,Lin Y

    更新日期:2017-08-07 00:00:00

  • Survivin-3B gene decreases the invasion-inhibitory effect of colon cancer cells with 5-fluorouracil.

    abstract::The expression of survivin molecules has been confirmed in many types of cancer cells, including colon cancer cells, and they are considered important antiapoptotic molecules. Recent studies have revealed the existence of different splicing forms of survivin molecules; however, no studies have examined their expressio...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504010x12767359113848

    authors: Sawai K,Goi T,Hirono Y,Katayama K,Yamaguchi A

    更新日期:2010-01-01 00:00:00