MicroRNA-384 Inhibits the Growth and Invasion of Renal Cell Carcinoma Cells by Targeting Astrocyte Elevated Gene 1.

Abstract:

:MicroRNAs (miRNAs) are emerging as pivotal regulators in the development and progression of various cancers, including renal cell carcinoma (RCC). MicroRNA-384 (miR-384) has been found to be an important cancer-related miRNA in several types of cancers. However, the role of miR-384 in RCC remains unclear. In this study, we aimed to investigate the potential function of miR-384 in regulating tumorigenesis in RCC. Here we found that miR-384 was significantly downregulated in RCC tissues and cell lines. Overexpression of miR-384 significantly inhibited the growth and invasion of RCC cells, whereas inhibition of miR-384 had the opposite effects. Bioinformatic analysis and luciferase reporter assay showed that miR-384 directly targeted the 3'-untranslated region of astrocyte elevated gene 1 (AEG-1). Further data showed that miR-384 could negatively regulate the expression of AEG-1 in RCC cells. Importantly, miR-384 expression was inversely correlated with AEG-1 expression in clinical RCC specimens. Moreover, miR-384 regulates the activation of Wnt signaling. Overexpression of AEG-1 significantly reversed the antitumor effects of miR-384. Overall, these findings suggest that miR-384 suppresses the growth and invasion of RCC cells via downregulation of AEG-1, providing a potential therapeutic target for the treatment of RCC.

journal_name

Oncol Res

journal_title

Oncology research

authors

Song H,Rao Y,Zhang G,Kong X

doi

10.3727/096504017X15035025554553

subject

Has Abstract

pub_date

2018-04-10 00:00:00

pages

457-466

issue

3

eissn

0965-0407

issn

1555-3906

journal_volume

26

pub_type

杂志文章
  • MicroRNA-21 Inhibits the Apoptosis of Osteosarcoma Cell Line SAOS-2 via Targeting Caspase 8.

    abstract::Currently, multiple microRNAs (miRNAs) have been found to play vital roles in the pathogenesis of osteosarcoma. This study aimed to investigate the role of miR-21 in osteosarcoma. The level of miR-21 in 20 pairs of osteosarcoma and corresponding adjacent tissues was monitored by qPCR. Human osteosarcoma cell line SAOS...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X14841698396829

    authors: Xu B,Xia H,Cao J,Wang Z,Yang Y,Lin Y

    更新日期:2017-08-07 00:00:00

  • The effect of acquired cisplatin resistance on sensitivity to EGFR tyrosine kinase inhibitors in EGFR mutant lung cancer cells.

    abstract::Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are used as first-line agents for treating nonsquamous cell lung cancer with EGFR mutation, there are many patients who have to receive these drugs following platinum-based chemotherapy. This study was designed to define whether exposure ...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504012x13285365944337

    authors: Rho JK,Choi YJ,Choi YR,Kim SY,Choi SJ,Choi CM,Na II,Lee JC

    更新日期:2011-01-01 00:00:00

  • miR-767-3p Inhibits Growth and Migration of Lung Adenocarcinoma Cells by Regulating CLDN18.

    abstract::Claudin18 (CLDN18) is necessary for intercellular junctions and is reported to be involved in cell migration and metastasis, making it like an oncogene in various cancer types. However, the biological function and regulatory mechanisms of CLDN18 in lung adenocarcinoma are not yet clear. In this study, we found downreg...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X15112639918174

    authors: Wan YL,Dai HJ,Liu W,Ma HT

    更新日期:2018-05-07 00:00:00

  • HPIP Silencing Prevents Epithelial-Mesenchymal Transition Induced by TGF-β1 in Human Ovarian Cancer Cells.

    abstract::Hematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP/PBXIP1) is a nucleo-cytoplasmic shuttling protein, and its expression is associated with cancer aggressiveness. However, the role of HPIP in ovarian cancer is still unclear. Here, we aimed to clarify the role of HPIP in epithelial-m...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504016X14575597858654

    authors: Zhang GY,Liu AH,Li GM,Wang JR

    更新日期:2016-01-01 00:00:00

  • A comparison of the effects of aphidicolin and other inhibitors on topoisomerase II-directed cytotoxic drugs.

    abstract::We have compared the effects of a number of inhibitors including aphidicolin, 2,4-dinitrophenol (DNP) and novobiocin on the in vitro cytotoxicity of several topoisomerase II (topo II)-directed agents, using cultured murine Lewis lung carcinoma cells. These agents comprised amsacrine, CI-921 (9-[(2-methoxy-4-methylsulf...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Haldane A,Finlay GJ,Baguley BC

    更新日期:1993-01-01 00:00:00

  • Superior cytotoxic potency of mitoxantrone in interaction with DNA: comparison with that of daunorubicin.

    abstract::The mechanism of action of the anthraquinone antileukemic drug mitoxantrone (MIT) was investigated and compared with that of daunorubicin (DNR) with emphasis on the interaction with DNA to clarify the more potent cytotoxic activity of MIT than DNR in human leukemia cells. MIT showed similar characteristics to those of...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Fukushima T,Kawai Y,Nakayama T,Yamauchi T,Yoshida A,Urasaki Y,Imamura S,Kamiya K,Tsutani H,Ueda T,Nakamura T

    更新日期:1996-01-01 00:00:00

  • Inhibitory effect of vasoactive intestinal polypeptide (VIP) on experimental liver metastasis by murine colon 26-L5 carcinoma cells.

    abstract::We previously reported that vasoactive intestinal polypeptide (VIP) significantly inhibited Matrigel invasion and haptotactic migration of murine colon 26-L5 carcinoma in vitro. To extend our study, we investigated the inhibitory mechanisms of VIP on Matrigel invasion of colon 26-L5 carcinoma, and the effect on metast...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Ogasawara M,Murata J,Ayukawa K,Saiki I

    更新日期:1998-01-01 00:00:00

  • Inhibition of Proliferation by Knockdown of Transmembrane (TMEM) 168 in Glioblastoma Cells via Suppression of Wnt/β-Catenin Pathway.

    abstract::Human glioblastoma multiforme (GBM) accounts for the majority of human brain gliomas. Several TMEM proteins, such as TMEM 45A, TMEM 97, and TMEM 140, are implicated in human brain gliomas. However, the roles of TMEM168 in human GBM remain poorly understood. Herein we found that mRNA levels of TMEM168 were overexpresse...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504018X15478559215014

    authors: Xu J,Su Z,Ding Q,Shen L,Nie X,Pan X,Yan A,Yan R,Zhou Y,Li L,Lu B

    更新日期:2019-07-12 00:00:00

  • Piceatannol Enhances the Antitumor Efficacy of Gemcitabine in Human A549 Non-Small Cell Lung Cancer Cells.

    abstract::To enhance the anticancer efficacy of gemcitabine in the treatment of non-small cell lung cancer (NSCLC), the potential synergistic effect of piceatannol on gemcitabine cytotoxicity was investigated in the human NSCLC A459 cell line. The MTT cell viability assay showed that piceatannol significantly enhanced the cytot...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504015X14386062091398

    authors: Xu B,Tao ZZ

    更新日期:2014-01-01 00:00:00

  • miR-183 Modulates Cell Apoptosis and Proliferation in Tongue Squamous Cell Carcinoma SCC25 Cell Line.

    abstract::This study was designed to investigate the role of miR-183 in modulating cell growth and apoptosis of tongue squamous cell carcinoma SCC25 cell line. Human squamous epithelial cell and squamous cell carcinoma cell line SCC25 was used, and miR-183 was inhibited. Cell growth, colony formation, and apoptotic rate, as wel...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504016X14685034103239

    authors: Yan D,Cai X,Feng Y

    更新日期:2016-10-27 00:00:00

  • Bone marrow-derived progenitor cells could modulate pancreatic cancer tumorigenesis via peritumoral microenvironment in a rat model.

    abstract::Metaplastic tubular complexes (MTC) have been proposed as precursor lesions for pancreatic adenocarcinoma (PDAC). In this study, we investigated the potential role of bone marrow-derived progenitor cells (BMPC) in the formation of MTC and PDAC in a rat model. F344 rats defective for CD26 (dipeptidyl peptidase IV, DPPI...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504009788428424

    authors: Pan JJ,Oh SH,Lee WC,Petersen BE

    更新日期:2009-01-01 00:00:00

  • Methionine dependence of tumor cells: programmed cell survival?

    abstract::A majority of tumor cell lines are considered to be "methionine-dependent" because of their inability to grow in culture when methionine is replaced by its precursor, homocysteine. We have previously shown that this phenotype is not due to the incapacity to synthesize methionine from homocysteine but rather to a defic...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Dumontet C,Roch AM,Quash G

    更新日期:1996-01-01 00:00:00

  • miR-632 Promotes Laryngeal Carcinoma Cell Proliferation, Migration, and Invasion Through Negative Regulation of GSK3β.

    abstract::Laryngeal cancer, one of the most common head and neck malignancies, is an aggressive neoplasm. Increasing evidence has demonstrated that microRNAs (miRNAs) exert important roles in oncogenesis and progression of diverse types of human cancers. miR-632, a tumor-related miRNA, has been reported to be dysregulated and i...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504018X15213142076069

    authors: Zhou ZX,Zhang ZP,Tao ZZ,Tan TZ

    更新日期:2020-02-07 00:00:00

  • Elemene Increases Autophagic Apoptosis and Drug Sensitivity in Human Cisplatin (DDP)-Resistant Lung Cancer Cell Line SPC-A-1/DDP By Inducing Beclin-1 Expression.

    abstract::Drug resistance is the major obstacle for the successful therapy of lung adenocarcinoma. It was suggested that ß-elemene, a major isoform of elemene, could reverse the drug resistance in lung cancer cells. However, the underlying mechanisms remains poorly known. Here, we aimed to investigate whether elemene is involve...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X14954936991990

    authors: Zhou K,Wang L,Cheng R,Liu X,Mao S,Yan Y

    更新日期:2017-05-23 00:00:00

  • miR-186 Represses Proliferation, Migration, Invasion, and EMT of Hepatocellular Carcinoma via Directly Targeting CDK6.

    abstract::The present study aimed to investigate the effect of miR-186 on proliferation, migration, invasion, and epithelialmesenchymal transition (EMT) of hepatocellular carcinoma (HCC). In this work, miR-186 was downregulated in HCC tissues and cells, and low miR-186 level helped predict the occurrence of vascular invasion an...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504020X15954139263808

    authors: Lu J,Zhao Z,Ma Y

    更新日期:2020-12-10 00:00:00

  • A Wnt Pathway Activator Induces Apoptosis and Cell Death in Mouse Monocytic Leukemia Cells.

    abstract::A Wnt agonist, 2-amino-4-[3,4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl) pyrimidine, is a cell-permeable pyrimidine compound that has been shown to mimic the effect of Wnt. In this study, leukemic mouse cell lines, RAW 264.7 and J774.1, were incubated with the Wnt agonist. The Wnt agonist showed cell death in th...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504016X14721731148893

    authors: Kato Y,Naiki Y,Komatsu T,Takahashi K,Nakamura J,Koide N

    更新日期:2017-04-14 00:00:00

  • Toremifene enhances cell cycle block and growth inhibition by vinblastine in multidrug resistant human breast cancer cells.

    abstract::The clinical study of compounds that modulate multidrug resistance has been hindered by both the toxicities of these agents and the inability to monitor their effectiveness at the level of the tumor cell. Previously, toremifene has been shown to be well tolerated clinically and to sensitize multidrug resistant cells t...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Baker WJ,Maenpaa JU,Wurz GT,Koester SK,Seymour RC,Emshoff VD,Wiebe VJ,DeGregorio MW

    更新日期:1993-01-01 00:00:00

  • Detection of Necroptosis in Ligand-Mediated and Hypoxia-Induced Injury of Hepatocytes Using a Novel Optic Probe-Detecting Receptor-Interacting Protein (RIP)1/RIP3 Binding.

    abstract::Liver injury is often observed in various pathological conditions including posthepatectomy state and cancer chemotherapy. It occurs mainly as a consequence of the combined necrotic and apoptotic types of cell death. In order to study liver/hepatocyte injury by the necrotic type of cell death, we studied signal-regula...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X15005102445191

    authors: Haga S,Kanno A,Ozawa T,Morita N,Asano M,Ozaki M

    更新日期:2018-04-10 00:00:00

  • DNA damage, gene expression, growth arrest and cell death.

    abstract::The sequence of biochemical and molecular events that mediate growth arrest and cell death in tumor cells exposed to agents that induce DNA damage is poorly defined. This commentary exploits the recent explosion of information regarding oncogenes, tumor suppressor genes, and cell-cycle regulatory genes to develop a mo...

    journal_title:Oncology research

    pub_type: 杂志文章,评审

    doi:

    authors: Gewirtz DA

    更新日期:1993-01-01 00:00:00

  • Potential Role of CD133 Expression in the Susceptibility of Human Liver Cancer Stem-Like Cells to TRAIL.

    abstract::Hepatocellular carcinoma (HCC) is one of the most common malignancies, with a poor prognosis and high recurrence rate. In the present study, we identified CD133, one of the markers of cancer stem cells, as a novel molecular target of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). In four human HCC ce...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504016X14685034103950

    authors: Lee SH,Hyun SK,Kim HB,Kang CD,Kim SH

    更新日期:2016-10-27 00:00:00

  • miRNA-214 Inhibits Cellular Proliferation and Migration in Glioma Cells Targeting Caspase 1 Involved in Pyroptosis.

    abstract::Pyroptosis is a type of proinflammatory programmed cell death mediated by caspase 1 activity and occurs in several types of eukaryotic tumor cells, including gliomas. MicroRNAs (miRNAs), small endogenous noncoding RNAs, have been demonstrated to be advantageous in glioma therapy. However, the question of whether miRNA...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504016X14813859905646

    authors: Jiang Z,Yao L,Ma H,Xu P,Li Z,Guo M,Chen J,Bao H,Qiao S,Zhao Y,Shen J,Zhu M,Meyers C,Ma G,Xie C,Liu L,Wang H,Zhang W,Dong Q,Shen H,Lin Z

    更新日期:2017-07-05 00:00:00

  • Tea polyphenols induce apoptosis through mitochondrial pathway and by inhibiting nuclear factor-kappaB and Akt activation in human cervical cancer cells.

    abstract::Phytochemicals present in tea, particularly polyphenols, have anticancer properties against several cancer types. However, studies elucidating the role and the mechanism(s) of action of tea polyphenols in cervical cancer are sparse. In this study, we investigated the mechanism of antiproliferative and apoptotic action...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504011x13021877989711

    authors: Singh M,Singh R,Bhui K,Tyagi S,Mahmood Z,Shukla Y

    更新日期:2011-01-01 00:00:00

  • Developmental origins of hematopoietic stem cells.

    abstract::Hematopoietic stem cells (HSCs) are at the foundation of the hematopoietic hierarchy and give rise to all blood lineages in the adult organism. A thorough understanding of the molecular, cellular, and developmental biology of HSCs is of fundamental importance, but is also clinically relevant for the advancement of cel...

    journal_title:Oncology research

    pub_type: 杂志文章,评审

    doi:10.3727/096504003108748519

    authors: Robin C,Ottersbach K,de Bruijn M,Ma X,van der Horn K,Dzierzak E

    更新日期:2003-01-01 00:00:00

  • secErbB4-26/549 antagonizes ligand-induced ErbB4 tyrosine phosphorylation.

    abstract::ErbB4 is a member of the ErbB family of receptor tyrosine kinases. Because of a paucity of appropriate pharmacologic tools, little is known about ErbB4 functions in vivo. In response to this need, we hypothesized that a recombinant form of the extracellular domain of ErbB4 would antagonize ligand-induced receptor tyro...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/0965040042707907

    authors: Gilmore JL,Riese DJ 2nd

    更新日期:2004-01-01 00:00:00

  • Characterization of insulin-like growth factor receptors in the insulin-responsive R3230AC mammary adenocarcinoma.

    abstract::To ascertain whether insulin-like growth factors (IGF-1 and IGF-2) affect the estrogen- and insulin-responsive R3230AC mammary carcinoma, studies of IGF-1 and IGF-2 receptors were conducted on primary-culture tumor cells and on membranes purified from whole tumors. By saturation binding analysis, cells in culture disp...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Korc-Grodzicki B,Furlanetto RW,Hilf R

    更新日期:1992-01-01 00:00:00

  • Antitumor effect of keto-diepoxides isolated from the fungus Nattrassia mangiferae.

    abstract::A novel keto-diepoxide Sch 49209 and its derivative Sch 50672, produced by the fungus Nattrassia mangiferae, inhibited tumor cell invasion through an artificial basement membrane. These compounds, at nontoxic concentrations, inhibited invasion of HT-1080 cells in a dose-dependent manner. The IC50 values for Sch 49209 ...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: King I,Blood C,Chu M,Patel M,Liu M,Li Z,Robertson N,Maxwell E,Catino JJ

    更新日期:1995-01-01 00:00:00

  • G-Protein Signaling Protein-17 (RGS17) Is Upregulated and Promotes Tumor Growth and Migration in Human Colorectal Carcinoma.

    abstract::Colorectal carcinoma is one of the leading causes of cancer-related deaths and has a high tendency for metastasis, which makes it a priority to find novel methods to diagnose and treat colorectal carcinoma at a very early stage. We studied the role of the regulator of G-protein signaling (RGS) family of proteins RGS17...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X14900515946914

    authors: Li L,Luo HS

    更新日期:2018-01-19 00:00:00

  • Inhibition of Carbonic Anhydrase IX by Ureidosulfonamide Inhibitor U104 Reduces Prostate Cancer Cell Growth, But Does Not Modulate Daunorubicin or Cisplatin Cytotoxicity.

    abstract::Carbonic anhydrase (CA) IX has emerged as a promising target for cancer therapy. It is highly upregulated in hypoxic regions and mediates pH regulation critical for tumor cell survival as well as extracellular acidification of the tumor microenvironment, which promotes tumor aggressiveness via various mechanisms, such...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X14965111926391

    authors: Riemann A,Güttler A,Haupt V,Wichmann H,Reime S,Bache M,Vordermark D,Thews O

    更新日期:2018-03-05 00:00:00

  • Cloning of a novel splicing variant of RIN1 and its expression in gastric and colon cancer.

    abstract::The regular RIN1 gene is a molecule located on chromosome 1lq13.2, and contains a coding region of 2352 bp with a 3' domain that binds to H-Ras protein, suggesting that it is an important molecule in the intracellular signaling pathway. In this study, we confirmed the existence of a novel form of the RIN1 gene with a ...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504009789745566

    authors: Fujioka M,Goi T,Hirono Y,Katayama K,Yamaguchi A

    更新日期:2009-01-01 00:00:00

  • PAQR3 Inhibits the Proliferation and Tumorigenesis in Esophageal Cancer Cells.

    abstract::Progestin and adipoQ receptor family member III (PAQR3), a member of the PAQR family, is frequently downregulated in different types of human cancer. However, its expression and functions in esophageal cancer are still unknown. This study aimed to explore the expression of PAQR3 in esophageal cancer cell lines and to ...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504016X14761384026719

    authors: Zhou F,Wang S,Wang J

    更新日期:2017-05-24 00:00:00