Cisplatin resistance in an ovarian carcinoma is associated with a defect in programmed cell death control through XIAP regulation.

abstract：:Ovarian cancer is highly malignant with a gradually increasing incidence and a high mortality rate. Immunosuppression is induced in ovarian cancer, although the mechanism detail is not clear. It has been indicated that HVEM (herpesvirus entry mediator) B- and T-lymphocyte attenuator (BTLA) negatively regulates the imm...

journal_title：Oncology research

authors： Zhang T,Ye L,Han L,He Q,Zhu J

更新日期：2016-01-01 00:00:00

abstract：:Numerous data indicate that cellular oxidoreductases may be responsible for the cardiotoxic effects of antitumor anthracycline drugs as a consequence of the mediation by these agents of one-electron transfer from reduced nucleotides to atmospheric oxygen. This process is catalyzed primarily by NADH dehydrogenase, NADP...

journal_title：Oncology research

authors： Pawłowska J,Priebe W,Paine MJ,Wolf CR,Borowski E,Tarasiuk J

更新日期：2004-01-01 00:00:00

abstract：:The potential of American ginseng (AG) ( Panax quinquefolium), a commonly used herbal remedy believed to have anticarcinogenic effects, to prevent the development of mammary tumors was evaluated in a mouse model of dimethylbenzanthracene (DMBA)-induced mammary carcinoma. Ginsenosides, believed to be the active compone...

journal_title：Oncology research

authors： Wurz GT,Marchisano-Karpman C,DeGregorio MW

更新日期：2006-01-01 00:00:00

abstract：:Colorectal cancer is an aggressive malignancy for which there are limited treatment options. Oncolytic vaccinia virus isbeing developed as a novel strategy for cancer therapy. Arming vaccinia virus with immunostimulatory cytokines can enhance the tumor cell-specific replication and antitumor efficacy. Interleukin-24 (...

journal_title：Oncology research

authors： Deng L,Yang X,Fan J,Ding Y,Peng Y,Xu D,Huang B,Hu Z

更新日期：2020-07-08 00:00:00

abstract：:Progestin and adipoQ receptor family member III (PAQR3), a member of the PAQR family, is frequently downregulated in different types of human cancer. However, its expression and functions in esophageal cancer are still unknown. This study aimed to explore the expression of PAQR3 in esophageal cancer cell lines and to ...

journal_title：Oncology research

authors： Zhou F,Wang S,Wang J

更新日期：2017-05-24 00:00:00

abstract：:Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are used as first-line agents for treating nonsquamous cell lung cancer with EGFR mutation, there are many patients who have to receive these drugs following platinum-based chemotherapy. This study was designed to define whether exposure ...

journal_title：Oncology research

authors： Rho JK,Choi YJ,Choi YR,Kim SY,Choi SJ,Choi CM,Na II,Lee JC

更新日期：2011-01-01 00:00:00

abstract：:We previously reported that 9-methylstreptimidone, a piperidine compound isolated from a culture filtrate of Streptomyces, induces apoptosis selectively in adult T-cell leukemia cells. It was screened for a compound that inhibits LPS-induced NF-kappaB and NO production in mouse macrophages. However, 9-methystreptimido...

journal_title：Oncology research

authors： Takeiri M,Ota E,Nishiyama S,Kiyota H,Umezawa K

更新日期：2012-01-01 00:00:00

abstract：:Venous thromboembolism (VTE) occurs at an increased incidence in cancer patients. A cancer-related hypercoagulable state has been considered to play role in this phenomenon. Preclinical data suggest an association between tumor expression of MET proto-oncogene (MET) and a hypercoagulable state, resulting in VTE. We in...

journal_title：Oncology research

authors： Sayar H,Bunning JT,Bocklage TJ,Lee SJ,Libby E,Rabinowitz I

更新日期：2010-01-01 00:00:00

abstract：:It has been reported that upregulated SIRT1 (NAD(+)-dependent class III histone deacetylase) deacetylates the p53 protein, represses its function, and allows for tumor cell growth in various cancers. Here we investigated antitumor effects of tenovin-6, a small-molecule inhibitor of SIRT1 and SIRT2, in various colon ca...

journal_title：Oncology research

authors： Ueno T,Endo S,Saito R,Hirose M,Hirai S,Suzuki H,Yamato K,Hyodo I

更新日期：2013-01-01 00:00:00

abstract：:Human colon tumor cell lines that were adapted to grow in chemically defined medium were tested for their growth sensitivity to exogenous transferrin, insulin, and epidermal growth factor (EGF). Less differentiated cell lines, C and HCT116, were able to grow in the presence of a single peptide supplement, to respond s...

journal_title：Oncology research

authors： Yeoman LC,Wan CW,Zorbas MA

更新日期：1996-01-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is commonly overexpressed in non-small cell lung cancer (NSCLC) and its tyrosine kinase phosphorylation is thought to be an ideal target in the treatment of patients with NSCLC. In the present study, we examined surgically obtained specimens from a series of 36 NSCLC patients fo...

journal_title：Oncology research

authors： Kanematsu T,Yano S,Uehara H,Bando Y,Sone S

更新日期：2003-01-01 00:00:00

abstract：:PPAR-gamma is known to have a growth-suppressive effect in different cancers. In this study, we investigated the role of PPAR-gamma in the development of Barrett's esophagus (BE) and esophageal adenocarcinoma (EA). We used immunohistochemistry and real-time PCR to analyze differences in PPAR-gamma protein and mRNA exp...

journal_title：Oncology research

authors： Wang W,Wang R,Zhang Z,Li D,Yut Y

更新日期：2011-01-01 00:00:00

abstract：:Kiss-1 has been identified as a putative metastasis suppressor gene in various human malignancies. However, there is little information about its possible role in gastric carcinoma. In this study, we determined whether the Kiss-1 gene negatively regulates MMP-9 expression. cDNA microarray technology was used to identi...

journal_title：Oncology research

authors： Lee KH,Kim JR

更新日期：2009-01-01 00:00:00

abstract：:Accumulating evidence indicates that microRNA-205 (miR-205) is involved in tumor initiation, development, and metastasis in various cancers. However, its functions in neuroblastoma (NB) remain largely unclear. Here we found that miR-205 was significantly downregulated in human NB tissue samples and cell lines. miR-205...

journal_title：Oncology research

authors： Chen S,Jin L,Nie S,Han L,Lu N,Zhou Y

更新日期：2018-04-10 00:00:00

abstract：:Sixteen desmuramyl analogs of muramyl dipeptide (MDP) were tested for their abilities to stimulate cytotoxic factor secretion by mouse peritoneal macrophages. Among them, the pseudohexapeptide Boc-Gly psi [CH2O]-D-Ala-Ala-D-Glu[Lys(H-Gly)NHEt]-NH2 appeared to be four times more effective than MDP. From this study, the...

journal_title：Oncology research

authors： Breton P,Petit C,Bousser MT,Monsigny M,Mayer R,Roche AC

更新日期：1992-01-01 00:00:00

abstract：:It has been demonstrated that microRNAs (miRNAs) act as oncogenes or tumor suppressors in a variety of cancers. Our previous work suggested that miR-10a/b functioned as a tumor suppressor in gastric cancer, and miR-10b was also reported to be significantly downregulated in advanced stage cervical cancer tissues. Howev...

journal_title：Oncology research

authors： Zou D,Zhou Q,Wang D,Guan L,Yuan L,Li S

更新日期：2016-01-01 00:00:00

abstract：:Ameloblastoma is the most frequently encountered odontogenic tumor, characterized by a locally invasive behavior, frequent recurrences, and, although rare, metastatic capacity. Loss or inactivation of tumor suppressor genes (TSGs) allows cells to acquire neoplastic growth. The ING family proteins are tumor suppressors...

journal_title：Oncology research

authors： Borkosky SS,Gunduz M,Beder L,Tsujigiwa H,Tamamura R,Gunduz E,Katase N,Rodriguez AP,Sasaki A,Nagai N,Nagatsuka H

更新日期：2010-01-01 00:00:00

abstract：:Protein disulfide isomerases A6 (PDIA6) belongs to the PDI family. Recently, PDIA6 was found to have a close association with various cancers. However, there has been little investigation into the biological functions of PDIA6 in bladder cancer (BC). In this study, we explored the expression pattern and functional sig...

journal_title：Oncology research

authors： Cheng HP,Liu Q,Li Y,Li XD,Zhu CY

更新日期：2017-04-14 00:00:00

abstract：:Agosterol A (AG-A) is a novel agent that reverses P-glycoprotein (P-gp) and multidrug resistance protein-1 (MRP1)-meditated multidrug resistance (MDR). We have synthesized [125I]11-azidophenyl agosterol A (azidoAG-A), a photoaffinity analog of AG-A, and characterized its binding to P-gp in membrane vesicles prepared f...

journal_title：Oncology research

authors： Mitsuo M,Noguchi T,Nakajima Y,Aoki S,Ren XQ,Sumizawa T,Haraguchi M,Kobayashi M,Baba M,Nagata Y,Akiyama S,Furukawa T

更新日期：2003-01-01 00:00:00

abstract：:Hematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP/PBXIP1) is a nucleo-cytoplasmic shuttling protein, and its expression is associated with cancer aggressiveness. However, the role of HPIP in ovarian cancer is still unclear. Here, we aimed to clarify the role of HPIP in epithelial-m...

journal_title：Oncology research

authors： Zhang GY,Liu AH,Li GM,Wang JR

更新日期：2016-01-01 00:00:00

abstract：:The anticancer drug Adriamycin is widely used in cancer chemotherapy and is classified as a topoisomerase II inhibitor. However, in the presence of formaldehyde, Adriamycin also forms high levels of DNA adducts. In this study, a new series of butyric acid and formaldehyde-releasing drugs related to AN9 (pivaloyloxymet...

journal_title：Oncology research

authors： Cutts SM,Nudelman A,Pillay V,Spencer DM,Levovich I,Rephaeli A,Phillips DR

更新日期：2005-01-01 00:00:00

abstract：:We have compared the effects of a number of inhibitors including aphidicolin, 2,4-dinitrophenol (DNP) and novobiocin on the in vitro cytotoxicity of several topoisomerase II (topo II)-directed agents, using cultured murine Lewis lung carcinoma cells. These agents comprised amsacrine, CI-921 (9-[(2-methoxy-4-methylsulf...

journal_title：Oncology research

authors： Haldane A,Finlay GJ,Baguley BC

更新日期：1993-01-01 00:00:00

abstract：:We have investigated the role of protein kinase C (PKC) in the multidrug resistance (MDR) phenotype of human KB carcinoma cell lines. The PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced daunomycin accumulation in both drug-sensitive KB-3-1 and MDR KB-C1 cells in a time-dependent manner. The inactive p...

journal_title：Oncology research

authors： Drew L,Groome N,Warr JR,Rumsby MG

更新日期：1996-01-01 00:00:00

abstract：:Ubiquitin-specific protease 22 (USP22), a novel deubiquitinating enzyme, belongs to an extended family of proteins that have ubiquitin hydrolase activity. Recently, USP22 has attracted widespread attention because of its implication in carcinogenesis. However, there have been no studies, to our knowledge, investigatin...

journal_title：Oncology research

authors： Zhang D,Jiang F,Wang X,Li G

更新日期：2017-05-24 00:00:00

abstract：:A series of bis-aziridinylnaphthoquinone derivatives has been prepared. The cytotoxic activities and DNA alkylation abilities of these synthetic bis-aziridinylnaphthoquinone derivatives were investigated. They displayed significant cytotoxicity against human carcinomna cell lines and weak cytotoxic activities against ...

journal_title：Oncology research

authors： Huang ST,Kuo HS,Lin CM,Tsai HD,Peng YC,Chen CT,Lin YL

更新日期：2003-01-01 00:00:00

abstract：:The sequence of biochemical and molecular events that mediate growth arrest and cell death in tumor cells exposed to agents that induce DNA damage is poorly defined. This commentary exploits the recent explosion of information regarding oncogenes, tumor suppressor genes, and cell-cycle regulatory genes to develop a mo...

journal_title：Oncology research

authors： Gewirtz DA

更新日期：1993-01-01 00:00:00

abstract：:We investigated the susceptibility of three inbred strains of rats to the hepatocarcinogen, N-nitrosomorpholine (NNM), to establish a spontaneous metastatic model of hepatocellular carcinoma (HCC). WS/Shi. SD/gShi, and F344/DuCrj rats were given 0.02% NNM in drinking water for 8 weeks and thereafter left without any t...

journal_title：Oncology research

authors： Murai T,Mori S,Hosono M,Iwakura Y,Takashima A,Oohara T,Makino S,Takeda R,Fukushima S

更新日期：2000-01-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is an uncommon and highly aggressive tumor of the neuroendocrine system, which derives from the neuroendocrine C cells of the thyroid gland. Except for surgical resection, there are not very many effective systemic treatment options for MTC. N-Myc downstream-regulated gene 2 (NDRG2) h...

journal_title：Oncology research

authors： Yin A,Wang C,Sun J,Gao J,Tao L,Du X,Zhao H,Yang J,Li Y

更新日期：2016-01-01 00:00:00

abstract：:Phytochemicals present in tea, particularly polyphenols, have anticancer properties against several cancer types. However, studies elucidating the role and the mechanism(s) of action of tea polyphenols in cervical cancer are sparse. In this study, we investigated the mechanism of antiproliferative and apoptotic action...

journal_title：Oncology research

authors： Singh M,Singh R,Bhui K,Tyagi S,Mahmood Z,Shukla Y

更新日期：2011-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated mortality worldwide. Although the mechanisms of HCC progression are not well understood, recent studies demonstrated the potential contribution of uric acid transporter SLC2A9 to tumor suppression. However, the roles and underlying mechanis...

journal_title：Oncology research

authors： Han X,Yang J,Li D,Guo Z

更新日期：2019-05-07 00:00:00