Abstract:
:Hematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP/PBXIP1) is a nucleo-cytoplasmic shuttling protein, and its expression is associated with cancer aggressiveness. However, the role of HPIP in ovarian cancer is still unclear. Here, we aimed to clarify the role of HPIP in epithelial-mesenchymal transition (EMT) process of ovarian cancer cells, stimulated by transforming growth factor (TGF)-β1. In this study, we found that HPIP was highly expressed in ovarian cancer cells, and TGF-β1 treatment induced HPIP expression in ovarian cancer cells. In addition, knockdown of HPIP suppressed TGF-β1-induced EMT and migration/invasion in ovarian cancer cells. Moreover, knockdown of HPIP significantly blocked the phosphorylated pattern of both PI3K and Akt induced by TGF-β1 in SKOV3 cells. In conclusion, the present study showed that HPIP silencing might prevent TGF-β1-induced EMT in ovarian cancer cells. Thus, HPIP may be a potential therapeutic target for the treatment of ovarian cancer.
journal_name
Oncol Resjournal_title
Oncology researchauthors
Zhang GY,Liu AH,Li GM,Wang JRdoi
10.3727/096504016X14575597858654subject
Has Abstractpub_date
2016-01-01 00:00:00pages
33-9issue
1eissn
0965-0407issn
1555-3906journal_volume
24pub_type
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504012x13342463747450
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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doi:10.3727/096504013X13685487925095
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journal_title:Oncology research
pub_type: 杂志文章
doi:
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journal_title:Oncology research
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journal_title:Oncology research
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doi:10.3727/096504017X14882829077237
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journal_title:Oncology research
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