Abstract:
:To enhance the anticancer efficacy of gemcitabine in the treatment of non-small cell lung cancer (NSCLC), the potential synergistic effect of piceatannol on gemcitabine cytotoxicity was investigated in the human NSCLC A459 cell line. The MTT cell viability assay showed that piceatannol significantly enhanced the cytotoxic effects of gemcitabine by lowering the gemcitabine IC50 value. Flow cytometry analysis revealed that piceatannol exerted its pharmacological effect mainly by increasing the late apoptotic population. Western blot analysis showed that gemcitabine induced the expression of the proapoptotic proteins Bad and Bak, and pretreatment with piceatannol further increased Bak expression, leading to an increased number of cells undergoing late apoptosis. The findings from this study show that piceatannol can enhance the cytotoxic effects of gemcitabine by enhancing expression of the proapoptotic protein Bak, thereby providing the rational basis for a novel combination strategy for the treatment of NSCLC.
journal_name
Oncol Resjournal_title
Oncology researchauthors
Xu B,Tao ZZdoi
10.3727/096504015X14386062091398subject
Has Abstractpub_date
2014-01-01 00:00:00pages
213-7issue
4eissn
0965-0407issn
1555-3906journal_volume
22pub_type
杂志文章abstract::Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the initiation and development of many solid tumors, including osteosarcoma (OS). In this study, we showed that MALAT1 was increased in human OS tissues and cell lines. MALAT1 knockdown suppressed OS ce...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X14957939026111
更新日期:2018-04-27 00:00:00
abstract::The poly(ADP-ribose) polymerase (PARP) enzymes play a key role in the regulation of cellular processes (e.g., DNA damage repair, genomic stability). It has been shown that PARP inhibitors (PARPIs) are selectively cytotoxic against cells having dysfunctions in genes involved in DNA repair mechanisms (synthetic lethalit...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X14926854178616
更新日期:2017-11-02 00:00:00
abstract::Treatment of female SKH-1 hairless mice with ultraviolet B light twice a week for 20 weeks resulted in a population of tumor-free mice with a high risk of developing skin tumors during the next several months in the absence of additional UVB treatment (high-risk mice). Topical applications of nondenatured soymilk but ...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/0965040041292350
更新日期:2004-01-01 00:00:00
abstract::Claudin18 (CLDN18) is necessary for intercellular junctions and is reported to be involved in cell migration and metastasis, making it like an oncogene in various cancer types. However, the biological function and regulatory mechanisms of CLDN18 in lung adenocarcinoma are not yet clear. In this study, we found downreg...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X15112639918174
更新日期:2018-05-07 00:00:00
abstract::Epidermal growth factor receptor (EGFR) is commonly overexpressed in non-small cell lung cancer (NSCLC) and its tyrosine kinase phosphorylation is thought to be an ideal target in the treatment of patients with NSCLC. In the present study, we examined surgically obtained specimens from a series of 36 NSCLC patients fo...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504003108748348
更新日期:2003-01-01 00:00:00
abstract::Because of lack of effective treatment options for hormone-refractory prostate cancer at the present time, the need for developing novel therapeutic strategies and targets to treat and prevent the progression of hormone-sensitive prostate cancer to the hormone-refractory stage is paramount. Our previous in vitro studi...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504008786991611
更新日期:2008-01-01 00:00:00
abstract::Medullary thyroid carcinoma (MTC) is an uncommon and highly aggressive tumor of the neuroendocrine system, which derives from the neuroendocrine C cells of the thyroid gland. Except for surgical resection, there are not very many effective systemic treatment options for MTC. N-Myc downstream-regulated gene 2 (NDRG2) h...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504015X14452563486093
更新日期:2016-01-21 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504010x12671222663593
更新日期:2010-01-01 00:00:00
abstract::A1, a member of the Bcl-2 gene family, was originally identified as a hemopoietic-specific early response gene. Later it was found that A1 was overexpressed in human stomach cancer tissues and was induced by tumor necrosis factor-alpha (TNF-alpha) in human vascular endothelial cells. However, its expression in human c...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Adaptive changes occurring in C1300 murine neuroblastoma cell lines developed for resistance to nucleoside analogue inhibitors of S-adenosyl-L-homocysteine hydrolase (AdoHcyase, EC 3.3.1.1) were investigated. Two drug-resistant cell lines, rMNB-MDL-7-2 and rMNB-Deaz-7-2, were established from wild-type C1300 neuroblas...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Transforming growth factor-β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) of non-small cell lung cancer (NSCLC) may contribute to tumor metastasis. TGF-β1-induced EMT in H1975 cells (a human NSCLC cell line) resulted in the adoption of mesenchymal responses that were predominantly mediated via the TGF-β1-...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X15051723858706
更新日期:2019-05-07 00:00:00
abstract:: THIS ARTICLE WAS WITHDRAWN BY THE PUBLISHER IN NOVEMBER 2020. ...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504018X15165493852990
更新日期:2018-10-17 00:00:00
abstract::PPAR-gamma is known to have a growth-suppressive effect in different cancers. In this study, we investigated the role of PPAR-gamma in the development of Barrett's esophagus (BE) and esophageal adenocarcinoma (EA). We used immunohistochemistry and real-time PCR to analyze differences in PPAR-gamma protein and mRNA exp...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504011x12935427587849
更新日期:2011-01-01 00:00:00
abstract::Medullary thyroid carcinoma (MTC) is an uncommon and highly aggressive tumor of the neuroendocrine system, which derives from the neuroendocrine C cells of the thyroid gland. Except for surgical resection, there are not very many effective systemic treatment options for MTC. N-Myc downstream-regulated gene 2 (NDRG2) h...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504015X14452563486093
更新日期:2016-01-01 00:00:00
abstract::The beta-adrenergic receptors transduce catecholamine signals to the G protein, which through a cascade of chemical reactions in cells generates highly specific parallel signals. The beta2-adrenergic receptor (ADRB2) is the most involved in the carcinogenic processes. Previous studies have determined the relationship ...
journal_title:Oncology research
pub_type: 杂志文章,评审
doi:10.3727/096504010x12828372551867
更新日期:2010-01-01 00:00:00
abstract::Although arsenic trioxide (ATO) is a well-known antileukemic drug used for acute promyelocytic leukemia treatment, the development of ATO resistance is still a big challenge. We previously reported that microRNA-204 (miR-204) was involved in the regulation of acute myeloid leukemia (AML) cell apoptosis, but its role i...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504019X15528367532612
更新日期:2019-09-23 00:00:00
abstract::Laryngeal cancer, one of the most common head and neck malignancies, is an aggressive neoplasm. Increasing evidence has demonstrated that microRNAs (miRNAs) exert important roles in oncogenesis and progression of diverse types of human cancers. miR-632, a tumor-related miRNA, has been reported to be dysregulated and i...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504018X15213142076069
更新日期:2020-02-07 00:00:00
abstract::The ability of mitoxantrone to form DNA adducts was investigated in a series of human tumor cell lines consisting of human cervical cancer (HeLa), human breast cancer (MCF-7), and human neuroblastoma (IMR-32) cells. The mitoxantrone-resistant human promyelocytic leukemia cell line HL60/MX2 was also compared to the par...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504003773994815
更新日期:2004-01-01 00:00:00
abstract::Recently, increasing evidence has shown that CDGSH iron sulfur domain 2 (CISD2) is involved in the initiation and metastasis of several cancers. However, the evidence of its potential role in pancreatic cancer is still lacking. In our present study, CISD2 was found to be increased in pancreatic cancer samples and mult...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504016X14767450526417
更新日期:2017-04-14 00:00:00
abstract::3'-Azido-3'-deoxythymidine (AZT) competitively inhibited the transport of thymidine (Km = 0.23 mM) into human erythrocytes with a Ki of 1.0 mM at 37 degrees C. The principal human metabolite of AZT in plasma, the 5'-glucuronide (GAZT), was a weak inhibitor of the nucleoside transporter (< 20% inhibition of the influx ...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::The pre-mRNA splicing regulator serine-arginine protein kinase 1 (SRPK1), a member of the SR kinase family, plays an essential role in cancer development and various pathophysiological processes. However, its expression pattern and functions in renal cell carcinoma (RCC) remain unknown. Therefore, the aim of this stud...
journal_title:Oncology research
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doi:10.3727/096504016X14743324568129
更新日期:2017-03-13 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504016X14685034103239
更新日期:2016-10-27 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504014X13983417587320
更新日期:2013-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Recently, there has been significant effort in developing techniques designed to detect disseminated tumor cells in the peripheral blood (PB). These techniques include immunocytochemical staining of cytocentrifuge slides, flow cytometry, and RT-PCR. Several authors reported various results concerning the sensitivity o...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504001108747594
更新日期:2000-01-01 00:00:00
abstract::Lung cancer is the leading cause of deaths due to cancer. Studies suggest an important role of microRNAs (miRNAs) in a variety of cancers, including lung cancer. In the present study, we evaluated the role of miR-641 in human lung cancer A549 cells. Quantitative RT-PCR and Western blot were used to measure mRNA and pr...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X15021536183490
更新日期:2018-06-11 00:00:00
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journal_title:Oncology research
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更新日期:2002-01-01 00:00:00
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journal_title:Oncology research
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/000000003108747983
更新日期:2003-01-01 00:00:00