Abstract:
:The pre-mRNA splicing regulator serine-arginine protein kinase 1 (SRPK1), a member of the SR kinase family, plays an essential role in cancer development and various pathophysiological processes. However, its expression pattern and functions in renal cell carcinoma (RCC) remain unknown. Therefore, the aim of this study was to assess the role of SRPK1 in RCC. Our data showed that SRPK1 was significantly upregulated in human RCC tissues and cell lines. SRPK1 interference significantly inhibited the proliferation of RCC cells and inhibited tumor growth in vivo. In addition, SRPK1 interference also suppressed migration and invasion in RCC cells. A mechanistic study showed that SRPK1 interference inhibited the phosphorylation of PI3K and Akt in RCC cells. In conclusion, our findings suggest that SRPK1 interference inhibits the growth and invasion of RCC cells through suppressing the PI3K/Akt signaling pathway. Thus, SRPK1 might be a therapeutic target for the treatment of RCC.
journal_name
Oncol Resjournal_title
Oncology researchauthors
Han X,Yang J,Jia Z,Wei P,Zhang H,Lv W,Sun J,Huo Qdoi
10.3727/096504016X14743324568129subject
Has Abstractpub_date
2017-03-13 00:00:00pages
389-395issue
3eissn
0965-0407issn
1555-3906pii
content-orm-a-770_hanjournal_volume
25pub_type
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