G-Protein Signaling Protein-17 (RGS17) Is Upregulated and Promotes Tumor Growth and Migration in Human Colorectal Carcinoma.

abstract：:Oncogene Bmi-1 (B-cell-specific Moloney murine leukemia virus integration site 1) has attracted much attention for its involvement in the initiation of a variety of tumors. Our previous study showed that Bmi-1 was highly expressed in gastric cancer and correlated with patient prognosis. However, whether aberrant Bmi-1...

journal_title：Oncology research

authors： Chen Y,Lian G,Zhang Q,Zeng L,Qian C,Chen S,Huang K

更新日期：2013-01-01 00:00:00

abstract：:3'-Azido-3'-deoxythymidine (AZT) competitively inhibited the transport of thymidine (Km = 0.23 mM) into human erythrocytes with a Ki of 1.0 mM at 37 degrees C. The principal human metabolite of AZT in plasma, the 5'-glucuronide (GAZT), was a weak inhibitor of the nucleoside transporter (< 20% inhibition of the influx ...

journal_title：Oncology research

authors： Zimmerman TP,Domin BA,Mahony WB

更新日期：1993-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies, with a poor prognosis and high recurrence rate. In the present study, we identified CD133, one of the markers of cancer stem cells, as a novel molecular target of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). In four human HCC ce...

journal_title：Oncology research

authors： Lee SH,Hyun SK,Kim HB,Kang CD,Kim SH

更新日期：2016-10-27 00:00:00

abstract：:Ubiquitin-specific protease 22 (USP22), a novel deubiquitinating enzyme, belongs to an extended family of proteins that have ubiquitin hydrolase activity. Recently, USP22 has attracted widespread attention because of its implication in carcinogenesis. However, there have been no studies, to our knowledge, investigatin...

journal_title：Oncology research

authors： Zhang D,Jiang F,Wang X,Li G

更新日期：2017-05-24 00:00:00

abstract：:Human skin fibroblasts were exposed to global system for mobile communication (GSM) cellular phone radiofrequency for 1 h. GSM exposure induced alterations in cell morphology and increased the expression of mitogenic signal transduction genes (e.g., MAP kinase kinase 3, G2/mitotic-specific cyclin G1), cell growth inhi...

journal_title：Oncology research

authors： Pacini S,Ruggiero M,Sardi I,Aterini S,Gulisano F,Gulisano M

更新日期：2002-01-01 00:00:00

abstract：:Cyclin Y (CCNY) is a novel cyclin and almost nothing is known about its expression level and role in human cancers. In the present study, we found that lentivirus-mediated RNA interference (RNAi) of CCNY significantly downregulated its expression level. More importantly, knockdown of CCNY inhibited cell proliferation,...

journal_title：Oncology research

authors： Xu Y,Wang Z,Wang J,Li J,Wang H,Yue W

更新日期：2010-01-01 00:00:00

abstract：:Synthesis of poly(gamma-glutamyl) metabolites of many antifolates, such as methotrexate (MTX), by folylpolyglutamate synthetase (FPGS) is often essential to their cytotoxic activity. FPGS expression in the MTX-sensitive human T-lymphoblastic leukemia cell line CCRF-CEM and a number of MTX-resistant sublines was previo...

journal_title：Oncology research

authors： McGuire JJ,Russell CA

更新日期：1998-01-01 00:00:00

abstract：:This study aimed to explore the effects of lncRNA BCAR4 on the viability and aggressiveness of non-small cell lung cancer (NSCLC) cells. qRT-PCR was used to determine the expression of BCAR4 and GLI2 downstream genes in NSCLC tissues and cell lines. Chromatin isolation by RNA purification (CHIRP) and Western blot were...

journal_title：Oncology research

authors： Yang H,Yan L,Sun K,Sun X,Zhang X,Cai K,Song T

更新日期：2019-02-21 00:00:00

abstract：:A majority of tumor cell lines are considered to be "methionine-dependent" because of their inability to grow in culture when methionine is replaced by its precursor, homocysteine. We have previously shown that this phenotype is not due to the incapacity to synthesize methionine from homocysteine but rather to a defic...

journal_title：Oncology research

authors： Dumontet C,Roch AM,Quash G

更新日期：1996-01-01 00:00:00

abstract：:Our recent studies have shown that vanadium, a dietary micronutrient, has an inhibitory response against experimentally induced rat liver carcinogenesis. In the present study, the effect of vanadium on hepatic xenobiotic biotransformation in rats exposed to diethylnitrosamine (DENA, 200 mg/kg, IP) was investigated to ...

journal_title：Oncology research

authors： Bishayee A,Roy S,Chatterjee M

更新日期：1999-01-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) play a predominant role in regulating tumor progression. Understanding how CAFs communicate with osteosarcoma is crucial for developing novel approaches for osteosarcoma therapy. Exosomes are able to transmit messages between cells. In this study, we demonstrated that CAFs transfer...

journal_title：Oncology research

authors： Wang JW,Wu XF,Gu XJ,Jiang XH

更新日期：2019-09-23 00:00:00

abstract：:Astragaloside IV (AS-IV) is an active ingredient in Astragalus membranaceus and is involved in various biological processes, such as regulating the immune system, and counteracting inflammation and malignancy. The aim of this study was to explore the effect of AS-IV on non-small cell lung cancer (NSCLC) cells. Cell co...

journal_title：Oncology research

authors： Jia L,Lv D,Zhang S,Wang Z,Zhou B

更新日期：2019-03-29 00:00:00

abstract：:Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the initiation and development of many solid tumors, including osteosarcoma (OS). In this study, we showed that MALAT1 was increased in human OS tissues and cell lines. MALAT1 knockdown suppressed OS ce...

journal_title：Oncology research

authors： Zhang Y,Dai Q,Zeng F,Liu H

更新日期：2018-04-27 00:00:00

abstract：:It has been reported that upregulated SIRT1 (NAD(+)-dependent class III histone deacetylase) deacetylates the p53 protein, represses its function, and allows for tumor cell growth in various cancers. Here we investigated antitumor effects of tenovin-6, a small-molecule inhibitor of SIRT1 and SIRT2, in various colon ca...

journal_title：Oncology research

authors： Ueno T,Endo S,Saito R,Hirose M,Hirai S,Suzuki H,Yamato K,Hyodo I

更新日期：2013-01-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) are at the foundation of the hematopoietic hierarchy and give rise to all blood lineages in the adult organism. A thorough understanding of the molecular, cellular, and developmental biology of HSCs is of fundamental importance, but is also clinically relevant for the advancement of cel...

journal_title：Oncology research

authors： Robin C,Ottersbach K,de Bruijn M,Ma X,van der Horn K,Dzierzak E

更新日期：2003-01-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is commonly overexpressed in non-small cell lung cancer (NSCLC) and its tyrosine kinase phosphorylation is thought to be an ideal target in the treatment of patients with NSCLC. In the present study, we examined surgically obtained specimens from a series of 36 NSCLC patients fo...

journal_title：Oncology research

authors： Kanematsu T,Yano S,Uehara H,Bando Y,Sone S

更新日期：2003-01-01 00:00:00

abstract：:Numerous data indicate that cellular oxidoreductases may be responsible for the cardiotoxic effects of antitumor anthracycline drugs as a consequence of the mediation by these agents of one-electron transfer from reduced nucleotides to atmospheric oxygen. This process is catalyzed primarily by NADH dehydrogenase, NADP...

journal_title：Oncology research

authors： Pawłowska J,Priebe W,Paine MJ,Wolf CR,Borowski E,Tarasiuk J

更新日期：2004-01-01 00:00:00

abstract：:Apoptosis proteins may play a role in prognosis and therapy response; however, they have not been fully investigated in gastric cancer. We aimed to assess the expression of proteins in the Bcl-2 family. Immunohistochemistry was employed to examine the expression of the antiapoptotic proteins Bcl-2 and Bcl-XL and the p...

journal_title：Oncology research

authors： Smith L,Berrieman HK,O'Kane SL,Campbell A,Maraveyas A,Cawkwell L

更新日期：2006-01-01 00:00:00

abstract：:HeLa cells were transfected with full-length multidrug resistance protein (MRP) cDNA and with MRP cDNAs that had been mutated at certain nucleotide binding domains. Stable transfectants were isolated and those producing equivalent amounts of P190 were tested in cytotoxicity assays using a variety of chemotherapeutic a...

journal_title：Oncology research

authors： Zhu Q,Sun H,Center MS

更新日期：1997-01-01 00:00:00

abstract：:We evaluated the effects of ultrasound-mediated microbubble transfection of VEGF-C siRNA on breast cancer cells in vitro and in vivo. MCF-7 cells were transfected with VEGF-C siRNA and the protein and mRNA expression of VEGF-C was tested using Western blot and qRT-PCR. Twenty nude mice tumors were established by injec...

journal_title：Oncology research

authors： Xu Q,Sun T,Tian H,Wang C,Zhou H

更新日期：2013-01-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) plays an important role in the progression of several malignancies including breast cancer. However, its role in breast cancer metastasis is still ambiguous. In this study, we observed the effect of HO-1 on mouse mammary carcinoma metastasis using the in vivo tumor metastasis model. Our results...

journal_title：Oncology research

authors： Li Q,Liu Q,Cheng W,Wei H,Jiang W,E F,Yu Y,Jin J,Zou C

更新日期：2019-06-21 00:00:00

abstract：:Grb2-associated binder 1 (Gab1) is often aberrant in cancerous cells and tissues, whose alteration is responsible for aggressive phenotypes. In this study, we examined the Gab1 expression in human oral squamous cell carcinoma (OSCC) tissues and investigated the cellular and molecular effect of Gab1 on migration, invas...

journal_title：Oncology research

authors： Xu L,Li J,Kuang Z,Kuang Y,Wu H

更新日期：2018-05-07 00:00:00

abstract：:Increasing evidence shows that beyond its role in coagulation, thrombosis interferes with carcinogenesis. Endothelial cell protein C receptor (EPCR) is a cellular receptor for protein C and activated protein C (APC). Such EPCR-induced signal transduction promotes cancer cell migration, invasion, and angiogenesis and i...

journal_title：Oncology research

authors： Heng W,Huang JA,Wang ZY

更新日期：2012-01-01 00:00:00

abstract：:Ovarian cancer is the most lethal disease among gynecological malignancies. More effective therapy is required to counter high recurrence rates and chemotherapy resistance. We investigated the efficacy and molecular mechanisms of three combined treatments (TCTs)-a novel histone deacetylase (HDAC) inhibitor OBP-801/YM7...

journal_title：Oncology research

authors： Akiyama M,Sowa Y,Taniguchi T,Watanabe M,Yogosawa S,Kitawaki J,Sakai T

更新日期：2017-09-21 00:00:00

abstract：:Mutational inactivation of the cyclin-dependent kinase inhibitors (CDKIs) (p16INK4A/MTS1) tumor suppressor gene has been found in a variety of human tumor types. To investigate the involvement of CDKI abnormality in mesenchymal chondrosarcoma, alterations of CDKIs were examined in human mesenchymal chondrosarcoma tiss...

journal_title：Oncology research

authors： Bae DK,Park YK,Chi SG,Lee CW,Unni KK

更新日期：2000-01-01 00:00:00

abstract：:Osteosarcoma is the most common primary bone malignancy manifested predominantly in children and young adults. Studies indicate that miR-107 is involved in the pathogenesis of osteosarcoma and that tropomyosin 1 (TPM1) acts as a tumor suppressor in many types of cancer. In this study, we analyzed the effect of miR-107...

journal_title：Oncology research

authors： Jiang R,Zhang C,Liu G,Gu R,Wu H

更新日期：2017-09-21 00:00:00

abstract：:Expression of sphingosine kinase 1 (SPHK1) plays a role in colorectal cancer progression. This study aimed to demonstrate the mechanism of human colorectal cancer cell metastatic phenotype through SPHK1 knockdown. Human colorectal cancer HT-29 cells were stimulated by phorbol 12-myristate 13-acetate (PMA) with or with...

journal_title：Oncology research

authors： Qin MB,Huang JA,Liu SQ,Tang GD,Jiang HX

更新日期：2011-01-01 00:00:00

abstract：:Liver injury is often observed in various pathological conditions including posthepatectomy state and cancer chemotherapy. It occurs mainly as a consequence of the combined necrotic and apoptotic types of cell death. In order to study liver/hepatocyte injury by the necrotic type of cell death, we studied signal-regula...

journal_title：Oncology research

authors： Haga S,Kanno A,Ozawa T,Morita N,Asano M,Ozaki M

更新日期：2018-04-10 00:00:00

abstract：:Phytochemicals present in tea, particularly polyphenols, have anticancer properties against several cancer types. However, studies elucidating the role and the mechanism(s) of action of tea polyphenols in cervical cancer are sparse. In this study, we investigated the mechanism of antiproliferative and apoptotic action...

journal_title：Oncology research

authors： Singh M,Singh R,Bhui K,Tyagi S,Mahmood Z,Shukla Y

更新日期：2011-01-01 00:00:00

abstract：:Chemoresistance is a major impediment to the successful treatment of cancer. It involves various mechanisms, including defects in the apoptosis program that is induced by anticancer drugs. To further explore the mechanisms underlying the development of chemoresistance in ovarian carcinoma after cisplatin (CDDP) treatm...

journal_title：Oncology research

authors： Mansouri A,Zhang Q,Ridgway LD,Tian L,Claret FX

更新日期：2003-01-01 00:00:00