Abstract:
:Oncogene Bmi-1 (B-cell-specific Moloney murine leukemia virus integration site 1) has attracted much attention for its involvement in the initiation of a variety of tumors. Our previous study showed that Bmi-1 was highly expressed in gastric cancer and correlated with patient prognosis. However, whether aberrant Bmi-1 expression was critical for the transformation of gastric epithelial cells remains unknown. In this study, we stably expressed Bmi-1 in a human gastric epithelial immortalized cell line, GES-1. The overexpression of Bmi-1 promoted cell growth and proliferation, inhibited apoptosis, enhanced clone formation capability, possessed the characteristics of anchorage-independent growth, and increased migration and invasion abilities. Therefore, our findings demonstrated that ectopic expression of Bmi-1 played an important role in the malignant transformation of gastric epithelial cells.
journal_name
Oncol Resjournal_title
Oncology researchauthors
Chen Y,Lian G,Zhang Q,Zeng L,Qian C,Chen S,Huang Kdoi
10.3727/096504013X13786659070316subject
Has Abstractpub_date
2013-01-01 00:00:00pages
33-41issue
1eissn
0965-0407issn
1555-3906journal_volume
21pub_type
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journal_title:Oncology research
pub_type: 杂志文章
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journal_title:Oncology research
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504016X14813859905646
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journal_title:Oncology research
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doi:
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journal_title:Oncology research
pub_type: 杂志文章
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abstract::Ahead of Print article withdrawn by publisher. ...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504016X14747357310629
更新日期:2016-09-30 00:00:00
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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doi:10.3727/096504017X15005102445191
更新日期:2018-04-10 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504018X15188747585738
更新日期:2018-10-17 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504016X14816352324532
更新日期:2017-07-05 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章,评审
doi:10.3727/096504010x12828372551867
更新日期:2010-01-01 00:00:00
abstract::Accumulation of beta-catenin in cytoplasm and nuclei is frequently observed in a wide variety of tumors arising, for example, in the colon, liver, uterus, or brain. In association with Tcf/LEF transcription factors, beta-catenin regulates expression of genes involved in the Wnt/wingless signaling pathway, but the prec...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504001108747477
更新日期:2001-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X15128550060375
更新日期:2018-04-10 00:00:00
abstract::Accumulating evidence indicates that microRNA-205 (miR-205) is involved in tumor initiation, development, and metastasis in various cancers. However, its functions in neuroblastoma (NB) remain largely unclear. Here we found that miR-205 was significantly downregulated in human NB tissue samples and cell lines. miR-205...
journal_title:Oncology research
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doi:10.3727/096504017X14974834436195
更新日期:2018-04-10 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504020X15954139263808
更新日期:2020-12-10 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504018X15220594629967
更新日期:2019-02-21 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504008785114156
更新日期:2008-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504005776382305
更新日期:2005-01-01 00:00:00
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journal_title:Oncology research
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doi:
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X14886494526344
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abstract:: THIS ARTICLE WAS WITHDRAWN BY THE PUBLISHER IN NOVEMBER 2020. ...
journal_title:Oncology research
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doi:10.3727/096504018X15165493852990
更新日期:2018-10-17 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
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abstract::Adaptive changes occurring in C1300 murine neuroblastoma cell lines developed for resistance to nucleoside analogue inhibitors of S-adenosyl-L-homocysteine hydrolase (AdoHcyase, EC 3.3.1.1) were investigated. Two drug-resistant cell lines, rMNB-MDL-7-2 and rMNB-Deaz-7-2, were established from wild-type C1300 neuroblas...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Pancreatic cancer is characterized as a type of gastrointestinal tumor with a poor prognosis and high degree of malignancy. CIITA gene was found highly methylated in pancreatic carcinoma cell line PANC-1 and responsible for the low expression of major histocompatability complex II (MHC-II) that may lead to immune evas...
journal_title:Oncology research
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doi:10.3727/096504014X13983417587320
更新日期:2013-01-01 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504016X14575597858654
更新日期:2016-01-01 00:00:00
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journal_title:Oncology research
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doi:10.3727/000000006783981017
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journal_title:Oncology research
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doi:10.3727/096504019X15753718797664
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journal_title:Oncology research
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doi:
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