Abstract:
:Pyroptosis is a type of proinflammatory programmed cell death mediated by caspase 1 activity and occurs in several types of eukaryotic tumor cells, including gliomas. MicroRNAs (miRNAs), small endogenous noncoding RNAs, have been demonstrated to be advantageous in glioma therapy. However, the question of whether miRNAs regulate pyroptosis in glioma remains unknown. The current study found that caspase 1 expression was substantially increased in both glioma tissues and glioma cell lines, U87 and T98G, while miR-214 expression was significantly downregulated. Luciferase reporter assay recognized caspase 1 as a target gene of miR-214. These findings demonstrate that miR-214 could inhibit cell proliferation and migration through the regulation of pyroptosis intermediated by caspase 1 in glioma U87 and T98G cells and may suggest a novel therapeutic for the intervention of glioma.
journal_name
Oncol Resjournal_title
Oncology researchauthors
Jiang Z,Yao L,Ma H,Xu P,Li Z,Guo M,Chen J,Bao H,Qiao S,Zhao Y,Shen J,Zhu M,Meyers C,Ma G,Xie C,Liu L,Wang H,Zhang W,Dong Q,Shen H,Lin Zdoi
10.3727/096504016X14813859905646subject
Has Abstractpub_date
2017-07-05 00:00:00pages
1009-1019issue
6eissn
0965-0407issn
1555-3906journal_volume
25pub_type
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