Abstract:
:Cancer-associated fibroblasts (CAFs) play a predominant role in regulating tumor progression. Understanding how CAFs communicate with osteosarcoma is crucial for developing novel approaches for osteosarcoma therapy. Exosomes are able to transmit messages between cells. In this study, we demonstrated that CAFs transfer exosomes to osteosarcoma cells, which promotes osteosarcoma cell migration and invasion. Using a miRNA microarray analysis, we identified 13 miRNAs that are significantly increased in exosomes derived from cancer-associated fibroblasts (CAFs) and corresponding paracancer fibroblasts (PAFs). In vitro studies further validated that the levels of microRNA-1228 (miR-1228) were increased in CAFs, its secreted exosomes, and in recipient osteosarcoma cells, which can downregulate endogenous SCAI mRNA and protein level in osteosarcoma. Furthermore, our findings demonstrate that SCAI was downregulated in osteosarcoma tissues. Taken together, this study provides evidence that CAF exosomal miR-1228 is able to promote osteosarcoma invasion and migration by targeting SCAI, which may represent a critical therapeutic target for osteosarcoma treatment.
journal_name
Oncol Resjournal_title
Oncology researchauthors
Wang JW,Wu XF,Gu XJ,Jiang XHdoi
10.3727/096504018X15336368805108subject
Has Abstractpub_date
2019-09-23 00:00:00pages
979-986issue
9eissn
0965-0407issn
1555-3906journal_volume
27pub_type
杂志文章abstract::This study evaluated the survival effects of metronomic maintenance therapy with oral fluoropyrimidine in patients with stage III colorectal cancer (CRC) according to epidermal growth factor receptor (EGFR) expression. We enrolled 197 patients with stage III CRC who had undergone radical resection and FOLFOX regimen a...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504020X15986099915822
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abstract::Liver injury is often observed in various pathological conditions including posthepatectomy state and cancer chemotherapy. It occurs mainly as a consequence of the combined necrotic and apoptotic types of cell death. In order to study liver/hepatocyte injury by the necrotic type of cell death, we studied signal-regula...
journal_title:Oncology research
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504005776568246
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journal_title:Oncology research
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doi:10.3727/096504013X13685487925095
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abstract::A series of bis-aziridinylnaphthoquinone derivatives has been prepared. The cytotoxic activities and DNA alkylation abilities of these synthetic bis-aziridinylnaphthoquinone derivatives were investigated. They displayed significant cytotoxicity against human carcinomna cell lines and weak cytotoxic activities against ...
journal_title:Oncology research
pub_type: 杂志文章
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abstract::To ascertain whether insulin-like growth factors (IGF-1 and IGF-2) affect the estrogen- and insulin-responsive R3230AC mammary carcinoma, studies of IGF-1 and IGF-2 receptors were conducted on primary-culture tumor cells and on membranes purified from whole tumors. By saturation binding analysis, cells in culture disp...
journal_title:Oncology research
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abstract::Currently, multiple microRNAs (miRNAs) have been found to play vital roles in the pathogenesis of osteosarcoma. This study aimed to investigate the role of miR-21 in osteosarcoma. The level of miR-21 in 20 pairs of osteosarcoma and corresponding adjacent tissues was monitored by qPCR. Human osteosarcoma cell line SAOS...
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
pub_type: 杂志文章,评审
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journal_title:Oncology research
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journal_title:Oncology research
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doi:10.3727/096504017X14888987683152
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journal_title:Oncology research
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doi:10.3727/096504012x13522227232156
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journal_title:Oncology research
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更新日期:2003-01-01 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504018X15199489058224
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journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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