Induction of hepatocellular carcinoma with high metastatic potential in WS/Shi rats: discovery of an inbred strain highly susceptible to the liver carcinogen N-nitrosomorpholine.

abstract：:Recently, increasing evidence has shown that CDGSH iron sulfur domain 2 (CISD2) is involved in the initiation and metastasis of several cancers. However, the evidence of its potential role in pancreatic cancer is still lacking. In our present study, CISD2 was found to be increased in pancreatic cancer samples and mult...

journal_title：Oncology research

authors： Yang Y,Bai YS,Wang Q

更新日期：2017-04-14 00:00:00

abstract：:Spinal osteosarcoma (OS) is a malignant tumor that has a poor outcome. MicroRNA-520b (miR-520b) acts as a cancer suppressor in various types of cancer. Because of the limited amount of literature on OS, we aimed to identify the role of miR-520b in OS. The miR-520b level in clinical spinal OS tissues and adjacent nontu...

journal_title：Oncology research

authors： Wang J,Pang W,Zuo Z,Zhang W,He W

更新日期：2017-09-21 00:00:00

abstract：:Recently, there has been significant effort in developing techniques designed to detect disseminated tumor cells in the peripheral blood (PB). These techniques include immunocytochemical staining of cytocentrifuge slides, flow cytometry, and RT-PCR. Several authors reported various results concerning the sensitivity o...

journal_title：Oncology research

authors： Stimpfl M,Schmid BC,Obermair A,Tong D,Schiebel I,Gitsch G,Leodolter S,Zeillinger R

更新日期：1999-01-01 00:00:00

abstract：:Ameloblastoma is the most frequently encountered odontogenic tumor, characterized by a locally invasive behavior, frequent recurrences, and, although rare, metastatic capacity. Loss or inactivation of tumor suppressor genes (TSGs) allows cells to acquire neoplastic growth. The ING family proteins are tumor suppressors...

journal_title：Oncology research

authors： Borkosky SS,Gunduz M,Beder L,Tsujigiwa H,Tamamura R,Gunduz E,Katase N,Rodriguez AP,Sasaki A,Nagai N,Nagatsuka H

更新日期：2010-01-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is an uncommon and highly aggressive tumor of the neuroendocrine system, which derives from the neuroendocrine C cells of the thyroid gland. Except for surgical resection, there are not very many effective systemic treatment options for MTC. N-Myc downstream-regulated gene 2 (NDRG2) h...

journal_title：Oncology research

authors： Yin A,Wang C,Sun J,Gao J,Tao L,Du X,Zhao H,Yang J,Li Y

更新日期：2016-01-21 00:00:00

abstract：:Carbonic anhydrase (CA) IX has emerged as a promising target for cancer therapy. It is highly upregulated in hypoxic regions and mediates pH regulation critical for tumor cell survival as well as extracellular acidification of the tumor microenvironment, which promotes tumor aggressiveness via various mechanisms, such...

journal_title：Oncology research

authors： Riemann A,Güttler A,Haupt V,Wichmann H,Reime S,Bache M,Vordermark D,Thews O

更新日期：2018-03-05 00:00:00

abstract：:The patterns of DNA fragmentation were evaluated following a brief exposure (2 h) of the human ileocecal adenocarcinoma cell line, HCT-8, to several specific thymidylate synthase inhibitors, a quinazoline (ZD1694) and benz[cd]indole-containing molecule (AG-331). The magnitude and size of DNA fragmentation induced by t...

journal_title：Oncology research

authors： Panadero A,Yin MB,Voigt W,Rustum YM

更新日期：1995-01-01 00:00:00

abstract：:The expression of survivin molecules has been confirmed in many types of cancer cells, including colon cancer cells, and they are considered important antiapoptotic molecules. Recent studies have revealed the existence of different splicing forms of survivin molecules; however, no studies have examined their expressio...

journal_title：Oncology research

authors： Sawai K,Goi T,Hirono Y,Katayama K,Yamaguchi A

更新日期：2010-01-01 00:00:00

abstract：:Empty spiracles homeobox 2 (EMX2) is a homeodomain-containing transcription factor that plays an essential role in tumorigenesis. However, to the best of our knowledge, the role of EMX2 in human colorectal cancer (CRC) is still unclear. Thus, the aim of this study was to investigate the expression and role of EMX2 in ...

journal_title：Oncology research

authors： Zhang Y,Cao G,Yuan QG,Li JH,Yang WB

更新日期：2017-04-14 00:00:00

abstract：:Agosterol A (AG-A) is a novel agent that reverses P-glycoprotein (P-gp) and multidrug resistance protein-1 (MRP1)-meditated multidrug resistance (MDR). We have synthesized [125I]11-azidophenyl agosterol A (azidoAG-A), a photoaffinity analog of AG-A, and characterized its binding to P-gp in membrane vesicles prepared f...

journal_title：Oncology research

authors： Mitsuo M,Noguchi T,Nakajima Y,Aoki S,Ren XQ,Sumizawa T,Haraguchi M,Kobayashi M,Baba M,Nagata Y,Akiyama S,Furukawa T

更新日期：2003-01-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is an uncommon and highly aggressive tumor of the neuroendocrine system, which derives from the neuroendocrine C cells of the thyroid gland. Except for surgical resection, there are not very many effective systemic treatment options for MTC. N-Myc downstream-regulated gene 2 (NDRG2) h...

journal_title：Oncology research

authors： Yin A,Wang C,Sun J,Gao J,Tao L,Du X,Zhao H,Yang J,Li Y

更新日期：2016-01-01 00:00:00

abstract：:MTA1 was reported as a metastasis-associated gene. Tumors with higher MTA1 mRNA level were shown to have higher rates of invasion and lymph node metastasis and tended to have higher rates of vascular involvement. The majority of invasive breast carcinomas were demonstrated to overexpress MTA1 compared to surrounding n...

journal_title：Oncology research

authors： Tong D,Heinze G,Schremmer M,Schuster E,Czerwenka K,Leodolter S,Zeillinger R

更新日期：2007-01-01 00:00:00

abstract：:The potency of flavonoids (isoflavones, flavones, and flavanones) to inhibit efflux of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein (BCPCF) from human erythrocytes was investigated. Structure-activity relationship analysis showed that the strongest inhibitors were found among flavanones bearing a hydrophobic pren...

journal_title：Oncology research

authors： Bobrowska-Hägerstrand M,Wróbel A,Mrówczyńska L,Söderström T,Shirataki Y,Motohashi N,Molnár J,Michalak K,Hägerstrand H

更新日期：2003-01-01 00:00:00

abstract：:Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are used as first-line agents for treating nonsquamous cell lung cancer with EGFR mutation, there are many patients who have to receive these drugs following platinum-based chemotherapy. This study was designed to define whether exposure ...

journal_title：Oncology research

authors： Rho JK,Choi YJ,Choi YR,Kim SY,Choi SJ,Choi CM,Na II,Lee JC

更新日期：2011-01-01 00:00:00

abstract：:DT-diaphorase [also called NAD(P)H:menadione oxidoreductase; NAD(P)H:(quinone acceptor) oxidoreductase; quinone reductase, azo-dye reductase] (EC.1.6.99.2) has been shown to have a role in activation of quinone-containing cancer chemotherapeutic prodrugs to their active form, as well as inactivation of a variety of xe...

journal_title：Oncology research

authors： Rauth AM,Goldberg Z,Misra V

更新日期：1997-01-01 00:00:00

abstract：:Topotecan, a topoisomerase I poison and water-soluble derivative of camptothecin, has shown promise in treating solid tumors; however, the drug is unstable under physiological conditions and converts to an inactive form within 30 minutes. Encapsulating topotecan in liposomes (LIP-TPT) minimizes inactivation. The effic...

journal_title：Oncology research

authors： Subramanian D,Muller MT

更新日期：1995-01-01 00:00:00

abstract：:Colorectal carcinoma is one of the leading causes of cancer-related deaths and has a high tendency for metastasis, which makes it a priority to find novel methods to diagnose and treat colorectal carcinoma at a very early stage. We studied the role of the regulator of G-protein signaling (RGS) family of proteins RGS17...

journal_title：Oncology research

authors： Li L,Luo HS

更新日期：2018-01-19 00:00:00

abstract：:Solid tumors involving glandular organs express mucin glycoprotein that is eventually shed into the circulation. As a result, these proteins can easily be measured in the serum and be used as potential tumor markers. The most commonly used tumor markers for breast cancer are CA27-29 and CA15-3, which both measure the ...

journal_title：Oncology research

authors： Copur MS,Wurdeman JM,Nelson D,Ramaekers R,Gauchan D,Crockett D

更新日期：2018-04-10 00:00:00

abstract：:Chemoresistance is a major impediment to the successful treatment of cancer. It involves various mechanisms, including defects in the apoptosis program that is induced by anticancer drugs. To further explore the mechanisms underlying the development of chemoresistance in ovarian carcinoma after cisplatin (CDDP) treatm...

journal_title：Oncology research

authors： Mansouri A,Zhang Q,Ridgway LD,Tian L,Claret FX

更新日期：2003-01-01 00:00:00

abstract：:Whether the phenotypes of drug resistance and metastatic activity in cancer are dependent on each other or not is controversial. We compared in vitro invasive properties of human hepatoma cells resistant to epirubicin and rich in P-glycoprotein (Pgp) (HB8065/R) with the parental epirubicin-sensitive, Pgp-poor cells (H...

journal_title：Oncology research

authors： Bjørnland K,Lehne G,Johansen HT,Fodstad O,Rugstad HE,Aasen AO,Ree AH

更新日期：1998-01-01 00:00:00

abstract：:This study evaluated the survival effects of metronomic maintenance therapy with oral fluoropyrimidine in patients with stage III colorectal cancer (CRC) according to epidermal growth factor receptor (EGFR) expression. We enrolled 197 patients with stage III CRC who had undergone radical resection and FOLFOX regimen a...

journal_title：Oncology research

authors： Huang CW,Ma CJ,Su WC,Chen YT,Tsai HL,Yeh YS,Chang TK,Hsu WH,Yu FJ,Wang JY

更新日期：2020-08-28 00:00:00

abstract：:The clinical study of compounds that modulate multidrug resistance has been hindered by both the toxicities of these agents and the inability to monitor their effectiveness at the level of the tumor cell. Previously, toremifene has been shown to be well tolerated clinically and to sensitize multidrug resistant cells t...

journal_title：Oncology research

authors： Baker WJ,Maenpaa JU,Wurz GT,Koester SK,Seymour RC,Emshoff VD,Wiebe VJ,DeGregorio MW

更新日期：1993-01-01 00:00:00

abstract：:Accumulation of beta-catenin in cytoplasm and nuclei is frequently observed in a wide variety of tumors arising, for example, in the colon, liver, uterus, or brain. In association with Tcf/LEF transcription factors, beta-catenin regulates expression of genes involved in the Wnt/wingless signaling pathway, but the prec...

journal_title：Oncology research

authors： Miwa N,Furuse M,Tsukita S,Niikawa N,Nakamura Y,Furukawa Y

更新日期：2001-01-01 00:00:00

abstract：:The present study evaluated the modulatory effects of zinc on colonic membrane fluidity and surface abnormalities following 1,2 dimethylhydrazine (DMH)-induced colon carcinogenesis. Rats were segregated into four groups: normal control, DMH treated, zinc treated, DMH + zinc treated. Colon carcinogenesis was initiated ...

journal_title：Oncology research

authors： Chadha VD,Dhawan DK

更新日期：2009-01-01 00:00:00

abstract：:Numerous studies have observed that workers in ferriferous industries have an elevated risk of respiratory tract neoplasia. Research at the cellular and animal model levels indicates that iron compounds, per se, are carcinogenic. However, some investigators have suggested that inhaled iron compounds are merely carrier...

journal_title：Oncology research

authors： Weinberg ED

更新日期：1999-01-01 00:00:00

abstract：:The beta-adrenergic receptors transduce catecholamine signals to the G protein, which through a cascade of chemical reactions in cells generates highly specific parallel signals. The beta2-adrenergic receptor (ADRB2) is the most involved in the carcinogenic processes. Previous studies have determined the relationship ...

journal_title：Oncology research

authors： Pérez-Sayáns M,Somoza-Martín JM,Barros-Angueira F,Diz PG,Gándara Rey JM,García-García A

更新日期：2010-01-01 00:00:00

abstract：:All-trans-Retinoic acid (RA) induces differentiation and inhibits growth of many tumor types. Whereas the RA nuclear receptors mediate genomic effects of RA, there also are many nongenomic effects that do not have defined mechanisms. Some nongenomic effects of RA may involve retinoylation (RA acylation), a posttransla...

journal_title：Oncology research

authors： Takahashi N,Iwahori A,Breitman TR,Fukui T

更新日期：1997-01-01 00:00:00

abstract：:The aim of this study was to assess serum levels of vascular endothelial growth factor C and D (VEGF-C, VEGF-D) and soluble VEGF receptor 2 (sVEGFR-2) in patients with lung cancer during chemotherapy. The study included 80 patients (64 men and 16 women; mean age 61.1) diagnosed histologically with lung cancer. Forty-f...

journal_title：Oncology research

authors： Naumnik W,Izycki T,Swidzińska E,Ossolińiska M,Chyczewska E

更新日期：2007-01-01 00:00:00

abstract：:Metaplastic tubular complexes (MTC) have been proposed as precursor lesions for pancreatic adenocarcinoma (PDAC). In this study, we investigated the potential role of bone marrow-derived progenitor cells (BMPC) in the formation of MTC and PDAC in a rat model. F344 rats defective for CD26 (dipeptidyl peptidase IV, DPPI...

journal_title：Oncology research

authors： Pan JJ,Oh SH,Lee WC,Petersen BE

更新日期：2009-01-01 00:00:00

abstract：:Although arsenic trioxide (ATO) is a well-known antileukemic drug used for acute promyelocytic leukemia treatment, the development of ATO resistance is still a big challenge. We previously reported that microRNA-204 (miR-204) was involved in the regulation of acute myeloid leukemia (AML) cell apoptosis, but its role i...

journal_title：Oncology research

authors： Wang Z,Fang Z,Lu R,Zhao H,Gong T,Liu D,Hong L,Ma J,Zhang M

更新日期：2019-09-23 00:00:00