Abstract:
:MTA1 was reported as a metastasis-associated gene. Tumors with higher MTA1 mRNA level were shown to have higher rates of invasion and lymph node metastasis and tended to have higher rates of vascular involvement. The majority of invasive breast carcinomas were demonstrated to overexpress MTA1 compared to surrounding normal tissues. MTA1 was also found to be more expressed in metastatic breast cancer cell lines than in nonmetastatic ones. Originally we were interested in analyzing factors differently expressed in invasive and noninvasive breast cancer cell lines. Therefore we analyzed expression of MTA1 together with several other genes in correlation with cell invasiveness in 25 breast epithelial cell lines. Furthermore, we analyzed it in 90 primary breast tumor tissues and examined its correlation with expression of estrogen receptor, progesterone receptor, plasminogen activator inhibitor-1, E-cadherin, histopathological data, disease-free survival, and overall survival. Our results demonstrated that MTA1 expression was significantly higher in noninvasive cell lines than in invasive ones. It also correlated positively with expression of noninvasive factors and reverse correlated with invasive factors in both cell lines and tumor tissues.
journal_name
Oncol Resjournal_title
Oncology researchauthors
Tong D,Heinze G,Schremmer M,Schuster E,Czerwenka K,Leodolter S,Zeillinger Rdoi
10.3727/096504007783338322subject
Has Abstractpub_date
2007-01-01 00:00:00pages
465-70issue
10eissn
0965-0407issn
1555-3906journal_volume
16pub_type
杂志文章abstract::The aim of this study was to analyze the efficacy according to EGFR status and predictors of TKIs in Chinese advanced lung adenocarcinoma patients in a single institute. We retrospectively enrolled 253 patients with advanced or recurrent adenocarcinoma and history of EGFR-TKI treatment attended at Beijing Chest Hospit...
journal_title:Oncology research
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journal_title:Oncology research
pub_type: 杂志文章
doi:
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504016X14756640150695
更新日期:2017-04-14 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504008784523667
更新日期:2008-01-01 00:00:00
abstract::Epidermal growth factor receptor (EGFR) is commonly overexpressed in non-small cell lung cancer (NSCLC) and its tyrosine kinase phosphorylation is thought to be an ideal target in the treatment of patients with NSCLC. In the present study, we examined surgically obtained specimens from a series of 36 NSCLC patients fo...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504003108748348
更新日期:2003-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/0965040041292350
更新日期:2004-01-01 00:00:00
abstract::We previously reported that vasoactive intestinal polypeptide (VIP) significantly inhibited Matrigel invasion and haptotactic migration of murine colon 26-L5 carcinoma in vitro. To extend our study, we investigated the inhibitory mechanisms of VIP on Matrigel invasion of colon 26-L5 carcinoma, and the effect on metast...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504011x13079697132790
更新日期:2011-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504011x12935427587849
更新日期:2011-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504007783438349
更新日期:2007-01-01 00:00:00
abstract::Agosterol A (AG-A) is a novel agent that reverses P-glycoprotein (P-gp) and multidrug resistance protein-1 (MRP1)-meditated multidrug resistance (MDR). We have synthesized [125I]11-azidophenyl agosterol A (azidoAG-A), a photoaffinity analog of AG-A, and characterized its binding to P-gp in membrane vesicles prepared f...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/000000003108748595
更新日期:2003-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504016X14747335734344
更新日期:2017-03-13 00:00:00
abstract::This commentary proposes the working hypothesis that transforming growth factor-beta (TGF-beta) can play two different and opposite roles with respect to the process of malignant progression. During the earliest stages of carcinogenesis, TGF-beta can act as potent tumor suppressor and may mediate the actions of chemop...
journal_title:Oncology research
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
abstract::This study aimed to explore the effects of lncRNA BCAR4 on the viability and aggressiveness of non-small cell lung cancer (NSCLC) cells. qRT-PCR was used to determine the expression of BCAR4 and GLI2 downstream genes in NSCLC tissues and cell lines. Chromatin isolation by RNA purification (CHIRP) and Western blot were...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504018X15220594629967
更新日期:2019-02-21 00:00:00
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pub_type: 杂志文章
doi:10.3727/096504001108747594
更新日期:2000-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/000000003108748612
更新日期:2003-01-01 00:00:00
abstract::Although arsenic trioxide (ATO) is a well-known antileukemic drug used for acute promyelocytic leukemia treatment, the development of ATO resistance is still a big challenge. We previously reported that microRNA-204 (miR-204) was involved in the regulation of acute myeloid leukemia (AML) cell apoptosis, but its role i...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504019X15528367532612
更新日期:2019-09-23 00:00:00
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doi:10.3727/096504016X14641336229602
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journal_title:Oncology research
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doi:10.3727/096504002108747926
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journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
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journal_title:Oncology research
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doi:
更新日期:2007-01-01 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504012x13285365944337
更新日期:2011-01-01 00:00:00
abstract::In colorectal cancers, the local cytokine network and the levels of nitric oxide (NO) and reactive oxygen species (ROS) are known to be closely related to cancer progression and metastasis, but the influence of the currently administered therapies on the cancer microenvironment is not completely understood. We analyze...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504010x12671222663593
更新日期:2010-01-01 00:00:00
abstract::DT-diaphorase [also called NAD(P)H:menadione oxidoreductase; NAD(P)H:(quinone acceptor) oxidoreductase; quinone reductase, azo-dye reductase] (EC.1.6.99.2) has been shown to have a role in activation of quinone-containing cancer chemotherapeutic prodrugs to their active form, as well as inactivation of a variety of xe...
journal_title:Oncology research
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
abstract::Angiogenesis, the formation of new vessels, is essential for tumor growth and metastasis. Mutations of p53 tumor suppressor gene are frequent and play an important role in colorectal oncogenesis. A role of p53 as an angiogenesis inhibitor has also been proposed. We evaluated angiogenesis and p53 expression in 16 hyper...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504001108747693
更新日期:2000-01-01 00:00:00
abstract::Progestin and adipoQ receptor family member III (PAQR3), a member of the PAQR family, is frequently downregulated in different types of human cancer. However, its expression and functions in esophageal cancer are still unknown. This study aimed to explore the expression of PAQR3 in esophageal cancer cell lines and to ...
journal_title:Oncology research
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doi:10.3727/096504016X14761384026719
更新日期:2017-05-24 00:00:00
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journal_title:Oncology research
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::To elucidate the proteins related to the development and progress of esophageal squamous cell carcinoma (ESCC), we performed gene expression profile analysis of 14 ESCC tissues. We identified 182 genes that were commonly upregulated (p < 10(-5)) and 54 genes that were downregulated in ESCC tissues (p < 10(-6)). In ord...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504009790217407
更新日期:2009-01-01 00:00:00
abstract::Apoptosis proteins may play a role in prognosis and therapy response; however, they have not been fully investigated in gastric cancer. We aimed to assess the expression of proteins in the Bcl-2 family. Immunohistochemistry was employed to examine the expression of the antiapoptotic proteins Bcl-2 and Bcl-XL and the p...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504005776568246
更新日期:2006-01-01 00:00:00