Abstract:
:A Wnt agonist, 2-amino-4-[3,4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl) pyrimidine, is a cell-permeable pyrimidine compound that has been shown to mimic the effect of Wnt. In this study, leukemic mouse cell lines, RAW 264.7 and J774.1, were incubated with the Wnt agonist. The Wnt agonist showed cell death in the concentration of 1-10 μM. The Wnt agonist did not show inhibition of GSK-3β activity but induced β-catenin accumulation in the nucleus. The Wnt agonist showed caspase-independent cell death, but no further involvement in cell death ER stress signaling. Here we discuss the possible mechanism of Wnt agonist-induced apoptotic cell death in RAW 264.7 cells.
journal_name
Oncol Resjournal_title
Oncology researchauthors
Kato Y,Naiki Y,Komatsu T,Takahashi K,Nakamura J,Koide Ndoi
10.3727/096504016X14721731148893subject
Has Abstractpub_date
2017-04-14 00:00:00pages
479-483issue
4eissn
0965-0407issn
1555-3906journal_volume
25pub_type
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journal_title:Oncology research
pub_type: 杂志文章
doi:
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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doi:10.3727/096504017X15031557924141
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journal_title:Oncology research
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更新日期:2000-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:
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journal_title:Oncology research
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journal_title:Oncology research
pub_type: 杂志文章
doi:
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abstract::Apoptosis proteins may play a role in prognosis and therapy response; however, they have not been fully investigated in gastric cancer. We aimed to assess the expression of proteins in the Bcl-2 family. Immunohistochemistry was employed to examine the expression of the antiapoptotic proteins Bcl-2 and Bcl-XL and the p...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504005776568246
更新日期:2006-01-01 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504018X15478559215014
更新日期:2019-07-12 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X15043589260618
更新日期:2018-05-07 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504008786991611
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journal_title:Oncology research
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doi:10.3727/096504012x13285365944337
更新日期:2011-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X14873430389189
更新日期:2017-09-21 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504014X13907540404833
更新日期:2014-01-01 00:00:00
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journal_title:Oncology research
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doi:
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journal_title:Oncology research
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doi:10.3727/096504017X15004613574679
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journal_title:Oncology research
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doi:
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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