Abstract:
:Sixteen desmuramyl analogs of muramyl dipeptide (MDP) were tested for their abilities to stimulate cytotoxic factor secretion by mouse peritoneal macrophages. Among them, the pseudohexapeptide Boc-Gly psi [CH2O]-D-Ala-Ala-D-Glu[Lys(H-Gly)NHEt]-NH2 appeared to be four times more effective than MDP. From this study, the D configuration of the pseudo-alanyl (or lactyl) residue appears to be essential for activity.
journal_name
Oncol Resjournal_title
Oncology researchauthors
Breton P,Petit C,Bousser MT,Monsigny M,Mayer R,Roche ACsubject
Has Abstractpub_date
1992-01-01 00:00:00pages
103-7issue
3eissn
0965-0407issn
1555-3906journal_volume
4pub_type
杂志文章abstract::A1, a member of the Bcl-2 gene family, was originally identified as a hemopoietic-specific early response gene. Later it was found that A1 was overexpressed in human stomach cancer tissues and was induced by tumor necrosis factor-alpha (TNF-alpha) in human vascular endothelial cells. However, its expression in human c...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract:: THIS ARTICLE WAS WITHDRAWN BY THE PUBLISHER IN NOVEMBER 2020. ...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504018X15165493852990
更新日期:2018-10-17 00:00:00
abstract::Hematopoietic stem cells (HSCs) are at the foundation of the hematopoietic hierarchy and give rise to all blood lineages in the adult organism. A thorough understanding of the molecular, cellular, and developmental biology of HSCs is of fundamental importance, but is also clinically relevant for the advancement of cel...
journal_title:Oncology research
pub_type: 杂志文章,评审
doi:10.3727/096504003108748519
更新日期:2003-01-01 00:00:00
abstract::Claudin18 (CLDN18) is necessary for intercellular junctions and is reported to be involved in cell migration and metastasis, making it like an oncogene in various cancer types. However, the biological function and regulatory mechanisms of CLDN18 in lung adenocarcinoma are not yet clear. In this study, we found downreg...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X15112639918174
更新日期:2018-05-07 00:00:00
abstract::Cancer-associated fibroblasts (CAFs) play a predominant role in regulating tumor progression. Understanding how CAFs communicate with osteosarcoma is crucial for developing novel approaches for osteosarcoma therapy. Exosomes are able to transmit messages between cells. In this study, we demonstrated that CAFs transfer...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504018X15336368805108
更新日期:2019-09-23 00:00:00
abstract::Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the initiation and development of many solid tumors, including osteosarcoma (OS). In this study, we showed that MALAT1 was increased in human OS tissues and cell lines. MALAT1 knockdown suppressed OS ce...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X14957939026111
更新日期:2018-04-27 00:00:00
abstract::Treatment of female SKH-1 hairless mice with ultraviolet B light twice a week for 20 weeks resulted in a population of tumor-free mice with a high risk of developing skin tumors during the next several months in the absence of additional UVB treatment (high-risk mice). Topical applications of nondenatured soymilk but ...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/0965040041292350
更新日期:2004-01-01 00:00:00
abstract::All-trans-Retinoic acid (RA) induces differentiation and inhibits growth of many tumor types. Whereas the RA nuclear receptors mediate genomic effects of RA, there also are many nongenomic effects that do not have defined mechanisms. Some nongenomic effects of RA may involve retinoylation (RA acylation), a posttransla...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Colorectal cancer is an aggressive malignancy for which there are limited treatment options. Oncolytic vaccinia virus isbeing developed as a novel strategy for cancer therapy. Arming vaccinia virus with immunostimulatory cytokines can enhance the tumor cell-specific replication and antitumor efficacy. Interleukin-24 (...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504020X15942028641011
更新日期:2020-07-08 00:00:00
abstract::Neuroendocrine tumors (NETs) represent a relatively rare form of neoplasias for which, in advanced unresectable stages, palliative treatment options remain limited largely to the use of somatostatin analogues or chemotherapy. Several newer targeted therapeutic options, alone or in combination with somatostatin analogu...
journal_title:Oncology research
pub_type: 杂志文章,评审
doi:10.3727/096504011x13123323849799
更新日期:2011-01-01 00:00:00
abstract::Hematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP/PBXIP1) is a nucleo-cytoplasmic shuttling protein, and its expression is associated with cancer aggressiveness. However, the role of HPIP in ovarian cancer is still unclear. Here, we aimed to clarify the role of HPIP in epithelial-m...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504016X14575597858654
更新日期:2016-01-01 00:00:00
abstract::This commentary proposes the working hypothesis that transforming growth factor-beta (TGF-beta) can play two different and opposite roles with respect to the process of malignant progression. During the earliest stages of carcinogenesis, TGF-beta can act as potent tumor suppressor and may mediate the actions of chemop...
journal_title:Oncology research
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
abstract::Venous thromboembolism (VTE) occurs at an increased incidence in cancer patients. A cancer-related hypercoagulable state has been considered to play role in this phenomenon. Preclinical data suggest an association between tumor expression of MET proto-oncogene (MET) and a hypercoagulable state, resulting in VTE. We in...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504010x12828372551786
更新日期:2010-01-01 00:00:00
abstract::Apoptosis proteins may play a role in prognosis and therapy response; however, they have not been fully investigated in gastric cancer. We aimed to assess the expression of proteins in the Bcl-2 family. Immunohistochemistry was employed to examine the expression of the antiapoptotic proteins Bcl-2 and Bcl-XL and the p...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504005776568246
更新日期:2006-01-01 00:00:00
abstract::We investigated the susceptibility of three inbred strains of rats to the hepatocarcinogen, N-nitrosomorpholine (NNM), to establish a spontaneous metastatic model of hepatocellular carcinoma (HCC). WS/Shi. SD/gShi, and F344/DuCrj rats were given 0.02% NNM in drinking water for 8 weeks and thereafter left without any t...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504001108747594
更新日期:2000-01-01 00:00:00
abstract::Heme oxygenase-1 (HO-1) plays an important role in the progression of several malignancies including breast cancer. However, its role in breast cancer metastasis is still ambiguous. In this study, we observed the effect of HO-1 on mouse mammary carcinoma metastasis using the in vivo tumor metastasis model. Our results...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504018X15415906335771
更新日期:2019-06-21 00:00:00
abstract::Ameloblastoma is the most frequently encountered odontogenic tumor, characterized by a locally invasive behavior, frequent recurrences, and, although rare, metastatic capacity. Loss or inactivation of tumor suppressor genes (TSGs) allows cells to acquire neoplastic growth. The ING family proteins are tumor suppressors...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504010x12704916124864
更新日期:2010-01-01 00:00:00
abstract::A number of previous investigations have reported that physical exercise renders immunopotentiating and antitumor therapeutic benefits to the tumor-bearing host. As these effects of physical exercise are mainly mediated through the modulation of hormonal and cytokine repertoire, it remains unclear if male and female t...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504010x12629634366142
更新日期:2010-01-01 00:00:00
abstract::Constitutive canonical Wnt signaling, resulting from mutations in the adenomatous polyposis coli (APC), beta-catenin, or axin genes, has been implicated in the initiation of most human colorectal cancers (CRCs). Some of the proposed approaches for CRC prevention and treatment involve the downregulation of canonical Wn...
journal_title:Oncology research
pub_type: 杂志文章,评审
doi:10.3727/096504008784046108
更新日期:2008-01-01 00:00:00
abstract::We evaluated the effects of ultrasound-mediated microbubble transfection of VEGF-C siRNA on breast cancer cells in vitro and in vivo. MCF-7 cells were transfected with VEGF-C siRNA and the protein and mRNA expression of VEGF-C was tested using Western blot and qRT-PCR. Twenty nude mice tumors were established by injec...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504013x13639794277680
更新日期:2013-01-01 00:00:00
abstract::The aim of this study was to assess serum levels of vascular endothelial growth factor C and D (VEGF-C, VEGF-D) and soluble VEGF receptor 2 (sVEGFR-2) in patients with lung cancer during chemotherapy. The study included 80 patients (64 men and 16 women; mean age 61.1) diagnosed histologically with lung cancer. Forty-f...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::Medullary thyroid carcinoma (MTC) is an uncommon and highly aggressive tumor of the neuroendocrine system, which derives from the neuroendocrine C cells of the thyroid gland. Except for surgical resection, there are not very many effective systemic treatment options for MTC. N-Myc downstream-regulated gene 2 (NDRG2) h...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504015X14452563486093
更新日期:2016-01-01 00:00:00
abstract::Medroxyprogesterone (MPA) is used for the conservative treatment of endometrial cancer. Unfortunately, progesterone resistance seriously affects its therapeutic effect. The purpose of the current study was to investigate the influence of deletion of AT-rich interactive domain 1A (ARID1A) in progesterone resistance in ...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504019X15561873320465
更新日期:2019-09-23 00:00:00
abstract::Pancreatic cancer (PC) is a devastating malignant disease with a poor prognosis. This study aimed to investigate the role of urothelial carcinoma associated 1 (UCA1) in the progression of PC. Our results revealed that long noncoding RNA (lncRNA) UCA1 was overexpressed in PC tissues compared with adjacent histologicall...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X14888987683152
更新日期:2017-11-02 00:00:00
abstract::N-Butyl-N-(4-hydroxybutyl)-nitrosamine (BBN), which induces bladder carcinoma in female Wistar rats and female C3H/HeJ mice, was given as 0.025% (w/v) solution to rats and 0.05% to mice in the drinking water. Thymosin fraction 5 (TF5) or thymosin alpha 1 (T alpha 1) dissolved in normal saline, and normal saline (contr...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::This study was designed to investigate the role of miR-183 in modulating cell growth and apoptosis of tongue squamous cell carcinoma SCC25 cell line. Human squamous epithelial cell and squamous cell carcinoma cell line SCC25 was used, and miR-183 was inhibited. Cell growth, colony formation, and apoptotic rate, as wel...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504016X14685034103239
更新日期:2016-10-27 00:00:00
abstract::The expression of survivin molecules has been confirmed in many types of cancer cells, including colon cancer cells, and they are considered important antiapoptotic molecules. Recent studies have revealed the existence of different splicing forms of survivin molecules; however, no studies have examined their expressio...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504010x12767359113848
更新日期:2010-01-01 00:00:00
abstract::Tripartite motif-containing protein 37 (TRIM37), a new member of the RING-B-box-coiled-coil (RBCC) subfamily of zinc finger proteins, was found to be involved in the development and progression of several cancers. However, the expression pattern and biological functions of TRIM37 in colorectal cancer (CRC) remain unkn...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504016X14732772150181
更新日期:2017-01-02 00:00:00
abstract::The present study aimed to investigate the effect of miR-186 on proliferation, migration, invasion, and epithelialmesenchymal transition (EMT) of hepatocellular carcinoma (HCC). In this work, miR-186 was downregulated in HCC tissues and cells, and low miR-186 level helped predict the occurrence of vascular invasion an...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504020X15954139263808
更新日期:2020-12-10 00:00:00
abstract::Solid tumors involving glandular organs express mucin glycoprotein that is eventually shed into the circulation. As a result, these proteins can easily be measured in the serum and be used as potential tumor markers. The most commonly used tumor markers for breast cancer are CA27-29 and CA15-3, which both measure the ...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X15128550060375
更新日期:2018-04-10 00:00:00