Abstract:
:Apoptosis proteins may play a role in prognosis and therapy response; however, they have not been fully investigated in gastric cancer. We aimed to assess the expression of proteins in the Bcl-2 family. Immunohistochemistry was employed to examine the expression of the antiapoptotic proteins Bcl-2 and Bcl-XL and the proapoptotic proteins Bad, Bak, Bax, Bid, Bim, and p53 in 21 cases of gastric cancer. Immunopositivity was observed in 12/21 (57%) cases for p53, 16/21 (76%) cases for Bcl-XL, and 5/21 (23%) cases for Bcl-2. For the proapoptotic members of the Bcl family, loss of protein expression was observed: Bid (14/21 cases; 66%), Bad (13/21 cases; 61%), Bax (12/21 cases; 57%), Bak (9/21 cases; 42%), and Bim (4/21 cases; 19%). This study identified apoptosis proteins that exhibit heterogeneous expression between primary gastric carcinomas.
journal_name
Oncol Resjournal_title
Oncology researchauthors
Smith L,Berrieman HK,O'Kane SL,Campbell A,Maraveyas A,Cawkwell Ldoi
10.3727/096504005776568246subject
Has Abstractpub_date
2006-01-01 00:00:00pages
441-4issue
9eissn
0965-0407issn
1555-3906journal_volume
15pub_type
杂志文章abstract::Point mutations and deletions in the p53 tumor suppressor gene occur frequently in advanced stage bladder tumors. To extend these observations to an in vitro model of bladder tumorigenicity, we have evaluated the presence of p53 mutations in a panel of bladder carcinoma cell lines. p53 alleles were cloned using the re...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Spinal osteosarcoma (OS) is a malignant tumor that has a poor outcome. MicroRNA-520b (miR-520b) acts as a cancer suppressor in various types of cancer. Because of the limited amount of literature on OS, we aimed to identify the role of miR-520b in OS. The miR-520b level in clinical spinal OS tissues and adjacent nontu...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X14873430389189
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504018X15220594629967
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journal_title:Oncology research
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doi:10.3727/096504016X14747335734344
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504010x12828372551786
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journal_title:Oncology research
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doi:10.3727/096504016X14816352324532
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journal_title:Oncology research
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journal_title:Oncology research
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
abstract::Aclacinomycin (ACR) is an anthracycline anticancer drug that shows marked effects in Adriamycin (ADM)-resistant tumors. ADM, however, is not effective against ACR-resistant tumor cells. When tumor cells acquire resistance to ACR, though the resistance is not easily acquired, they show strong cross-resistance to ADM. T...
journal_title:Oncology research
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更新日期:1995-01-01 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504016X14829256525028
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journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章,评审
doi:
更新日期:1993-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Whether the phenotypes of drug resistance and metastatic activity in cancer are dependent on each other or not is controversial. We compared in vitro invasive properties of human hepatoma cells resistant to epirubicin and rich in P-glycoprotein (Pgp) (HB8065/R) with the parental epirubicin-sensitive, Pgp-poor cells (H...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::The patterns of DNA fragmentation were evaluated following a brief exposure (2 h) of the human ileocecal adenocarcinoma cell line, HCT-8, to several specific thymidylate synthase inhibitors, a quinazoline (ZD1694) and benz[cd]indole-containing molecule (AG-331). The magnitude and size of DNA fragmentation induced by t...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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doi:10.3727/096504018X15336368805108
更新日期:2019-09-23 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504017X15051723858706
更新日期:2019-05-07 00:00:00
abstract::Angiogenesis, the formation of new vessels, is essential for tumor growth and metastasis. Mutations of p53 tumor suppressor gene are frequent and play an important role in colorectal oncogenesis. A role of p53 as an angiogenesis inhibitor has also been proposed. We evaluated angiogenesis and p53 expression in 16 hyper...
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journal_title:Oncology research
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doi:
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