Inhibition of human telomerase activity by alterperylenol.

abstract：:We applied a differential display method to screen mRNAs isolated from a newly established cell line that carried a wild-type p53 transgene under control of the lactose operon. To investigate the p53 signaling pathway, we looked for genes whose expression was significantly induced or suppressed by induction of wild-ty...

journal_title：Oncology research

authors： Okamura S,Ng CC,Koyama K,Takei Y,Arakawa H,Monden M,Nakamura Y

更新日期：1999-01-01 00:00:00

abstract：:Chemoresistance is a major impediment to the successful treatment of cancer. It involves various mechanisms, including defects in the apoptosis program that is induced by anticancer drugs. To further explore the mechanisms underlying the development of chemoresistance in ovarian carcinoma after cisplatin (CDDP) treatm...

journal_title：Oncology research

authors： Mansouri A,Zhang Q,Ridgway LD,Tian L,Claret FX

更新日期：2003-01-01 00:00:00

abstract：:Ubiquitin-specific protease 22 (USP22), a novel deubiquitinating enzyme, belongs to an extended family of proteins that have ubiquitin hydrolase activity. Recently, USP22 has attracted widespread attention because of its implication in carcinogenesis. However, there have been no studies, to our knowledge, investigatin...

journal_title：Oncology research

authors： Zhang D,Jiang F,Wang X,Li G

更新日期：2017-05-24 00:00:00

abstract：:Kaempferol is a flavonoid that has been extensively investigated owing to its antitumor effects. Nevertheless, little is known about its underlying mechanisms of action. We aimed to explore the role of kaempferol in breast cancer (BC), and thus we investigated how kaempferol suppresses the growth of BC cells. The cell...

journal_title：Oncology research

authors： Zhu L,Xue L

更新日期：2019-06-21 00:00:00

abstract：:Adaptive changes occurring in C1300 murine neuroblastoma cell lines developed for resistance to nucleoside analogue inhibitors of S-adenosyl-L-homocysteine hydrolase (AdoHcyase, EC 3.3.1.1) were investigated. Two drug-resistant cell lines, rMNB-MDL-7-2 and rMNB-Deaz-7-2, were established from wild-type C1300 neuroblas...

journal_title：Oncology research

authors： Hamre MR,Clark SH,Mirkin BL

更新日期：1995-01-01 00:00:00

abstract：:Phytochemicals present in tea, particularly polyphenols, have anticancer properties against several cancer types. However, studies elucidating the role and the mechanism(s) of action of tea polyphenols in cervical cancer are sparse. In this study, we investigated the mechanism of antiproliferative and apoptotic action...

journal_title：Oncology research

authors： Singh M,Singh R,Bhui K,Tyagi S,Mahmood Z,Shukla Y

更新日期：2011-01-01 00:00:00

abstract：:Cervical cancer is one of the most common neoplastic diseases affecting women, with a combined worldwide incidence of almost half a million new cases. Considering the fact that IL-18 plays an important role in the interactions among T cells, NK cells, and macrophages and induces IFN-gamma production, efforts should be...

journal_title：Oncology research

authors： Sobti RC,Shekari M,Tamandani DM,Malekzadeh K,Suri V

更新日期：2008-01-01 00:00:00

abstract：:Thymosin-beta-4 (TB4) as an actin-sequestering peptide has been detected outside of cells in blood plasma or in wound fluid. TB4 induces tumor metastasis and paclitaxel resistance, which is the most significant obstacle to successful therapy in tumors. Here we investigated the inhibitory effect of TB4 peptides on tumo...

journal_title：Oncology research

authors： Moon EY,Song JH,Yang KH

更新日期：2007-01-01 00:00:00

abstract：:The patterns of DNA fragmentation were evaluated following a brief exposure (2 h) of the human ileocecal adenocarcinoma cell line, HCT-8, to several specific thymidylate synthase inhibitors, a quinazoline (ZD1694) and benz[cd]indole-containing molecule (AG-331). The magnitude and size of DNA fragmentation induced by t...

journal_title：Oncology research

authors： Panadero A,Yin MB,Voigt W,Rustum YM

更新日期：1995-01-01 00:00:00

abstract：:Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are used as first-line agents for treating nonsquamous cell lung cancer with EGFR mutation, there are many patients who have to receive these drugs following platinum-based chemotherapy. This study was designed to define whether exposure ...

journal_title：Oncology research

authors： Rho JK,Choi YJ,Choi YR,Kim SY,Choi SJ,Choi CM,Na II,Lee JC

更新日期：2011-01-01 00:00:00

abstract：:It has been reported that upregulated SIRT1 (NAD(+)-dependent class III histone deacetylase) deacetylates the p53 protein, represses its function, and allows for tumor cell growth in various cancers. Here we investigated antitumor effects of tenovin-6, a small-molecule inhibitor of SIRT1 and SIRT2, in various colon ca...

journal_title：Oncology research

authors： Ueno T,Endo S,Saito R,Hirose M,Hirai S,Suzuki H,Yamato K,Hyodo I

更新日期：2013-01-01 00:00:00

abstract：:Neuroendocrine tumors (NETs) represent a relatively rare form of neoplasias for which, in advanced unresectable stages, palliative treatment options remain limited largely to the use of somatostatin analogues or chemotherapy. Several newer targeted therapeutic options, alone or in combination with somatostatin analogu...

journal_title：Oncology research

authors： Pusceddu S,Milione M,Procopio G

更新日期：2011-01-01 00:00:00

abstract：:HL-60 cells isolated for resistance to vincristine are multidrug resistant and defective in the cellular accumulation of drug. Further studies demonstrate that these cells are also highly defective in 12-O-tetradecanoylphorbol-13-acetate (TPA) induced differentiation to macrophages. Analysis of this system demonstrate...

journal_title：Oncology research

authors： Ma L,Krishnamachary N,Perbal B,Center MS

更新日期：1992-01-01 00:00:00

abstract：:Medroxyprogesterone (MPA) is used for the conservative treatment of endometrial cancer. Unfortunately, progesterone resistance seriously affects its therapeutic effect. The purpose of the current study was to investigate the influence of deletion of AT-rich interactive domain 1A (ARID1A) in progesterone resistance in ...

journal_title：Oncology research

authors： Wang H,Tang Z,Li T,Liu M,Li Y,Xing B

更新日期：2019-09-23 00:00:00

abstract：:Tamoxifen causes a mitochondrial transmembrane potential dysfunction and ATP depletion, which may play a role in tamoxifen cytotoxicity. Administration of oligomycin-2 deoxy glucose (2DG) enhanced tamoxifen antiproliferative effects, which may be due to exacerbated ATP depletion following tamoxifen and oligomycin-2DG ...

journal_title：Oncology research

authors： Seyedabadi M,Ghahremani MH,Ostad SN

更新日期：2009-01-01 00:00:00

abstract：:Apoptosis proteins may play a role in prognosis and therapy response; however, they have not been fully investigated in gastric cancer. We aimed to assess the expression of proteins in the Bcl-2 family. Immunohistochemistry was employed to examine the expression of the antiapoptotic proteins Bcl-2 and Bcl-XL and the p...

journal_title：Oncology research

authors： Smith L,Berrieman HK,O'Kane SL,Campbell A,Maraveyas A,Cawkwell L

更新日期：2006-01-01 00:00:00

abstract：:Aclacinomycin (ACR) is an anthracycline anticancer drug that shows marked effects in Adriamycin (ADM)-resistant tumors. ADM, however, is not effective against ACR-resistant tumor cells. When tumor cells acquire resistance to ACR, though the resistance is not easily acquired, they show strong cross-resistance to ADM. T...

journal_title：Oncology research

authors： Dong J,Naito M,Tatsuta T,Seimiya H,Johdo O,Tsuruo T

更新日期：1995-01-01 00:00:00

abstract：:Expression of sphingosine kinase 1 (SPHK1) plays a role in colorectal cancer progression. This study aimed to demonstrate the mechanism of human colorectal cancer cell metastatic phenotype through SPHK1 knockdown. Human colorectal cancer HT-29 cells were stimulated by phorbol 12-myristate 13-acetate (PMA) with or with...

journal_title：Oncology research

authors： Qin MB,Huang JA,Liu SQ,Tang GD,Jiang HX

更新日期：2011-01-01 00:00:00

abstract：:The potency of flavonoids (isoflavones, flavones, and flavanones) to inhibit efflux of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein (BCPCF) from human erythrocytes was investigated. Structure-activity relationship analysis showed that the strongest inhibitors were found among flavanones bearing a hydrophobic pren...

journal_title：Oncology research

authors： Bobrowska-Hägerstrand M,Wróbel A,Mrówczyńska L,Söderström T,Shirataki Y,Motohashi N,Molnár J,Michalak K,Hägerstrand H

更新日期：2003-01-01 00:00:00

abstract：:The mechanism of action of the anthraquinone antileukemic drug mitoxantrone (MIT) was investigated and compared with that of daunorubicin (DNR) with emphasis on the interaction with DNA to clarify the more potent cytotoxic activity of MIT than DNR in human leukemia cells. MIT showed similar characteristics to those of...

journal_title：Oncology research

authors： Fukushima T,Kawai Y,Nakayama T,Yamauchi T,Yoshida A,Urasaki Y,Imamura S,Kamiya K,Tsutani H,Ueda T,Nakamura T

更新日期：1996-01-01 00:00:00

abstract：:Ameloblastoma is the most frequently encountered odontogenic tumor, characterized by a locally invasive behavior, frequent recurrences, and, although rare, metastatic capacity. Loss or inactivation of tumor suppressor genes (TSGs) allows cells to acquire neoplastic growth. The ING family proteins are tumor suppressors...

journal_title：Oncology research

authors： Borkosky SS,Gunduz M,Beder L,Tsujigiwa H,Tamamura R,Gunduz E,Katase N,Rodriguez AP,Sasaki A,Nagai N,Nagatsuka H

更新日期：2010-01-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) of non-small cell lung cancer (NSCLC) may contribute to tumor metastasis. TGF-β1-induced EMT in H1975 cells (a human NSCLC cell line) resulted in the adoption of mesenchymal responses that were predominantly mediated via the TGF-β1-...

journal_title：Oncology research

authors： Ruan JS,Zhou H,Yang L,Wang L,Jiang ZS,Sun H,Wang SM

更新日期：2019-05-07 00:00:00

abstract：:A1, a member of the Bcl-2 gene family, was originally identified as a hemopoietic-specific early response gene. Later it was found that A1 was overexpressed in human stomach cancer tissues and was induced by tumor necrosis factor-alpha (TNF-alpha) in human vascular endothelial cells. However, its expression in human c...

journal_title：Oncology research

authors： Pang XP,Hershman JM,Karsan A

更新日期：1997-01-01 00:00:00

abstract：:Our recent studies demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) has pharmacological activity for the treatment of acute myelocytic leukemia patients. In the present study, we investigated the potential synergistic effect of all-trans retinoic acid (RA), 1alpha,25-dihydroxyvitamin D3 (VD3), and sodium b...

journal_title：Oncology research

authors： Zheng X,Chang RL,Cui XX,Kelly KA,Shih WJ,Lin Y,Strair R,Suh J,Han ZT,Rabson A,Conney AH

更新日期：2000-01-01 00:00:00

abstract：:Whether the phenotypes of drug resistance and metastatic activity in cancer are dependent on each other or not is controversial. We compared in vitro invasive properties of human hepatoma cells resistant to epirubicin and rich in P-glycoprotein (Pgp) (HB8065/R) with the parental epirubicin-sensitive, Pgp-poor cells (H...

journal_title：Oncology research

authors： Bjørnland K,Lehne G,Johansen HT,Fodstad O,Rugstad HE,Aasen AO,Ree AH

更新日期：1998-01-01 00:00:00

abstract：:Human glioblastoma multiforme (GBM) accounts for the majority of human brain gliomas. Several TMEM proteins, such as TMEM 45A, TMEM 97, and TMEM 140, are implicated in human brain gliomas. However, the roles of TMEM168 in human GBM remain poorly understood. Herein we found that mRNA levels of TMEM168 were overexpresse...

journal_title：Oncology research

authors： Xu J,Su Z,Ding Q,Shen L,Nie X,Pan X,Yan A,Yan R,Zhou Y,Li L,Lu B

更新日期：2019-07-12 00:00:00

abstract：:Kiss-1 has been identified as a putative metastasis suppressor gene in various human malignancies. However, there is little information about its possible role in gastric carcinoma. In this study, we determined whether the Kiss-1 gene negatively regulates MMP-9 expression. cDNA microarray technology was used to identi...

journal_title：Oncology research

authors： Lee KH,Kim JR

更新日期：2009-01-01 00:00:00

abstract：:The aim of this study was to analyze the efficacy according to EGFR status and predictors of TKIs in Chinese advanced lung adenocarcinoma patients in a single institute. We retrospectively enrolled 253 patients with advanced or recurrent adenocarcinoma and history of EGFR-TKI treatment attended at Beijing Chest Hospit...

journal_title：Oncology research

authors： Wang J,Nong J,Jia H,Qin N,Li X,Zhang H,Zhang Q,Zhang Z,Zhang S

更新日期：2014-01-01 00:00:00

abstract：:There is growing evidence on the clinical significance of Tumor Microenvironment (TME) cells in predicting prognosis and therapeutic effects. However, cell interactionsin tumor microenvironments have not been thoroughly studied or systematicallyanalyzed so far. In this study, 22 immune cell components in the lung aden...

journal_title：Oncology research

authors： Ling B,Huang Z,Huang S,Qian L,Li G,Tang Q

更新日期：2020-05-29 00:00:00

abstract：:The regular RIN1 gene is a molecule located on chromosome 1lq13.2, and contains a coding region of 2352 bp with a 3' domain that binds to H-Ras protein, suggesting that it is an important molecule in the intracellular signaling pathway. In this study, we confirmed the existence of a novel form of the RIN1 gene with a ...

journal_title：Oncology research

authors： Fujioka M,Goi T,Hirono Y,Katayama K,Yamaguchi A

更新日期：2009-01-01 00:00:00