Abstract：
:Cervical cancer is one of the most common neoplastic diseases affecting women, with a combined worldwide incidence of almost half a million new cases. Considering the fact that IL-18 plays an important role in the interactions among T cells, NK cells, and macrophages and induces IFN-gamma production, efforts should be made to understand the clinical impact of IL-18 cytokine in patients with solid malignancies, as not much study has been conducted in cervix carcinoma. In this study, we have observed in GC genotype statistically significant marginal increased risk of developing of cervical cancer (OR 1.8, 95% CI 1.17-2.76, p = 0.006). Similarly, when the GC with CC genotypes were combined results were once more statistically significant with borderline risk of developing cervix cancer (OR 1.6,95% CI 1.09-2.50, p = 0.01). Likewise, we found statistically significant increased risk between cases and controls in GC genotype and passive smokers with risk of cervical cancer (OR 4.3, 95%CI 2.13-8.99, p = 0.00001). Our investigation suggests that IL-18 gene -137 in different genotypes, as also in passive smokers, may increase risk of cervix carcinogenesis in north Indian women.
journal_name
Oncol Resjournal_title
Oncology researchauthors
Sobti RC,Shekari M,Tamandani DM,Malekzadeh K,Suri Vdoi
10.3727/096504008785114156subject
Has Abstractpub_date
2008-01-01 00:00:00pages
159-66issue
4eissn
0965-0407issn
1555-3906journal_volume
17pub_type
杂志文章abstract：:There is growing evidence on the clinical significance of Tumor Microenvironment (TME) cells in predicting prognosis and therapeutic effects. However, cell interactionsin tumor microenvironments have not been thoroughly studied or systematicallyanalyzed so far. In this study, 22 immune cell components in the lung aden...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/096504020X15907428281601
更新日期：2020-05-29 00:00:00
abstract：: THIS ARTICLE WAS WITHDRAWN BY THE PUBLISHER IN NOVEMBER 2020. ...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/096504018X15165493852990
更新日期：2018-10-17 00:00:00
abstract：:Point mutations and deletions in the p53 tumor suppressor gene occur frequently in advanced stage bladder tumors. To extend these observations to an in vitro model of bladder tumorigenicity, we have evaluated the presence of p53 mutations in a panel of bladder carcinoma cell lines. p53 alleles were cloned using the re...
journal_title：Oncology research
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Baicalein, a flavonoid derived from the root of Scutellaria baicalensis, has been reported to possess multiple pharmacological activities, such as anticancer and anti-inflammatory properties. This study investigated the effect of baicalein in cervical cancer cells. Cell growth curve and MTT assay were performed and re...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/096504017X15031557924141
更新日期：2018-05-07 00:00:00
abstract：:Human colon tumor cell lines that were adapted to grow in chemically defined medium were tested for their growth sensitivity to exogenous transferrin, insulin, and epidermal growth factor (EGF). Less differentiated cell lines, C and HCT116, were able to grow in the presence of a single peptide supplement, to respond s...
journal_title：Oncology research
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:The melanin biosynthetic pathway from tyrosine is a potential target for combating malignant melanoma. N-Acetyl-4-S-cysteaminylphenol 1 is a previously synthesized analogue of tyrosine that probably acts by this pathway. It interferes with cell growth and proliferation via selective oxidation in melanocytes to an oqui...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/000000006783981206
更新日期：2006-01-01 00:00:00
abstract：:Epithelial ovarian cancer (EOC) has remained an enigmatic disease, the etiology of which is mostly unknown. Considering the age incidence around menopause, a "gonadotrophin theory" has been proposed, and considering the association with infertility, an "incessant ovulation" theory has been proposed. EOC originates fro...
journal_title：Oncology research
pub_type： 杂志文章,评审
doi：10.3727/096504008786111383
更新日期：2008-01-01 00:00:00
abstract：:It has been demonstrated that microRNAs (miRNAs) act as oncogenes or tumor suppressors in a variety of cancers. Our previous work suggested that miR-10a/b functioned as a tumor suppressor in gastric cancer, and miR-10b was also reported to be significantly downregulated in advanced stage cervical cancer tissues. Howev...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/096504016X14611963142173
更新日期：2016-01-01 00:00:00
abstract：:In colorectal cancers, the local cytokine network and the levels of nitric oxide (NO) and reactive oxygen species (ROS) are known to be closely related to cancer progression and metastasis, but the influence of the currently administered therapies on the cancer microenvironment is not completely understood. We analyze...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/096504010x12671222663593
更新日期：2010-01-01 00:00:00
abstract：:This commentary proposes the working hypothesis that transforming growth factor-beta (TGF-beta) can play two different and opposite roles with respect to the process of malignant progression. During the earliest stages of carcinogenesis, TGF-beta can act as potent tumor suppressor and may mediate the actions of chemop...
journal_title：Oncology research
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：:Constitutive canonical Wnt signaling, resulting from mutations in the adenomatous polyposis coli (APC), beta-catenin, or axin genes, has been implicated in the initiation of most human colorectal cancers (CRCs). Some of the proposed approaches for CRC prevention and treatment involve the downregulation of canonical Wn...
journal_title：Oncology research
pub_type： 杂志文章,评审
doi：10.3727/096504008784046108
更新日期：2008-01-01 00:00:00
abstract：:Tripartite motif-containing protein 37 (TRIM37), a new member of the RING-B-box-coiled-coil (RBCC) subfamily of zinc finger proteins, was found to be involved in the development and progression of several cancers. However, the expression pattern and biological functions of TRIM37 in colorectal cancer (CRC) remain unkn...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/096504016X14732772150181
更新日期：2017-01-02 00:00:00
abstract：:Ubiquitin-specific protease 22 (USP22), a novel deubiquitinating enzyme, belongs to an extended family of proteins that have ubiquitin hydrolase activity. Recently, USP22 has attracted widespread attention because of its implication in carcinogenesis. However, there have been no studies, to our knowledge, investigatin...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/096504016X14772395226335
更新日期：2017-05-24 00:00:00
abstract：:Heme oxygenase-1 (HO-1) plays an important role in the progression of several malignancies including breast cancer. However, its role in breast cancer metastasis is still ambiguous. In this study, we observed the effect of HO-1 on mouse mammary carcinoma metastasis using the in vivo tumor metastasis model. Our results...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/096504018X15415906335771
更新日期：2019-06-21 00:00:00
abstract：:Concentrations of the flame retardant 2,2',4,4'-tetrabrominated diphenyl ether (2,2',4,4'-TeBDE) in the adipose tissue of 77 individuals from Sweden were determined. The subjects were recruited during the time period 1995-97 and encompassed both men and women ranging from 28 to 85 years in age. Of the subjects include...
journal_title：Oncology research
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:Thymosin-beta-4 (TB4) as an actin-sequestering peptide has been detected outside of cells in blood plasma or in wound fluid. TB4 induces tumor metastasis and paclitaxel resistance, which is the most significant obstacle to successful therapy in tumors. Here we investigated the inhibitory effect of TB4 peptides on tumo...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/096504007783438349
更新日期：2007-01-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is a disease with poor prognosis rates and ineffective therapeutic options. Previous studies have reported the involvement of mitogen-inducible gene 6 (MIG-6) as a negative regulator in tumor formation. MicroRNAs (miRNAs) play crucial roles in the development of different types of cancer...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/096504017X15000784459799
更新日期：2018-05-07 00:00:00
abstract：:Human glioblastoma multiforme (GBM) accounts for the majority of human brain gliomas. Several TMEM proteins, such as TMEM 45A, TMEM 97, and TMEM 140, are implicated in human brain gliomas. However, the roles of TMEM168 in human GBM remain poorly understood. Herein we found that mRNA levels of TMEM168 were overexpresse...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/096504018X15478559215014
更新日期：2019-07-12 00:00:00
abstract：:Grb2-associated binder 1 (Gab1) is often aberrant in cancerous cells and tissues, whose alteration is responsible for aggressive phenotypes. In this study, we examined the Gab1 expression in human oral squamous cell carcinoma (OSCC) tissues and investigated the cellular and molecular effect of Gab1 on migration, invas...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/096504017X15043589260618
更新日期：2018-05-07 00:00:00
abstract：:HeLa cells were transfected with full-length multidrug resistance protein (MRP) cDNA and with MRP cDNAs that had been mutated at certain nucleotide binding domains. Stable transfectants were isolated and those producing equivalent amounts of P190 were tested in cytotoxicity assays using a variety of chemotherapeutic a...
journal_title：Oncology research
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Laryngeal cancer, one of the most common head and neck malignancies, is an aggressive neoplasm. Increasing evidence has demonstrated that microRNAs (miRNAs) exert important roles in oncogenesis and progression of diverse types of human cancers. miR-632, a tumor-related miRNA, has been reported to be dysregulated and i...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/096504018X15213142076069
更新日期：2020-02-07 00:00:00
abstract：:HL-60 cells isolated for resistance to vincristine are multidrug resistant and defective in the cellular accumulation of drug. Further studies demonstrate that these cells are also highly defective in 12-O-tetradecanoylphorbol-13-acetate (TPA) induced differentiation to macrophages. Analysis of this system demonstrate...
journal_title：Oncology research
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
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journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/096504010x12644422320582
更新日期：2010-01-01 00:00:00
abstract：:The effects of treatment of HeLa cells with the antitumor nucleoside analog 2'-deoxy-2'-(fluoromethylene) cytidine (FMdC) on ultraviolet and X-ray sensitivity were examined. A 1-h pretreatment with FMdC increased cellular sensitivity to both X-rays and ultraviolet irradiation as determined by survival curve analysis. ...
journal_title：Oncology research
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:The anticancer drug Adriamycin is widely used in cancer chemotherapy and is classified as a topoisomerase II inhibitor. However, in the presence of formaldehyde, Adriamycin also forms high levels of DNA adducts. In this study, a new series of butyric acid and formaldehyde-releasing drugs related to AN9 (pivaloyloxymet...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/096504005776382305
更新日期：2005-01-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated mortality worldwide. Although the mechanisms of HCC progression are not well understood, recent studies demonstrated the potential contribution of uric acid transporter SLC2A9 to tumor suppression. However, the roles and underlying mechanis...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/096504018X15199489058224
更新日期：2019-05-07 00:00:00
abstract：:Human papillomavirus type 16 (HPV16) is a major causative factor in the development of uterine cervical carcinomas. We investigated the role of E6/E7 in tumor formation. Skin-specific E6/E7 transgenic mice showed approximately twice as many tumors compared with nontransgenic mice in dimethylbenz[a]anthracene (DMBA)-in...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/000000006783980964
更新日期：2007-01-01 00:00:00
abstract：:This study aimed to explore the effects of lncRNA BCAR4 on the viability and aggressiveness of non-small cell lung cancer (NSCLC) cells. qRT-PCR was used to determine the expression of BCAR4 and GLI2 downstream genes in NSCLC tissues and cell lines. Chromatin isolation by RNA purification (CHIRP) and Western blot were...
journal_title：Oncology research
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doi：10.3727/096504018X15220594629967
更新日期：2019-02-21 00:00:00
abstract：:We have compared the effects of a number of inhibitors including aphidicolin, 2,4-dinitrophenol (DNP) and novobiocin on the in vitro cytotoxicity of several topoisomerase II (topo II)-directed agents, using cultured murine Lewis lung carcinoma cells. These agents comprised amsacrine, CI-921 (9-[(2-methoxy-4-methylsulf...
journal_title：Oncology research
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doi：
更新日期：1993-01-01 00:00:00
abstract：:The poly(ADP-ribose) polymerase (PARP) enzymes play a key role in the regulation of cellular processes (e.g., DNA damage repair, genomic stability). It has been shown that PARP inhibitors (PARPIs) are selectively cytotoxic against cells having dysfunctions in genes involved in DNA repair mechanisms (synthetic lethalit...
journal_title：Oncology research
pub_type： 杂志文章
doi：10.3727/096504017X14926854178616
更新日期：2017-11-02 00:00:00
