Abstract：
:S100 binding protein A16 (S100A16) expression levels are closely associated with microRNA (miRNA) processing. Higher levels of S100A16 are reported during the progression of many cancers. Our study mainly explored the interaction between S100A16 and miR-6884-5p in gastric cancer (GC). Quantitative real-time polymerase chain reaction (qRT-PCR) was used to determine the level of S100A16 and miR-6884-5p in GC tissues and cell lines. The si-S100A16, pcDNA-S100A16, miR-6884-5p mimic or inhibitor was transfected into GC cells, and the effects of S100A16 and miR-6884-5p on the proliferation, invasion, and epithelial-mesenchymal transition (EMT) were explored by qRT-PCR and Western blot assays. Luciferase assays were performed to validate S100A16 as an miR-6884-5p target in GC cells. In our study, we found that the level of miR-6884-5p was significantly decreased and the expression of S100A16 was significantly increased in GC tissues and cell lines. There was a close association between these changes. Knockdown of S100A16 significantly inhibited the proliferation, invasion, and EMT of GC cells. The bioinformatics analysis predicted that S100A16 is a potential target gene of miR-6884-5p, and the luciferase reporter assay confirmed that miR-6884-5p could directly target S100A16. Introduction of miR-6884-5p to GC cells had similar effects to S100A16 silencing. Overexpression of S100A16 in GC cells partially reversed the inhibitory effects of the miR-6884-5p mimic. miR-6884-5p inhibited the proliferation, invasion, and EMT of GC cells by directly decreasing S100A16 expression.
journal_name
Oncol Resjournal_title
Oncology researchauthors
Lv H,Hou H,Lei H,Nie C,Chen B,Bie L,Han L,Chen Xdoi
10.3727/096504019X15753718797664subject
Has Abstractpub_date
2020-05-29 00:00:00pages
225-236issue
3eissn
0965-0407issn
1555-3906journal_volume
28pub_type
杂志文章abstract：:Numerous studies have observed that workers in ferriferous industries have an elevated risk of respiratory tract neoplasia. Research at the cellular and animal model levels indicates that iron compounds, per se, are carcinogenic. However, some investigators have suggested that inhaled iron compounds are merely carrier...
journal_title：Oncology research
pub_type： 杂志文章,评审
doi：
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journal_title：Oncology research
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journal_title：Oncology research
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doi：10.3727/096504002108747926
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journal_title：Oncology research
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journal_title：Oncology research
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doi：
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journal_title：Oncology research
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更新日期：1994-01-01 00:00:00
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journal_title：Oncology research
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journal_title：Oncology research
pub_type： 杂志文章
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更新日期：1994-01-01 00:00:00
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journal_title：Oncology research
pub_type： 杂志文章
doi：
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doi：10.3727/0965040042707907
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journal_title：Oncology research
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更新日期：2003-01-01 00:00:00
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更新日期：2017-01-26 00:00:00
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journal_title：Oncology research
pub_type： 杂志文章
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更新日期：2017-08-07 00:00:00
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journal_title：Oncology research
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
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journal_title：Oncology research
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