Membrane fluidity and surface changes during initiation of 1,2 dimethylhydrazine-induced colon carcinogenesis: protection by zinc.

abstract：:A Wnt agonist, 2-amino-4-[3,4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl) pyrimidine, is a cell-permeable pyrimidine compound that has been shown to mimic the effect of Wnt. In this study, leukemic mouse cell lines, RAW 264.7 and J774.1, were incubated with the Wnt agonist. The Wnt agonist showed cell death in th...

journal_title：Oncology research

authors： Kato Y,Naiki Y,Komatsu T,Takahashi K,Nakamura J,Koide N

更新日期：2017-04-14 00:00:00

abstract：:We previously reported that vasoactive intestinal polypeptide (VIP) significantly inhibited Matrigel invasion and haptotactic migration of murine colon 26-L5 carcinoma in vitro. To extend our study, we investigated the inhibitory mechanisms of VIP on Matrigel invasion of colon 26-L5 carcinoma, and the effect on metast...

journal_title：Oncology research

authors： Ogasawara M,Murata J,Ayukawa K,Saiki I

更新日期：1998-01-01 00:00:00

abstract：:Cyclin Y (CCNY) is a novel cyclin and almost nothing is known about its expression level and role in human cancers. In the present study, we found that lentivirus-mediated RNA interference (RNAi) of CCNY significantly downregulated its expression level. More importantly, knockdown of CCNY inhibited cell proliferation,...

journal_title：Oncology research

authors： Xu Y,Wang Z,Wang J,Li J,Wang H,Yue W

更新日期：2010-01-01 00:00:00

abstract：:Tripartite motif-containing protein 37 (TRIM37), a new member of the RING-B-box-coiled-coil (RBCC) subfamily of zinc finger proteins, was found to be involved in the development and progression of several cancers. However, the expression pattern and biological functions of TRIM37 in colorectal cancer (CRC) remain unkn...

journal_title：Oncology research

authors： Zhao P,Guan HT,Dai ZJ,Ma YG,Liu XX,Wang XJ

更新日期：2017-01-02 00:00:00

abstract：:Ameloblastoma is the most frequently encountered odontogenic tumor, characterized by a locally invasive behavior, frequent recurrences, and, although rare, metastatic capacity. Loss or inactivation of tumor suppressor genes (TSGs) allows cells to acquire neoplastic growth. The ING family proteins are tumor suppressors...

journal_title：Oncology research

authors： Borkosky SS,Gunduz M,Beder L,Tsujigiwa H,Tamamura R,Gunduz E,Katase N,Rodriguez AP,Sasaki A,Nagai N,Nagatsuka H

更新日期：2010-01-01 00:00:00

abstract：:Kaempferol is a flavonoid that has been extensively investigated owing to its antitumor effects. Nevertheless, little is known about its underlying mechanisms of action. We aimed to explore the role of kaempferol in breast cancer (BC), and thus we investigated how kaempferol suppresses the growth of BC cells. The cell...

journal_title：Oncology research

authors： Zhu L,Xue L

更新日期：2019-06-21 00:00:00

abstract：:Recently, there has been significant effort in developing techniques designed to detect disseminated tumor cells in the peripheral blood (PB). These techniques include immunocytochemical staining of cytocentrifuge slides, flow cytometry, and RT-PCR. Several authors reported various results concerning the sensitivity o...

journal_title：Oncology research

authors： Stimpfl M,Schmid BC,Obermair A,Tong D,Schiebel I,Gitsch G,Leodolter S,Zeillinger R

更新日期：1999-01-01 00:00:00

abstract：:Chemoresistance is a major impediment to the successful treatment of cancer. It involves various mechanisms, including defects in the apoptosis program that is induced by anticancer drugs. To further explore the mechanisms underlying the development of chemoresistance in ovarian carcinoma after cisplatin (CDDP) treatm...

journal_title：Oncology research

authors： Mansouri A,Zhang Q,Ridgway LD,Tian L,Claret FX

更新日期：2003-01-01 00:00:00

abstract：:To investigate the effect of Kim-1 on 786-0 cells in vivo and in vitro, several experiments such as quantitative real-time PCR, Western blot, MTT, colony formation, and flow cytometry were performed to evaluate the biological behavior of 786-0 cells treated with Kim-1 siRNA. Furthermore, the tumor xenograft model was ...

journal_title：Oncology research

authors： Xu J,Sun L,Sun W,Tian J,Guo H

更新日期：2018-08-23 00:00:00

abstract：:Carbonic anhydrase (CA) IX has emerged as a promising target for cancer therapy. It is highly upregulated in hypoxic regions and mediates pH regulation critical for tumor cell survival as well as extracellular acidification of the tumor microenvironment, which promotes tumor aggressiveness via various mechanisms, such...

journal_title：Oncology research

authors： Riemann A,Güttler A,Haupt V,Wichmann H,Reime S,Bache M,Vordermark D,Thews O

更新日期：2018-03-05 00:00:00

abstract：:Pyroptosis is a type of proinflammatory programmed cell death mediated by caspase 1 activity and occurs in several types of eukaryotic tumor cells, including gliomas. MicroRNAs (miRNAs), small endogenous noncoding RNAs, have been demonstrated to be advantageous in glioma therapy. However, the question of whether miRNA...

journal_title：Oncology research

authors： Jiang Z,Yao L,Ma H,Xu P,Li Z,Guo M,Chen J,Bao H,Qiao S,Zhao Y,Shen J,Zhu M,Meyers C,Ma G,Xie C,Liu L,Wang H,Zhang W,Dong Q,Shen H,Lin Z

更新日期：2017-07-05 00:00:00

abstract：:Pancreatic cancer is characterized as a type of gastrointestinal tumor with a poor prognosis and high degree of malignancy. CIITA gene was found highly methylated in pancreatic carcinoma cell line PANC-1 and responsible for the low expression of major histocompatability complex II (MHC-II) that may lead to immune evas...

journal_title：Oncology research

authors： Tao Y,Lin F,Li T,Xie J,Shen C,Zhu Z

更新日期：2013-01-01 00:00:00

abstract：:A number of previous investigations have reported that physical exercise renders immunopotentiating and antitumor therapeutic benefits to the tumor-bearing host. As these effects of physical exercise are mainly mediated through the modulation of hormonal and cytokine repertoire, it remains unclear if male and female t...

journal_title：Oncology research

authors： Verma VK,Singh V,Singh MP,Singh SM

更新日期：2010-01-01 00:00:00

abstract：:The regular RIN1 gene is a molecule located on chromosome 1lq13.2, and contains a coding region of 2352 bp with a 3' domain that binds to H-Ras protein, suggesting that it is an important molecule in the intracellular signaling pathway. In this study, we confirmed the existence of a novel form of the RIN1 gene with a ...

journal_title：Oncology research

authors： Fujioka M,Goi T,Hirono Y,Katayama K,Yamaguchi A

更新日期：2009-01-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) has remained an enigmatic disease, the etiology of which is mostly unknown. Considering the age incidence around menopause, a "gonadotrophin theory" has been proposed, and considering the association with infertility, an "incessant ovulation" theory has been proposed. EOC originates fro...

journal_title：Oncology research

authors： Bose CK

更新日期：2008-01-01 00:00:00

abstract：:Baicalein, a flavonoid derived from the root of Scutellaria baicalensis, has been reported to possess multiple pharmacological activities, such as anticancer and anti-inflammatory properties. This study investigated the effect of baicalein in cervical cancer cells. Cell growth curve and MTT assay were performed and re...

journal_title：Oncology research

authors： Wu X,Yang Z,Dang H,Peng H,Dai Z

更新日期：2018-05-07 00:00:00

abstract：:Triptorelin, a kind of GnRH agonist, is widely used in the treatment of hormone-responsive cancers in the clinic. This study aimed to discover the underlying mechanism of triptorelin in protection from 5-fluorouracil (5-FU)-induced ovarian damage in Sprague-Dawley rats. In the present study, after using 5-FU to induce...

journal_title：Oncology research

authors： Wang Y,Tian X,Liang L,Wang Y,Wang R,Cheng X,Yan Z,Chen Y,Qi P

更新日期：2014-01-01 00:00:00

abstract：:Topotecan, a topoisomerase I poison and water-soluble derivative of camptothecin, has shown promise in treating solid tumors; however, the drug is unstable under physiological conditions and converts to an inactive form within 30 minutes. Encapsulating topotecan in liposomes (LIP-TPT) minimizes inactivation. The effic...

journal_title：Oncology research

authors： Subramanian D,Muller MT

更新日期：1995-01-01 00:00:00

abstract：:Tamoxifen causes a mitochondrial transmembrane potential dysfunction and ATP depletion, which may play a role in tamoxifen cytotoxicity. Administration of oligomycin-2 deoxy glucose (2DG) enhanced tamoxifen antiproliferative effects, which may be due to exacerbated ATP depletion following tamoxifen and oligomycin-2DG ...

journal_title：Oncology research

authors： Seyedabadi M,Ghahremani MH,Ostad SN

更新日期：2009-01-01 00:00:00

abstract：:Colorectal cancer is an aggressive malignancy for which there are limited treatment options. Oncolytic vaccinia virus isbeing developed as a novel strategy for cancer therapy. Arming vaccinia virus with immunostimulatory cytokines can enhance the tumor cell-specific replication and antitumor efficacy. Interleukin-24 (...

journal_title：Oncology research

authors： Deng L,Yang X,Fan J,Ding Y,Peng Y,Xu D,Huang B,Hu Z

更新日期：2020-07-08 00:00:00

abstract：:Liver injury is often observed in various pathological conditions including posthepatectomy state and cancer chemotherapy. It occurs mainly as a consequence of the combined necrotic and apoptotic types of cell death. In order to study liver/hepatocyte injury by the necrotic type of cell death, we studied signal-regula...

journal_title：Oncology research

authors： Haga S,Kanno A,Ozawa T,Morita N,Asano M,Ozaki M

更新日期：2018-04-10 00:00:00

abstract：:This study aimed to explore the effects of lncRNA BCAR4 on the viability and aggressiveness of non-small cell lung cancer (NSCLC) cells. qRT-PCR was used to determine the expression of BCAR4 and GLI2 downstream genes in NSCLC tissues and cell lines. Chromatin isolation by RNA purification (CHIRP) and Western blot were...

journal_title：Oncology research

authors： Yang H,Yan L,Sun K,Sun X,Zhang X,Cai K,Song T

更新日期：2019-02-21 00:00:00

abstract：:Currently, multiple microRNAs (miRNAs) have been found to play vital roles in the pathogenesis of osteosarcoma. This study aimed to investigate the role of miR-21 in osteosarcoma. The level of miR-21 in 20 pairs of osteosarcoma and corresponding adjacent tissues was monitored by qPCR. Human osteosarcoma cell line SAOS...

journal_title：Oncology research

authors： Xu B,Xia H,Cao J,Wang Z,Yang Y,Lin Y

更新日期：2017-08-07 00:00:00

abstract：:Oncogene Bmi-1 (B-cell-specific Moloney murine leukemia virus integration site 1) has attracted much attention for its involvement in the initiation of a variety of tumors. Our previous study showed that Bmi-1 was highly expressed in gastric cancer and correlated with patient prognosis. However, whether aberrant Bmi-1...

journal_title：Oncology research

authors： Chen Y,Lian G,Zhang Q,Zeng L,Qian C,Chen S,Huang K

更新日期：2013-01-01 00:00:00

abstract：:The mechanism of action of the anthraquinone antileukemic drug mitoxantrone (MIT) was investigated and compared with that of daunorubicin (DNR) with emphasis on the interaction with DNA to clarify the more potent cytotoxic activity of MIT than DNR in human leukemia cells. MIT showed similar characteristics to those of...

journal_title：Oncology research

authors： Fukushima T,Kawai Y,Nakayama T,Yamauchi T,Yoshida A,Urasaki Y,Imamura S,Kamiya K,Tsutani H,Ueda T,Nakamura T

更新日期：1996-01-01 00:00:00

abstract：:Kiss-1 has been identified as a putative metastasis suppressor gene in various human malignancies. However, there is little information about its possible role in gastric carcinoma. In this study, we determined whether the Kiss-1 gene negatively regulates MMP-9 expression. cDNA microarray technology was used to identi...

journal_title：Oncology research

authors： Lee KH,Kim JR

更新日期：2009-01-01 00:00:00

abstract：:O6-Alkylguanine-DNA alkyltransferase (AGT) is a DNA repair protein that reverses alkylation damage produced by chloroethylnitrosoureas and is a major determinant of cellular resistance to adjuvant chemotherapy with these drugs. AGT activity was measured in 119 samples from 69 patients, including normal, tumor, and dis...

journal_title：Oncology research

authors： White A,Kibitel J,Garcia Y,Belanich M,Yarosh D,Wideroff J,Levin L,Held D,Fuchs A,Citron M

更新日期：1997-01-01 00:00:00

abstract：:The patterns of DNA fragmentation were evaluated following a brief exposure (2 h) of the human ileocecal adenocarcinoma cell line, HCT-8, to several specific thymidylate synthase inhibitors, a quinazoline (ZD1694) and benz[cd]indole-containing molecule (AG-331). The magnitude and size of DNA fragmentation induced by t...

journal_title：Oncology research

authors： Panadero A,Yin MB,Voigt W,Rustum YM

更新日期：1995-01-01 00:00:00

abstract：:Solid tumors involving glandular organs express mucin glycoprotein that is eventually shed into the circulation. As a result, these proteins can easily be measured in the serum and be used as potential tumor markers. The most commonly used tumor markers for breast cancer are CA27-29 and CA15-3, which both measure the ...

journal_title：Oncology research

authors： Copur MS,Wurdeman JM,Nelson D,Ramaekers R,Gauchan D,Crockett D

更新日期：2018-04-10 00:00:00

abstract：:Aberrant expression of microRNA-92a (miR-92a) has been investigated in various cancers. However, the function and mechanism of miR-92a in acute myeloid leukemia (AML) remain to be elucidated. Our data showed that miR-92a was evidently downregulated and methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) was remarkably ...

journal_title：Oncology research

authors： Gu Y,Si J,Xiao X,Tian Y,Yang S

更新日期：2017-08-07 00:00:00