MicroRNA-21 Inhibits the Apoptosis of Osteosarcoma Cell Line SAOS-2 via Targeting Caspase 8.

abstract：:We investigated the susceptibility of three inbred strains of rats to the hepatocarcinogen, N-nitrosomorpholine (NNM), to establish a spontaneous metastatic model of hepatocellular carcinoma (HCC). WS/Shi. SD/gShi, and F344/DuCrj rats were given 0.02% NNM in drinking water for 8 weeks and thereafter left without any t...

journal_title：Oncology research

authors： Murai T,Mori S,Hosono M,Iwakura Y,Takashima A,Oohara T,Makino S,Takeda R,Fukushima S

更新日期：2000-01-01 00:00:00

abstract：:This study was designed to investigate the role of miR-183 in modulating cell growth and apoptosis of tongue squamous cell carcinoma SCC25 cell line. Human squamous epithelial cell and squamous cell carcinoma cell line SCC25 was used, and miR-183 was inhibited. Cell growth, colony formation, and apoptotic rate, as wel...

journal_title：Oncology research

authors： Yan D,Cai X,Feng Y

更新日期：2016-10-27 00:00:00

abstract：:Apoptosis proteins may play a role in prognosis and therapy response; however, they have not been fully investigated in gastric cancer. We aimed to assess the expression of proteins in the Bcl-2 family. Immunohistochemistry was employed to examine the expression of the antiapoptotic proteins Bcl-2 and Bcl-XL and the p...

journal_title：Oncology research

authors： Smith L,Berrieman HK,O'Kane SL,Campbell A,Maraveyas A,Cawkwell L

更新日期：2006-01-01 00:00:00

abstract：:Cyclin Y (CCNY) is a novel cyclin and almost nothing is known about its expression level and role in human cancers. In the present study, we found that lentivirus-mediated RNA interference (RNAi) of CCNY significantly downregulated its expression level. More importantly, knockdown of CCNY inhibited cell proliferation,...

journal_title：Oncology research

authors： Xu Y,Wang Z,Wang J,Li J,Wang H,Yue W

更新日期：2010-01-01 00:00:00

abstract：:Synthesis of poly(gamma-glutamyl) metabolites of many antifolates, such as methotrexate (MTX), by folylpolyglutamate synthetase (FPGS) is often essential to their cytotoxic activity. FPGS expression in the MTX-sensitive human T-lymphoblastic leukemia cell line CCRF-CEM and a number of MTX-resistant sublines was previo...

journal_title：Oncology research

authors： McGuire JJ,Russell CA

更新日期：1998-01-01 00:00:00

abstract：:Lung cancer remains a critical health concern worldwide. Long noncoding RNAs with ultraconserved elements have recently been implicated in human tumorigenesis. The present study investigated the role of ultraconserved element 338 (uc.338) in the regulation of cell proliferation and metastasis in human lung cancer. Our...

journal_title：Oncology research

authors： Gao X,Gao X,Li C,Zhang Y,Gao L

更新日期：2016-01-01 00:00:00

abstract：:Dysregulation of SUMO-specific protease 1 (SENP1) expression has been reported in several kinds of cancer, including human colorectal and prostate cancers, proposing SENP1 as an oncogene with a critical role in cancer progression. miR-133a-3p has been reported as a tumor suppressor in several malignant neoplasias. How...

journal_title：Oncology research

authors： Zhou GQ,Han F,Shi ZL,Yu L,Li XF,Yu C,Shen CL,Wan DW,Zhu XG,Li R,He SB

更新日期：2018-06-11 00:00:00

abstract：:Human skin fibroblasts were exposed to global system for mobile communication (GSM) cellular phone radiofrequency for 1 h. GSM exposure induced alterations in cell morphology and increased the expression of mitogenic signal transduction genes (e.g., MAP kinase kinase 3, G2/mitotic-specific cyclin G1), cell growth inhi...

journal_title：Oncology research

authors： Pacini S,Ruggiero M,Sardi I,Aterini S,Gulisano F,Gulisano M

更新日期：2002-01-01 00:00:00

abstract：:Numerous studies have observed that workers in ferriferous industries have an elevated risk of respiratory tract neoplasia. Research at the cellular and animal model levels indicates that iron compounds, per se, are carcinogenic. However, some investigators have suggested that inhaled iron compounds are merely carrier...

journal_title：Oncology research

authors： Weinberg ED

更新日期：1999-01-01 00:00:00

abstract：:Recently, increasing evidence has shown that CDGSH iron sulfur domain 2 (CISD2) is involved in the initiation and metastasis of several cancers. However, the evidence of its potential role in pancreatic cancer is still lacking. In our present study, CISD2 was found to be increased in pancreatic cancer samples and mult...

journal_title：Oncology research

authors： Yang Y,Bai YS,Wang Q

更新日期：2017-04-14 00:00:00

abstract：:Electron-affinic compounds with strong DNA intercalating properties have demonstrated less than the expected radiosensitization due to restriction of their mobility along the DNA backbone and their lower extravascular diffusion in tumors. A 2-nitroimidazole linked 1,2,3,4-tetrahydroacridine derivative (THNLA-1) has be...

journal_title：Oncology research

authors： Papadopoulou MV,Rosenzweig HS,Doddi M,Bloomer WD

更新日期：1994-01-01 00:00:00

abstract：:Human telomerase is a ribonucleoprotein that maintains telomeres by adding TTAGGG tandem repeat sequences using RNA template of the enzyme. Telomerase activity is highly expressed in immortalized cells but not in most somatic cells, except for some renewal tissues, such as hematopoietic stem cells. Therefore, telomera...

journal_title：Oncology research

authors： Togashi K,Kakeya H,Morishita M,Song YX,Osada H

更新日期：1998-01-01 00:00:00

abstract：:Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the initiation and development of many solid tumors, including osteosarcoma (OS). In this study, we showed that MALAT1 was increased in human OS tissues and cell lines. MALAT1 knockdown suppressed OS ce...

journal_title：Oncology research

authors： Zhang Y,Dai Q,Zeng F,Liu H

更新日期：2018-04-27 00:00:00

abstract：:It has been reported that upregulated SIRT1 (NAD(+)-dependent class III histone deacetylase) deacetylates the p53 protein, represses its function, and allows for tumor cell growth in various cancers. Here we investigated antitumor effects of tenovin-6, a small-molecule inhibitor of SIRT1 and SIRT2, in various colon ca...

journal_title：Oncology research

authors： Ueno T,Endo S,Saito R,Hirose M,Hirai S,Suzuki H,Yamato K,Hyodo I

更新日期：2013-01-01 00:00:00

abstract：:To ascertain whether insulin-like growth factors (IGF-1 and IGF-2) affect the estrogen- and insulin-responsive R3230AC mammary carcinoma, studies of IGF-1 and IGF-2 receptors were conducted on primary-culture tumor cells and on membranes purified from whole tumors. By saturation binding analysis, cells in culture disp...

journal_title：Oncology research

authors： Korc-Grodzicki B,Furlanetto RW,Hilf R

更新日期：1992-01-01 00:00:00

abstract：:The purpose of this study was to investigate the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) treatment in Chinese hepatocellular carcinoma (HCC) patients and the prognostic factors for treatment response as well as survival. A total of 275 HCC patients were included in this pro...

journal_title：Oncology research

authors： Sun J,Zhou G,Xie X,Gu W,Huang J,Zhu D,Hu W,Hou Q,Shi C,Li T,Zhang X,Ji W,Ying S,Peng Z,Zhou J,Yu Z,Ji J,Du H,Guo X,Fang J,Han J,Xu H,Sun Z,Yu W,Shao G,Wu X,Hu H,Li L,Zheng J,Luo J,Chen Y,Cao

更新日期：2020-02-07 00:00:00

abstract：:Grb2-associated binder 1 (Gab1) is often aberrant in cancerous cells and tissues, whose alteration is responsible for aggressive phenotypes. In this study, we examined the Gab1 expression in human oral squamous cell carcinoma (OSCC) tissues and investigated the cellular and molecular effect of Gab1 on migration, invas...

journal_title：Oncology research

authors： Xu L,Li J,Kuang Z,Kuang Y,Wu H

更新日期：2018-05-07 00:00:00

abstract：:Sixteen desmuramyl analogs of muramyl dipeptide (MDP) were tested for their abilities to stimulate cytotoxic factor secretion by mouse peritoneal macrophages. Among them, the pseudohexapeptide Boc-Gly psi [CH2O]-D-Ala-Ala-D-Glu[Lys(H-Gly)NHEt]-NH2 appeared to be four times more effective than MDP. From this study, the...

journal_title：Oncology research

authors： Breton P,Petit C,Bousser MT,Monsigny M,Mayer R,Roche AC

更新日期：1992-01-01 00:00:00

abstract：:We observed a putative immunocytolytic factor secreted in the supernatant of several pancreatic adenocarcinoma cell lines that induces apoptosis in lymphocytes. A marked reduction in the viability of the target splenocytes was evident after coincubation with the supernatants from various pancreatic adenocarcinoma cell...

journal_title：Oncology research

authors： Divino CM,Angel LP,Brower ST,Chen SH

更新日期：1999-01-01 00:00:00

abstract：:This study aimed to explore the effects of lncRNA BCAR4 on the viability and aggressiveness of non-small cell lung cancer (NSCLC) cells. qRT-PCR was used to determine the expression of BCAR4 and GLI2 downstream genes in NSCLC tissues and cell lines. Chromatin isolation by RNA purification (CHIRP) and Western blot were...

journal_title：Oncology research

authors： Yang H,Yan L,Sun K,Sun X,Zhang X,Cai K,Song T

更新日期：2019-02-21 00:00:00

abstract：:Neuroendocrine tumors (NETs) represent a relatively rare form of neoplasias for which, in advanced unresectable stages, palliative treatment options remain limited largely to the use of somatostatin analogues or chemotherapy. Several newer targeted therapeutic options, alone or in combination with somatostatin analogu...

journal_title：Oncology research

authors： Pusceddu S,Milione M,Procopio G

更新日期：2011-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies, with a poor prognosis and high recurrence rate. In the present study, we identified CD133, one of the markers of cancer stem cells, as a novel molecular target of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). In four human HCC ce...

journal_title：Oncology research

authors： Lee SH,Hyun SK,Kim HB,Kang CD,Kim SH

更新日期：2016-10-27 00:00:00

abstract：:Mutations in the APC gene contribute to development of sporadic desmoid tumors as well as to the hereditary tumors that usually accompany familial adenomatous polyposis (FAP). Adenomatous polyposis coli (APC) mutations cause an intracellular accumulation of beta-catenin that results in abnormal signaling in the wnt/wi...

journal_title：Oncology research

authors： Miyoshi Y,Iwao K,Nawa G,Yoshikawa H,Ochi T,Nakamura Y

更新日期：1998-01-01 00:00:00

abstract：:Aberrant expression of microRNA-92a (miR-92a) has been investigated in various cancers. However, the function and mechanism of miR-92a in acute myeloid leukemia (AML) remain to be elucidated. Our data showed that miR-92a was evidently downregulated and methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) was remarkably ...

journal_title：Oncology research

authors： Gu Y,Si J,Xiao X,Tian Y,Yang S

更新日期：2017-08-07 00:00:00

abstract：:Because of lack of effective treatment options for hormone-refractory prostate cancer at the present time, the need for developing novel therapeutic strategies and targets to treat and prevent the progression of hormone-sensitive prostate cancer to the hormone-refractory stage is paramount. Our previous in vitro studi...

journal_title：Oncology research

authors： Andrzejewski T,Deeb D,Gao X,Danyluk A,Arbab AS,Dulchavsky SA,Gautam SC

更新日期：2008-01-01 00:00:00

abstract：:ErbB4 is a member of the ErbB family of receptor tyrosine kinases. Because of a paucity of appropriate pharmacologic tools, little is known about ErbB4 functions in vivo. In response to this need, we hypothesized that a recombinant form of the extracellular domain of ErbB4 would antagonize ligand-induced receptor tyro...

journal_title：Oncology research

authors： Gilmore JL,Riese DJ 2nd

更新日期：2004-01-01 00:00:00

abstract：:Our recent studies demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) has pharmacological activity for the treatment of acute myelocytic leukemia patients. In the present study, we investigated the potential synergistic effect of all-trans retinoic acid (RA), 1alpha,25-dihydroxyvitamin D3 (VD3), and sodium b...

journal_title：Oncology research

authors： Zheng X,Chang RL,Cui XX,Kelly KA,Shih WJ,Lin Y,Strair R,Suh J,Han ZT,Rabson A,Conney AH

更新日期：2000-01-01 00:00:00

abstract：:A Wnt agonist, 2-amino-4-[3,4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl) pyrimidine, is a cell-permeable pyrimidine compound that has been shown to mimic the effect of Wnt. In this study, leukemic mouse cell lines, RAW 264.7 and J774.1, were incubated with the Wnt agonist. The Wnt agonist showed cell death in th...

journal_title：Oncology research

authors： Kato Y,Naiki Y,Komatsu T,Takahashi K,Nakamura J,Koide N

更新日期：2017-04-14 00:00:00

abstract：:Ahead of Print article withdrawn by publisher. ...

journal_title：Oncology research

authors： Liu H,Shi B,Yan Y,Niu L,Zhou Y,Cai H,Ge G

更新日期：2016-09-30 00:00:00

abstract：:The ability of mitoxantrone to form DNA adducts was investigated in a series of human tumor cell lines consisting of human cervical cancer (HeLa), human breast cancer (MCF-7), and human neuroblastoma (IMR-32) cells. The mitoxantrone-resistant human promyelocytic leukemia cell line HL60/MX2 was also compared to the par...

journal_title：Oncology research

authors： Parker BS,Rephaeli A,Nudelman A,Phillips DR,Cutts SM

更新日期：2004-01-01 00:00:00