Abstract:
:This study was designed to investigate the role of miR-183 in modulating cell growth and apoptosis of tongue squamous cell carcinoma SCC25 cell line. Human squamous epithelial cell and squamous cell carcinoma cell line SCC25 was used, and miR-183 was inhibited. Cell growth, colony formation, and apoptotic rate, as well as the expression of caspase 3 and BCL-xL, were detected. Results showed that miR-183 was significantly overexpressed in the SCC25 cell line when compared with normal control. The miR-183 inhibitor reduced cell growth and colony formation, while the apoptosis percentage was significantly increased. The expression of activated caspase 3 and BCL-xL was obviously up- and downregulated in siRNA-transfected cells, respectively. In conclusion, miR-183 contributed to cell growth and proliferation, and suppressed cell apoptosis in SCC25 cells. Therefore, miR-183 might serve as a therapeutic target in tongue squamous cell carcinoma (TSCC).
journal_name
Oncol Resjournal_title
Oncology researchauthors
Yan D,Cai X,Feng Ydoi
10.3727/096504016X14685034103239subject
Has Abstractpub_date
2016-10-27 00:00:00pages
399-404issue
6eissn
0965-0407issn
1555-3906journal_volume
24pub_type
杂志文章abstract::It has been demonstrated that microRNAs (miRNAs) act as oncogenes or tumor suppressors in a variety of cancers. Our previous work suggested that miR-10a/b functioned as a tumor suppressor in gastric cancer, and miR-10b was also reported to be significantly downregulated in advanced stage cervical cancer tissues. Howev...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504016X14611963142173
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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abstract::Ahead of Print article withdrawn by publisher. ...
journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
pub_type: 杂志文章
doi:
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journal_title:Oncology research
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journal_title:Oncology research
pub_type: 杂志文章
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journal_title:Oncology research
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doi:10.3727/096504010x12644422320582
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journal_title:Oncology research
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doi:10.3727/096504016X14747335734344
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journal_title:Oncology research
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doi:10.3727/096504013x13589503482932
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journal_title:Oncology research
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journal_title:Oncology research
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更新日期:2019-05-07 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:
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journal_title:Oncology research
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doi:10.3727/096504017X15005102445191
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journal_title:Oncology research
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doi:
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journal_title:Oncology research
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