Inhibition of cellular growth and migration by suppression of endothelial protein C receptor (EPCR) in lung carcinoma cells.

abstract：:Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the initiation and development of many solid tumors, including osteosarcoma (OS). In this study, we showed that MALAT1 was increased in human OS tissues and cell lines. MALAT1 knockdown suppressed OS ce...

journal_title：Oncology research

authors： Zhang Y,Dai Q,Zeng F,Liu H

更新日期：2018-04-27 00:00:00

abstract：:HL-60 cells isolated for resistance to vincristine are multidrug resistant and defective in the cellular accumulation of drug. Further studies demonstrate that these cells are also highly defective in 12-O-tetradecanoylphorbol-13-acetate (TPA) induced differentiation to macrophages. Analysis of this system demonstrate...

journal_title：Oncology research

authors： Ma L,Krishnamachary N,Perbal B,Center MS

更新日期：1992-01-01 00:00:00

abstract：:Aberrantly expressed microRNAs (miRNAs/miRs) and their role in cancer development have recently gained more attention. However, the potential role of miRNAs in hepatocellular carcinoma (HCC) remains largely unknown. In this study, we demonstrated that miR-377 was markedly downregulated in HCC cell lines and primary hu...

journal_title：Oncology research

authors： Ge H,Zou D,Wang Y,Jiang H,Wang L

更新日期：2017-01-02 00:00:00

abstract：:Tripartite motif-containing protein 37 (TRIM37), a new member of the RING-B-box-coiled-coil (RBCC) subfamily of zinc finger proteins, was found to be involved in the development and progression of several cancers. However, the expression pattern and biological functions of TRIM37 in colorectal cancer (CRC) remain unkn...

journal_title：Oncology research

authors： Zhao P,Guan HT,Dai ZJ,Ma YG,Liu XX,Wang XJ

更新日期：2017-01-02 00:00:00

abstract：:Point mutations and deletions in the p53 tumor suppressor gene occur frequently in advanced stage bladder tumors. To extend these observations to an in vitro model of bladder tumorigenicity, we have evaluated the presence of p53 mutations in a panel of bladder carcinoma cell lines. p53 alleles were cloned using the re...

journal_title：Oncology research

authors： Cooper MJ,Haluschak JJ,Johnson D,Schwartz S,Morrison LJ,Lippa M,Hatzivassiliou G,Tan J

更新日期：1994-01-01 00:00:00

abstract：:A novel keto-diepoxide Sch 49209 and its derivative Sch 50672, produced by the fungus Nattrassia mangiferae, inhibited tumor cell invasion through an artificial basement membrane. These compounds, at nontoxic concentrations, inhibited invasion of HT-1080 cells in a dose-dependent manner. The IC50 values for Sch 49209 ...

journal_title：Oncology research

authors： King I,Blood C,Chu M,Patel M,Liu M,Li Z,Robertson N,Maxwell E,Catino JJ

更新日期：1995-01-01 00:00:00

abstract：:Although arsenic trioxide (ATO) is a well-known antileukemic drug used for acute promyelocytic leukemia treatment, the development of ATO resistance is still a big challenge. We previously reported that microRNA-204 (miR-204) was involved in the regulation of acute myeloid leukemia (AML) cell apoptosis, but its role i...

journal_title：Oncology research

authors： Wang Z,Fang Z,Lu R,Zhao H,Gong T,Liu D,Hong L,Ma J,Zhang M

更新日期：2019-09-23 00:00:00

abstract：:Lung cancer is a lethal solid tumor with poor prognosis because of its high metastasis and resistance to current therapies. Recently, cancer stem cells (CSCs) were suggested to be major contributors to tumorigenicity and cancer relapse. However, therapeutic targets for lung cancer-related CSCs remain undetermined. The...

journal_title：Oncology research

authors： Huang Y,Zeng F,Xu L,Zhou J,Liu X,Le H

更新日期：2013-01-01 00:00:00

abstract：:Combretastatin A4 phosphate (CA4P) is currently undergoing clinical trials as a tumor vascular-targeting agent. Here, we defined the antivascular effect and programmed cell death (PCD) induced by CA4P in vascular endothelial cells. CA4P induced time- and dose-dependent antiproliferative activities against human umbili...

journal_title：Oncology research

authors： Ding X,Zhang Z,Li S,Wang A

更新日期：2011-01-01 00:00:00

abstract：:The beta-adrenergic receptors transduce catecholamine signals to the G protein, which through a cascade of chemical reactions in cells generates highly specific parallel signals. The beta2-adrenergic receptor (ADRB2) is the most involved in the carcinogenic processes. Previous studies have determined the relationship ...

journal_title：Oncology research

authors： Pérez-Sayáns M,Somoza-Martín JM,Barros-Angueira F,Diz PG,Gándara Rey JM,García-García A

更新日期：2010-01-01 00:00:00

abstract：:Kiss-1 has been identified as a putative metastasis suppressor gene in various human malignancies. However, there is little information about its possible role in gastric carcinoma. In this study, we determined whether the Kiss-1 gene negatively regulates MMP-9 expression. cDNA microarray technology was used to identi...

journal_title：Oncology research

authors： Lee KH,Kim JR

更新日期：2009-01-01 00:00:00

abstract：:The importance of receptors involved in the clearance of proteases and protease/inhibitor complexes in tumor invasion is unknown. We studied the expression of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP/alpha 2-MR), the major receptor involved in the clearance of protease/i...

journal_title：Oncology research

authors： Kancha RK,Stearns ME,Hussain MM

更新日期：1994-01-01 00:00:00

abstract：:Angiogenesis, the formation of new vessels, is essential for tumor growth and metastasis. Mutations of p53 tumor suppressor gene are frequent and play an important role in colorectal oncogenesis. A role of p53 as an angiogenesis inhibitor has also been proposed. We evaluated angiogenesis and p53 expression in 16 hyper...

journal_title：Oncology research

authors： Kakolyris SA,Kaklamanis LG,Koukourakis MJ,Giatromanolaki A,Rousomoustakaki M,Souglakos JC,Reppa DK,Georgoulias VA,Gatter KC,Harris AL

更新日期：2000-01-01 00:00:00

abstract：:The ability of mitoxantrone to form DNA adducts was investigated in a series of human tumor cell lines consisting of human cervical cancer (HeLa), human breast cancer (MCF-7), and human neuroblastoma (IMR-32) cells. The mitoxantrone-resistant human promyelocytic leukemia cell line HL60/MX2 was also compared to the par...

journal_title：Oncology research

authors： Parker BS,Rephaeli A,Nudelman A,Phillips DR,Cutts SM

更新日期：2004-01-01 00:00:00

abstract：:Currently, multiple microRNAs (miRNAs) have been found to play vital roles in the pathogenesis of osteosarcoma. This study aimed to investigate the role of miR-21 in osteosarcoma. The level of miR-21 in 20 pairs of osteosarcoma and corresponding adjacent tissues was monitored by qPCR. Human osteosarcoma cell line SAOS...

journal_title：Oncology research

authors： Xu B,Xia H,Cao J,Wang Z,Yang Y,Lin Y

更新日期：2017-08-07 00:00:00

abstract：:Colorectal cancer is an aggressive malignancy for which there are limited treatment options. Oncolytic vaccinia virus isbeing developed as a novel strategy for cancer therapy. Arming vaccinia virus with immunostimulatory cytokines can enhance the tumor cell-specific replication and antitumor efficacy. Interleukin-24 (...

journal_title：Oncology research

authors： Deng L,Yang X,Fan J,Ding Y,Peng Y,Xu D,Huang B,Hu Z

更新日期：2020-07-08 00:00:00

abstract：:Inflammation plays a major role in the pathogenesis of cervical cancer. Chemokines are involved in inflammation, cancer, and infectious diseases. Therefore, we evaluated the association of the chemokine receptor gene polymorphism CCR5 Delta32 with risk of cervical cancer. A total of 150 histopathologically confirmed p...

journal_title：Oncology research

authors： Singh H,Sachan R,Jain M,Mittal B

更新日期：2008-01-01 00:00:00

abstract：:The human nucleolar protein p120 is highly expressed in human cancers. Its high expression in breast cancer correlates with a poor prognosis, and its overexpression in 3T3 mouse fibroblasts causes malignant transformation. This study reports that a combination of monoclonal anti-p 120 antibody (MAbp120), liposomes (Li...

journal_title：Oncology research

authors： Perlaky L,Busch RK,Busch H

更新日期：1996-01-01 00:00:00

abstract：:Recently, increasing evidence has shown that CDGSH iron sulfur domain 2 (CISD2) is involved in the initiation and metastasis of several cancers. However, the evidence of its potential role in pancreatic cancer is still lacking. In our present study, CISD2 was found to be increased in pancreatic cancer samples and mult...

journal_title：Oncology research

authors： Yang Y,Bai YS,Wang Q

更新日期：2017-04-14 00:00:00

abstract：:We observed a putative immunocytolytic factor secreted in the supernatant of several pancreatic adenocarcinoma cell lines that induces apoptosis in lymphocytes. A marked reduction in the viability of the target splenocytes was evident after coincubation with the supernatants from various pancreatic adenocarcinoma cell...

journal_title：Oncology research

authors： Divino CM,Angel LP,Brower ST,Chen SH

更新日期：1999-01-01 00:00:00

abstract：:Whether the phenotypes of drug resistance and metastatic activity in cancer are dependent on each other or not is controversial. We compared in vitro invasive properties of human hepatoma cells resistant to epirubicin and rich in P-glycoprotein (Pgp) (HB8065/R) with the parental epirubicin-sensitive, Pgp-poor cells (H...

journal_title：Oncology research

authors： Bjørnland K,Lehne G,Johansen HT,Fodstad O,Rugstad HE,Aasen AO,Ree AH

更新日期：1998-01-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) play a predominant role in regulating tumor progression. Understanding how CAFs communicate with osteosarcoma is crucial for developing novel approaches for osteosarcoma therapy. Exosomes are able to transmit messages between cells. In this study, we demonstrated that CAFs transfer...

journal_title：Oncology research

authors： Wang JW,Wu XF,Gu XJ,Jiang XH

更新日期：2019-09-23 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is an uncommon and highly aggressive tumor of the neuroendocrine system, which derives from the neuroendocrine C cells of the thyroid gland. Except for surgical resection, there are not very many effective systemic treatment options for MTC. N-Myc downstream-regulated gene 2 (NDRG2) h...

journal_title：Oncology research

authors： Yin A,Wang C,Sun J,Gao J,Tao L,Du X,Zhao H,Yang J,Li Y

更新日期：2016-01-01 00:00:00

abstract：:There is an urgent need to improve the clinical management of hepatocellular carcinoma (HCC), one of the most common causes of global cancer-related deaths. Zingibar officinale is a medicinal herb used throughout history for both culinary and medicinal purposes. It has antioxidant, anticarcinogenic, and free radical s...

journal_title：Oncology research

authors： Elkady AI,Abu-Zinadah OA,Hussein RAEH

更新日期：2017-07-05 00:00:00

abstract：:Medroxyprogesterone (MPA) is used for the conservative treatment of endometrial cancer. Unfortunately, progesterone resistance seriously affects its therapeutic effect. The purpose of the current study was to investigate the influence of deletion of AT-rich interactive domain 1A (ARID1A) in progesterone resistance in ...

journal_title：Oncology research

authors： Wang H,Tang Z,Li T,Liu M,Li Y,Xing B

更新日期：2019-09-23 00:00:00

abstract：:Because of lack of effective treatment options for hormone-refractory prostate cancer at the present time, the need for developing novel therapeutic strategies and targets to treat and prevent the progression of hormone-sensitive prostate cancer to the hormone-refractory stage is paramount. Our previous in vitro studi...

journal_title：Oncology research

authors： Andrzejewski T,Deeb D,Gao X,Danyluk A,Arbab AS,Dulchavsky SA,Gautam SC

更新日期：2008-01-01 00:00:00

abstract：:N-Butyl-N-(4-hydroxybutyl)-nitrosamine (BBN), which induces bladder carcinoma in female Wistar rats and female C3H/HeJ mice, was given as 0.025% (w/v) solution to rats and 0.05% to mice in the drinking water. Thymosin fraction 5 (TF5) or thymosin alpha 1 (T alpha 1) dissolved in normal saline, and normal saline (contr...

journal_title：Oncology research

authors： Wada S,Kinoshita Y,Kamizuru M,Asai Y,Iwata H,Ikemoto S,Hato F,Kishimoto T,Fukushima S

更新日期：1996-01-01 00:00:00

abstract：:A number of previous investigations have reported that physical exercise renders immunopotentiating and antitumor therapeutic benefits to the tumor-bearing host. As these effects of physical exercise are mainly mediated through the modulation of hormonal and cytokine repertoire, it remains unclear if male and female t...

journal_title：Oncology research

authors： Verma VK,Singh V,Singh MP,Singh SM

更新日期：2010-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in the carcinogenesis of cervical cancer. However, the expression and underlying mechanisms of miRNA in cervical cancer progression remain unclear. In the present study, our data showed that the expression of miR-138-5p was significantly downregulated in cervical cancer tissues,...

journal_title：Oncology research

authors： Ou L,Wang D,Zhang H,Yu Q,Hua F

更新日期：2018-04-10 00:00:00

abstract：:Our recent studies demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) has pharmacological activity for the treatment of acute myelocytic leukemia patients. In the present study, we investigated the potential synergistic effect of all-trans retinoic acid (RA), 1alpha,25-dihydroxyvitamin D3 (VD3), and sodium b...

journal_title：Oncology research

authors： Zheng X,Chang RL,Cui XX,Kelly KA,Shih WJ,Lin Y,Strair R,Suh J,Han ZT,Rabson A,Conney AH

更新日期：2000-01-01 00:00:00