Abstract：
:MicroRNAs (miRNAs) play important roles in the carcinogenesis of cervical cancer. However, the expression and underlying mechanisms of miRNA in cervical cancer progression remain unclear. In the present study, our data showed that the expression of miR-138-5p was significantly downregulated in cervical cancer tissues, and decreased expression of miR-138-5p was correlated with advanced FIGO stage, poor differentiation, lymph node metastasis, and poor overall survival of cervical cancer patients. Function assays showed that overexpression of miR-138-5p reduced cervical cancer cell proliferation, arrested cells in the G0/G1 phase, and induced cell apoptosis in vitro. Remarkably, SIRT1 was confirmed as a direct target of miR-138-5p in cervical cancer, and miR-138-5p exerted the reduced tumor functions by suppressing SIRT1 expression. Moreover, we further identified that lncRNA H19 could act as a molecular sponge of miR-138-5p in cervical cancer progression. Taken together, these results suggested that miR-138-5p could suppress cervical cancer cell progression by targeting SIRT1.
journal_name
Oncol Resjournal_title
Oncology researchauthors
Ou L,Wang D,Zhang H,Yu Q,Hua Fdoi
10.3727/096504017X15017209042610subject
Has Abstractpub_date
2018-04-10 00:00:00pages
401-410issue
3eissn
0965-0407issn
1555-3906journal_volume
26pub_type
杂志文章abstract：:We observed a putative immunocytolytic factor secreted in the supernatant of several pancreatic adenocarcinoma cell lines that induces apoptosis in lymphocytes. A marked reduction in the viability of the target splenocytes was evident after coincubation with the supernatants from various pancreatic adenocarcinoma cell...
journal_title：Oncology research
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更新日期：1999-01-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Oncology research
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journal_title：Oncology research
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journal_title：Oncology research
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更新日期：1998-01-01 00:00:00
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journal_title：Oncology research
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journal_title：Oncology research
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journal_title：Oncology research
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journal_title：Oncology research
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journal_title：Oncology research
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doi：
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journal_title：Oncology research
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journal_title：Oncology research
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doi：
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journal_title：Oncology research
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更新日期：2003-01-01 00:00:00
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更新日期：1995-01-01 00:00:00
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journal_title：Oncology research
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