Exposure to global system for mobile communication (GSM) cellular phone radiofrequency alters gene expression, proliferation, and morphology of human skin fibroblasts.

abstract：:The clinical study of compounds that modulate multidrug resistance has been hindered by both the toxicities of these agents and the inability to monitor their effectiveness at the level of the tumor cell. Previously, toremifene has been shown to be well tolerated clinically and to sensitize multidrug resistant cells t...

journal_title：Oncology research

authors： Baker WJ,Maenpaa JU,Wurz GT,Koester SK,Seymour RC,Emshoff VD,Wiebe VJ,DeGregorio MW

更新日期：1993-01-01 00:00:00

abstract：:Synthesis of poly(gamma-glutamyl) metabolites of many antifolates, such as methotrexate (MTX), by folylpolyglutamate synthetase (FPGS) is often essential to their cytotoxic activity. FPGS expression in the MTX-sensitive human T-lymphoblastic leukemia cell line CCRF-CEM and a number of MTX-resistant sublines was previo...

journal_title：Oncology research

authors： McGuire JJ,Russell CA

更新日期：1998-01-01 00:00:00

abstract：:We previously reported that vasoactive intestinal polypeptide (VIP) significantly inhibited Matrigel invasion and haptotactic migration of murine colon 26-L5 carcinoma in vitro. To extend our study, we investigated the inhibitory mechanisms of VIP on Matrigel invasion of colon 26-L5 carcinoma, and the effect on metast...

journal_title：Oncology research

authors： Ogasawara M,Murata J,Ayukawa K,Saiki I

更新日期：1998-01-01 00:00:00

abstract：:Accumulation of beta-catenin in cytoplasm and nuclei is frequently observed in a wide variety of tumors arising, for example, in the colon, liver, uterus, or brain. In association with Tcf/LEF transcription factors, beta-catenin regulates expression of genes involved in the Wnt/wingless signaling pathway, but the prec...

journal_title：Oncology research

authors： Miwa N,Furuse M,Tsukita S,Niikawa N,Nakamura Y,Furukawa Y

更新日期：2001-01-01 00:00:00

abstract：:DNA topoisomerase II alpha is a nuclear enzyme essential for DNA metabolism and cell cycle progression. Previous studies have shown that human tumor cell lines can express more than one topoisomerase II alpha isoform through alternative splicing. A 160-kDa isoform of topoisomerase II alpha has been described in severa...

journal_title：Oncology research

authors： Mo YY,Beck WT

更新日期：1997-01-01 00:00:00

abstract：:Liver injury is often observed in various pathological conditions including posthepatectomy state and cancer chemotherapy. It occurs mainly as a consequence of the combined necrotic and apoptotic types of cell death. In order to study liver/hepatocyte injury by the necrotic type of cell death, we studied signal-regula...

journal_title：Oncology research

authors： Haga S,Kanno A,Ozawa T,Morita N,Asano M,Ozaki M

更新日期：2018-04-10 00:00:00

abstract：:Metaplastic tubular complexes (MTC) have been proposed as precursor lesions for pancreatic adenocarcinoma (PDAC). In this study, we investigated the potential role of bone marrow-derived progenitor cells (BMPC) in the formation of MTC and PDAC in a rat model. F344 rats defective for CD26 (dipeptidyl peptidase IV, DPPI...

journal_title：Oncology research

authors： Pan JJ,Oh SH,Lee WC,Petersen BE

更新日期：2009-01-01 00:00:00

abstract：:Cyclin Y (CCNY) is a novel cyclin and almost nothing is known about its expression level and role in human cancers. In the present study, we found that lentivirus-mediated RNA interference (RNAi) of CCNY significantly downregulated its expression level. More importantly, knockdown of CCNY inhibited cell proliferation,...

journal_title：Oncology research

authors： Xu Y,Wang Z,Wang J,Li J,Wang H,Yue W

更新日期：2010-01-01 00:00:00

abstract：:Pyroptosis is a type of proinflammatory programmed cell death mediated by caspase 1 activity and occurs in several types of eukaryotic tumor cells, including gliomas. MicroRNAs (miRNAs), small endogenous noncoding RNAs, have been demonstrated to be advantageous in glioma therapy. However, the question of whether miRNA...

journal_title：Oncology research

authors： Jiang Z,Yao L,Ma H,Xu P,Li Z,Guo M,Chen J,Bao H,Qiao S,Zhao Y,Shen J,Zhu M,Meyers C,Ma G,Xie C,Liu L,Wang H,Zhang W,Dong Q,Shen H,Lin Z

更新日期：2017-07-05 00:00:00

abstract：:Claudin18 (CLDN18) is necessary for intercellular junctions and is reported to be involved in cell migration and metastasis, making it like an oncogene in various cancer types. However, the biological function and regulatory mechanisms of CLDN18 in lung adenocarcinoma are not yet clear. In this study, we found downreg...

journal_title：Oncology research

authors： Wan YL,Dai HJ,Liu W,Ma HT

更新日期：2018-05-07 00:00:00

abstract：:Cervical cancer is one of the most common neoplastic diseases affecting women, with a combined worldwide incidence of almost half a million new cases. Considering the fact that IL-18 plays an important role in the interactions among T cells, NK cells, and macrophages and induces IFN-gamma production, efforts should be...

journal_title：Oncology research

authors： Sobti RC,Shekari M,Tamandani DM,Malekzadeh K,Suri V

更新日期：2008-01-01 00:00:00

abstract：:Ameloblastoma is the most frequently encountered odontogenic tumor, characterized by a locally invasive behavior, frequent recurrences, and, although rare, metastatic capacity. Loss or inactivation of tumor suppressor genes (TSGs) allows cells to acquire neoplastic growth. The ING family proteins are tumor suppressors...

journal_title：Oncology research

authors： Borkosky SS,Gunduz M,Beder L,Tsujigiwa H,Tamamura R,Gunduz E,Katase N,Rodriguez AP,Sasaki A,Nagai N,Nagatsuka H

更新日期：2010-01-01 00:00:00

abstract：:The present study aimed to investigate the effect of miR-186 on proliferation, migration, invasion, and epithelialmesenchymal transition (EMT) of hepatocellular carcinoma (HCC). In this work, miR-186 was downregulated in HCC tissues and cells, and low miR-186 level helped predict the occurrence of vascular invasion an...

journal_title：Oncology research

authors： Lu J,Zhao Z,Ma Y

更新日期：2020-12-10 00:00:00

abstract：:Agosterol A (AG-A) is a novel agent that reverses P-glycoprotein (P-gp) and multidrug resistance protein-1 (MRP1)-meditated multidrug resistance (MDR). We have synthesized [125I]11-azidophenyl agosterol A (azidoAG-A), a photoaffinity analog of AG-A, and characterized its binding to P-gp in membrane vesicles prepared f...

journal_title：Oncology research

authors： Mitsuo M,Noguchi T,Nakajima Y,Aoki S,Ren XQ,Sumizawa T,Haraguchi M,Kobayashi M,Baba M,Nagata Y,Akiyama S,Furukawa T

更新日期：2003-01-01 00:00:00

abstract：:The expression of survivin molecules has been confirmed in many types of cancer cells, including colon cancer cells, and they are considered important antiapoptotic molecules. Recent studies have revealed the existence of different splicing forms of survivin molecules; however, no studies have examined their expressio...

journal_title：Oncology research

authors： Sawai K,Goi T,Hirono Y,Katayama K,Yamaguchi A

更新日期：2010-01-01 00:00:00

abstract：:Human telomerase is a ribonucleoprotein that maintains telomeres by adding TTAGGG tandem repeat sequences using RNA template of the enzyme. Telomerase activity is highly expressed in immortalized cells but not in most somatic cells, except for some renewal tissues, such as hematopoietic stem cells. Therefore, telomera...

journal_title：Oncology research

authors： Togashi K,Kakeya H,Morishita M,Song YX,Osada H

更新日期：1998-01-01 00:00:00

abstract：:ErbB4 is a member of the ErbB family of receptor tyrosine kinases. Because of a paucity of appropriate pharmacologic tools, little is known about ErbB4 functions in vivo. In response to this need, we hypothesized that a recombinant form of the extracellular domain of ErbB4 would antagonize ligand-induced receptor tyro...

journal_title：Oncology research

authors： Gilmore JL,Riese DJ 2nd

更新日期：2004-01-01 00:00:00

abstract：:Recently, microRNA (miR)-33b has been demonstrated to act as a tumor suppressor in osteosarcoma. However, the regulatory mechanism of miR-33b in osteosarcoma cell proliferation and migration remains largely unknown. In this study, real-time PCR showed that miR-33b was significantly downregulated in osteosarcoma tissue...

journal_title：Oncology research

authors： Zhou Y,Yang C,Wang K,Liu X,Liu Q

更新日期：2017-03-13 00:00:00

abstract：:The melanin biosynthetic pathway from tyrosine is a potential target for combating malignant melanoma. N-Acetyl-4-S-cysteaminylphenol 1 is a previously synthesized analogue of tyrosine that probably acts by this pathway. It interferes with cell growth and proliferation via selective oxidation in melanocytes to an oqui...

journal_title：Oncology research

authors： Nicoll K,Robertson J,Lant N,Kelland LR,Rogers PM,Robins DJ

更新日期：2006-01-01 00:00:00

abstract：:Tripartite motif-containing protein 37 (TRIM37), a new member of the RING-B-box-coiled-coil (RBCC) subfamily of zinc finger proteins, was found to be involved in the development and progression of several cancers. However, the expression pattern and biological functions of TRIM37 in colorectal cancer (CRC) remain unkn...

journal_title：Oncology research

authors： Zhao P,Guan HT,Dai ZJ,Ma YG,Liu XX,Wang XJ

更新日期：2017-01-02 00:00:00

abstract：:Adaptive changes occurring in C1300 murine neuroblastoma cell lines developed for resistance to nucleoside analogue inhibitors of S-adenosyl-L-homocysteine hydrolase (AdoHcyase, EC 3.3.1.1) were investigated. Two drug-resistant cell lines, rMNB-MDL-7-2 and rMNB-Deaz-7-2, were established from wild-type C1300 neuroblas...

journal_title：Oncology research

authors： Hamre MR,Clark SH,Mirkin BL

更新日期：1995-01-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most frequent cancer worldwide. HNSCC cell lines are typically refractory to transforming growth factor-beta (TGF-beta)-mediated cell cycle arrest. A number of these cell lines carry inactivating mutations of the TGF-beta type II (TbetaR-II) receptor, an...

journal_title：Oncology research

authors： Xie W,Bharathy S,Kim D,Haffty BG,Rimm DL,Reiss M

更新日期：2003-01-01 00:00:00

abstract：:Combretastatin A4 phosphate (CA4P) is currently undergoing clinical trials as a tumor vascular-targeting agent. Here, we defined the antivascular effect and programmed cell death (PCD) induced by CA4P in vascular endothelial cells. CA4P induced time- and dose-dependent antiproliferative activities against human umbili...

journal_title：Oncology research

authors： Ding X,Zhang Z,Li S,Wang A

更新日期：2011-01-01 00:00:00

abstract：:Whether the phenotypes of drug resistance and metastatic activity in cancer are dependent on each other or not is controversial. We compared in vitro invasive properties of human hepatoma cells resistant to epirubicin and rich in P-glycoprotein (Pgp) (HB8065/R) with the parental epirubicin-sensitive, Pgp-poor cells (H...

journal_title：Oncology research

authors： Bjørnland K,Lehne G,Johansen HT,Fodstad O,Rugstad HE,Aasen AO,Ree AH

更新日期：1998-01-01 00:00:00

abstract：:The sequence of biochemical and molecular events that mediate growth arrest and cell death in tumor cells exposed to agents that induce DNA damage is poorly defined. This commentary exploits the recent explosion of information regarding oncogenes, tumor suppressor genes, and cell-cycle regulatory genes to develop a mo...

journal_title：Oncology research

authors： Gewirtz DA

更新日期：1993-01-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) are at the foundation of the hematopoietic hierarchy and give rise to all blood lineages in the adult organism. A thorough understanding of the molecular, cellular, and developmental biology of HSCs is of fundamental importance, but is also clinically relevant for the advancement of cel...

journal_title：Oncology research

authors： Robin C,Ottersbach K,de Bruijn M,Ma X,van der Horn K,Dzierzak E

更新日期：2003-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are endogenous small noncoding RNAs that negatively regulate gene expression at the posttranscriptional level and play an important role in carcinogenesis. Herein, we characterized the global expression of miRNA in distal gastric adenocarcinomas and determined if circulating miRNAs could be used as ...

journal_title：Oncology research

authors： Zhang WH,Gui JH,Wang CZ,Chang Q,Xu SP,Cai CH,Li YN,Tian YP,Yan L,Wu B

更新日期：2012-01-01 00:00:00

abstract：:Osteosarcoma is the most common primary bone malignancy manifested predominantly in children and young adults. Studies indicate that miR-107 is involved in the pathogenesis of osteosarcoma and that tropomyosin 1 (TPM1) acts as a tumor suppressor in many types of cancer. In this study, we analyzed the effect of miR-107...

journal_title：Oncology research

authors： Jiang R,Zhang C,Liu G,Gu R,Wu H

更新日期：2017-09-21 00:00:00

abstract：:Drug resistance is the major obstacle for the successful therapy of lung adenocarcinoma. It was suggested that ß-elemene, a major isoform of elemene, could reverse the drug resistance in lung cancer cells. However, the underlying mechanisms remains poorly known. Here, we aimed to investigate whether elemene is involve...

journal_title：Oncology research

authors： Zhou K,Wang L,Cheng R,Liu X,Mao S,Yan Y

更新日期：2017-05-23 00:00:00

abstract：:We evaluated the effects of ultrasound-mediated microbubble transfection of VEGF-C siRNA on breast cancer cells in vitro and in vivo. MCF-7 cells were transfected with VEGF-C siRNA and the protein and mRNA expression of VEGF-C was tested using Western blot and qRT-PCR. Twenty nude mice tumors were established by injec...

journal_title：Oncology research

authors： Xu Q,Sun T,Tian H,Wang C,Zhou H

更新日期：2013-01-01 00:00:00