Abstract:
:We investigated the regulatory effect of interleukin (IL) 10 on IL-12-inducible killer activity of blood mononuclear cells (MNC) of healthy subjects. IL-10 suppressed non-MHC-restricted killer activity induced by IL-12 in a dose-dependent manner. Cytotoxicity against Daudi cells of blood MNC activated with optimal dose (100 U/ml) of IL-12 was significantly suppressed from 36.6 +/- 6.8% (mean +/- SE) to 26.0 +/- 5.0% by 100 ng/ml of IL-10 (n = 5; P < 0.05) at an E/T ratio of 20. IL-10, however, did not suppress killer induction by IL-2 from blood MNC. On the other hand, IL-4, a known inhibitor of IL-2-mediated killer induction, had no effect on IL-12-mediated killer induction from blood MNC. Moreover, production of interferon-gamma by IL-12-stimulated MNC was suppressed by IL-10. Because the presence of IL-10 is reported in the tumor-growing site, these observations suggest that IL-10 acts as a key cytokine in the suppression of IL-12-mediated antitumor response in situ.
journal_name
Oncol Resjournal_title
Oncology researchauthors
Pai K,Yanagawa H,Takauchi E,Suzuki Y,Hanibuchi M,Parajuli P,Sone Ssubject
Has Abstractpub_date
1998-01-01 00:00:00pages
295-300issue
6eissn
0965-0407issn
1555-3906journal_volume
10pub_type
杂志文章abstract::The mechanism of action of the anthraquinone antileukemic drug mitoxantrone (MIT) was investigated and compared with that of daunorubicin (DNR) with emphasis on the interaction with DNA to clarify the more potent cytotoxic activity of MIT than DNR in human leukemia cells. MIT showed similar characteristics to those of...
journal_title:Oncology research
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
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journal_title:Oncology research
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更新日期:1999-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::Colorectal carcinoma is one of the leading causes of cancer-related deaths and has a high tendency for metastasis, which makes it a priority to find novel methods to diagnose and treat colorectal carcinoma at a very early stage. We studied the role of the regulator of G-protein signaling (RGS) family of proteins RGS17...
journal_title:Oncology research
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doi:10.3727/096504017X14900515946914
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/000000007783630006
更新日期:2007-01-01 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504016X14732772150389
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journal_title:Oncology research
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doi:10.3727/000000003108748595
更新日期:2003-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
abstract::The potency of flavonoids (isoflavones, flavones, and flavanones) to inhibit efflux of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein (BCPCF) from human erythrocytes was investigated. Structure-activity relationship analysis showed that the strongest inhibitors were found among flavanones bearing a hydrophobic pren...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/000000003108747983
更新日期:2003-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504015X14386062091398
更新日期:2014-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504001108747477
更新日期:2001-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::The expression of survivin molecules has been confirmed in many types of cancer cells, including colon cancer cells, and they are considered important antiapoptotic molecules. Recent studies have revealed the existence of different splicing forms of survivin molecules; however, no studies have examined their expressio...
journal_title:Oncology research
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doi:10.3727/096504010x12767359113848
更新日期:2010-01-01 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504013X13685487925095
更新日期:2013-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Oncology research
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更新日期:1992-01-01 00:00:00
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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更新日期:2007-01-01 00:00:00
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journal_title:Oncology research
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journal_title:Oncology research
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更新日期:2017-04-14 00:00:00
abstract::There is an urgent need to improve the clinical management of hepatocellular carcinoma (HCC), one of the most common causes of global cancer-related deaths. Zingibar officinale is a medicinal herb used throughout history for both culinary and medicinal purposes. It has antioxidant, anticarcinogenic, and free radical s...
journal_title:Oncology research
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journal_title:Oncology research
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