MicroRNA-377 Downregulates Bcl-xL and Increases Apoptosis in Hepatocellular Carcinoma Cells.

abstract：:The present study aimed to investigate the effect of miR-186 on proliferation, migration, invasion, and epithelialmesenchymal transition (EMT) of hepatocellular carcinoma (HCC). In this work, miR-186 was downregulated in HCC tissues and cells, and low miR-186 level helped predict the occurrence of vascular invasion an...

journal_title：Oncology research

authors： Lu J,Zhao Z,Ma Y

更新日期：2020-12-10 00:00:00

abstract：:The potency of flavonoids (isoflavones, flavones, and flavanones) to inhibit efflux of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein (BCPCF) from human erythrocytes was investigated. Structure-activity relationship analysis showed that the strongest inhibitors were found among flavanones bearing a hydrophobic pren...

journal_title：Oncology research

authors： Bobrowska-Hägerstrand M,Wróbel A,Mrówczyńska L,Söderström T,Shirataki Y,Motohashi N,Molnár J,Michalak K,Hägerstrand H

更新日期：2003-01-01 00:00:00

abstract：:Point mutations and deletions in the p53 tumor suppressor gene occur frequently in advanced stage bladder tumors. To extend these observations to an in vitro model of bladder tumorigenicity, we have evaluated the presence of p53 mutations in a panel of bladder carcinoma cell lines. p53 alleles were cloned using the re...

journal_title：Oncology research

authors： Cooper MJ,Haluschak JJ,Johnson D,Schwartz S,Morrison LJ,Lippa M,Hatzivassiliou G,Tan J

更新日期：1994-01-01 00:00:00

abstract：:Increasing evidence shows that beyond its role in coagulation, thrombosis interferes with carcinogenesis. Endothelial cell protein C receptor (EPCR) is a cellular receptor for protein C and activated protein C (APC). Such EPCR-induced signal transduction promotes cancer cell migration, invasion, and angiogenesis and i...

journal_title：Oncology research

authors： Heng W,Huang JA,Wang ZY

更新日期：2012-01-01 00:00:00

abstract：:To investigate the effect of Kim-1 on 786-0 cells in vivo and in vitro, several experiments such as quantitative real-time PCR, Western blot, MTT, colony formation, and flow cytometry were performed to evaluate the biological behavior of 786-0 cells treated with Kim-1 siRNA. Furthermore, the tumor xenograft model was ...

journal_title：Oncology research

authors： Xu J,Sun L,Sun W,Tian J,Guo H

更新日期：2018-08-23 00:00:00

abstract：:MTA1 was reported as a metastasis-associated gene. Tumors with higher MTA1 mRNA level were shown to have higher rates of invasion and lymph node metastasis and tended to have higher rates of vascular involvement. The majority of invasive breast carcinomas were demonstrated to overexpress MTA1 compared to surrounding n...

journal_title：Oncology research

authors： Tong D,Heinze G,Schremmer M,Schuster E,Czerwenka K,Leodolter S,Zeillinger R

更新日期：2007-01-01 00:00:00

abstract：:Currently, multiple microRNAs (miRNAs) have been found to play vital roles in the pathogenesis of osteosarcoma. This study aimed to investigate the role of miR-21 in osteosarcoma. The level of miR-21 in 20 pairs of osteosarcoma and corresponding adjacent tissues was monitored by qPCR. Human osteosarcoma cell line SAOS...

journal_title：Oncology research

authors： Xu B,Xia H,Cao J,Wang Z,Yang Y,Lin Y

更新日期：2017-08-07 00:00:00

abstract：:It has been reported that upregulated SIRT1 (NAD(+)-dependent class III histone deacetylase) deacetylates the p53 protein, represses its function, and allows for tumor cell growth in various cancers. Here we investigated antitumor effects of tenovin-6, a small-molecule inhibitor of SIRT1 and SIRT2, in various colon ca...

journal_title：Oncology research

authors： Ueno T,Endo S,Saito R,Hirose M,Hirai S,Suzuki H,Yamato K,Hyodo I

更新日期：2013-01-01 00:00:00

abstract：:Carbonic anhydrase (CA) IX has emerged as a promising target for cancer therapy. It is highly upregulated in hypoxic regions and mediates pH regulation critical for tumor cell survival as well as extracellular acidification of the tumor microenvironment, which promotes tumor aggressiveness via various mechanisms, such...

journal_title：Oncology research

authors： Riemann A,Güttler A,Haupt V,Wichmann H,Reime S,Bache M,Vordermark D,Thews O

更新日期：2018-03-05 00:00:00

abstract：:Empty spiracles homeobox 2 (EMX2) is a homeodomain-containing transcription factor that plays an essential role in tumorigenesis. However, to the best of our knowledge, the role of EMX2 in human colorectal cancer (CRC) is still unclear. Thus, the aim of this study was to investigate the expression and role of EMX2 in ...

journal_title：Oncology research

authors： Zhang Y,Cao G,Yuan QG,Li JH,Yang WB

更新日期：2017-04-14 00:00:00

abstract：:Signal peptide CUB EGF-like domain-containing protein 2 (SCUBE2), a member of the SCUBE family of proteins, was recently found to play an important role in cancer development. However, little is known regarding its biological function in glioma. In the present study, we investigated the effect of SCUBE2 on glioma and ...

journal_title：Oncology research

authors： Guo E,Liu H,Liu X

更新日期：2017-03-13 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated mortality worldwide. Although the mechanisms of HCC progression are not well understood, recent studies demonstrated the potential contribution of uric acid transporter SLC2A9 to tumor suppression. However, the roles and underlying mechanis...

journal_title：Oncology research

authors： Han X,Yang J,Li D,Guo Z

更新日期：2019-05-07 00:00:00

abstract：:Cyclin Y (CCNY) is a novel cyclin and almost nothing is known about its expression level and role in human cancers. In the present study, we found that lentivirus-mediated RNA interference (RNAi) of CCNY significantly downregulated its expression level. More importantly, knockdown of CCNY inhibited cell proliferation,...

journal_title：Oncology research

authors： Xu Y,Wang Z,Wang J,Li J,Wang H,Yue W

更新日期：2010-01-01 00:00:00

abstract：:A number of previous investigations have reported that physical exercise renders immunopotentiating and antitumor therapeutic benefits to the tumor-bearing host. As these effects of physical exercise are mainly mediated through the modulation of hormonal and cytokine repertoire, it remains unclear if male and female t...

journal_title：Oncology research

authors： Verma VK,Singh V,Singh MP,Singh SM

更新日期：2010-01-01 00:00:00

abstract：:Laryngeal cancer, one of the most common head and neck malignancies, is an aggressive neoplasm. Increasing evidence has demonstrated that microRNAs (miRNAs) exert important roles in oncogenesis and progression of diverse types of human cancers. miR-632, a tumor-related miRNA, has been reported to be dysregulated and i...

journal_title：Oncology research

authors： Zhou ZX,Zhang ZP,Tao ZZ,Tan TZ

更新日期：2020-02-07 00:00:00

abstract：:The sequence of biochemical and molecular events that mediate growth arrest and cell death in tumor cells exposed to agents that induce DNA damage is poorly defined. This commentary exploits the recent explosion of information regarding oncogenes, tumor suppressor genes, and cell-cycle regulatory genes to develop a mo...

journal_title：Oncology research

authors： Gewirtz DA

更新日期：1993-01-01 00:00:00

abstract：:Aclacinomycin (ACR) is an anthracycline anticancer drug that shows marked effects in Adriamycin (ADM)-resistant tumors. ADM, however, is not effective against ACR-resistant tumor cells. When tumor cells acquire resistance to ACR, though the resistance is not easily acquired, they show strong cross-resistance to ADM. T...

journal_title：Oncology research

authors： Dong J,Naito M,Tatsuta T,Seimiya H,Johdo O,Tsuruo T

更新日期：1995-01-01 00:00:00

abstract：:The importance of receptors involved in the clearance of proteases and protease/inhibitor complexes in tumor invasion is unknown. We studied the expression of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP/alpha 2-MR), the major receptor involved in the clearance of protease/i...

journal_title：Oncology research

authors： Kancha RK,Stearns ME,Hussain MM

更新日期：1994-01-01 00:00:00

abstract：:Electron-affinic compounds with strong DNA intercalating properties have demonstrated less than the expected radiosensitization due to restriction of their mobility along the DNA backbone and their lower extravascular diffusion in tumors. A 2-nitroimidazole linked 1,2,3,4-tetrahydroacridine derivative (THNLA-1) has be...

journal_title：Oncology research

authors： Papadopoulou MV,Rosenzweig HS,Doddi M,Bloomer WD

更新日期：1994-01-01 00:00:00

abstract：:To enhance the anticancer efficacy of gemcitabine in the treatment of non-small cell lung cancer (NSCLC), the potential synergistic effect of piceatannol on gemcitabine cytotoxicity was investigated in the human NSCLC A459 cell line. The MTT cell viability assay showed that piceatannol significantly enhanced the cytot...

journal_title：Oncology research

authors： Xu B,Tao ZZ

更新日期：2014-01-01 00:00:00

abstract：:Human papillomavirus type 16 (HPV16) is a major causative factor in the development of uterine cervical carcinomas. We investigated the role of E6/E7 in tumor formation. Skin-specific E6/E7 transgenic mice showed approximately twice as many tumors compared with nontransgenic mice in dimethylbenz[a]anthracene (DMBA)-in...

journal_title：Oncology research

authors： Kim MO,Kim SH,Shin MJ,Yu DH,Kim BS,Chang KT,Lee S,Park YB,Lee TH,Ryoo ZY

更新日期：2007-01-01 00:00:00

abstract：:Lung cancer is a lethal solid tumor with poor prognosis because of its high metastasis and resistance to current therapies. Recently, cancer stem cells (CSCs) were suggested to be major contributors to tumorigenicity and cancer relapse. However, therapeutic targets for lung cancer-related CSCs remain undetermined. The...

journal_title：Oncology research

authors： Huang Y,Zeng F,Xu L,Zhou J,Liu X,Le H

更新日期：2013-01-01 00:00:00

abstract：:Tamoxifen causes a mitochondrial transmembrane potential dysfunction and ATP depletion, which may play a role in tamoxifen cytotoxicity. Administration of oligomycin-2 deoxy glucose (2DG) enhanced tamoxifen antiproliferative effects, which may be due to exacerbated ATP depletion following tamoxifen and oligomycin-2DG ...

journal_title：Oncology research

authors： Seyedabadi M,Ghahremani MH,Ostad SN

更新日期：2009-01-01 00:00:00

abstract：:Protein disulfide isomerases A6 (PDIA6) belongs to the PDI family. Recently, PDIA6 was found to have a close association with various cancers. However, there has been little investigation into the biological functions of PDIA6 in bladder cancer (BC). In this study, we explored the expression pattern and functional sig...

journal_title：Oncology research

authors： Cheng HP,Liu Q,Li Y,Li XD,Zhu CY

更新日期：2017-04-14 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is commonly overexpressed in non-small cell lung cancer (NSCLC) and its tyrosine kinase phosphorylation is thought to be an ideal target in the treatment of patients with NSCLC. In the present study, we examined surgically obtained specimens from a series of 36 NSCLC patients fo...

journal_title：Oncology research

authors： Kanematsu T,Yano S,Uehara H,Bando Y,Sone S

更新日期：2003-01-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) are at the foundation of the hematopoietic hierarchy and give rise to all blood lineages in the adult organism. A thorough understanding of the molecular, cellular, and developmental biology of HSCs is of fundamental importance, but is also clinically relevant for the advancement of cel...

journal_title：Oncology research

authors： Robin C,Ottersbach K,de Bruijn M,Ma X,van der Horn K,Dzierzak E

更新日期：2003-01-01 00:00:00

abstract：:Astragaloside IV (AS-IV) is an active ingredient in Astragalus membranaceus and is involved in various biological processes, such as regulating the immune system, and counteracting inflammation and malignancy. The aim of this study was to explore the effect of AS-IV on non-small cell lung cancer (NSCLC) cells. Cell co...

journal_title：Oncology research

authors： Jia L,Lv D,Zhang S,Wang Z,Zhou B

更新日期：2019-03-29 00:00:00

abstract：:DT-diaphorase [also called NAD(P)H:menadione oxidoreductase; NAD(P)H:(quinone acceptor) oxidoreductase; quinone reductase, azo-dye reductase] (EC.1.6.99.2) has been shown to have a role in activation of quinone-containing cancer chemotherapeutic prodrugs to their active form, as well as inactivation of a variety of xe...

journal_title：Oncology research

authors： Rauth AM,Goldberg Z,Misra V

更新日期：1997-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a disease with poor prognosis rates and ineffective therapeutic options. Previous studies have reported the involvement of mitogen-inducible gene 6 (MIG-6) as a negative regulator in tumor formation. MicroRNAs (miRNAs) play crucial roles in the development of different types of cancer...

journal_title：Oncology research

authors： Li H,Chen H,Wang H,Dong Y,Yin M,Zhang L,Wei J

更新日期：2018-05-07 00:00:00

abstract：:In colorectal cancers, the local cytokine network and the levels of nitric oxide (NO) and reactive oxygen species (ROS) are known to be closely related to cancer progression and metastasis, but the influence of the currently administered therapies on the cancer microenvironment is not completely understood. We analyze...

journal_title：Oncology research

authors： Paduch R,Kandefer-Szerszeń M,Piersiak T

更新日期：2010-01-01 00:00:00