Abstract:
BACKGROUND:The plantar surface is one of the commonest sites of malignant melanoma in the Japanese; however, the biological behavior is not sufficiently clarified, because of the paucity of long-term studies. We attempted an epidemiologic survey of the cases of plantar melanoma treated in our institute to study the survival rate in the recent period. METHODS:Of the 207 cases of malignant melanoma observed over the past 28 years, 62 patients were diagnosed as having plantar melanoma. The proportion of plantar melanoma to all melanomas, the sex and age of the patients, and the histologic type, stage, and prognosis were evaluated by comparing those registered in the first half (1969-1982) and the second half (1983-1996) of the period. RESULTS:The proportions of plantar melanoma in the first and second half periods were 31% (28 out of 90) and 29% (34 out of 117), respectively. No sex difference in the patients was observed. The mean age of the patients was 67 years. Fifty-one lesions were histologically proven to be acral lentiginous melanoma (ALM), two were superficial spreading melanoma (SSM), and nine were nodular melanoma (NM). Of the nine NMs, eight were registered in the second half period. The heel was affected in 33 (53%), the metatarsal regions in nine (14%), the toes in six (10%), and the arch areas in 14 (23%). The proportion of the weight-bearing areas, including the heel, metatarsal areas, and toes, decreased in the second half period. A comparison of the stages of plantar melanoma showed that, in the first half period, there were 18% of patients with stage IV disease in contrast to none in the second half period. Conversely, the proportion of stage I and II disease was 50% in the second half period, whereas it was only 39% in the first half period. The 5-year survival rates in the first and second half periods were 56% and 71%, respectively. CONCLUSIONS:The prognosis of plantar melanoma has improved recently at our institute. The possible explanation for a trend to better survival in the second half period may be related to a decrease in stage IV disease as well as to an increase in the frequency of diagnosis of early stage disease.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Kato T,Suetake T,Tabata N,Takahashi K,Tagami Hdoi
10.1046/j.1365-4362.1999.00736.xsubject
Has Abstractpub_date
1999-07-01 00:00:00pages
515-9issue
7eissn
0011-9059issn
1365-4632journal_volume
38pub_type
杂志文章abstract:UNLABELLED:Methotrexate (MTX) treatment for psoriasis is most often administered weekly, because the drug has been considered more hepatotoxic when taken daily. However, some patients may tolerate smaller, more frequent doses better. OBJECTIVE:To study the efficacy and toxicity of daily vs. weekly MTX. PATIENTS AND M...
journal_title:International journal of dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-4632.2011.04967.x
更新日期:2011-10-01 00:00:00
abstract:INTRODUCTION:Diffuse dermal angiomatosis is an entity in the spectrum of reactive angiomatoses characterized by erythematous plaques that mainly affect the lower extremities of patients with a personal history of peripheral vascular disease. Involvement of the breast is a rare event that has only been described as sing...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05812.x
更新日期:2014-04-01 00:00:00
abstract::Gardner-Diamond syndrome (GDS) is a rare psychodermatological condition characterized by the formation of spontaneous, painful skin lesions that develop into ecchymosis following episodes of severe physiological or psychological stress. The majority of GDS cases occur in young adult females, and although the etiology ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.14235
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:There are few published guidelines that describe the forethought and logistical considerations needed to create a dermatology-specific medical mission. OBJECTIVE:To report the experience of planning and executing a successful medical mission to an underserved community in Puerto Rico. METHODS:We identified...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05750.x
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Sporotrichosis is a chronic granulomatous infection caused by Sporothrichum schenckii. The disease has worldwide distribution. Majority of cases from India are reported from North-eastern states. METHODS:The demographic, clinico-investigative profile and therapeutic results of nine patients with cutaneous s...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.03538.x
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:As a variation of the curettage and destruction technique, cryosurgery can be used in place of electrodesiccation for the destructive component when managing superficial basal and squamous cell carcinomas. There are few studies, though, demonstrating the long-term cure rate associated with similar methods. T...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-4632.2011.04969.x
更新日期:2011-09-01 00:00:00
abstract:INTRODUCTION:Treatment of keloids is a challenge as a result of paucity of effective treatment modalities, significant side effects, and their recurrent nature. In this study, various treatment modalities were compared to search for a treatment option with maximum efficacy and minimum side effects. METHODS:One hundred...
journal_title:International journal of dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ijd.14069
更新日期:2018-10-01 00:00:00
abstract::Although tamoxifen (TAM) is routinely used in advanced melanoma, it is still uncertain whether evidence exists to support this practice. This review assesses the benefits and harms of systemic therapy with TAM vs. without TAM on response and mortality in patients with advanced melanoma. MEDLINE, The Cochrane Database ...
journal_title:International journal of dermatology
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1365-4632.2010.04529.x
更新日期:2010-10-01 00:00:00
abstract::The porphyrias are diverse in pathophysiology, clinical presentation, severity, and prognosis, presenting a diagnostic and therapeutic challenge. Although not easily curable, the dermatological manifestations of these diseases, photosensitivity and associated cutaneous pathology, can be effectively prevented and manag...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.12016
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The rate of human immunodeficiency virus (HIV) infection in women of reproductive age has increased dramatically in the last decade. The effects of pregnancy on the prevalence of cutaneous diseases in this group is unclear. OBJECTIVES:To compare the prevalence of cutaneous diseases in healthy pregnant women...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2003.01776.x
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Melanocytic nevi are well-known, important precursors of melanoma among children and adults. The adolescence period is an important period for nevi formation and evolution. This study provides data of a longitudinal study of nevi in a Hispanic adolescent population. MATERIALS AND METHODS:A cross-sectional s...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.5784.x
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Epidermal autografting has been used to treat vitiligo. The pigmentation achieved at the recipient site can be variegated and incomplete compared with that of the surrounding normal skin, and sometimes remains that way for a fairly long time. OBJECTIVE:We investigated whether the clinical results from epide...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.1998.00437.x
更新日期:1998-07-01 00:00:00
abstract::Bazex-Dupré-Christol syndrome is a rare genodermatosis that manifests with the classical triad of basal cell carcinoma, follicular atrophoderma, and hypotrichosis; yet it may be accompanied by milia, ichthyosis, neurological symptoms, and visceral malignancies. Symptom onset is nonsimultaneous, and hence the diagnosis...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.14065
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:The patient with xeroderma pigmentosum provides an appropriate human model for the evaluation of tumor development and progression. METHODS:We describe a patient with variant-type xeroderma pigmentosum who developed actinic keratoses, a squamous cell carcinoma, and its metastasis into a lymph node. DNA ploi...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1994.tb00990.x
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Sun exposure, light skin pigmentation, and melanocortin 1 receptor (MC1R) gene variants are independent risk factors for skin cancer. The Canary Islands have a sunny and temperate climate, but data regarding the phenotypic and genotypic risk factors among the population are lacking. METHODS:The main phenoty...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.03680.x
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Acral lentiginous melanoma (ALM) is a clinicopathologic subtype of cutaneous malignant melanoma. ALM is the most common type of melanoma amongst Asians, Africans, and patients with mixed ancestry. In Brazil, ALM comprises 10% of cutaneous melanoma. ALM develops on palmar, plantar, and subungual skin, and its...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.04009.x
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Basal cell carcinoma (BCC) is the most common cutaneous malignancy in the white population and occurs infrequently in dark-pigmented individuals. Albinism is an established risk factor for skin cancer in black Africans. METHODS:We evaluated the clinical histories and treatment outcomes of patients with a hi...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2007.03272.x
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Dysfunction of adhesion molecules is believed to play an early and important role in developing cancer. Accordingly, this study aims to compare beta-catenin (β-catenin) and CD44 expression in oral lichen planus (OLP) as a condition with malignant potential and oral squamous cell carcinoma (OSCC). METHODS:β-...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.14007
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:A 42-year-old male patient suffering from the rare Comèl-Netherton syndrome is reported, and the symptoms are discussed together with the results of light and electron microscopic examinations. CASE REPORT:Our case presented peeling skin syndrome type B with spontaneous, lifelong skin shedding with underlyi...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2002.01418.x
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To report three cases of mycosis fungoides with milia formation in the regressing lesions. PATIENTS AND SETTING:Dermatology clinic of a university hospital (referral center). Three patients with mycosis fungoides with body surface involvement of 10% in one case (stage IIb) and exceeding 30% in two cases (sta...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.01944.x
更新日期:2004-12-01 00:00:00
abstract::A 57-year-old woman with mycosis fungoides developed blisters within cutaneous plaques while receiving PUVA therapy and topical nitrogen mustard. Direct and indirect immunofluorescence studies showed the findings of bullous pemphigoid. Her bullous disease was controlled after cessation of these therapies and instituti...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1985.tb05751.x
更新日期:1985-04-01 00:00:00
abstract::Grover disease (GD) is a benign eruption that causes a papulovesicular rash on the trunk and proximal extremities. It often resolves spontaneously but can follow a more chronic and fluctuating course that may last several years. Although the etiology remains unknown, several associated triggers have been identified in...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.14700
更新日期:2020-05-01 00:00:00
abstract::Twenty-nine patients who had decubitus ulcers and a variety of underlying diseases had good responses to the use of the Clinitron Bed, an air-fluidized system. More research is needed to determine its place in dermatologic care. ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1980.tb00379.x
更新日期:1980-11-01 00:00:00
abstract::Histoid leprosy is a rare variant of leprosy with a unique clinical presentation and bacilli rich histology. These patients are large reservoirs for disease and vectors for spread, making prompt diagnosis and treatment crucial. To date, no consensus on treatment and duration exists. This paper aims to investigate the ...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.14962
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND: Leprosy is a chronic infection of the skin and peripheral nerves caused by the bacterium Mycobacterium leprae, which causes peripheral insensitivity and disfigurements of the skin, limbs, and digits. Social stigma is a common consequence of leprosy and may differ according to level of physical disfiguremen...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05226.x
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Prompt management of acute graft-versus-host disease (GVHD) may prevent its morbidity and mortality. Maculopapular (MP) eruption is a presenting sign of acute GVHD, but differentiation from other causes of MP rash is challenging. METHODS:A retrospective study was conducted among patients developing MP erupt...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.15186
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Dithranol is a potent reducing substance and is thought to achieve its effect on psoriasis by reduction of cell turnover. It was shown to be efficacious in adults, but its efficacy has not been documented in children. METHODS:The efficacy of short-contact therapy, a dithranol cream preparation, was retrospe...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1994.tb01005.x
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Regulatory T cells (Tregs) play an important role in autoimmune diseases. In skin, the presence of Tregs is thought to be mandatory for suppression of autoreactive T cells. Here, we assess the number of Tregs in skin of healthy subjects and patients with an autoimmune dermatosis. METHODS:Immunohistochemical...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05808.x
更新日期:2014-03-01 00:00:00
abstract::Dermatosis papulosa nigra (DPN) is a disorder commonly encountered in the adult black population. We describe 20 cases of clinicopathologically confirmed DPN cases treated with light abrasive curettage without local anesthesia. We found this procedure to be an effective therapy, which did not cause postoperative scarr...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1983.tb02131.x
更新日期:1983-12-01 00:00:00
abstract:OBJECTIVES:Nadifloxacin is a fluoroquinolone with broad-spectrum antibacterial activity. Although it is used as an acne treatment in some European countries, it has not been used to treat Korean acne patients. We aimed to evaluate the clinical efficacy and safety of 1% nadifloxacin cream and the histological changes it...
journal_title:International journal of dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-4632.2010.04701.x
更新日期:2011-03-01 00:00:00