Milia in regressing plaques of mycosis fungoides: provoked by topical nitrogen mustard or not?

Abstract:

OBJECTIVE:To report three cases of mycosis fungoides with milia formation in the regressing lesions. PATIENTS AND SETTING:Dermatology clinic of a university hospital (referral center). Three patients with mycosis fungoides with body surface involvement of 10% in one case (stage IIb) and exceeding 30% in two cases (stages IIb and III). All patients were treated with photochemotherapy and topical nitrogen mustard ointment in a concentration of 0.01%. After approximately 3 months multiple milia erupted on regressing plaques. RESULTS:The presence of milia was evident and was confirmed by histopathology. Regression of mycosis fungoides was noted in these plaques both clinically and in comparison with the pretreatment histologic appearance. Two of the patients showed a histological picture of follicular mucinosis. CONCLUSIONS:We do not know the significance of milia in mycosis fungoides (MF). However, we suggest that follicular rupture or a degenerative process might result in milia formation.

journal_name

Int J Dermatol

authors

Kalayciyan A,Oguz O,Demirkesen C,Serdaroglu S,Kotogyan A

doi

10.1111/j.1365-4632.2004.01944.x

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

953-6

issue

12

eissn

0011-9059

issn

1365-4632

pii

IJD1944

journal_volume

43

pub_type

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