Abstract:
BACKGROUND:Leishmaniasis is endemic in 88 countries in the world, and 350 million individuals are at risk of acquiring the disease. Treatment for American cutaneous leishmaniasis (ACL) is long, expensive, and associated with important side-effects. METHODS:In this double-blind, placebo-controlled study, we treated 102 patients with ACL using either a combination of a single-strain Leishmania amazonensis killed promastigote vaccine plus a half dose of meglumine antimoniate, or placebo plus the same half dose regimen of meglumine antimoniate, in 10-day series followed by 10-day intervals. RESULTS:Of the 47 patients in the experimental arm, 47 (100%) were cured after four series of treatment, compared to four of 49 (8.2%) in the control group (P < 0.0001). Six patients were lost to follow-up. CONCLUSIONS:The combination of a single-strain Leishmania (Leishmania) amazonensis killed promastigote vaccine with a half dose regimen of antimonial is highly effective for the treatment of ACL.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Machado-Pinto J,Pinto J,da Costa CA,Genaro O,Marques MJ,Modabber F,Mayrink Wdoi
10.1046/j.1365-4362.2002.01336.xsubject
Has Abstractpub_date
2002-02-01 00:00:00pages
73-8issue
2eissn
0011-9059issn
1365-4632pii
1336journal_volume
41pub_type
临床试验,杂志文章,随机对照试验abstract::In December of 2002, the FDA approved azelaic acid 15% gel for the topical treatment of inflammatory papules and pustules of mild to moderate rosacea. Azelaic acid is a saturated dicarboxylic acid, which is naturally occurring and has been used in the treatment of rosacea, acne, and melasma. The 15% gel has a high eff...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2005.02769.x
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women. Topical 5% cysteamine is an antioxidant and tyrosinase inhibitor that has been shown to be effective in the treatment of melasma. However, to date, no study has compared the performan...
journal_title:International journal of dermatology
pub_type: 杂志文章
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abstract::A male fetus which was the product of full-term pregnancy and normal delivery with no family history is presented. The skin was hard and thick, waxy, yellowish in color, and was crossed by horizontal and or perpendicular red fissures. The eyelids were semiclosed, hard, and stiff resulting in ectropion and the conjunct...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1982.tb03144.x
更新日期:1982-07-01 00:00:00
abstract::A 39-year-old female patient with systemic lupus erythematosus was treated with terbinafine for onychomycosis. After only 7 days of treatment with 250 mg terbinafine, a widespread severe erythematous eruption developed. The results of clinical, histological and immunofluorescent examinations confirmed the diagnosis of...
journal_title:International journal of dermatology
pub_type: 杂志文章
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abstract:BACKGROUND:Chemotherapy-induced acral erythema is a distinct localized cutaneous response to certain systemic chemotherapeutic agents. METHODS:Between January 1990 and December 1994, from a total of 76 leukemic patients who have received combination chemotherapy consisting of cytosine arabinoside and anthracycline ant...
journal_title:International journal of dermatology
pub_type: 杂志文章
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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abstract::Histoid leprosy is a rare variant of leprosy with a unique clinical presentation and bacilli rich histology. These patients are large reservoirs for disease and vectors for spread, making prompt diagnosis and treatment crucial. To date, no consensus on treatment and duration exists. This paper aims to investigate the ...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
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journal_title:International journal of dermatology
pub_type: 杂志文章,随机对照试验
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journal_title:International journal of dermatology
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abstract:BACKGROUND:This study sought to gain a better understanding of the patient population in Kampala and was further designed to elucidate barriers that may delay individuals from receiving proper dermatologic care. METHODS:The study took place at the dermatovenereology clinic of a tertiary care hospital in Kampala. New a...
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journal_title:International journal of dermatology
pub_type: 杂志文章
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journal_title:International journal of dermatology
pub_type: 杂志文章
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journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
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更新日期:1975-04-01 00:00:00
abstract:BACKGROUND:Chronic arsenic exposure can lead to palmoplantar keratosis. In the stratum corneum of skin, linoleic acid is of the utmost importance to the inflammation, keratinization, and regeneration processes. OBJECTIVES:The aims of this study were: (i) to present quantitative information on the linoleic acid fractio...
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1988-11-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:International journal of dermatology
pub_type: 杂志文章
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journal_title:International journal of dermatology
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abstract:BACKGROUND:Mohs micrographic surgery (MMS) is used to treat cutaneous malignancies in locations to maximize tissue sparing. The authors' aim is to demonstrate the utility of conservative thickness layers (CTL) in MMS and review patient and tumor characteristics and the potential anatomic locations where this technique ...
journal_title:International journal of dermatology
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Mycetoma is a chronic suppurative and/or granulomatous inflammatory lesion of skin, subcutaneous tissue, fascia, and tendons caused by the traumatic inoculation of either fungal (eumycotic) or bacterial (actinomycotic) organisms present in the soil. The disease is characterized by triad of tumefaction, disch...
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pub_type: 杂志文章
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journal_title:International journal of dermatology
pub_type: 杂志文章
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