Abstract:
:A 60-year-old man presented to the Emergency Department (ED) with large, painful, indurated plaques on the right thigh, left abdomen, left chest, and right chest, which began without any preceding trauma on the right thigh 3 weeks prior to presentation in the ED. He was initially treated with cefazolin 1 g three times daily as home infusions. When the lesions continued to progress, he was admitted to the hospital and placed on amoxicillin/clavulanate and vancomycin. He had a single episode of fever of 102 degrees F, but his white blood cell count and differential remained normal. An initial biopsy showed a dermal inflammatory infiltrate composed primarily of neutrophils and eosinophils with rare flame figures in the dermis. There was minimal fat seen in this biopsy. A differential diagnosis of Wells or Sweet's syndrome was entertained, and he was placed on 60 mg/day prednisone with no resolution of his symptoms. The patient's past medical history included hypertension, hyperlipidemia, peripheral neuropathy, and hiatal hernia. His family history was significant for emphysema in both parents and coronary artery disease in his father. Both of his parents smoked cigarettes. His grandfather, who was a coal miner, also had emphysema. Whilst on antibiotics and prednisone, the plaques on the patient's right thigh, right abdomen, and left chest expanded and ulcerated, draining an oily liquid (Figs 1 and 2). An incisional biopsy was obtained from his thigh. Histopathology showed a septal and lobular panniculitis with fat necrosis, neutrophils, and histiocytes (Fig. 3). Special stains for organisms were negative. Tissue sent for bacterial and fungal culture had no growth. Amylase and lipase levels were normal. Rheumatoid factor, antinuclear antibody (ANA), antineutrophil cytoplasmic antibody (ANCA), cryoglobulins, and antiphospholipid antibodies were all normal. The alpha1-antitrypsin level was low at 25 mg/dL (ref. 75-135). The alpha1-antitrypsin phenotype was PiZZ. The patient had a normal glucose-6-phosphate dehydrogenase level and was placed on dapsone 200 mg/day. The inflammation resolved and, over the course of several months, the involved areas healed with scarring. The patient denied any pulmonary complaints but, during his hospitalization, was found incidentally to have an oxygen saturation of 88% on room air. He was sent for evaluation by a pulmonologist, and pulmonary function tests revealed a mixed restrictive and obstructive pattern with a forced expiratory volume in 1 to forced vital capacity (FEV(1)/FVC) ratio of 63% of predicted. He had never smoked. He was placed on supplemental oxygen but, as his pulmonary disease has been stable, he has not been treated with intravenous antitrypsin inhibitor.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Korver G,Liu C,Petersen Mdoi
10.1111/j.1365-4632.2006.03067.xsubject
Has Abstractpub_date
2007-10-01 00:00:00pages
1078-80issue
10eissn
0011-9059issn
1365-4632pii
IJD3067journal_volume
46pub_type
杂志文章abstract:BACKGROUND:Melanocytic nevi are well-known, important precursors of melanoma among children and adults. The adolescence period is an important period for nevi formation and evolution. This study provides data of a longitudinal study of nevi in a Hispanic adolescent population. MATERIALS AND METHODS:A cross-sectional s...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.5784.x
更新日期:2014-03-01 00:00:00
abstract::Challenge: Clinical and research responsibilities often leave little or no time to plan thoughtful teaching encounters with trainees. This "Teaching & Learning Tips" series is designed to be an accessible guide for dermatologists who want to improve their teaching skills. It is comprised of 12 articles about how to en...
journal_title:International journal of dermatology
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doi:10.1111/ijd.13751
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Harlequin ichthyosis (HI) is a severe genetic disorder caused by the mutation in the ABCA12 gene. Infants born with this condition have markedly thickened, hard stratum corneum skin all over the body. METHODS:A female child born with a thick white plate of skin with deep cracks all over the body was investi...
journal_title:International journal of dermatology
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doi:10.1111/ijd.13923
更新日期:2018-04-01 00:00:00
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journal_title:International journal of dermatology
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doi:10.1111/j.1365-4362.1982.tb02076.x
更新日期:1982-05-01 00:00:00
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
pub_type: 杂志文章
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abstract::The syndrome of tinea pedis caused by human-adapted Trichophyton mentagrophytes (interdigitale) can be recognized by two signs not characteristically seen in tinea pedis caused by T. rubrum and Epidermophyton floccosum:1 bullous > 2 mm vesicles in the thin skin of the plantar arch and along the sides of the feet and h...
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journal_title:International journal of dermatology
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更新日期:2011-07-01 00:00:00
abstract::Vitiligo is one of the most important skin disorders that does not cause much physical impairment, but due to its disfiguring appearance, patients have disturbances in mental health and quality of life (QoL). The dermatology life quality index (DLQI), as one of the most specific QoL instruments, is now used widely for...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
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更新日期:2016-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-11-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1111/ijd.15362
更新日期:2020-12-17 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.01944.x
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:The relationships between androgenetic alopecia (AGA) and various factors related to metabolic syndrome have been demonstrated in previous studies. However, it remains unclear because of inconsistent results. We investigated the associations between AGA and various risk factors related to metabolic syndrome ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13843
更新日期:2018-02-01 00:00:00
abstract::A 14-year-old boy was referred to the Dermatology Clinic of the Medical University of Mashhad, Iran, with numerous cutaneous telangiectasias on the face, ears, lips, and back of the hands, with lesions in the temporal region being the first to appear (Figs 1-3). His mother stated that the lesions had been present for ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2006.02775.x
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) infection induces variable dermatologic manifestations. Our purpose was to determine whether there is an association between HCV infection and oral lichen planus (OLP). METHODS:Antibodies to HCV were determined in patients with OLP (263 patients; 156 women and 107 men, with a mean ag...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.1998.00510.x
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.15043
更新日期:2020-10-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2009.03490.x
更新日期:2009-04-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1979.tb01972.x
更新日期:1979-09-01 00:00:00
abstract:OBJECTIVE:We performed a prospective study to evaluate the diagnostic accuracy of cytologic examination in basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs), in order to assess its clinical value. Study design Samples were taken by the "scraping" technique which involves scraping with a scalpel blade dir...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2000.00893.x
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Leishmaniasis is endemic in 88 countries in the world, and 350 million individuals are at risk of acquiring the disease. Treatment for American cutaneous leishmaniasis (ACL) is long, expensive, and associated with important side-effects. METHODS:In this double-blind, placebo-controlled study, we treated 102...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-02-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4362.1975.tb00088.x
更新日期:1975-12-01 00:00:00
abstract:BACKGROUND:Venous ulcer is the most serious consequence of chronic venous insufficiency and is responsible for almost 70% of chronic leg ulcers. The main purpose of this research was to describe social, demographic and clinical characteristics of patients with venous ulcers and to identify some professional repercussio...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02276.x
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Cases of hydroa vacciniforme-like eruptions caused by latent Epstein-Barr virus (EBV) infection have been reported in Asia and Mexico, some of which progressed to lymphoproliferative disorders. The precise clinical features of the disease are not, however, clear. METHODS:We performed an artificial provocati...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2003.01307_2.x
更新日期:2003-06-01 00:00:00