A comparison of anti-desmoglein antibodies and indirect immunofluorescence in the serodiagnosis of pemphigus vulgaris.

Abstract:

BACKGROUND:Indirect immunofluorescence (IIF) is the standard method for the detection of pemphigus autoantibodies. Commercially available enzyme-linked immunosorbent assays (ELISAs) have recently become available to measure serum antibodies (Abs) against desmoglein1 (Dsg1) and desmoglein3 (Dsg3). It has been suggested that patients with mucosal-dominant pemphigus vulgaris (PV) have serum Abs against Dsg3 only, patients with mucocutaneous PV have Abs to both Dsg1 and Dsg3, and patients with pemphigus foliaceus (PF) have Abs against Dsg1 only. AIM:To compare the sensitivity and specificity of the IIF and ELISA tests in the diagnosis of pemphigus and its subsets. METHODS:Thirty-three patients with PV and five patients with PF were studied, and compared with 50 healthy individuals or patients with unrelated skin diseases. Monkey esophagus was used as a substrate for the IIF test. RESULTS:The IIF and ELISA tests were each positive in 26 of the 32 (81%) PV patients, and in none (0%) and 3 (6%) of the 50 controls, respectively. Both the IIF and ELISA results were concordant in 69% of the PV patients, and only one of these two tests was positive in the remaining 31% of patients. Forty-six per cent of the PV patients with a positive ELISA test did not have the PV phenotype (mucosal or mucocutaneous) predicted by their autoantibody profile. CONCLUSION:The IIF and ELISA tests may be used as complementary tests for the serologic diagnosis of pemphigus.

journal_name

Int J Dermatol

authors

Zagorodniuk I,Weltfriend S,Shtruminger L,Sprecher E,Kogan O,Pollack S,Bergman R

doi

10.1111/j.1365-4632.2004.02541.x

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

541-4

issue

7

eissn

0011-9059

issn

1365-4632

pii

IJD2541

journal_volume

44

pub_type

杂志文章
  • Treatment of histoid leprosy: a lack of consensus.

    abstract::Histoid leprosy is a rare variant of leprosy with a unique clinical presentation and bacilli rich histology. These patients are large reservoirs for disease and vectors for spread, making prompt diagnosis and treatment crucial. To date, no consensus on treatment and duration exists. This paper aims to investigate the ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.14962

    authors: Bartos G,Sheuring R,Combs A,Rivlin D

    更新日期:2020-10-01 00:00:00

  • Chemotherapy-induced acral erythema in leukemic patients: a report of 15 cases.

    abstract:BACKGROUND:Chemotherapy-induced acral erythema is a distinct localized cutaneous response to certain systemic chemotherapeutic agents. METHODS:Between January 1990 and December 1994, from a total of 76 leukemic patients who have received combination chemotherapy consisting of cytosine arabinoside and anthracycline ant...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-4362.1997.00040.x

    authors: Demirçay Z,Gürbüz O,Alpdoğan TB,Yücelten D,Alpdoğan O,Kurtkaya O,Bayik M

    更新日期:1997-08-01 00:00:00

  • Immunohistochemistry in histoid leprosy.

    abstract:BACKGROUND:Histoid leprosy is a rare form of multibacillary leprosy as the result of secondary or even primary resistance to dapsone. The etiopathogenesis has not been clarified up to now. METHODS:An immunohistochemical study was carried out for the expression of various markers on epidermal and dermal cell population...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1995.tb04396.x

    authors: Kontochristopoulos GJ,Aroni K,Panteleos DN,Tosca AD

    更新日期:1995-11-01 00:00:00

  • Alopecia in congenital hidrotic ectodermal dysplasia responding to treatment with a combination of topical minoxidil and tretinoin.

    abstract::Clouston's syndrome is an ectodermal dysplasia characterized by dystrophic nails, alopecia, and palmoplantar hyperkeratosis. Alopecia is due to decrease in number and degree of maturation of the hair follicles. Tretinoin is a mitogen by itself and also enhances the absorption of minoxidil which acts by enlarging the m...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2009.03907.x

    authors: Melkote S,Dhurat RS,Palav A,Jerajani HR

    更新日期:2009-02-01 00:00:00

  • Cutaneous manifestations of Corynebacterium jeikeium sepsis.

    abstract::Corynebacterium jeikeium is a rare but increasingly important cause of septicemia in neutropenic patients that can present with characteristic cutaneous findings. A 61-year-old man with myelodysplastic syndrome developed C. jeikeium sepsis and an erythematous papular eruption while neutropenic from induction chemother...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-4632.2008.03984.x

    authors: Olson JM,Nguyen VQ,Yoo J,Kuechle MK

    更新日期:2009-08-01 00:00:00

  • Cutaneous manifestations associated with antiphospholipid antibodies.

    abstract:BACKGROUND:Primary Antiphospholipid Antibody Syndrome (PAAS) is characterized by detection of antiphospholipid antibodies associated with venous or arterial thrombosis and/or miscarriages by patients with no other associated disease such as systemic lupus erythematosus (SLE). Primary Antiphospholipid Antibody Syndrome ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2004.01939.x

    authors: Diógenes MJ,Diógenes PC,de Morais Carneiro RM,Neto CC,Duarte FB,Holanda RR

    更新日期:2004-09-01 00:00:00

  • Pneumocystis jiroveci pneumonia in patients treated with systemic immunosuppressive agents for dermatologic conditions: a systematic review with recommendations for prophylaxis.

    abstract::Pneumocystis jiroveci pneumonia is an opportunistic infection associated with substantial rates of mortality in immunosuppressed patients. Prophylaxis recommendations are mostly targeted toward patients with non-dermatologic diagnoses. This study was conducted to determine when dermatology patients treated with immuno...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.13231

    authors: Gonzalez Santiago TM,Wetter DA,Kalaaji AN,Limper AH,Lehman JS

    更新日期:2016-08-01 00:00:00

  • Oxymatrine inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth factor-β1/Smad signaling pathway.

    abstract:BACKGROUND:Keloids are benign dermal tumors characterized by fibroblastic proliferation and excessive accumulation of collagen. Oxymatrine (OMT) is an alkaloid extracted from the Chinese herb Sophora japonica with capacities of anti-fibrosis. OBJECTIVE:To evaluate the effects of OMT on collagen production and to explo...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2011.05234.x

    authors: Fan DL,Zhao WJ,Wang YX,Han SY,Guo S

    更新日期:2012-04-01 00:00:00

  • Magnetic resonance imaging with gadolinium enhancement in renal failure: a need for caution.

    abstract::A 36-year-old Asian man with von Hippel-Lindau syndrome was referred to the dermatology clinic in January 2005 with stiff fingers and ankles of 3 months' duration. He had undergone bilateral nephrectomy for renal squamous cell carcinoma in 2002 and had started hemodialysis. Multiple cerebellar hemangiomata were resect...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2008.03655.x

    authors: Gulati A,Harwood CA,Raftery M,Cerio R,Ashman N,Proby CA

    更新日期:2008-09-01 00:00:00

  • Clinical and histological evaluation of 1% nadifloxacin cream in the treatment of acne vulgaris in Korean patients.

    abstract:OBJECTIVES:Nadifloxacin is a fluoroquinolone with broad-spectrum antibacterial activity. Although it is used as an acne treatment in some European countries, it has not been used to treat Korean acne patients. We aimed to evaluate the clinical efficacy and safety of 1% nadifloxacin cream and the histological changes it...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-4632.2010.04701.x

    authors: Jung JY,Kwon HH,Yeom KB,Yoon MY,Suh DH

    更新日期:2011-03-01 00:00:00

  • Successful treatment of eosinophilic pustular folliculitis with topical tacrolimus.

    abstract::We present two cases of Eosinophilic pustular folliclulitis (EPF) who were successfully treated with topical tacrolimus. Indomethacin is the most frequently used agent for the treatment of EPF, however, tacrolimus ointment may become the treatment of choice for patients with EPF. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2004.02109.x

    authors: Kawaguchi M,Mitsuhashi Y,Kondo S

    更新日期:2004-08-01 00:00:00

  • Scleromyxedema revisited.

    abstract::Scleromyxedema is a rare disease characterized by papular mucinous deposits, dermal fibroblast proliferation, and a monoclonal paraproteinemia. Its chronic course tends to be complicated by gastrointestinal, muscular, pulmonary, and neurologic disorders. We review the literature to identify the common systemic manifes...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-4362.2003.01565.x

    authors: Pomann JJ,Rudner EJ

    更新日期:2003-01-01 00:00:00

  • Nargile (Hubble-Bubble) smoking-induced hand eczema.

    abstract::A 65-year-old retired man with hand eczema presented to the Dermatology clinic in October of 2001. He complained of scaly, fissured plaque-type lesions over the radial margin of his right index finger and thumb (Fig. 1). He first noticed these changes 2 years ago. There was no history of irritation from his occupation...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-4362.2002.01533.x

    authors: Onder M,Oztas M,Arnavut O

    更新日期:2002-11-01 00:00:00

  • Satellite repigmentation after punch grafting.

    abstract::Punch grafting is an established treatment modality for management of localized, nonprogressive vitiligo resistant to conventional therapies.(1) In our set up, punch grafting is routinely carried out in focal vitiligo, segmental vitiligo and even in few cases of generalized vitiligo, especially when it is a serious co...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2004.01889.x

    authors: Agarwal US,Gulati R,Shukla SR,Mathur N

    更新日期:2004-04-01 00:00:00

  • Prurigo pigmentosa: not an uncommon disease in the Turkish population.

    abstract:BACKGROUND:Prurigo pigmentosa (PP) is a rare inflammatory dermatosis of unknown etiology. It is characterized by erythematous papules of the trunk that resolve leaving a reticulate hyperpigmentation. The original report from Japan in 1971 was followed by new cases, mostly of Japanese origin. METHODS:We scrutinized PP ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-4632.2006.02857.x

    authors: Baykal C,Buyukbabani N,Akinturk S,Saglik E

    更新日期:2006-10-01 00:00:00

  • Epidemiological studies on head lice infestation in Israel. I. Parasitological examination of children.

    abstract::Of 3,079 children in a medium-sized community near Jerusalem, 11.2% were found to be infested with living lice and eggs and another 23.4% had only nits. Boys and girls were equally infested. The incidence of infestation was highest among children 4-11 years of age. About 78% of the infested children had from one to te...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1990.tb04845.x

    authors: Mumcuoglu KY,Miller J,Gofin R,Adler B,Ben-Ishai F,Almog R,Kafka D,Klaus S

    更新日期:1990-09-01 00:00:00

  • Squamous cell carcinoma in southern and northern Australia.

    abstract::Squamous cell carcinoma (scc) of the skin was studied in two similar populations, one living in the temperate zone of Australia, the other living in the tropics. In the tropics, the patients were significantly younger, the man to woman ratio approached unity, and women had significantly more sccs on the legs. In the t...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1992.tb02697.x

    authors: Czarnecki D,Collins N,Meehan C,O'Brien T,Leahy S,Nash CA

    更新日期:1992-07-01 00:00:00

  • New treatment of atrophic acne scars by iontophoresis with estriol and tretinoin.

    abstract:BACKGROUND:Common treatment of atrophic acne scars consists of invasive methods such as dermabrasion, chemopeeling, or implantation of bovine collagen. In our study a new noninvasive treatment method consisting of local iontophoresis is demonstrated. Local iontophoresis was performed with either estriol--a mainly topic...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-4362.1995.tb04381.x

    authors: Schmidt JB,Binder M,Macheiner W,Bieglmayer C

    更新日期:1995-01-01 00:00:00

  • Specific causes of death in patients with bullous pemphigoid as measured by death certificate data: a retrospective cohort study.

    abstract:BACKGROUND:Mortality rates in patients with bullous pemphigoid (BP) are higher than those in age-matched counterparts. However, the specific causes of death in BP subjects have not been evaluated systematically. OBJECTIVES:We sought to characterize the causes of death in patients with BP as recorded by death certifica...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.12243

    authors: Barrick BJ,Lohse CM,Lehman JS

    更新日期:2015-01-01 00:00:00

  • Leukocyte chemotaxis and pyoderma gangrenosum.

    abstract::Leukocyte chemotaxis (in five patients with pyoderma gangrenosum) was studied using a modification of the Boyden chamber method. In all patients the chemotactic response was significantly lower than in the controls. This abnormal chemotaxis was a result of an intrinsic neutrophil dysfunction. No significant difference...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1985.tb05359.x

    authors: Nerella P,Daniela A,Guido M,Fabbri P

    更新日期:1985-01-01 00:00:00

  • Keratosis lichenoides chronica in an Indian child following erythroderma.

    abstract::A 4-year-old boy presented with mildly itchy, linear, skin lesions over the trunk, arms, and face of 3 months' duration. He had previously been admitted to a private hospital for generalized exfoliation of the skin following drug intake for fever and throat pain. The nature of the drugs was not known. The exfoliative ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2008.03618.x

    authors: Ghorpade A

    更新日期:2008-09-01 00:00:00

  • A randomized, controlled and blinded study of papulopustular lesions in Turkish Behçet's patients.

    abstract:BACKGROUND:Papulopustular lesions (PPL), the commonest presentation of skin lesions in Behcet's disease (BD) are cutaneous, sterile folliculitis or acne-like lesions on erythematous base. Our purpose was to determine the true frequency and anatomic location of the PPL and compare this with controls. We also sought to d...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-4362.1998.00401.x

    authors: Alpsoy E,Aktekin M,Er H,Durusoy C,Yilmaz E

    更新日期:1998-11-01 00:00:00

  • Circulating level of CD4+ CD25+ FOXP3+ T cells in patients with chronic urticaria.

    abstract:BACKGROUND:CD4+ CD25+ T-regulatory (Treg) cells play critical roles in maintaining peripheral tolerance and preventing autoimmunity. As characteristics of Treg cells have not been precisely investigated in chronic urticaria (CU) yet, this study was performed. OBJECTIVE:To determine the frequencies of circulating CD4+ ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.12630

    authors: Arshi S,Babaie D,Nabavi M,Tebianian M,Ghalehbaghi B,Jalali F,Ahmadvand A,Gholami R

    更新日期:2014-12-01 00:00:00

  • IgA dermatosis in an adult Chinese population. A 10-year study of linear IgA and dermatitis herpetiformis in Singapore.

    abstract::During a 10-year period (1976-1985), eight Chinese patients from a population of 2.5 million fulfilled the criteria for dermatitis herpetiformis and linear IgA bullous dermatosis (LABD). These rare diseases among Asians presented during the third decade of life with homogenous linear IgA deposits along the dermoepider...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1988.tb02328.x

    authors: Ratnam KV

    更新日期:1988-01-01 00:00:00

  • Hidradenitis suppurativa in a cohort of overweight and obese children and adolescents.

    abstract:BACKGROUND:Hidradenitis suppurativa (HS) is a chronic, inflammatory, and recurring disease mainly observed in adults. Obesity is considered an important independent factor in HS development and is associated with a higher prevalence of HS in children. We aimed to characterize the clinical presentation of HS in overweig...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.14639

    authors: Lindsø Andersen P,Kromann C,Fonvig CE,Theut Riis P,Jemec GBE,Holm JC

    更新日期:2019-09-09 00:00:00

  • Paraneoplastic pyoderma gangrenosum in solid organ malignancy: a literature review.

    abstract::Pyoderma gangrenosum (PG) is a rare destructive, ulcerative, and inflammatory cutaneous disease. PG can be associated with inflammatory bowel disease (IBD), arthritis, autoinflammatory syndromes, and hematological malignancies. Multiple reports in the literature have found an association between PG and solid organ tum...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.14637

    authors: Shah M,Sachdeva M,Gefri A,Jfri A

    更新日期:2020-02-01 00:00:00

  • Staging of necrotizing fasciitis based on the evolving cutaneous features.

    abstract:BACKGROUND:Necrotizing fasciitis is a severe soft-tissue infection characterized by a fulminant course and high mortality. Early recognition is difficult as the disease is often clinically indistinguishable from cellulitis and other soft-tissue infections early in its evolution. Our aim was to study the manifestations ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2007.03201.x

    authors: Wang YS,Wong CH,Tay YK

    更新日期:2007-10-01 00:00:00

  • Is narrowband ultraviolet B monotherapy effective in the treatment of pityriasis lichenoides?

    abstract:BACKGROUND:Pityriasis lichenoides (PL) is a self-limiting papulosquamous disease that may persist for years and is associated with a high relapse rate. To date, few comparative studies have investigated the efficacy of narrowband ultraviolet B (NB-UVB) phototherapy and other therapies in the treatment of PL. OBJECTIVE...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2012.05814.x

    authors: Park JM,Jwa SW,Song M,Kim HS,Chin HW,Ko HC,Kim MB,Kim BS

    更新日期:2013-08-01 00:00:00

  • Efficacy of topical calcineurin inhibitors in vitiligo.

    abstract::Topical tacrolimus and pimecrolimus are indicated for the treatment of atopic dermatitis, but they have been studied in many off-label uses. We reviewed the English language literature to define their roles in treatment of vitiligo. Double-blind studies show that tacrolimus 0.1% ointment combined with excimer laser is...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-4632.2012.05697.x

    authors: Wong R,Lin AN

    更新日期:2013-04-01 00:00:00

  • Demodex infestation in a child with leukaemia: treatment with ivermectin and permethrin.

    abstract:BACKGROUND:Demodex mites are almost ubiquitous on older adult skin but are infrequent in young children. In immunocompromised patients, demodicosis may be more frequent and severe, and systemic therapy may be needed to achieve clinical resolution. CASE REPORT:A six-year-old boy having maintenance chemotherapy for acut...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-4362.2003.01916.x

    authors: Damian D,Rogers M

    更新日期:2003-09-01 00:00:00