Abstract:
BACKGROUND:CD4+ CD25+ T-regulatory (Treg) cells play critical roles in maintaining peripheral tolerance and preventing autoimmunity. As characteristics of Treg cells have not been precisely investigated in chronic urticaria (CU) yet, this study was performed. OBJECTIVE:To determine the frequencies of circulating CD4+ CD25+ FOXP3+ T cells and serum levels of interleukin (IL)-10, transforming growth factor (TGF)-β, and IL-17 in patients with chronic autoimmune urticaria and chronic idiopathic urticaria compared to healthy controls. METHODS:Peripheral blood mononuclear cells (PBMCs) were obtained from patients with CU and healthy controls. The frequency of CD4+ CD25+ T cells in PBMCs and expression levels of FOXP3 were detected by flow cytometry. The serum levels of IL-10, TGF-β, and IL-17 were measured by enzyme-linked immunosorbent assay. RESULTS:A significant decrease in the percentage of circulating CD4+ CD25+ FOXP3+ T cells was detected in patients with CU, compared to control subjects. However, no significant difference was detected on the serum levels of IL-10, TGF-β, and IL-17 between patients with CU and control subjects. CONCLUSIONS:This study demonstrated that the frequency of Treg cells in PBMCs was decreased in patients with CU. Further studies are needed to clarify the exact role of Treg cells in the pathogenesis of CU and factors regulating their function.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Arshi S,Babaie D,Nabavi M,Tebianian M,Ghalehbaghi B,Jalali F,Ahmadvand A,Gholami Rdoi
10.1111/ijd.12630subject
Has Abstractpub_date
2014-12-01 00:00:00pages
e561-6issue
12eissn
0011-9059issn
1365-4632journal_volume
53pub_type
杂志文章abstract:BACKGROUND:Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin disease. Angiopoietin is an intrinsic mediator induced by T helper 2 cytokines and has been reported it to play a critical role in the pathogenesis of AD. OBJECTIVES:To determine the relationship between circulating angiopoietin-2 (Ang-2) in AD...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.14620
更新日期:2019-11-04 00:00:00
abstract::Ten patients with chronic purpuric and pigmented angiodermatitis in the extremities and two patients with acute and disseminated eczematoid-like purpura angiodermatitis were studied with current hemostasis parameters: (1) platelet aggregation, (2) platelet circulating aggregates, (3) clotting factor measurements and h...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1992.tb04244.x
更新日期:1992-11-01 00:00:00
abstract::A survey of 115 pemphigus patients who have been followed for 4-24 years was carried out in an attempt to analyze the possible factors influencing the course and prognosis of the disease. At the time of the study, 45 patients were in complete remission, 45 still had lesions, and 25 had died. In 12 cases, the death occ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1988.tb02409.x
更新日期:1988-10-01 00:00:00
abstract:BACKGROUND:The use of Isotretinoin (Iso) for cystic acne (CA) therapy includes marked side-effects such as dyslipidemia, increased liver enzymes, and reduction of biotinidase activity. Moreover, Homocysteine (Hcy), an amino acid, is metabolized in the liver requiring folate, vitamin B6, vitamin B12, and the activity of...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1046/j.1365-4362.2001.00146.x
更新日期:2001-01-01 00:00:00
abstract:UNLABELLED:Methotrexate (MTX) treatment for psoriasis is most often administered weekly, because the drug has been considered more hepatotoxic when taken daily. However, some patients may tolerate smaller, more frequent doses better. OBJECTIVE:To study the efficacy and toxicity of daily vs. weekly MTX. PATIENTS AND M...
journal_title:International journal of dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-4632.2011.04967.x
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Isotretinoin, for acne treatment, is associated with high rates of permanent remission. However, at recommended doses of 0.5-1.0 mg/kg/day for 5-6 months [average cumulative dose: 120-150 mg/kg], more than 20% of patients experience a relapse within two years that requires further medical management. OBJECT...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05409.x
更新日期:2012-09-01 00:00:00
abstract::Asiaticoside, isolated from Centella asiatica, promotes fibroblast proliferation and extracullar matrix synthesis in wound healing. The precise mechanism, however, in molecular and gene expression levels still remains partially understood. Using cDNA microarray technology, the alternation of genes expression profiles ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02047.x
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:Leishmaniasis is endemic in 88 countries in the world, and 350 million individuals are at risk of acquiring the disease. Treatment for American cutaneous leishmaniasis (ACL) is long, expensive, and associated with important side-effects. METHODS:In this double-blind, placebo-controlled study, we treated 102...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1365-4362.2002.01336.x
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:Keloids are benign dermal tumors characterized by fibroblastic proliferation and excessive accumulation of collagen. Oxymatrine (OMT) is an alkaloid extracted from the Chinese herb Sophora japonica with capacities of anti-fibrosis. OBJECTIVE:To evaluate the effects of OMT on collagen production and to explo...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05234.x
更新日期:2012-04-01 00:00:00
abstract::A survey on communicable dermatoses in economically weak villages in India showed wide variations in prevalence rates in similar ecologic setup. A skin diseases, on-spot-treatment, 1-day-camp was organized to treat 1787 subjects in five villages. Two applications of 1% lindane 1 week apart was the only treatment used ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1985.tb05790.x
更新日期:1985-06-01 00:00:00
abstract::Necrolytic migratory erythema (NME) is a rare skin disorder that is a cutaneous manifestation of the glucagonoma syndrome. It presents with annular eruptions of migrating erythematous papules and plaques with superficial epidermal necrosis, central flaccid bullae, and crusted erosions located primarily in the intertri...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.13947
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Clindamycin phosphate (CLDMP) is effective against Gram-positive and anaerobic bacteria, and is known to have anti-inflammatory properties. METHODS:To further study the anti-inflammatory properties of CLDMP, we examined the scavenging effects on superoxide anion and hydroxyl radical using an electron spin r...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2007.03338.x
更新日期:2007-11-01 00:00:00
abstract::Erosive pustular dermatosis of the scalp is a rare condition which primarily affects older women after local trauma and has historically been treated with topical steroids. As it is a rare entity and resembles other dermatologic conditions, it may easily be misdiagnosed. Identifying the causes and evaluating the effic...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.14955
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Self-reported complaints in people having tattoos, including swelling, itch, and photosensitivity, are frequent. Tattooists are usually heavily tattooed with multiple extended colored tattoos and constitute a specific population of interest. OBJECTIVES:To assess the prevalence of cutaneous complications on ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13030
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:This is the first epidemiologic study of pemphigus in the southern region of Saudi Arabia. METHODS:Data were collected from patient records in the outpatient and inpatient departments of Asir Central Hospital during the period 1990-99. The diagnosis of pemphigus was based on the clinical, histopathologic, a...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2001.01247.x
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Considerable studies showed that tumor suppressor phosphatase and tensin homolog (PTEN) deleted on chromosome 10 is a major tumor suppressor, which inhibits cell proliferation through inactivation of the PI3 kinase (PI3K)/Akt signal pathway. In many human tumors, there is loss of function or mutations in PTE...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12061
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:The literature includes only a few reports of oral isotretinoin for the treatment of folliculitis decalvans (FD). This study aimed to determine the most effective dose and duration of oral isotretinoin monotherapy for achieving remission in FD patients. METHODS:This retrospective case series study included ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13874
更新日期:2018-02-01 00:00:00
abstract::The patient, aged 50 years, with no relevant clinical history, complained of a symptomless, soft tumor of the right buttock that had been present for many years. On examination, it was found to be pediculate, oval, somewhat erythematous, firm on palpation, and with a central keratin plug. The greatest diameter of the ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1995.tb04659.x
更新日期:1995-10-01 00:00:00
abstract::Previous reports have shown that alterations in cutaneous and plasmatic fibrinolytic activity are found in cutaneous necrotizing vasculitis (CNV). In a combined investigation with direct immunofluorescence and autohistographic evaluation of tissue fibrinolytic activity in the lesional skin of 20 subjects affected by S...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1983.tb03323.x
更新日期:1983-03-01 00:00:00
abstract::Aquatic dermatoses encompass a broad spectrum of cutaneous injuries. These injuries may present through contact with invertebrate organisms such as jellyfish, sea urchins, corals, and molluscs. Each organism is equipped with a unique method of causing harm to man, therefore a myriad of presenting signs and symptoms sh...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2011.05431.x
更新日期:2013-02-01 00:00:00
abstract::Punch grafting is an established treatment modality for management of localized, nonprogressive vitiligo resistant to conventional therapies.(1) In our set up, punch grafting is routinely carried out in focal vitiligo, segmental vitiligo and even in few cases of generalized vitiligo, especially when it is a serious co...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.01889.x
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Steatocystoma multiplex is an uncommon disorder which usually begins in adolescence or early adult life. The condition can be hereditary, as an autosomal dominant trait, or nonhereditary, as in this case. METHODS:A 40-year-old woman presented with a history of asymptomatic nodules that began around puberty ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2003.01309.x
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Matrine is a traditional Chinese medicine with significant inhibitory activity against malignant tumors. Its effects on the invasiveness and metastasis of malignant tumors have rarely been reported. AIM:To investigate whether matrine can inhibit the metastasis-related activities of the human malignant melan...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.03627.x
更新日期:2008-05-01 00:00:00
abstract::We report the occurrence of myiasis owing to Dermatobia hominis (Dh) in a HIV-infected subject. HIV infection did not modify the pathogenicity of myiasis. However, the clinical presentation seemed unusual with voluminous inflammatory nodules. Use of topical ivermectin killed the larvae and facilitated their extraction...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2006.03028.x
更新日期:2007-01-01 00:00:00
abstract::Fifty patients (42 men, 8 women) with seborrheic dermatitis were included in the trial. Ketoconazole 2% emulsion or the same emulsion without active drug was applied b.i.d. for 4 weeks. Two patients dropped out in the ketoconazole group and nine in the placebo group. Pityrosporum ovale was cultured from all patients a...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-4362.1991.tb04793.x
更新日期:1991-11-01 00:00:00
abstract::Five cases of chronic bullous dermatosis of childhood (CBDC), a rare bullous disease, are presented. Also known as linear IgA bullous dermatitis, it has significant immunofluorescence findings. Treatment with dapsone, 50 mg daily, is recommended. ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1986.tb03400.x
更新日期:1986-01-01 00:00:00
abstract::A 58-year-old woman with progressive systemic sclerosis developed a butterfly erythematous eruption, hemorrhagic maculae, crusting, and erosions on the face 15 days following administration of D-penicillamine. This appeared to be a lupus erythematosus-like eruption due to an adverse drug reaction to D-penicillamine be...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1990.tb03471.x
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND:Cutaneous larva migrans (CLM) is caused by the penetration of larvae of animal hookworms into the skin. Knowledge about this ectoparasitosis is mainly based on the examination of travelers or other expatriates. Population-based studies in an endemic area have never been performed. METHODS:A representative p...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02152.x
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Several types of dermatofibroma (DF) have been identified dermatopathologically and with dermatoscopic correlation, the dermatopathology has been predictable in limited studies so far. We identify DFs with specific dermatoscopic structures and determine the respective dermatopathological correlates. METHODS...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.14559
更新日期:2020-01-01 00:00:00
abstract::The mechanism of infection in South American blastomycosis is discussed, and the probability of a mild or asymptomatic form of the disease, regressing spontaneously with subsequent immunity, in persons living in endemic areas. Primary lesions in the oral mucosa or in the skin have not been convincingly shown to occur ...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4362.1975.tb01428.x
更新日期:1975-03-01 00:00:00