Abstract:
:Asiaticoside, isolated from Centella asiatica, promotes fibroblast proliferation and extracullar matrix synthesis in wound healing. The precise mechanism, however, in molecular and gene expression levels still remains partially understood. Using cDNA microarray technology, the alternation of genes expression profiles was determined in a human dermal fibroblast in vitro in the presence of asiaticoside (30 microg/ml). Fifty-four genes, with known functions for cell proliferation, cell-cycle progression and synthesis of the extracellular matrix, were significantly up-regulated in our "whole-genes nest" expression profile at various timepoints. Furthermore, mRNA levels and protein productions of certain genes responsible for extracellular matrix (ECM) synthesis (e.g. encoding type I and type III collagen proteins) were evaluated by Northern blot and radioimmunoassay, respectively. As a result, there is a close correlation among the gene profile, mRNA and protein production in the cells response to asiaticoside stimulation. This information could be used for exploring the target genes in response to asiaticoside in fibroblasts.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Lu L,Ying K,Wei S,Fang Y,Liu Y,Lin H,Ma L,Mao Ydoi
10.1111/j.1365-4632.2004.02047.xsubject
Has Abstractpub_date
2004-11-01 00:00:00pages
801-7issue
11eissn
0011-9059issn
1365-4632pii
IJD2047journal_volume
43pub_type
杂志文章abstract:BACKGROUND:Neutrophils play a critical role in host defense against a variety of microbial pathogens. There is much information to suggest a role for vitamin C in the physiology of neutrophils. Thus, the effects of vitamin C treatment were studied in a patient with a history of recurrent furunculosis who showed altered...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1993.tb02780.x
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Although the causes of striae distensae (SD) remain to be elucidated, the condition is known to relate to changes in the structures that provide the skin with its tensile strength and elasticity. OBJECTIVE:This study was conducted to evaluate whether premature birth is a risk factor for SD. METHODS:A total...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.04899.x
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Sarcoidosis is a chronic granulomatous disease of unknown etiology. Cutaneous disease is common and includes two clinicopathologic categories: granulomatous infiltration or a reactive phenomenon. In the granulomatous infiltrative group, clinical manifestations can be variable. Ulcers in sarcoidosis are uncom...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.01896.x
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:Pediculosis capitis is an endemic parasitosis affecting many countries of the world. The aim of this study was to investigate the incidence of head lice infestation in Mersin, Turkey. METHODS:A total of 5318 elementary schoolchildren, aged 8-16 years, were examined for the presence of Pediculus capitis. If ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2003.01836.x
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Epidermal autografting has been used to treat vitiligo. The pigmentation achieved at the recipient site can be variegated and incomplete compared with that of the surrounding normal skin, and sometimes remains that way for a fairly long time. OBJECTIVE:We investigated whether the clinical results from epide...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.1998.00437.x
更新日期:1998-07-01 00:00:00
abstract::Skin lesions are frequent in human T-cell lymphotropic virus type 1 (HTLV-1) infection and may constitute an alert for the diagnosis of this condition. The most severe skin diseases related to this virus are adult T-cell leukemia/lymphoma (ATLL), an aggressive form of leukemia/lymphoma that fails to respond to chemoth...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2010.04568.x
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:The patient with xeroderma pigmentosum provides an appropriate human model for the evaluation of tumor development and progression. METHODS:We describe a patient with variant-type xeroderma pigmentosum who developed actinic keratoses, a squamous cell carcinoma, and its metastasis into a lymph node. DNA ploi...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1994.tb00990.x
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Several case reports and case series have recently explored the association between hidradenitis suppurativa (HS) and inflammatory bowel disease (IBD). OBJECTIVE:We performed a systematic review and meta-analysis of case-control studies to determine (i) the pooled prevalence of IBD in HS cohorts, and (ii) ...
journal_title:International journal of dermatology
pub_type: 杂志文章,meta分析
doi:10.1111/ijd.14697
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Edema commonly accompanies surgical procedures and when excessive, can adversely affect surgical outcomes. The skin extracellular matrix, including one of its primary components, hyaluronan (HA), is a significant barrier to effective drainage of accumulated edematous fluid. Recombinant human hyaluronidase (r...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12304
更新日期:2014-06-01 00:00:00
abstract::Erosive pustular dermatosis of the scalp is a rare condition which primarily affects older women after local trauma and has historically been treated with topical steroids. As it is a rare entity and resembles other dermatologic conditions, it may easily be misdiagnosed. Identifying the causes and evaluating the effic...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.14955
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the effect of topical paromomycin treatment on the development of immunity during cutaneous leishmaniasis. METHODS:Three parameters of immunity were measured in the course of the disease: leishmanicidal effector activity, lymphocyte proliferation (cell-mediated immunity...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-4362.1993.tb00975.x
更新日期:1993-01-01 00:00:00
abstract::Methotrexate, the most common systemic small molecule used in the treatment of moderate to severe psoriasis, is associated with significant toxicities and adverse events. Long-term continuous usage is not recommended due to potential liver toxicity, myelosuppression, and other side effects. Abrupt cessation of methotr...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.03419.x
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Intralesional bleomycin is effective for the treatment of various dermatologic conditions. However, the efficacy of intralesional bleomycin for the treatment of corns has not been established. METHODS:A total of 50 patients with plantar corns were recruited and equally divided between groups A and B. Groups...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12586
更新日期:2014-12-01 00:00:00
abstract::The calcipotriene/betamethasone dipropionate two-compound scalp formulation has been shown to be safe and effective in the treatment of scalp psoriasis over 8 weeks, but the patients studied were mainly White and non-Hispanic. The aim of this study was to evaluate the efficacy and safety of the two-compound scalp form...
journal_title:International journal of dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-4632.2010.04598.x
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Health-related quality of life instruments are typically developed and validated for use in developed countries by patients who can read and write. Little is known about the feasibility of using adaptations of validated instruments in situations where literacy rates are low. OBJECTIVE:We aimed to translate,...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.04894.x
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Though any drug can be a potential cause of such hypersensitivity reactions, paracetamol, an over-the-counter drug used extensively as an analgesic and antipyretic agent, is considered to be relatively safe, with hepatotoxicity as a major adverse effect only in large doses. MATERIALS AND METHODS:We report a...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12355
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Millions of people are infested by head lice every year. However, louse transfer between hosts is not well-understood. Our goals were to determine: (1) which stages were most likely to disperse and why, (2) the likelihood of fomites transmission, and (3) if host blood gender affects louse development. METHO...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2005.02418.x
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:The average incidence of pemphigus reported from European countries ranged between 0.5 and eight cases per one million inhabitants. Studies on epidemiology of pemphigus group in entire Province of Poland over a period of more than a decade are lacking. AIM:To analyze the incidence of pemphigus vulgaris (PV)...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.14078
更新日期:2018-08-01 00:00:00
abstract::During a 10-year period (1976-1985), eight Chinese patients from a population of 2.5 million fulfilled the criteria for dermatitis herpetiformis and linear IgA bullous dermatosis (LABD). These rare diseases among Asians presented during the third decade of life with homogenous linear IgA deposits along the dermoepider...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1988.tb02328.x
更新日期:1988-01-01 00:00:00
abstract::A case report of cutaneous onchocercias acquired during travels to Africa is presented. The salient epidemiologic, clinical, diagnostic, and therapeutic aspects are reviewed. Clinical and laboratory differences between onchocerciasis patients who are inhabitants of endemic areas and those who are occasional visitors t...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02203.x
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Mechanic's hand is a defined specific skin eruption associated with dermatomyositis; there are few reports concerning its histopathology. As mechanic's hand clinically resembles hand eczema, it is important to distinguish between these two conditions. AIM:To determine the characteristic clinical and histopa...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2009.04164.x
更新日期:2009-11-01 00:00:00
abstract::Aquatic dermatoses encompass a broad spectrum of cutaneous injuries. These injuries may present through contact with invertebrate organisms such as jellyfish, sea urchins, corals, and molluscs. Each organism is equipped with a unique method of causing harm to man, therefore a myriad of presenting signs and symptoms sh...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2011.05431.x
更新日期:2013-02-01 00:00:00
abstract::Clinical, histologic, and immunofluorescence studies were performed in 15 patients with pemphigus herpetiformis. The initial diagnosis was dermatitis herpetiformis, IgA linear bullous dermatosis or bullous pemphigoid. The histology varied depending on the character of skin lesions, and showed eosinophilic spongiosis o...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1987.tb02308.x
更新日期:1987-11-01 00:00:00
abstract::One hundred thirteen patients with fixed drug eruption (FDE) were studied for any drug-specific clinical pattern. The causative drugs were identified and confirmed by provocation tests. A trimethoprim-sulfamethoxazole combination caused maximum incidence (36.3%), followed by tetracycline (15.9%), pyrazolones (14.2%), ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1991.tb04354.x
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND:Genetic factors seem to play a significant role in the susceptibility to systemic lupus erythematosus (SLE). Some researchers have described amino acid polymorphisms within the interleukin-4 receptor (IL-4R) [isoleucine50valine (Ile50Val), arginine576glutamine (Arg576Gln), etc.], the IL-10R (G241A and G520A)...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2007.03258.x
更新日期:2007-11-01 00:00:00
abstract::The patient, aged 50 years, with no relevant clinical history, complained of a symptomless, soft tumor of the right buttock that had been present for many years. On examination, it was found to be pediculate, oval, somewhat erythematous, firm on palpation, and with a central keratin plug. The greatest diameter of the ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1995.tb04659.x
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Onychomycosis, a fungal infection of the nail, is caused by dermatophytes, yeasts, and nondermatophyte molds. The causative pathogen and incidence of onychomycosis depend on age, gender, geographic and climatic conditions, living habits, and immune status of the host. AIM:To determine the incidence and etio...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2009.04126.x
更新日期:2009-09-01 00:00:00
abstract::There are 70.8 million persons displaced worldwide due to war, persecution, and violence. Eighty percent of displaced persons reside in low- and middle-income countries with limited healthcare resources. Cutaneous diseases are commonly reported among displaced persons owing to numerous interrelated factors such as ina...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.15063
更新日期:2020-07-19 00:00:00
abstract:INTRODUCTION:Vitiligo is an acquired progressive disorder characterized by destruction of melanocytes in the lesion and the lesional hair follicles. A number of new therapeutic options for vitiligo have become available over the last decade or so both on the medical as well as surgical side. One among them is the smash...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05513.x
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Self-reported complaints in people having tattoos, including swelling, itch, and photosensitivity, are frequent. Tattooists are usually heavily tattooed with multiple extended colored tattoos and constitute a specific population of interest. OBJECTIVES:To assess the prevalence of cutaneous complications on ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13030
更新日期:2016-07-01 00:00:00