Prevalence of inflammatory bowel disease (IBD) in hidradenitis suppurativa (HS): systematic review and adjusted meta-analysis.

Abstract:

BACKGROUND:Several case reports and case series have recently explored the association between hidradenitis suppurativa (HS) and inflammatory bowel disease (IBD). OBJECTIVE:We performed a systematic review and meta-analysis of case-control studies to determine  (i) the pooled prevalence of IBD in HS cohorts, and (ii) whether HS is more strongly associated with Crohn's disease or ulcerative colitis. METHODS:Electronic searches were performed using five databases, from their inception to August 2018. Case-control studies reporting the proportion of IBD cases in HS cohorts were included and meta-analysis performed. RESULTS:From six included studies, a significant association between HS and IBD after pooling of adjusted effect sizes was identified (OR 2.12; 95% CI 1.62-2.77; P = 0.03). Subgroup analysis demonstrated a significant association between HS and Crohn's disease (OR 2.25; 95% CI 1.52-3.32; P < 0.0001, I2  = 92%) and with ulcerative colitis (OR 1.56; 95% CI 1.26-1.94; P < 0.0001; I2  = 36%). LIMITATIONS:Studies reviewed were observational by design which are susceptible to bias and lack of randomization. CONCLUSIONS:Our results indicate a statistically significant association between HS and IBD. Our results highlight that all patients with HS should be clinically screened for symptoms of IBD and symptomatic patients referred for further investigations.

journal_name

Int J Dermatol

authors

Phan K,Tatian A,Woods J,Cains G,Frew JW

doi

10.1111/ijd.14697

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

221-228

issue

2

eissn

0011-9059

issn

1365-4632

journal_volume

59

pub_type

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