Relapsing polychondritis, an underestimated dermatological urgency: case report and literature review.

Abstract:

BACKGROUND:Relapsing polychondritis is an autoimmune multisystemic disease with primary chondral involvement. Its high mortality and morbidity make it a real clinical challenge. CASE DESCRIPTION:A 32-year-old woman with a history of relapsing polychondritis, refractory to multiple treatments, with multisystem compromise, imminent risk of death due to severe tracheobronchial damage and difficult ventilatory support, and successful treatment with infliximab. DISCUSSION AND EVALUATION:Several treatments have been described in the literature, such as nonsteroidal anti-inflammatory drugs, corticosteroids, dapsone, azathioprine, cyclosporine, cyclophosphamide, and methotrexate. However, the cases refractory to conventional therapy may lead to chronicity, irreversibility, and death. As a result, a third-line therapy could improve the prognosis of these patients. CONCLUSIONS:Biological therapy is a good option for disease control and quality of life improvement. In addition, the physician should consider these treatments to avoid the chronicity and risk of death of these patients.

journal_name

Int J Dermatol

authors

Cuestas D,Peñaranda E,Mora S,Cortes C,Galvis I,Patiño M,Velasquez O

doi

10.1111/ijd.13755

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

1379-1386

issue

12

eissn

0011-9059

issn

1365-4632

journal_volume

56

pub_type

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