Expression of p16 protein in acral lentiginous melanoma.

Abstract:

BACKGROUND:Acral lentiginous melanoma (ALM) is a clinicopathologic subtype of cutaneous malignant melanoma. ALM is the most common type of melanoma amongst Asians, Africans, and patients with mixed ancestry. In Brazil, ALM comprises 10% of cutaneous melanoma. ALM develops on palmar, plantar, and subungual skin, and its biology is different from that of other cutaneous melanomas, where sunlight is the major known environmental determinant. Alterations and inactivation of the p16INK4 gene that encodes a specific inhibitor of cyclin-dependent kinase have been related to melanoma genesis and progression. Few studies, however, have addressed p16 expression in ALM. METHODS:In order to verify and compare p16 protein expression, 32 paraffin-embedded ALM specimens were subjected to a immunohistochemical technique using a monoclonal anti-p16 antibody. The tumors were classified according to thickness (up to 1.0 mm and thicker than 1.0 mm) and the presence of ulceration. RESULTS:Twenty-five (78%) ALMs displayed positive p16 protein expression: 21 of the 25 (84%) with a thickness of more than 1.0 mm, and four of the seven (57%) with a thickness of 1.0 mm or less. Thirteen of the 17 (76%) nonulcerated lesions and 12 of the 15 (80%) ulcerated lesions displayed positive p16 protein expression. CONCLUSION:The data obtained suggest that p16 protein expression per se may not represent a marker of retinoblastoma protein (pRb) pathway disturbance in ALM tumorigenesis.

journal_name

Int J Dermatol

authors

Hsieh R,Firmiano A,Sotto MN

doi

10.1111/j.1365-4632.2008.04009.x

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

1303-7

issue

12

eissn

0011-9059

issn

1365-4632

pii

IJD4009

journal_volume

48

pub_type

杂志文章
  • Multiple cutaneous lymphoproliferative disorders showing a retained tumor clone by T-cell receptor gene rearrangement analysis: a case series of four patients and review of the literature.

    abstract:BACKGROUND:Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma (CTCL), followed by CD30+ lymphoproliferative disorders, including lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (pcALCL). The objective was to report on a series of patients with different types o...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.12847

    authors: Stowman AM,Hsia LL,Kanner WA,Mahadevan MS,Bullock GC,Patterson JW

    更新日期:2016-02-01 00:00:00

  • Conservative thickness layers in Mohs micrographic surgery.

    abstract:BACKGROUND:Mohs micrographic surgery (MMS) is used to treat cutaneous malignancies in locations to maximize tissue sparing. The authors' aim is to demonstrate the utility of conservative thickness layers (CTL) in MMS and review patient and tumor characteristics and the potential anatomic locations where this technique ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.14043

    authors: Tolkachjov SN,Cappel JA,Bryant EA,Harmon CB

    更新日期:2018-09-01 00:00:00

  • Papulonecrotic tuberculid secondary to disseminated Mycobacterium avium complex.

    abstract:BACKGROUND:Papulonecrotic tuberculid is a rarely reported cutaneous reaction to the mycobacterium bacillus. It is most often encountered in association with tuberculosis. The clinical and histologic picture of the entity is a distinctive one, but the etiology of the disease process is uncertain. Therapy directed agains...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1994.tb01537.x

    authors: Williams JT,Pulitzer DR,DeVillez RL

    更新日期:1994-02-01 00:00:00

  • Netherton syndrome: a case report and review of the literature.

    abstract::Netherton syndrome is a rare disorder inherited in an autosomal recessive pattern consisting of ichthyosiform dermatosis, hair shaft abnormalities (trichorrhexis invaginata), and an atopic diathesis. Patients with Netherton syndrome have been found to have a mutation on chromosome 5q32 in a gene named SPINK5 (serine p...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-4632.2005.02637.x

    authors: Sun JD,Linden KG

    更新日期:2006-06-01 00:00:00

  • Dermatologists' level of compliance with the prescription guidelines of isotretinoin for females of childbearing potential.

    abstract:BACKGROUND:Potent teratogenicity limits the use of isotretinoin among females of childbearing potential (FCBP). OBJECTIVE:To explore the current practice of dermatologists for pregnancy prevention when prescribing isotretinoin for FCBP. MATERIALS AND METHODS:A self-administered questionnaire was distributed to 160 de...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2011.04875.x

    authors: AlGhamdi KM,Khurram H,Asiri YA,Mandil A

    更新日期:2011-09-01 00:00:00

  • Cell-mediated immunity in wart infection.

    abstract::The role of cell-mediated immunity (CMI) in wart infection was demonstrated. The correlation with humoral immunity was also suggested. Patients with cell-mediated immune deficiency were found to be more susceptible to wart infection than those with humoral immune deficiency. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1982.tb00510.x

    authors: Thivolet J,Viac J,Staquet MJ

    更新日期:1982-03-01 00:00:00

  • Prurigo pigmentosa: a clinicopathological study and analysis of associated factors.

    abstract:BACKGROUND:Prurigo pigmentosa (PP), a rare inflammatory disease of the skin, is mostly reported in the ethnic Japanese population. Its pathogenesis remains unclear. The chronic and recurrent nature of PP implies a possible role of viral infection in the pathogenesis. The anti-inflammatory mechanism of doxycycline, whic...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2010.04625.x

    authors: Lu PH,Hui RC,Yang LC,Yang CH,Chung WH

    更新日期:2011-01-01 00:00:00

  • Clinicodermoscopic study of histoid leprosy: a case series.

    abstract:BACKGROUND:Histoid leprosy (HL) is a highly bacilliferous form of leprosy which requires early diagnosis and management. Dermoscopy is a noninvasive diagnostic method for various malignant and nonmalignant disorders. The aim of this study was to describe the dermoscopic patterns of various types of HL lesions over diff...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.14731

    authors: Acharya P,Mathur MC

    更新日期:2020-03-01 00:00:00

  • Case of multiple myeloma associated with extramedullary cutaneous plasmacytoma and pyoderma gangrenosum.

    abstract::A variety of cutaneous manifestations has been described in multiple myeloma including extramedullary cutaneous plasmacytomas, cutaneous amyloidosis, pyoderma gangrenosum, leukocytoclastic vasculitis, necrobiotic xanthogranuloma, scleromyxedema, Sweet's syndrome, subcorneal pustular dermatosis, scleredema, and plane x...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2004.02414.x

    authors: Yoon YH,Cho WI,Seo SJ

    更新日期:2006-05-01 00:00:00

  • Multiple agminated pigmented Spitz nevi (mimicking acral lentiginous malignant melanoma and dysplastic nevus) in an African-American girl.

    abstract:BACKGROUND:Reed's nevi are distinguished from Sptiz tumors by their significant melanogenesis and growth pattern. They may be confused with melanoma on clinical and histologic grounds. CASE REPORT:An unusual case in which multiple agminated Reed's nevi mimicked acral lentiginous malignant melanoma in an African-Americ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1993.tb04268.x

    authors: Abramovits W,Gonzalez-Serva A

    更新日期:1993-04-01 00:00:00

  • The combination of overweight and smoking increases the severity of androgenetic alopecia.

    abstract:INTRODUCTION:Even though androgenetic alopecia (AGA) is the most common type of alopecia, factors associated with AGA severity have been poorly investigated. OBJECTIVES:The objective of our study was to investigate risk factors for AGA severity among a Caucasian population. METHODS:A cross-sectional study was conduct...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.13652

    authors: Fortes C,Mastroeni S,Mannooranparampil TJ,Ribuffo M

    更新日期:2017-08-01 00:00:00

  • Facial contact dermatitis. Pathogenetic factors in China.

    abstract::In 107 cases of facial contact dermatitis, routine Finn chamber epicutaneous tests with TROLAB European Standard Allergens (ESAs) were performed. Sixty-one (57%) had positive reaction. The most frequent contact allergens were paraphenylenediamine dihydrochloride (16%), followed by fragrance mix (15%), and nickel sulfa...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1991.tb04867.x

    authors: Zhao B,Fan WX

    更新日期:1991-07-01 00:00:00

  • Tinea versicolor in dark-skinned individuals.

    abstract::In this article, we review the salient features of tinea versicolor and describe the epidemiology, clinical presentation, and histopathology of this mycosis in dark-skinned individuals. Tinea versicolor is caused by an overgrowth of the Malassezia genus. It manifests clinically as asymptomatic hypopigmented macules, h...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.12345

    authors: Kallini JR,Riaz F,Khachemoune A

    更新日期:2014-02-01 00:00:00

  • Evaluation of 23 cutaneous anthrax patients in eastern Anatolia, Turkey: diagnosis and risk factors.

    abstract:BACKGROUND:Anthrax is a potentially fatal zoonotic disease. The diagnosis of cutaneous anthrax (CA) may be very difficult, particularly in atypical presentations and nonendemic regions. AIM:To evaluate the clinical features and diagnostic difficulties of 23 anthrax cases seen between May 2004 and September 2006. METH...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2008.03665.x

    authors: Ozcan H,Kayabas U,Bayindir Y,Bayraktar MR,Ay S

    更新日期:2008-10-01 00:00:00

  • Development of anthralin short-contact therapy in psoriasis: survey of published clinical trials.

    abstract::In a survey of clinical trials concerning the efficacy of short-contact therapy with anthralin in psoriasis vulgaris, focusing principally on methodologic issues, twenty-four papers published between January 1982 and December 1989, in English, French, and Italian, were selected. Nine of 24 papers reported on more than...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1365-4362.1992.tb03254.x

    authors: Naldi L,Carrel CF,Parazzini F,D'Oro LC,Cainelli T

    更新日期:1992-02-01 00:00:00

  • The antiproliferative function of violacein-like purple violet pigment (PVP) from an Antarctic Janthinobacterium sp. Ant5-2 in UV-induced 2237 fibrosarcoma.

    abstract:BACKGROUND:In this study, we have investigated the chemotherapeutic potential of a purple violet pigment (PVP), which was isolated from a previously undescribed Antarctic Janthinobacterium sp. (Ant5-2), against murine UV-induced 2237 fibrosarcoma and B16F10 melanoma cells. METHODS:The 2237, B16F10, C50, and NIH3T3 cel...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2010.04825.x

    authors: Mojib N,Nasti TH,Andersen DT,Attigada VR,Hoover RB,Yusuf N,Bej AK

    更新日期:2011-10-01 00:00:00

  • Telangiectasia macularis eruptiva perstans with an associated myeloproliferative disorder.

    abstract::Telangiectasia macularis eruptiva perstans (TMEP) is a cutaneous form of mastocytosis. It has been rarely associated with an underlying myeloproliferative disorder. We report the case of a patient, while receiving treatment for thrombocytosis, with both platelet production and function inhibitors presented with TMEP. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2004.02249.x

    authors: Martin LK,Romanelli P,Ahn YS,Kirsner RS

    更新日期:2004-12-01 00:00:00

  • Sporotrichosis in Uttarakhand (India): a report of nine cases.

    abstract:BACKGROUND:Sporotrichosis is a chronic granulomatous infection caused by Sporothrichum schenckii. The disease has worldwide distribution. Majority of cases from India are reported from North-eastern states. METHODS:The demographic, clinico-investigative profile and therapeutic results of nine patients with cutaneous s...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2008.03538.x

    authors: Agarwal S,Gopal K,Umesh,Kumar B

    更新日期:2008-04-01 00:00:00

  • Mortality from acquired bullous diseases of skin in Canadian adults 2000-2007.

    abstract:BACKGROUND:Bullous skin diseases are known to be associated with significant morbidity and mortality. There have been no studies on mortality from severe bullous skin diseases in Canada. METHODS:We used mortality data from the Statistics Canada website from 2000 to 2007 for three major bullous skin diseases: bullous p...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2011.05227.x

    authors: Baibergenova AT,Weinstock MA,Shear NH

    更新日期:2012-11-01 00:00:00

  • An unusual and serious complication of topical wart treatment with monochloroacetic acid.

    abstract::Numerous chemical agents are used in the topical treatment of warts. Monochloroacetic acid (MCAA) is one of these agents, which is used in low or high concentrations in most European countries. MCAA is a strong organic acid which is irritating and corrosive to the skin and has a high systemic toxicity. In addition to ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2008.03789.x

    authors: Baser NT,Yalaz B,Yilmaz AC,Tuncali D,Aslan G

    更新日期:2008-12-01 00:00:00

  • A randomized, controlled and blinded study of papulopustular lesions in Turkish Behçet's patients.

    abstract:BACKGROUND:Papulopustular lesions (PPL), the commonest presentation of skin lesions in Behcet's disease (BD) are cutaneous, sterile folliculitis or acne-like lesions on erythematous base. Our purpose was to determine the true frequency and anatomic location of the PPL and compare this with controls. We also sought to d...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-4362.1998.00401.x

    authors: Alpsoy E,Aktekin M,Er H,Durusoy C,Yilmaz E

    更新日期:1998-11-01 00:00:00

  • Long-term results of the use of oxybutynin for the treatment of plantar hyperhidrosis.

    abstract:BACKGROUND:Plantar hyperhidrosis is a common illness with significant impact on quality of life. Oxybutynin presents good short-term results, but longer follow-up results are lacking. We evaluated oxybutynin effectiveness in patients who were not surgically treated and who had at least six months of follow-up. METHODS...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.12729

    authors: Wolosker N,Teivelis MP,Krutman M,de Paula RP,Kauffman P,de Campos JR,Puech-Leão P

    更新日期:2015-01-01 00:00:00

  • Inhibition of MicroRNA-21 induces apoptosis in dermal fibroblasts of patients with systemic sclerosis.

    abstract:BACKGROUND:Prolonged activation of dermal fibroblasts is the main cause of progressive fibrosis in systemic sclerosis (SSc). It seems that inhibition of apoptosis in SSc fibroblasts deregulates fibrosis. MicroRNA-21 (miR-21) is a pro-fibrotic factor with high expression in lesional areas of SSc skin and fibroblasts. M...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.13308

    authors: Jafarinejad-Farsangi S,Farazmand A,Gharibdoost F,Karimizadeh E,Noorbakhsh F,Faridani H,Mahmoudi M,Jamshidi AR

    更新日期:2016-11-01 00:00:00

  • Basal cell carcinoma in five albino Africans from the south-eastern equatorial rain forest of Nigeria.

    abstract:BACKGROUND:Basal cell carcinoma (BCC) is the most common cutaneous malignancy in the white population and occurs infrequently in dark-pigmented individuals. Albinism is an established risk factor for skin cancer in black Africans. METHODS:We evaluated the clinical histories and treatment outcomes of patients with a hi...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2007.03272.x

    authors: Asuquo ME,Agweye P,Ugare G,Ebughe G

    更新日期:2007-07-01 00:00:00

  • Infection versus disease in South American blastomycosis.

    abstract::The mechanism of infection in South American blastomycosis is discussed, and the probability of a mild or asymptomatic form of the disease, regressing spontaneously with subsequent immunity, in persons living in endemic areas. Primary lesions in the oral mucosa or in the skin have not been convincingly shown to occur ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-4362.1975.tb01428.x

    authors: Furtado T

    更新日期:1975-03-01 00:00:00

  • Treatment of hyperhidrosis with topical methenamine.

    abstract::Idiopathic palmar and plantar hyperhidrosis is a relatively common disorder of eccrine sweat gland function. Treatment with glutaraldehyde of formaldehyde, although successful, may cause undesirable side effects. Methenamine is a polycyclic organic compound which release ammonia and formaldehyde at acid pH. Five per c...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-4362.1976.tb00240.x

    authors: Bergstresser PR,Quero R

    更新日期:1976-07-01 00:00:00

  • Basal cell carcinoma in tropical Australia.

    abstract::A survey of people with skin cancer in tropical Australia detected a change in site of the prevalent cancer. In the post-war generation more basal cell carcinomas are occurring on the back and fewer on the head and neck. A reversal of the sex ratio was also detected, with more women being afflicted. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1992.tb02667.x

    authors: Czarnecki D,Collins N,Nash C

    更新日期:1992-06-01 00:00:00

  • PTCH1 gene mutations in exon 17 and loss of heterozygosity on D9S180 microsatellite in sporadic and inherited human basal cell carcinomas.

    abstract:BACKGROUND:Basal cell carcinomas (BCCs) are the most frequent human cancer that results from malignant transformation of basal cells in the epidermis. Gorlin syndrome is a rare inherited autosomal dominant disease that predisposes with multiple BCCs and other birth defects. Both sporadic and inherited BCCs are associat...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2010.04866.x

    authors: Santos DC,Zaphiropoulos PG,Neto CF,Pimentel ER,Sanches JA Jr,Ruiz IR

    更新日期:2011-07-01 00:00:00

  • A comparison of botanical and synthetic substances commonly used to prevent head lice (Pediculus humanus var. capitis) infestation.

    abstract:BACKGROUND:Pediculosis, caused by head lice (Pediculidae: Pediculus humanus var. capitis), is experiencing a global resurgence, with the prevalence in primary schools averaging as high as 40% in some areas regardless of socioeconomic factors. Control efforts using chemical treatments are becoming increasingly ineffecti...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2007.03132.x

    authors: Canyon DV,Speare R

    更新日期:2007-04-01 00:00:00

  • Onychomycosis and AIDS. Clinical and laboratory findings in 62 patients.

    abstract::The results of a study on onychomycosis in AIDS related complex and AIDS patients presenting for dermatology consultation at an infectious diseases department are reported. The clinical results showed that most patients presented a proximal white superficial onychomycosis. The association with a clinical interdigital ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1990.tb04755.x

    authors: Dompmartin D,Dompmartin A,Deluol AM,Grosshans E,Coulaud JP

    更新日期:1990-06-01 00:00:00