Abstract:
BACKGROUND:Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma (CTCL), followed by CD30+ lymphoproliferative disorders, including lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (pcALCL). The objective was to report on a series of patients with different types of CTCL at different times in their clinical course, with a focus on clonality studies. METHODS:Four patients with multiple diagnoses of CTCLs were identified. The clinical information, treatment interventions, and histopathology were reviewed. T-cell receptor (TCR) gene rearrangement studies were performed on all available specimens. RESULTS:The four patients carried diagnoses of: (1) pcALCL and MF; (2) pcALCL, LyP, and pcALCL; (3) LyP, MF, and pcALCL; (4) LyP, pcALCL, and MF; each with characteristic presentation and histopathologic findings. The results of the TCR polymerase chain reaction showed that all tumors expressed and retained a TCR clone(s) as follows: (1) biallelic clone; (2) single clone; (3) biallelic clone with additional clone; and (4) single clone, respectively. CONCLUSION:We report a series of four cases of individual patients with coexisting diagnoses of some combination of MF, LyP, and pcALCL, whose lesions presented in nontraditional sequence and demonstrated a retained clone by gene rearrangement analysis.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Stowman AM,Hsia LL,Kanner WA,Mahadevan MS,Bullock GC,Patterson JWdoi
10.1111/ijd.12847subject
Has Abstractpub_date
2016-02-01 00:00:00pages
e62-71issue
2eissn
0011-9059issn
1365-4632journal_volume
55pub_type
杂志文章,评审abstract::With the advent of various new methods of treating psoriasis, it is necessary to remind physicians to consider an agent that is easy to administer, locally effective, relatively inexpensive, not time-consuming and without systemic toxic effects. Nineteen patients were treated with topical nitrogen mustard between 1972...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1979.tb05017.x
更新日期:1979-11-01 00:00:00
abstract:BACKGROUND:Tinea capitis is a dermatophyte infection of the scalp, eyebrows, and eyelashes caused by species of Microsporum and Trichophyton. The purpose of this study was to discover the incidence and causal agents of tinea capitis in Saudi Arabia. METHODS:Hair roots, skin scrapings, and pus swabs were collected from...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1993.tb00961.x
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:β-Cyclodextrin (βCD) xerogel containing silk fibroin (SF) was prepared, and the efficacy of the xerogel for a pressure sore developed on the back of an ICR mouse was investigated. MATERIALS AND METHODS:Tosyl βCD was conjugated to polyethyleneimine (PEI), and the βCD residues were cross-linked in an aqueous ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05389.x
更新日期:2012-08-01 00:00:00
abstract::Methicillin-resistant Staphylococcus aureus (MRSA) infections occurring within communities are increasing and can affect healthy individuals who have had little to no experience with hospital or healthcare settings (community-associated MRSA, CA-MRSA). CA-MRSA infections have multiple presentations which can make diag...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.13010
更新日期:2015-11-01 00:00:00
abstract::Dermatosis papulosa nigra (DPN) is a disorder commonly encountered in the adult black population. We describe 20 cases of clinicopathologically confirmed DPN cases treated with light abrasive curettage without local anesthesia. We found this procedure to be an effective therapy, which did not cause postoperative scarr...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1983.tb02131.x
更新日期:1983-12-01 00:00:00
abstract:BACKGROUND:Vitiligo is a common, acquired condition of unknown etiology. The only practical treatment for patients with vitiligo is psoralen ultraviolet A (PUVA). No satisfactory method is available to measure the influence of certain factors on the therapeutic response. METHODS:Twenty-nine patients with generalized v...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1995.tb01571.x
更新日期:1995-03-01 00:00:00
abstract::A 58-year-old woman with progressive systemic sclerosis developed a butterfly erythematous eruption, hemorrhagic maculae, crusting, and erosions on the face 15 days following administration of D-penicillamine. This appeared to be a lupus erythematosus-like eruption due to an adverse drug reaction to D-penicillamine be...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1990.tb03471.x
更新日期:1990-10-01 00:00:00
abstract::A 21-year-old student of sports science presented with a 12-month history of a painful nodule on the sole of her left foot, which severely constrained her sporting activities. She was otherwise well. On examination there was a bluish pink 7-mm nodule on the arch of her left foot (Fig. 1). It was firm, exquisitely tend...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.01964.x
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Different studies have shown a high prevalence of Helicobacter pylori (HP) infection in patients with chronic urticaria (CU), and occasional remission of the skin lesions after eradication therapy. Recent investigations, however, have failed to find a significant relationship between the two conditions. We d...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-4362.2000.00995.x
更新日期:2000-06-01 00:00:00
abstract::An 11-year-old girl who at 9 1/2 months was diagnosed as having keratoderma of the palms and soles, present since birth, developed typical granuloma annulare at the age of 11 years. To the authors' knowledge, this is the first report of epidermolytic palmo-plantar keratoderma associated with granuloma annulare. There ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1984.tb01225.x
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:The high rate of morbidity and mortality resulting from long-term use of corticosteroids in pemphigus vulgaris (PV) warrants discovery of a new treatment strategy. Based on a new theory on the pathophysiology of PV, cholinomimetics can block the process of blister formation. AIMS:This study was conducted to...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2006.02766.x
更新日期:2006-06-01 00:00:00
abstract::Peripheral blood lymphocyte assays using monoclonal antibodies were done in 66 patients with leprosy, consisting of 25 children and 41 adults. The results were statistically analyzed for correlations, if any, among the different age groups and matched controls. The results, however, failed to show any significant corr...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1991.tb04786.x
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Biologic therapies are more effective than conventional therapies in the treatment of psoriasis, but they are also more costly. OBJECTIVES:The aim of this study was to compare the cost-efficacy of etanercept, adalimumab, and ustekinumab therapies in the treatment of moderate to severe psoriasis in a Taiwane...
journal_title:International journal of dermatology
pub_type: 杂志文章,meta分析,评审
doi:10.1111/ijd.12462
更新日期:2014-09-01 00:00:00
abstract::A 73-year-old Celtic man presented with a linear pigmented 20-mm lesion on the left infraorbital cheek (Fig. 1). Clinical impression was pigmented basal cell epithelioma. Removal was accomplished by linear excision under local anesthesia. The wound was closed with a running 5-0 nylon subcuticular suture, which was rem...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1985.tb05396.x
更新日期:1985-03-01 00:00:00
abstract::Dextranomer, a high molecular weight dextran derivative, was evaluated in 43 patients, and found to be the treatment of choice for decubitus ulcers. It is useful in most leg ulcers and cutaneous wounds, and can aid in the nursing care of terminal patients with gangrene or uclerating carcinoma. Dextranomer hastens the ...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-4362.1979.tb01954.x
更新日期:1979-07-01 00:00:00
abstract:BACKGROUND:Psoriasis has been associated with depressive disease and case reports of completed suicide. METHODS:217 consenting psoriasis patients completed the Carroll Rating Scale for Depression (CRSD), a 52-item self-rated scale, with four of the items directly addressing wishes to be dead and suicidal ideation. The...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1993.tb02790.x
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) infection induces variable dermatologic manifestations. Our purpose was to determine whether there is an association between HCV infection and oral lichen planus (OLP). METHODS:Antibodies to HCV were determined in patients with OLP (263 patients; 156 women and 107 men, with a mean ag...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.1998.00510.x
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:Tuberous sclerosis is an autosomal dominant disorder with hamartomas in multiple organ systems. Facial angiofibromas (AF) are a common cutaneous manifestation of tuberous sclerosis. They may lead to significant cosmetic and psychological problems. Many treatment modalities have been used with variable satisf...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12384
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Photodynamic therapy (PDT) is a non-surgical method for treating non-melanoma skin cancer and precancerous lesions which involves the activation of a photosensitizer by visible light to produce activated oxygen species within target cells, resulting in the destruction of the latter. The present study evaluat...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2010.04700.x
更新日期:2011-03-01 00:00:00
abstract::Nine patients with cutaneous toxoplasmosis had slowly regressing erythema-multiforme-like eruptions or lichenoid, papulonodular and purpurictelangiectatic disorders. The most common histologic finding was subacute histiolymphocytic perivasculitis with frequent demonstration of the parasite. Another group of patients s...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1980.tb00351.x
更新日期:1980-07-01 00:00:00
abstract:OBJECTIVE:To characterize epidemiologic and clinical features of red primary amelanotic melanomas, an atypical presentation of melanoma that is underemphasized in patient and physician education. PATIENTS AND METHODS:Review of a prospectively collected melanoma database identified 46 patients with red amelanotic melan...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05066.x
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:The larvae of Lucilia sericata induce myiasis and transmit mycobacterial infections to humans and animals. Consequently, the blowfly should be controlled for human welfare and economic reasons. METHODS:The insecticidal effect of fenugreek (Trigonella foenum-graecum), celery (Apium graveolens), radish (Rapha...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2009.03937.x
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Recently, the reactivation during treatment with tumor necrosis factor (TNF) blockers has exceptionally been described in patients with hepatitis B virus (HBV) antigen-negative (HBsAg). The objective was to evaluate the influence of anti-TNF agents in patients with psoriasis and serology suggesting past hepa...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12313
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Although genital ulceration with or without scar formation is an important manifestation of Behçet's syndrome, formal data on the rate of genital scarring are lacking. OBJECTIVE:To study prospectively the frequency of genital scar formation after genital ulcers in patients with Behçet's syndrome. Methods On...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2006.02859.x
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:Although the etiology of Behcet's disease is not clarified yet, the vascular endothelial damage and thrombosis are prominent features of the disease. The underlying mechanisms of increased risk of thrombosis in Behcet's disease are not completely understood. It is stated that the changes in blood rheology suc...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2009.04229.x
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Though acral lentiginous melanoma (ALM) is a major type of malignant melanoma, no immunohistochemical study on this type of melanoma has been reported. OBJECTIVE:The purpose of this study is to analysis the immunohistochemical findings of ALM using routinely used immune markers. METHODS:An immunohistochemi...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2003.01583.x
更新日期:2003-02-01 00:00:00
abstract::The porphyrias are diverse in pathophysiology, clinical presentation, severity, and prognosis, presenting a diagnostic and therapeutic challenge. Although not easily curable, the dermatological manifestations of these diseases, photosensitivity and associated cutaneous pathology, can be effectively prevented and manag...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.12016
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Phenytoin (5,5 diphenylhydantoin), a widely-used anticonvulsant, has been employed both topically and systemically in the treatment of some dermatological disorders. Immunological and non-immunological defects suggests that phenytoin could be therapeutically effective for vitiligo repigmentation. AIM OF STU...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05551.x
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Cases of hydroa vacciniforme-like eruptions caused by latent Epstein-Barr virus (EBV) infection have been reported in Asia and Mexico, some of which progressed to lymphoproliferative disorders. The precise clinical features of the disease are not, however, clear. METHODS:We performed an artificial provocati...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2003.01307_2.x
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:The causative fungi of tinea capitis vary with geography and time. This study was planned to identify the etiologic agents and determine clinicoetiologic correlations of tinea capitis in Lahore, Pakistan. METHODS:From clinically suspected cases of tinea capitis, skin scrapings and hair samples were taken an...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1994.tb01037.x
更新日期:1994-04-01 00:00:00