Reduced erythrocyte deformability in active and untreated Behçet's disease patients.

Abstract:

OBJECTIVE:Although the etiology of Behcet's disease is not clarified yet, the vascular endothelial damage and thrombosis are prominent features of the disease. The underlying mechanisms of increased risk of thrombosis in Behcet's disease are not completely understood. It is stated that the changes in blood rheology such as erythrocyte deformability take part in the thrombosis. There are limited numbers of studies with conflicting results about the erythrocyte deformability in Behcet's disease. The previous studies were not limited to the untreated patients with active disease. METHOD:Blood samples were filtered immediately by "Imugard- leukocyte removal filter". After plasma and erythrocytes were separated by centrifugation, 10% erythrocyte suspensions were prepared with isotonic Tris NaCl buffer solution. These erythrocyte suspensions were filtered under gravitational force by "Nucleopore" to determine the filtration time. The filtration times of the erythrocyte and buffer solutions were referred as t1 and t2 respectively. Finally, deformability indices were obtained by dividing the t1 by t2. A decrease in the deformability of the erythrocytes would result in an increase in the filtration time of the erythrocyte suspension and deformability indices. RESULTS:The median deformability indices were 3.090 and 2.170 for patients and control subjects respectively and the difference was statistically significant (P = 0.000). CONCLUSION:We suggest that the decrease in erythrocyte deformability in Behcet's disease may be related to oxidative damage of erythrocytes and subsequently takes part in the development of thrombosis in Behcet's disease.

journal_name

Int J Dermatol

authors

Tatlican S,Duran FS,Eren C,Eskioglu F,Dikmenoglu N,Oktay B,Durmazlar SP,Canpolat F

doi

10.1111/j.1365-4632.2009.04229.x

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

167-71

issue

2

eissn

0011-9059

issn

1365-4632

pii

IJD4229

journal_volume

49

pub_type

杂志文章
  • Sonographic appearance of sebaceous cysts. Our experience and a review of the literature.

    abstract::Sebaceous cysts are benign enveloped nodules resulting from an obstruction of a hair follicle. Although they are very common, differential diagnosis is not obvious and may include many diseases. Ultrasound examination with high frequency probes, in the hands of a skilled operator, is the gold standard for noninvasive ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.14515

    authors: Solivetti FM,Desiderio F,Elia F,Guerrisi A,Cota C,Morrone A

    更新日期:2019-12-01 00:00:00

  • Clinical and dermoscopic response predictors in psoriatic patients undergoing narrowband ultraviolet B phototherapy: results from a prospective study.

    abstract:BACKGROUND:Although disease severity, gender, body weight, and previous treatments have all been reported to affect clinical response of psoriasis vulgaris to narrowband ultraviolet B (NB-UVB) therapy, little information about possible local (lesional) influencing factors is available. OBJECTIVE:To assess correlations...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.13983

    authors: Errichetti E,Stinco G

    更新日期:2018-06-01 00:00:00

  • Molluscum contagiosum in Greek children: a case series.

    abstract:BACKGROUND:Epidemiological studies of molluscum contagiosum (MC) in children are limited. PATIENTS AND METHOD:Between 1997 and 1999, 110 children with MC (60 boys, 50 girls, mean age: 4.8 years) were studied. Treatment consisted of removal of all MC lesions in a single session by sterilized tweezers. RESULTS:In child...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2004.02074.x

    authors: Kakourou T,Zachariades A,Anastasiou T,Architectonidou E,Georgala S,Theodoridou M

    更新日期:2005-03-01 00:00:00

  • Pneumocystis jiroveci pneumonia in patients treated with systemic immunosuppressive agents for dermatologic conditions: a systematic review with recommendations for prophylaxis.

    abstract::Pneumocystis jiroveci pneumonia is an opportunistic infection associated with substantial rates of mortality in immunosuppressed patients. Prophylaxis recommendations are mostly targeted toward patients with non-dermatologic diagnoses. This study was conducted to determine when dermatology patients treated with immuno...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.13231

    authors: Gonzalez Santiago TM,Wetter DA,Kalaaji AN,Limper AH,Lehman JS

    更新日期:2016-08-01 00:00:00

  • Evaluating serum prolactin and serum dehydroepiandrosterone sulfate levels in patients with pemphigus.

    abstract:BACKGROUND:Altered levels of sex hormones have been observed in many autoimmune disorders, but there is no considerable data about pemphigus. The aim of this study is to compare serum total and free prolactin and dehydroepiandrosterone sulfate (DHEAS) levels between patients with pemphigus and healthy controls and to d...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.13199

    authors: Yousefi M,Mozafari N,Hosseini MS,Gholamin S,Razavi SM,Namazi MR,Younespour S

    更新日期:2016-06-01 00:00:00

  • Necrolytic acral erythema: successful treatment with topical tacrolimus ointment.

    abstract::Necrolytic acral erythema is a relatively recently described psoriasis-like skin eruption seen in people infected with hepatitis C virus. Hepatitis C virus infection is endemic in many parts of the world with a steady increase of incidence in Pakistan. Recognition of this disorder is crucial to an early treatment of t...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2008.03710.x

    authors: Manzur A,Siddiqui AH

    更新日期:2008-10-01 00:00:00

  • Tamoxifen vs. non-tamoxifen treatment for advanced melanoma: a meta-analysis.

    abstract::Although tamoxifen (TAM) is routinely used in advanced melanoma, it is still uncertain whether evidence exists to support this practice. This review assesses the benefits and harms of systemic therapy with TAM vs. without TAM on response and mortality in patients with advanced melanoma. MEDLINE, The Cochrane Database ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1365-4632.2010.04529.x

    authors: Beguerie JR,Xingzhong J,Valdez RP

    更新日期:2010-10-01 00:00:00

  • Malignant melanoma in World War II veterans.

    abstract::In a consecutive series of 1,067 patients entered into the data base of the Melanoma Cooperative Group at New York University School of Medicine between 1972 and 1980, 120 men were of draft age (18-31 years) during World War II (1941-1945). Questionnaires were sent to these 120 individuals; 89 responded. Simultaneousl...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1984.tb01228.x

    authors: Brown J,Kopf AW,Rigel DS,Friedman RJ

    更新日期:1984-12-01 00:00:00

  • New and emerging concepts in managing and preventing community-associated methicillin-resistant Staphylococcus aureus infections.

    abstract::Methicillin-resistant Staphylococcus aureus (MRSA) infections occurring within communities are increasing and can affect healthy individuals who have had little to no experience with hospital or healthcare settings (community-associated MRSA, CA-MRSA). CA-MRSA infections have multiple presentations which can make diag...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.13010

    authors: Gupta AK,Lyons DC,Rosen T

    更新日期:2015-11-01 00:00:00

  • Transitioning patients from efalizumab to alternative psoriasis therapies: findings from an open-label, multicenter, Phase IIIb study.

    abstract:BACKGROUND:Rebound in psoriasis is, by definition, a rapid worsening of disease following the discontinuation of therapy for psoriasis; it occurs following the abrupt discontinuation of many therapies. To prevent rebound on discontinuation of efalizumab, this study evaluated the effectiveness of transitioning patients ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-4632.2007.03158.x

    authors: Menter A,Hamilton TK,Toth DP,Leung HM,Wetherill G,Hennessey B,Garovoy M,Kwon P,Pariser DM,Efalizumab Study Group.

    更新日期:2007-06-01 00:00:00

  • Epidemiological and clinical patterns of genital lesions.

    abstract::A 5-year study of 668 patients with genital lesions revealed that teenagers and those in the age group of 20 to 40 are most vunerable. The poor, the uneducated and unmarried persons are at high risk. Chancroid and syphilis are the majority of cases. Inguinal bubo, herpes pregenitalis, condylomata acuminata, erosive ba...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:

    authors: Sehgal VN,Rege VL,Sehgal N,Kharangate VN,Mascarenhas MF

    更新日期:1976-10-01 00:00:00

  • Outbreak of cercarial dermatitis in Thailand.

    abstract:BACKGROUND:An epidemic of cercarial dermatitis caused by Schistosoma spindale cercaria occurred in November 1988 in a district called Chaiya, Surajthani province, in Southern Thailand. CASE REPORTS:Fifty-eight Thai farmers in Chaiya, Surajthani gave a history of itch following immersion in water while planting rice. T...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1993.tb01448.x

    authors: Kullavanijaya P,Wongwaisayawan H

    更新日期:1993-02-01 00:00:00

  • Onychomycosis and AIDS. Clinical and laboratory findings in 62 patients.

    abstract::The results of a study on onychomycosis in AIDS related complex and AIDS patients presenting for dermatology consultation at an infectious diseases department are reported. The clinical results showed that most patients presented a proximal white superficial onychomycosis. The association with a clinical interdigital ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1990.tb04755.x

    authors: Dompmartin D,Dompmartin A,Deluol AM,Grosshans E,Coulaud JP

    更新日期:1990-06-01 00:00:00

  • Comparison of PTCH1, COX-2, p53, and Ki-67 protein expression in basal cell carcinomas of nodular and superficial subtypes arising on the head and trunk.

    abstract:BACKGROUND:There is some evidence that basal cell carcinomas (BCCs) arising on different anatomic sites and developing to different histological subtypes differ in their pathophysiology. The expression of a number of proteins, including PTCH1, COX-2, p53, and Ki-67, is frequently altered in BCC development. OBJECTIVES...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.13276

    authors: Khalesi M,Waterhouse M,Whiteman DC,Johns R,Rosendahl C,Hackett T,Pollak T,Kimlin MG,Hacker E,Neale RE,NHMRC Centre of Research Excellence in Sun and Health (CRESH).

    更新日期:2016-10-01 00:00:00

  • Comparative study of β-catenin and CD44 immunoexpression in oral lichen planus and squamous cell carcinoma.

    abstract:BACKGROUND:Dysfunction of adhesion molecules is believed to play an early and important role in developing cancer. Accordingly, this study aims to compare beta-catenin (β-catenin) and CD44 expression in oral lichen planus (OLP) as a condition with malignant potential and oral squamous cell carcinoma (OSCC). METHODS:β-...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.14007

    authors: Zargaran M,Baghaei F,Moghimbeigi A

    更新日期:2018-07-01 00:00:00

  • Epidemiologic approach to community dermatology.

    abstract::A survey on communicable dermatoses in economically weak villages in India showed wide variations in prevalence rates in similar ecologic setup. A skin diseases, on-spot-treatment, 1-day-camp was organized to treat 1787 subjects in five villages. Two applications of 1% lindane 1 week apart was the only treatment used ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1985.tb05790.x

    authors: Desai SC,Jagavkar CK,Oberai CM

    更新日期:1985-06-01 00:00:00

  • IgG from atopic dermatitis patients induces IL-17 and IL-10 production in infant intrathymic TCD4 and TCD8 cells.

    abstract:INTRODUCTION:Our group recently demonstrated that IgG modulates αβT cell cytokine production during the maturation process in the human thymus. The effects of this modulation are IgG repertoire dependent and can exert a systemic and long-term impact. OBJECTIVE:To investigate whether IgG from atopic dermatitis (AD) pat...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.13907

    authors: Sgnotto FDR,de Oliveira MG,Lira AAL,Inoue AHS,Titz TO,Orfali RL,Bento-de-Souza L,Sato MN,Aoki V,Duarte AJS,Victor JR

    更新日期:2018-04-01 00:00:00

  • Acyclovir-induced neuropsychosis successfully recovered after immediate hemodialysis in an end-stage renal disease patient.

    abstract::A 70-year-old man developed herpes zoster over the right L5-S2 region for 3 days and was admitted for acyclovir therapy. He had a medical history of rectal cancer status post-colostomy and end-stage renal disease undergoing thrice weekly hemodialysis. Without a prior loading dose, acyclovir 500 mg (7.7 mg/kg) daily wa...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2007.03269.x

    authors: Yang HH,Hsiao YP,Shih HC,Yang JH

    更新日期:2007-08-01 00:00:00

  • Candida folliculitis in heroin addicts.

    abstract::Three heroin addicts had Candida folliculitis of the scalp, beard, and pubis associated with fever, chills, headache, and fatigue. In each case, pseudohyphae were found within a hair and yeasts around it and Candida was recovered from urine. These facts support a systemic dissemination. Since serious ocular and osteoa...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1986.tb04547.x

    authors: Leclerc G,Weber M,Contet-Audonneau N,Beurey J

    更新日期:1986-03-01 00:00:00

  • Circulating level of CD4+ CD25+ FOXP3+ T cells in patients with chronic urticaria.

    abstract:BACKGROUND:CD4+ CD25+ T-regulatory (Treg) cells play critical roles in maintaining peripheral tolerance and preventing autoimmunity. As characteristics of Treg cells have not been precisely investigated in chronic urticaria (CU) yet, this study was performed. OBJECTIVE:To determine the frequencies of circulating CD4+ ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.12630

    authors: Arshi S,Babaie D,Nabavi M,Tebianian M,Ghalehbaghi B,Jalali F,Ahmadvand A,Gholami R

    更新日期:2014-12-01 00:00:00

  • Pemphigus vegetans of the oral cavity.

    abstract:BACKGROUND:Pemphigus vegetans, a variant of pemphigus vulgaris, constitutes a rare form of all pemphigus cases, and oral involvement is common. Two clinical subtypes of pemphigus vegetans exist, characterized initially by flaccid bullae and erosions (Neumann) or pustules (Hallopeau). Both subtypes subsequently develop ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2004.02480.x

    authors: Markopoulos AK,Antoniades DZ,Zaraboukas T

    更新日期:2006-04-01 00:00:00

  • Mycosis fungoides presenting as reticular erythematous mucinosis.

    abstract:BACKGROUND:Mycosis fungoides has numerous clinical presentations. METHODS:We present two cases in which mycosis fungoides clinically mimicked reticular erythematous mucinosis. RESULTS:Both patients had extracutaneous involvement. One had a fatal outcome. CONCLUSIONS:We suggest that full systemic evaluation be perfor...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2004.02434.x

    authors: Twersky JM,Mutasim DF

    更新日期:2006-03-01 00:00:00

  • Pseudallescheria boydii mycetoma in northern New England.

    abstract::Mycetoma is a chronic subcutaneous fungal infection characterized by tumefaction, draining sinuses, and grains. It is most common in the tropics but occasionally occurs in the United States. We report a case of a mycetoma affecting the foot of a 38-year-old mentally retarded man from northern New England. The causal o...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1988.tb02382.x

    authors: Stierstorfer MB,Schwartz BK,McGuire JB,Miller AC

    更新日期:1988-07-01 00:00:00

  • Antihistamines are superior to topical steroids in managing human immunodeficiency virus (HIV)-associated papular pruritic eruption.

    abstract::Papular pruritic eruption (PPE) is a frequent HIV-comorbidity in tropical countries. Because of constant itching and social stigma, effective treatment is highly valued. In our HIV cohort in rural Tanzania with 12% prevalence of PPE, we have retrospectively analyzed responses to available treatments. Oral promethazine...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2009.04279.x

    authors: Navarini AA,Stoeckle M,Navarini S,Mossdorf E,Jullu BS,Mchomvu R,Mbata M,Kibatala P,Tanner M,Hatz C,Schmid-Grendelmeier P

    更新日期:2010-01-01 00:00:00

  • Tinea versicolor in dark-skinned individuals.

    abstract::In this article, we review the salient features of tinea versicolor and describe the epidemiology, clinical presentation, and histopathology of this mycosis in dark-skinned individuals. Tinea versicolor is caused by an overgrowth of the Malassezia genus. It manifests clinically as asymptomatic hypopigmented macules, h...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.12345

    authors: Kallini JR,Riaz F,Khachemoune A

    更新日期:2014-02-01 00:00:00

  • Smoldering HTLV-1-induced T-cell lymphoma localized within the skin; a radiation-resistant tumor.

    abstract:BACKGROUND:Human T-cell lymphotrophic virus type 1 (HTLV-1)-induced lymphoproliferative disease occurs in approximately 3-5% of people in endemic areas who have been HTLV-1 positive for decades. Lymphoproliferative disease may present as four subtypes, including an acute adult T-cell leukemia/lymphoma (ATLL), an aggres...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-4362.2000.00937.x

    authors: Germain M,Williams J,Skelton HG,Smith KJ

    更新日期:2000-11-01 00:00:00

  • Treatment of cutaneous leishmaniasis recidivans with a combination of allopurinol and meglumine antimoniate: a clinical and histologic study.

    abstract:BACKGROUND:Cutaneous leishmaniasis (CL) is an endemic disease in Iran, particularly in Kerman Province. Leishmaniasis recidivans (LR) is one of the characteristics of this disease with a chronic course. Most patients with LR are resistant to the usual treatments. METHODS:Thirty-two patients (18 females and 14 males), ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2007.03086.x

    authors: Esfandiarpour I,Dabiri SH

    更新日期:2007-08-01 00:00:00

  • Venous ulcer: epidemiology, physiopathology, diagnosis and treatment.

    abstract::This review discusses the epidemiology, pathogenesis, diagnosis and current therapeutic options for venous ulcer. Venous ulcer is a severe clinical manifestation of chronic venous insufficiency (CVI). It is responsible for about 70% of chronic ulcers of the lower limbs. The high prevalence of venous ulcer has a signif...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-4632.2004.02456.x

    authors: Abbade LP,Lastória S

    更新日期:2005-06-01 00:00:00

  • Diffuse dermal angiomatosis of the breast: clinical and histopathological features.

    abstract:INTRODUCTION:Diffuse dermal angiomatosis is an entity in the spectrum of reactive angiomatoses characterized by erythematous plaques that mainly affect the lower extremities of patients with a personal history of peripheral vascular disease. Involvement of the breast is a rare event that has only been described as sing...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2012.05812.x

    authors: Sanz-Motilva V,Martorell-Calatayud A,Rongioletti F,Escutia-Muñoz B,López-Gómez S,Rodríguez-Peralto JL,Vanaclocha F

    更新日期:2014-04-01 00:00:00

  • Severe reactional state in lepromatous leprosy simulating Sweet's syndrome.

    abstract::A male patient with underlying lepromatous leprosy mimicked Sweet's syndrome clinically. He was believed to be in an atypical reactional state recognized as a variant form of erythema nodosum leprosum. In addition to the antileprosy treatment, steroid hormone was required to control the systemic symptoms. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1987.tb02293.x

    authors: Kou TT,Chan HL

    更新日期:1987-10-01 00:00:00