Abstract:
OBJECTIVE:To characterize epidemiologic and clinical features of red primary amelanotic melanomas, an atypical presentation of melanoma that is underemphasized in patient and physician education. PATIENTS AND METHODS:Review of a prospectively collected melanoma database identified 46 patients with red amelanotic melanomas, whose clinical features were compared with 329 patients with pigmented melanomas from the same database and same timeframe from January 1964 to September 2005. RESULTS:Red amelanotic melanomas represented 3.9% of all melanomas recorded in our database and accounted for nearly 70% of amelanotic melanomas. Melanoma was included in the clinical differential diagnosis in 32% of red amelanotic melanomas vs. 94% of pigmented melanomas (P<0.001). Red amelanotic melanomas more commonly underwent shave biopsy (55 vs. 12%, P<0.001) and more likely had positive deep margins (35 vs. 9%, P<0.001) but had comparable risks of metastasis and mortality. CONCLUSION:Red amelanotic melanomas are often misdiagnosed clinically but carry a mortality risk comparable to pigmented melanomas. Clinicians screening for melanoma should be more vigilant in considering melanoma in the differential diagnosis of red skin lesions.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
McClain SE,Mayo KB,Shada AL,Smolkin ME,Patterson JW,Slingluff CL Jrdoi
10.1111/j.1365-4632.2011.05066.xsubject
Has Abstractpub_date
2012-04-01 00:00:00pages
420-6issue
4eissn
0011-9059issn
1365-4632journal_volume
51pub_type
杂志文章abstract:BACKGROUND:Mucosa-associated epithelial chemokine (MEC; CCL28) is considered to be pivotal in mediating the migration of CC chemokine receptor 3- and 10- (CCR3- and CCR10)-expressing, skin-homing, memory, cutaneous lymphocyte-associated antigen-positive (CLA(+)) T cells. CCL28 is selectively and continuously expressed ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2009.04069.x
更新日期:2009-08-01 00:00:00
abstract::Erosive pustular dermatosis of the scalp is a rare condition which primarily affects older women after local trauma and has historically been treated with topical steroids. As it is a rare entity and resembles other dermatologic conditions, it may easily be misdiagnosed. Identifying the causes and evaluating the effic...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.14955
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Over a 3-year period (March 1999 to March 2002), 944 patients with scalp lesions attended a dermatology reference center in the city of Fortaleza, Ceará, Brazil. Clinical specimens were examined at the Specialized Medical Mycology Center, Federal University of Ceará, Fortaleza-CE, Brazil, to detect patients ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02150.x
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Castleman disease (CD) is a lymphoproliferative B-cell disease that is diagnosed from lymphoid hyperplasia with vascular proliferation. Symptoms may include fever, night sweats, and weight loss. Cutaneous manifestations often may go unnoticed since little has been described in the literature regarding them. ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.15043
更新日期:2020-10-01 00:00:00
abstract::Squamous cell carcinoma (scc) of the skin was studied in two similar populations, one living in the temperate zone of Australia, the other living in the tropics. In the tropics, the patients were significantly younger, the man to woman ratio approached unity, and women had significantly more sccs on the legs. In the t...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1992.tb02697.x
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:Dandruff is a common scalp condition characterized by flakes, pruritus and sometimes mild erythema. These symptoms reflect underlying histopathologic and biochemical events that must be reversed if treatment is to be effective. OBJECTIVES:This study aimed to better characterize the state of the epidermis in...
journal_title:International journal of dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-4632.2010.04629.x
更新日期:2011-01-01 00:00:00
abstract::Although tamoxifen (TAM) is routinely used in advanced melanoma, it is still uncertain whether evidence exists to support this practice. This review assesses the benefits and harms of systemic therapy with TAM vs. without TAM on response and mortality in patients with advanced melanoma. MEDLINE, The Cochrane Database ...
journal_title:International journal of dermatology
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1365-4632.2010.04529.x
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Tattoos have reached broadening mainstream acceptance. Medical professional societies have noted that tattoos may co-occur with high risk behaviors. METHODS:Using a variety of statistical models applied to a sample of 2,008 adults residing in the United States via Amazon's Mechanical Turk, we estimate the a...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.14372
更新日期:2019-07-01 00:00:00
abstract:PURPOSE:To investigate the effects of various types of Dead Sea mud (DSM) on skin barrier properties over a period of four weeks. METHODS:The effects of a 4-week application of three types of DSM (as is mud, mud with extra Dead Sea salt, and over the shelf mud) on the barrier properties of normal skin were investigate...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.15304
更新日期:2020-12-07 00:00:00
abstract::Acquired facial hyperpigmentation is a common problem among African patients, particularly women, where the causes of the dermatoses are identified largely from circumstantial evidence of exposure to known agents. These include hydroquinone-induced exogenous ochronosis from skin-bleaching creams, mercury deposits from...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4362.1991.tb03848.x
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Although tetracycline has been used to treat cutaneous sarcoidosis, the mechanism of action for this treatment remains unclear. This study evaluated the efficacy of minocycline treatment on cutaneous sarcoidosis and the relationship between its efficacy and the presence of Propionibacterium acnes in skin sar...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.14878
更新日期:2020-06-01 00:00:00
abstract::A 10-year-old immunocompetent boy presented with multiple, verrucous, disseminated pheohyphomycotic lesions caused by Exophiala spinifera. The patient was not responsive to combination antifungal therapy (itraconazole, terbinafine, fluconazole) and cryotherapy. As antifungal susceptibility is known to be variable for ...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2007.03430.x
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Reed's nevi are distinguished from Sptiz tumors by their significant melanogenesis and growth pattern. They may be confused with melanoma on clinical and histologic grounds. CASE REPORT:An unusual case in which multiple agminated Reed's nevi mimicked acral lentiginous malignant melanoma in an African-Americ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1993.tb04268.x
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:'"Inflammatory vitiligo" cases with clear lichenoid infiltrates have been reported. However, the inflammatory nature of common vitiligo has not gained wide acceptance because of its benign appearance and scanty cellular infiltrates. We have observed in our patients a few lesions with mild erythema, scaling a...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.03672.x
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:An epidemic of cercarial dermatitis caused by Schistosoma spindale cercaria occurred in November 1988 in a district called Chaiya, Surajthani province, in Southern Thailand. CASE REPORTS:Fifty-eight Thai farmers in Chaiya, Surajthani gave a history of itch following immersion in water while planting rice. T...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1993.tb01448.x
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:An allogeneic human skin graft is a temporary biologic dressing used in extensive burns that can be a providential treatment for affected patients. Skin quality depends directly on its microbial decontamination after processing in a tissue bank. Our objective was to describe the skin donor profiles in relati...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.14254
更新日期:2019-03-01 00:00:00
abstract::Immunodepressed patients in the intermediate phase of Chagas' disease may undergo reactivation of the disease together with atypical symptoms. The case of an immunodepressed kidney transplant patient with reactivation of Chagas' disease with skin symptoms is reported. A 65-year-old man presented with infiltrated eryth...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2007.03127.x
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin disease. Angiopoietin is an intrinsic mediator induced by T helper 2 cytokines and has been reported it to play a critical role in the pathogenesis of AD. OBJECTIVES:To determine the relationship between circulating angiopoietin-2 (Ang-2) in AD...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.14620
更新日期:2019-11-04 00:00:00
abstract:BACKGROUND:Crystal storing histiocytosis (CSH) imitating rhabdomyoma is a very rare disease entity involving different tissues. The skin is involved in extremely rare cases. OBJECTIVES:To describe the clinical and histopathological characteristics in a patient with unusually extensive skin involvement. OBSERVATIONS:A...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2006.02919.x
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Purpura annularis telangiectodes of Majocchi is an uncommon form of pigmented purpuric dermatosis which may present a therapeutic challenge. Given the rare nature of this condition, there is limited anecdotal information available regarding optimal therapy. Although pigmented purpuric dermatoses are generall...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2009.04160.x
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Pruritus is a common subjective symptom of psoriasis whose levels may be affected by a range of variables. The objective of this study was to evaluate the frequency of pruritus and its associations with clinical and psychological characteristics of psoriasis patients. MATERIALS AND METHODS:One-hundred and s...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12074
更新日期:2014-07-01 00:00:00
abstract::Psoriasis is a chronic inflammatory skin disorder which can impair general routine activities and has been closely related to poor quality of life. Pruritus and scratching are frequently observed, occurring mainly during sleep and precipitating nighttime arousals. Indeed, sleep quality has been shown to be negatively ...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.13026
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Ducatalon is a bipyridylium herbicide containing a mixture of diquat and paraquat, and is used in agriculture. Adverse reactions due to contact of this compound with the skin have rarely been described. CASE REPORTS:Two men were seen for severe pain due to extensive chemical burns in the perineal and scrota...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1995.tb04371.x
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Diagnostic errors appear to be the most common, costly, and dangerous of all medical mistakes. There has been a notable increase on the focus of error prevention as part of a growing patient safety movement. However, diagnostic errors have received less attention than other types of error. Our goal is to pre...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13532
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Skin disease is a common problem, accounting for significant morbidity in developing countries. Knowledge about the prevalence of different skin conditions allows appropriate planning for provision for these health needs. There are currently few data about the needs in rural areas; therefore, this study was ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1996.tb03688.x
更新日期:1996-09-01 00:00:00
abstract::A 70-year-old man developed herpes zoster over the right L5-S2 region for 3 days and was admitted for acyclovir therapy. He had a medical history of rectal cancer status post-colostomy and end-stage renal disease undergoing thrice weekly hemodialysis. Without a prior loading dose, acyclovir 500 mg (7.7 mg/kg) daily wa...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2007.03269.x
更新日期:2007-08-01 00:00:00
abstract::Topical drugs can be absorbed percutaneously in sufficient amounts to cause untoward systemic effects. Generally speaking, infants and young children appears to be more vulnerable than adults. It has been shown that the prolonged and extensive use of topical corticosteroids can induce iatrogenic hypercorticism and tha...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1978.tb05977.x
更新日期:1978-12-01 00:00:00
abstract:BACKGROUND:Clindamycin phosphate (CLDMP) is effective against Gram-positive and anaerobic bacteria, and is known to have anti-inflammatory properties. METHODS:To further study the anti-inflammatory properties of CLDMP, we examined the scavenging effects on superoxide anion and hydroxyl radical using an electron spin r...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2007.03338.x
更新日期:2007-11-01 00:00:00
abstract::Neuropathic ulcers or diabetic foot ulcers are preventable ulcers associated with diabetes mellitus. These ulcers occur in the setting of unrecognized trauma, peripheral neuropathy, and foot deformities; however, they are often complicated by peripheral arterial disease and infection. Approximately 15% of individuals ...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.15362
更新日期:2020-12-17 00:00:00
abstract:BACKGROUND:Regulatory T cells (Tregs) play an important role in autoimmune diseases. In skin, the presence of Tregs is thought to be mandatory for suppression of autoreactive T cells. Here, we assess the number of Tregs in skin of healthy subjects and patients with an autoimmune dermatosis. METHODS:Immunohistochemical...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05808.x
更新日期:2014-03-01 00:00:00