Amelanotic melanomas presenting as red skin lesions: a diagnostic challenge with potentially lethal consequences.


OBJECTIVE:To characterize epidemiologic and clinical features of red primary amelanotic melanomas, an atypical presentation of melanoma that is underemphasized in patient and physician education. PATIENTS AND METHODS:Review of a prospectively collected melanoma database identified 46 patients with red amelanotic melanomas, whose clinical features were compared with 329 patients with pigmented melanomas from the same database and same timeframe from January 1964 to September 2005. RESULTS:Red amelanotic melanomas represented 3.9% of all melanomas recorded in our database and accounted for nearly 70% of amelanotic melanomas. Melanoma was included in the clinical differential diagnosis in 32% of red amelanotic melanomas vs. 94% of pigmented melanomas (P<0.001). Red amelanotic melanomas more commonly underwent shave biopsy (55 vs. 12%, P<0.001) and more likely had positive deep margins (35 vs. 9%, P<0.001) but had comparable risks of metastasis and mortality. CONCLUSION:Red amelanotic melanomas are often misdiagnosed clinically but carry a mortality risk comparable to pigmented melanomas. Clinicians screening for melanoma should be more vigilant in considering melanoma in the differential diagnosis of red skin lesions.


Int J Dermatol


McClain SE,Mayo KB,Shada AL,Smolkin ME,Patterson JW,Slingluff CL Jr




Has Abstract


2012-04-01 00:00:00












  • Is season important for the diagnosis of cutaneous melanoma in southern Brazil? A 10-year hospital-based study.

    abstract:BACKGROUND:Exposure to sunlight is an important etiologic factor in cutaneous melanoma (CM). In several countries, more cases of CM are diagnosed in summer than in winter. AIM:To analyze whether there is seasonal variation in the diagnosis of CM in southern Brazil. METHODS:Data were collected from a hospital-based re...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Bakos L,Masiero NC,Burttet RM,Moreira LM,Santos KO,Brunetto LT,Benzano D

    更新日期:2010-01-01 00:00:00

  • Etanercept therapy allows the tapering of methotrexate and sustained clinical responses in patients with moderate to severe psoriasis.

    abstract::Methotrexate, the most common systemic small molecule used in the treatment of moderate to severe psoriasis, is associated with significant toxicities and adverse events. Long-term continuous usage is not recommended due to potential liver toxicity, myelosuppression, and other side effects. Abrupt cessation of methotr...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Yamauchi PS,Lowe NJ

    更新日期:2008-02-01 00:00:00

  • Favus.

    abstract::Favus has become a rarly found chronic fungal infection mainly caused by Trichophyton schoenleini and occasionally by Trichophyton violaceum or Microsporum gypseum. It can still be found in areas where the population suffers from poor hygiene and malnutrition. Cases are seen in the Mediterranean basin, the Middle East...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Dvoretzky I,Fisher BK,Movshovitz M,Schewach-Millet M

    更新日期:1980-03-01 00:00:00

  • Transmission potential of the human head louse, Pediculus capitis (Anoplura: Pediculidae).

    abstract:BACKGROUND:Millions of people are infested by head lice every year. However, louse transfer between hosts is not well-understood. Our goals were to determine: (1) which stages were most likely to disperse and why, (2) the likelihood of fomites transmission, and (3) if host blood gender affects louse development. METHO...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Takano-Lee M,Edman JD,Mullens BA,Clark JM

    更新日期:2005-10-01 00:00:00

  • Elevated plasma homocysteine levels in patients on isotretinoin therapy for cystic acne.

    abstract:BACKGROUND:The use of Isotretinoin (Iso) for cystic acne (CA) therapy includes marked side-effects such as dyslipidemia, increased liver enzymes, and reduction of biotinidase activity. Moreover, Homocysteine (Hcy), an amino acid, is metabolized in the liver requiring folate, vitamin B6, vitamin B12, and the activity of...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Schulpis KH,Karikas GA,Georgala S,Michas T,Tsakiris S

    更新日期:2001-01-01 00:00:00

  • Subcutaneous mycoses in Peru: a systematic review and meta-analysis for the burden of disease.

    abstract:BACKGROUND:There is a worrying lack of epidemiological data on the geographical distribution and burden of subcutaneous mycoses in Peru, hindering the implementation of surveillance and control programs. OBJECTIVES:This study aimed to estimate the disease burden of subcutaneous mycoses in Peru and identify which funga...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,meta分析,评审


    authors: Ramírez Soto MC,Malaga G

    更新日期:2017-10-01 00:00:00

  • Polymerase chain reaction in cutaneous tuberculosis: is it a reliable diagnostic method in paraffin-embedded tissues?

    abstract:BACKGROUND:Most cutaneous tuberculosis lesions contain few bacilli, so identification of Mycobacterium tuberculosis in conventional laboratory tests is difficult. In vitro amplification of specific DNA sequences using polymerase chain reaction (PCR) has become a valuable tool in the rapid detection of slow-growing orga...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Senturk N,Sahin S,Kocagoz T

    更新日期:2002-12-01 00:00:00

  • Cutaneous manifestations associated with antiphospholipid antibodies.

    abstract:BACKGROUND:Primary Antiphospholipid Antibody Syndrome (PAAS) is characterized by detection of antiphospholipid antibodies associated with venous or arterial thrombosis and/or miscarriages by patients with no other associated disease such as systemic lupus erythematosus (SLE). Primary Antiphospholipid Antibody Syndrome ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Diógenes MJ,Diógenes PC,de Morais Carneiro RM,Neto CC,Duarte FB,Holanda RR

    更新日期:2004-09-01 00:00:00

  • Dermatologic infestations.

    abstract::Head lice are transmitted by head to head contact. Optimal therapy includes malathion lotion 0.5% repeated in one week left on for 30 minutes to 8 hours. Spinosad topical suspension 0.9% repeated in one week left on for 10 minutes is another option. Scabies is transmitted mainly by direct contact but also via heavily ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Shmidt E,Levitt J

    更新日期:2012-02-01 00:00:00

  • Magnetic resonance imaging with gadolinium enhancement in renal failure: a need for caution.

    abstract::A 36-year-old Asian man with von Hippel-Lindau syndrome was referred to the dermatology clinic in January 2005 with stiff fingers and ankles of 3 months' duration. He had undergone bilateral nephrectomy for renal squamous cell carcinoma in 2002 and had started hemodialysis. Multiple cerebellar hemangiomata were resect...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Gulati A,Harwood CA,Raftery M,Cerio R,Ashman N,Proby CA

    更新日期:2008-09-01 00:00:00

  • Demographic and clinical features of 521 Turkish patients with Behçet's disease.

    abstract:BACKGROUND:The aim of this study is to reveal demographic and clinical features of Behçet's disease (BD) in a Turkish population. METHODS:We retrospectively evaluated the clinical findings of 521 patients with BD. RESULTS:A total of 521 patients (287 female and 234 male) were included in this study. Onset signs: oral...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Balta I,Akbay G,Kalkan G,Eksioglu M

    更新日期:2014-05-01 00:00:00

  • Clinicodermoscopic study of histoid leprosy: a case series.

    abstract:BACKGROUND:Histoid leprosy (HL) is a highly bacilliferous form of leprosy which requires early diagnosis and management. Dermoscopy is a noninvasive diagnostic method for various malignant and nonmalignant disorders. The aim of this study was to describe the dermoscopic patterns of various types of HL lesions over diff...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Acharya P,Mathur MC

    更新日期:2020-03-01 00:00:00

  • Tumor necrosis factor alpha gene promoter -238G/A polymorphism increases the risk of psoriasis vulgaris in Indian patients.

    abstract:BACKGROUND:Tumor necrosis factor alpha (TNFα) gene -238G/A polymorphism (rs361525) is associated with psoriasis in several populations worldwide. To the best of our knowledge, there is no information about this polymorphism in Indian psoriatic patients. This study was undertaken to fill the gap in knowledge. METHODS:T...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Rajesh D,Gurumurthy R,Kutty AV,Balakrishna S

    更新日期:2017-03-01 00:00:00

  • The risk of malignancy or progression of existing malignancy in patients with psoriasis treated with biologics: case report and review of the literature.

    abstract::There is some debate regarding the risk of developing malignancy and progression of malignancy in patients with psoriasis treated with biologics. The lack of extensive, long-term, and large studies, including patients with psoriasis, to assess these aforementioned risks makes it difficult to ascertain the safety profi...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Patel S,Patel T,Kerdel FA

    更新日期:2016-05-01 00:00:00

  • Suicidal ideation in psoriasis.

    abstract:BACKGROUND:Psoriasis has been associated with depressive disease and case reports of completed suicide. METHODS:217 consenting psoriasis patients completed the Carroll Rating Scale for Depression (CRSD), a 52-item self-rated scale, with four of the items directly addressing wishes to be dead and suicidal ideation. The...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Gupta MA,Schork NJ,Gupta AK,Kirkby S,Ellis CN

    更新日期:1993-03-01 00:00:00

  • Efficacy of lipectomy and liposuction in the treatment of multiple symmetric lipomatosis.

    abstract:BACKGROUND:Multiple symmetric lipomatosis (MSL) is a rare disease characterized by enlarging, symmetric, nonencapsulated, fat deposits mainly on the neck and upper trunk. Liposuction and lipectomy, although palliative, are the treatments of choice, especially indicated when vital structures are compromised. OBJECTIVE:...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Martínez-Escribano JA,Gonzalez R,Quecedo E,Febrer I

    更新日期:1999-07-01 00:00:00

  • Immunohistochemistry in histoid leprosy.

    abstract:BACKGROUND:Histoid leprosy is a rare form of multibacillary leprosy as the result of secondary or even primary resistance to dapsone. The etiopathogenesis has not been clarified up to now. METHODS:An immunohistochemical study was carried out for the expression of various markers on epidermal and dermal cell population...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Kontochristopoulos GJ,Aroni K,Panteleos DN,Tosca AD

    更新日期:1995-11-01 00:00:00

  • What lichen planus patients die of. A retrospective study.

    abstract::The causes of death of 50 patients who had had lichen planus have been investigated and compared with those of 50 patients with psoriasis and with those of the general population. Patients with lichen planus were as old as those with psoriasis and in the general population at the time of death, but the diseases causin...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Anonide A,Rebora A

    更新日期:1989-10-01 00:00:00

  • Prevalence and awareness of melasma during pregnancy.

    abstract:BACKGROUND:Melasma is an acquired hypermelanosis of the face. There is little information on its prevalence during pregnancy in Iran. Objective To determine the prevalence and awareness of melasma during pregnancy at the Shahed University Hospitals of Tehran, Iran. METHODS:A cross-sectional study was carried out by cl...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Moin A,Jabery Z,Fallah N

    更新日期:2006-03-01 00:00:00

  • A comparison of anti-desmoglein antibodies and indirect immunofluorescence in the serodiagnosis of pemphigus vulgaris.

    abstract:BACKGROUND:Indirect immunofluorescence (IIF) is the standard method for the detection of pemphigus autoantibodies. Commercially available enzyme-linked immunosorbent assays (ELISAs) have recently become available to measure serum antibodies (Abs) against desmoglein1 (Dsg1) and desmoglein3 (Dsg3). It has been suggested ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Zagorodniuk I,Weltfriend S,Shtruminger L,Sprecher E,Kogan O,Pollack S,Bergman R

    更新日期:2005-07-01 00:00:00

  • Comorbidity of psychiatric disorders in children and adolescents with alopecia areata in a child and adolescent psychiatry clinical sample.

    abstract:BACKGROUND:This study reports the comorbidity of lifetime psychiatric disorders in children and adolescents with alopecia areata (AA) in a child and adolescent psychiatry clinical sample. METHODS:Fourteen patients with AA were interviewed using the Diagnostic and Statistical Manual of Mental Disorders-Fourth edition (...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Ghanizadeh A

    更新日期:2008-11-01 00:00:00

  • The combined use of topical benzoyl peroxide and tretinoin in the treatment of acne vulgaris.

    abstract::A clinical trial using tretinoin lotion 0.05%, benzoyl peroxide 5% and 10% as topical application was performed on 250 ambulatory patients suffering from various degrees of acne vulgaris. The results indicate that tretinoin applied in the morning and benzoyl peroxide applied at night is the most efficacious regimen to...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Handojo I

    更新日期:1979-07-01 00:00:00

  • Squamous cell carcinoma in southern and northern Australia.

    abstract::Squamous cell carcinoma (scc) of the skin was studied in two similar populations, one living in the temperate zone of Australia, the other living in the tropics. In the tropics, the patients were significantly younger, the man to woman ratio approached unity, and women had significantly more sccs on the legs. In the t...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Czarnecki D,Collins N,Meehan C,O'Brien T,Leahy S,Nash CA

    更新日期:1992-07-01 00:00:00

  • Head louse infestations: the "no nit" policy and its consequences.

    abstract::Health authorities in the USA, Canada and Australia recommend a "no nit" policy, i.e. the immediate dismissal of all children who have head lice, eggs and/or nits on their hair from school, camp or child-care settings. These children would be readmitted to the institution only when all head lice, eggs and nits have be...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Mumcuoglu KY,Meinking TA,Burkhart CN,Burkhart CG

    更新日期:2006-08-01 00:00:00

  • Specific causes of death in patients with bullous pemphigoid as measured by death certificate data: a retrospective cohort study.

    abstract:BACKGROUND:Mortality rates in patients with bullous pemphigoid (BP) are higher than those in age-matched counterparts. However, the specific causes of death in BP subjects have not been evaluated systematically. OBJECTIVES:We sought to characterize the causes of death in patients with BP as recorded by death certifica...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Barrick BJ,Lohse CM,Lehman JS

    更新日期:2015-01-01 00:00:00

  • Comèl-Netherton syndrome and peeling skin syndrome type B: overlapping syndromes or one entity?

    abstract:BACKGROUND:A 42-year-old male patient suffering from the rare Comèl-Netherton syndrome is reported, and the symptoms are discussed together with the results of light and electron microscopic examinations. CASE REPORT:Our case presented peeling skin syndrome type B with spontaneous, lifelong skin shedding with underlyi...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Sárdy M,Fáy A,Kárpáti S,Horváth A

    更新日期:2002-05-01 00:00:00

  • Clindamycin phosphate scavenges hydroxyl radical.

    abstract:BACKGROUND:Clindamycin phosphate (CLDMP) is effective against Gram-positive and anaerobic bacteria, and is known to have anti-inflammatory properties. METHODS:To further study the anti-inflammatory properties of CLDMP, we examined the scavenging effects on superoxide anion and hydroxyl radical using an electron spin r...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Sato E,Kato M,Kohno M,Niwano Y

    更新日期:2007-11-01 00:00:00

  • Activation of melanoblasts and melanocytes after treatment with monochromatic excimer light and narrowband-ultraviolet B of skin of vitiligo patients.

    abstract:BACKGROUND:Vitiligo is a hypopigmentation disease characterized by achromatic or hypochromatic macules in several sites of human skin. Although monochromatic excimer light (MEL) and narrowband-ultraviolet B (NB-UVB) have recently been used for efficacious treatment of vitiligo, the repigmentation process and role of me...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Hirobe T,Enami H

    更新日期:2019-02-01 00:00:00

  • Pseudopelade: an inherited alopecia.

    abstract:BACKGROUND:Pseudopelade is a rare idiopathic progressive alopecia that has no initial inflammatory phase. Even so, pseudopelade has been classified as scarring alopecia with postinflammatory alopecias. Atrophy rather than true scarring is the cardinal feature of pseudopelade. MATERIALS AND METHODS:A review of reported...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Sahl WJ

    更新日期:1996-10-01 00:00:00

  • The investigation of autonomic functions in patients with psoriasis.

    abstract:BACKGROUND:Psoriasis is a common Th1-mediated skin disease whose etiology remains obscure. Loss of sweating caused by retention hyperkeratosis is seen in psoriasis plaques, which is likely to have resulted from autonomic dysfunction. OBJECTIVE:In the present study, we aimed to evaluate autonomic nervous system (ANS) f...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Halıgür BD,Cicek D,Bulut S,Berilgen MS

    更新日期:2012-05-01 00:00:00