Transdermal delivery of salicylic acid in the treatment of viral papillomas.

Abstract:

:Healthy adult (New Zealand, Dutch Belt, and Wild) rabbits were infected with rabbit papilloma virus (Shope variety). The resultant papillomas were treated with salicylic acid in a new transdermal drug delivery system utilizing a karaya gum glycol matrix. Biopsy samples of treated papillomas were taken at 1, 2, and 3 weeks after initiation of treatment and examined by electron microscopy. The observed changes during the course of treatment indicated that the karaya gum glycol matrix effectively released salicylic acid into the stratum corneum. Further, the rate of delivery of salicylic acid was such that the desired keratolytic activity was achieved with minimal inflammatory response.

journal_name

Int J Dermatol

authors

Mottaz JH,McKeever PJ,Neveaux JL,Zelickson AS

doi

10.1111/j.1365-4362.1988.tb02414.x

subject

Has Abstract

pub_date

1988-10-01 00:00:00

pages

596-600

issue

8

eissn

0011-9059

issn

1365-4632

journal_volume

27

pub_type

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