Treatment of histoid leprosy: a lack of consensus.


:Histoid leprosy is a rare variant of leprosy with a unique clinical presentation and bacilli rich histology. These patients are large reservoirs for disease and vectors for spread, making prompt diagnosis and treatment crucial. To date, no consensus on treatment and duration exists. This paper aims to investigate the efficacy, safety, and duration of varying treatment regimens in patients with histoid leprosy. A systematic PubMed review of all articles published before January 2020 containing the key words histoid leprosy. All patients included must have completed their prescribed treatments with comment on outcomes and treatment duration. The review generated 165 articles containing 62 cases that met inclusion criteria. A majority of cases reported excellent clinical outcomes with limited adverse events. Regimens included variations of rifampicin, dapsone, clofazimine, minocycline, ofloxacin, and sulforthormadine with most treatment duration lasting 12 or 24 months. Existing literature is limited to case reports or case series and may be subject to publication bias of successful cases. Many reports lack quantifiable data regarding outcomes and rely on clinical judgment. Continued observation for complete clearance or relapse was limited. The findings demonstrate that multibacillary-multidrug therapy is an efficacious and safe treatment for histoid leprosy. No significant differences were observed between 12 and 24 months of treatment. There remains no consensus on treatment duration for histoid leprosy.


Int J Dermatol


Bartos G,Sheuring R,Combs A,Rivlin D




Has Abstract


2020-10-01 00:00:00












  • Clinical and epidemiologic features of melasma: a multicentric cross-sectional study from India.

    abstract:BACKGROUND:Though melasma is a common skin condition in India, epidemiological studies are few and geographically confined. The present study was designed to gain insights into factors involved in causation and aggravation of melasma, demographic distribution, clinical presentations, and treatment patterns. METHODS:A ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,多中心研究


    authors: Sarkar R,Jagadeesan S,Basavapura Madegowda S,Verma S,Hassan I,Bhat Y,Minni K,Jha A,Das A,Jain G,Arya L,Mandlewala Z,Bagadia J,Garg V

    更新日期:2019-11-01 00:00:00

  • Perforating granuloma annulare.

    abstract:BACKGROUND:Perforating granuloma annulare (PGA) is considered an histologic subtype of granuloma annulare (GA) and it is described as a very rare disease, usually of children, affecting the dorsum of the hands. Mechanisms leading to perforation are unknown. Our experience suggested a different clinical presentation, so...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Penas PF,Jones-Caballero M,Fraga J,Sánchez-Pérez J,García-Díez A

    更新日期:1997-05-01 00:00:00

  • Tachyphylaxis to topical steroid measured by histamine-induced wheal suppression.

    abstract::Ten healthy volunteers were studied to find out whether tachyphylaxis occurs on repeated application of topical steroids. The Singh and Singh modification of the Reddy and Singh (1976) technique was used. Fluocinolone acetonide cream (0.1%) under occlusion was applied daily for 14 days on the flexor aspect of the fore...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Singh G,Singh PK

    更新日期:1986-06-01 00:00:00

  • The bidirectional interactions between psoriasis and obstructive sleep apnea.

    abstract::Psoriasis is a chronic inflammatory skin disorder which can impair general routine activities and has been closely related to poor quality of life. Pruritus and scratching are frequently observed, occurring mainly during sleep and precipitating nighttime arousals. Indeed, sleep quality has been shown to be negatively ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Hirotsu C,Nogueira H,Albuquerque RG,Tomimori J,Tufik S,Andersen ML

    更新日期:2015-12-01 00:00:00

  • Acyclovir-induced neuropsychosis successfully recovered after immediate hemodialysis in an end-stage renal disease patient.

    abstract::A 70-year-old man developed herpes zoster over the right L5-S2 region for 3 days and was admitted for acyclovir therapy. He had a medical history of rectal cancer status post-colostomy and end-stage renal disease undergoing thrice weekly hemodialysis. Without a prior loading dose, acyclovir 500 mg (7.7 mg/kg) daily wa...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Yang HH,Hsiao YP,Shih HC,Yang JH

    更新日期:2007-08-01 00:00:00

  • Nationwide skin cancer screening in Germany: Evaluation of the training program.

    abstract:BACKGROUND:In July 2008, the German statutory health insurance introduced a nationwide skin cancer screening program. Before the introduction, eligible physicians had to qualify to perform the screening test and counsel their patients on skin cancer screening. To educate physicians, a curriculum and training materials ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Anders MP,Fengler S,Volkmer B,Greinert R,Breitbart EW

    更新日期:2017-10-01 00:00:00

  • Prurigo pigmentosa: not an uncommon disease in the Turkish population.

    abstract:BACKGROUND:Prurigo pigmentosa (PP) is a rare inflammatory dermatosis of unknown etiology. It is characterized by erythematous papules of the trunk that resolve leaving a reticulate hyperpigmentation. The original report from Japan in 1971 was followed by new cases, mostly of Japanese origin. METHODS:We scrutinized PP ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Baykal C,Buyukbabani N,Akinturk S,Saglik E

    更新日期:2006-10-01 00:00:00

  • Cutaneous angiosarcoma in a site of healed herpes zoster.

    abstract::A 57-year-old woman presented with an erythematous plaque of the left postauricular area that was diagnosed as metastatic carcinoma on clinical and histologic bases. It was revealed that herpes zoster had been diagnosed in the same dermatomal distribution 10 years previously. The lesion recurred 2 years after irradiat...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Hudson CP,Hanno R,Callen JP

    更新日期:1984-07-01 00:00:00

  • Pityriasis in dermatology: an updated review.

    abstract::Dermatology has a very distinctive lexicon. The term pityriasis refers to several dermatologic conditions which all feature scaling of the skin. According to the Merriam-Webster dictionary, the term pityriasis was first used in print in 1684. Although the diseases beginning with the name pityriasis are of diverse caus...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Chin LD,Parvinnejad N,Haber RM

    更新日期:2020-08-11 00:00:00

  • Smoldering HTLV-1-induced T-cell lymphoma localized within the skin; a radiation-resistant tumor.

    abstract:BACKGROUND:Human T-cell lymphotrophic virus type 1 (HTLV-1)-induced lymphoproliferative disease occurs in approximately 3-5% of people in endemic areas who have been HTLV-1 positive for decades. Lymphoproliferative disease may present as four subtypes, including an acute adult T-cell leukemia/lymphoma (ATLL), an aggres...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Germain M,Williams J,Skelton HG,Smith KJ

    更新日期:2000-11-01 00:00:00

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    abstract:BACKGROUND:Plantar hyperhidrosis is a common illness with significant impact on quality of life. Oxybutynin presents good short-term results, but longer follow-up results are lacking. We evaluated oxybutynin effectiveness in patients who were not surgically treated and who had at least six months of follow-up. METHODS...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Wolosker N,Teivelis MP,Krutman M,de Paula RP,Kauffman P,de Campos JR,Puech-Leão P

    更新日期:2015-01-01 00:00:00

  • Elevated plasma homocysteine levels in patients on isotretinoin therapy for cystic acne.

    abstract:BACKGROUND:The use of Isotretinoin (Iso) for cystic acne (CA) therapy includes marked side-effects such as dyslipidemia, increased liver enzymes, and reduction of biotinidase activity. Moreover, Homocysteine (Hcy), an amino acid, is metabolized in the liver requiring folate, vitamin B6, vitamin B12, and the activity of...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Schulpis KH,Karikas GA,Georgala S,Michas T,Tsakiris S

    更新日期:2001-01-01 00:00:00

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    abstract:BACKGROUND:The Psoriasis Area and Severity Index (PASI) is used to quantify the extent of the disease, and to evaluate its improvement with treatment. It is considered to be a slow, rough, nonsensitive, and complex tool, with high interobserver variability and low reproducibility. OBJECTIVES AND METHODS:To develop a s...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Harari M,Shani J,Hristakieva E,Stanimirovic A,Seidl W,Burdo A

    更新日期:2000-12-01 00:00:00

  • Severe infliximab-induced psoriasis treated with adalimumab switching.

    abstract:BACKGROUND:Antitumor necrosis factor (anti-TNF) agents are a well-established treatment for various medical conditions, including psoriasis and psoriatic arthritis. However, anti-TNF agents may themselves induce psoriasis in some patients. METHODS:The authors report two cases of patients with severe and refractory inf...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Faillace C,Duarte GV,Cunha RS,de Carvalho JF

    更新日期:2013-02-01 00:00:00

  • Altered expression of keratin 14 in lesional epidermis of autoimmune skin diseases.

    abstract:BACKGROUND:Keratin 14 (K14) is an intermediate filament protein that is mainly expressed in the basal layer of healthy stratified epithelia. K14 has been identified as an autoantigen in the autoimmune-mediated skin disease of Scurfy mice and patients with the "immune dysregulation polyendocrinopathy, enteropathy, and X...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Wei X,Fricker K,Enk AH,Hadaschik EN

    更新日期:2016-06-01 00:00:00

  • A rare case of leishmaniasis recidiva cutis evolving for 31 years caused by Leishmania tropica.

    abstract::A 64-year-old woman presented with erythematous, infiltrative plaques with a central atrophic area on both zygomatic regions. Several yellow-reddish papules were seen at the periphery of the plaques and showed an "apple-jelly" color on diascopy (Fig. 1). No visceral involvement was detected. The past medical history r...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Stefanidou MP,Antoniou M,Koutsopoulos AV,Neofytou YT,Krasagakis K,Krüger-Krasagakis S,Tselentis Y,Tosca AD

    更新日期:2008-06-01 00:00:00

  • Successful treatment of eosinophilic pustular folliculitis with topical tacrolimus.

    abstract::We present two cases of Eosinophilic pustular folliclulitis (EPF) who were successfully treated with topical tacrolimus. Indomethacin is the most frequently used agent for the treatment of EPF, however, tacrolimus ointment may become the treatment of choice for patients with EPF. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Kawaguchi M,Mitsuhashi Y,Kondo S

    更新日期:2004-08-01 00:00:00

  • Longitudinal progress of transepidermal water loss, color, and sensory elements in split-thickness skin graft donor sites in East Asians.

    abstract:BACKGROUND:There is little research available that describes the natural progression of split-thickness skin graft (STSG) donor site wounds after re-epithelialization. The purpose of this study was to evaluate the longitudinal clinical progress of transepidermal water loss (TEWL), color, and sensory elements in STSG do...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Kim J,Kim R,Jeong W,Choi J,Park SW

    更新日期:2019-05-01 00:00:00

  • Deep mycoses in Amazon region.

    abstract::Patients with deep mycoses diagnosed in dermatologic clinics of Manaus (state of Amazonas, Brazil) were studied from November 1973 to December 1983. They came from the Brazilian states of Amazonas, Pará, Acre, and Rondônia and the Federal Territory of Roraima. All of these regions, with the exception of Pará, are situ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Talhari S,Cunha MG,Schettini AP,Talhari AC

    更新日期:1988-09-01 00:00:00

  • A surgical approach for dermatosis papulosa nigra.

    abstract::Dermatosis papulosa nigra (DPN) is a disorder commonly encountered in the adult black population. We describe 20 cases of clinicopathologically confirmed DPN cases treated with light abrasive curettage without local anesthesia. We found this procedure to be an effective therapy, which did not cause postoperative scarr...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Kauh YC,McDonald JW,Rapaport JA,Ruschak PJ,Luscombe HA

    更新日期:1983-12-01 00:00:00

  • The combined use of topical benzoyl peroxide and tretinoin in the treatment of acne vulgaris.

    abstract::A clinical trial using tretinoin lotion 0.05%, benzoyl peroxide 5% and 10% as topical application was performed on 250 ambulatory patients suffering from various degrees of acne vulgaris. The results indicate that tretinoin applied in the morning and benzoyl peroxide applied at night is the most efficacious regimen to...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Handojo I

    更新日期:1979-07-01 00:00:00

  • Epidemiological and clinical patterns of genital lesions.

    abstract::A 5-year study of 668 patients with genital lesions revealed that teenagers and those in the age group of 20 to 40 are most vunerable. The poor, the uneducated and unmarried persons are at high risk. Chancroid and syphilis are the majority of cases. Inguinal bubo, herpes pregenitalis, condylomata acuminata, erosive ba...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Sehgal VN,Rege VL,Sehgal N,Kharangate VN,Mascarenhas MF

    更新日期:1976-10-01 00:00:00

  • Comèl-Netherton syndrome and peeling skin syndrome type B: overlapping syndromes or one entity?

    abstract:BACKGROUND:A 42-year-old male patient suffering from the rare Comèl-Netherton syndrome is reported, and the symptoms are discussed together with the results of light and electron microscopic examinations. CASE REPORT:Our case presented peeling skin syndrome type B with spontaneous, lifelong skin shedding with underlyi...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Sárdy M,Fáy A,Kárpáti S,Horváth A

    更新日期:2002-05-01 00:00:00

  • Matrine inhibits invasiveness and metastasis of human malignant melanoma cell line A375 in vitro.

    abstract:BACKGROUND:Matrine is a traditional Chinese medicine with significant inhibitory activity against malignant tumors. Its effects on the invasiveness and metastasis of malignant tumors have rarely been reported. AIM:To investigate whether matrine can inhibit the metastasis-related activities of the human malignant melan...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Liu XY,Fang H,Yang ZG,Wang XY,Ruan LM,Fang DR,Ding YG,Wang YN,Zhang Y,Jiang XL,Chen HC

    更新日期:2008-05-01 00:00:00

  • Relapsing polychondritis, an underestimated dermatological urgency: case report and literature review.

    abstract:BACKGROUND:Relapsing polychondritis is an autoimmune multisystemic disease with primary chondral involvement. Its high mortality and morbidity make it a real clinical challenge. CASE DESCRIPTION:A 32-year-old woman with a history of relapsing polychondritis, refractory to multiple treatments, with multisystem compromi...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Cuestas D,Peñaranda E,Mora S,Cortes C,Galvis I,Patiño M,Velasquez O

    更新日期:2017-12-01 00:00:00

  • Tinea capitis in Saudi Arabia.

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    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Venugopal PV,Venugopal TV

    更新日期:1993-01-01 00:00:00

  • Adiponectin expression in subcutaneous adipose tissue is reduced in women with cellulite.

    abstract:BACKGROUND:Cellulite, which appears as orange peel-type or cottage cheese-like dimpling of the skin on the thighs and buttocks, is a complex, multifactorial, cosmetic disorder of the subcutaneous fat layer and the overlying superficial skin. Adiponectin is an adipocyte-derived hormone mainly produced by subcutaneous fa...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Emanuele E,Minoretti P,Altabas K,Gaeta E,Altabas V

    更新日期:2011-04-01 00:00:00

  • Cutaneous manifestations associated with HTLV-1 infection.

    abstract::Skin lesions are frequent in human T-cell lymphotropic virus type 1 (HTLV-1) infection and may constitute an alert for the diagnosis of this condition. The most severe skin diseases related to this virus are adult T-cell leukemia/lymphoma (ATLL), an aggressive form of leukemia/lymphoma that fails to respond to chemoth...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Bittencourt AL,de Oliveira Mde F

    更新日期:2010-10-01 00:00:00

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    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Otrofanowei E,Ayanlowo OO,Akinkugbe A,Oresanya FA

    更新日期:2018-02-01 00:00:00

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    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Fijałkowska M,Kasielska A,Antoszewski B

    更新日期:2014-08-01 00:00:00