Abstract:
:Hydroxyurea is a hydroxylated derivate of urea commonly used in the treatment of various hematologic disorders. Cutaneous side-effects such as alopecia, diffuse hyperpigmentation, scaling, poikiloderma, atrophy of the skin and subcutaneous tissues or nail changes can develop after long-term treatment with hydroxyurea. Painful leg ulcers in association with hydroxyurea have only rarely been reported. We present a report of a 52-year-old patient with essential thrombocythemia suffering from painful leg ulcers 3 years after starting therapy with hydroxyurea. We decided to treat the leg ulcers following a modern phase-adapted wound-healing strategy and continued hydroxyurea therapy until complete healing of the ulcers. In conclusion, cutaneous ulceration of the leg is one adverse effect in patients with essential thrombocythemia during hydroxyurea therapy. Healing does not necessarily require discontinuation of the drug. Therefore, therapists should first optimize a conservative and systematic wound-healing strategy. If these interventions fail, discontinuation of hydroxyurea therapy is advisable.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Dissemond J,Hoeft D,Knab J,Franckson T,Kroger K,Goos Mdoi
10.1111/j.1365-4632.2004.02450.xsubject
Has Abstractpub_date
2006-02-01 00:00:00pages
158-60issue
2eissn
0011-9059issn
1365-4632pii
IJD2450journal_volume
45pub_type
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journal_title:International journal of dermatology
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pub_type: 临床试验,杂志文章
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