Leg ulcer in a patient associated with hydroxyurea therapy.

Abstract:

:Hydroxyurea is a hydroxylated derivate of urea commonly used in the treatment of various hematologic disorders. Cutaneous side-effects such as alopecia, diffuse hyperpigmentation, scaling, poikiloderma, atrophy of the skin and subcutaneous tissues or nail changes can develop after long-term treatment with hydroxyurea. Painful leg ulcers in association with hydroxyurea have only rarely been reported. We present a report of a 52-year-old patient with essential thrombocythemia suffering from painful leg ulcers 3 years after starting therapy with hydroxyurea. We decided to treat the leg ulcers following a modern phase-adapted wound-healing strategy and continued hydroxyurea therapy until complete healing of the ulcers. In conclusion, cutaneous ulceration of the leg is one adverse effect in patients with essential thrombocythemia during hydroxyurea therapy. Healing does not necessarily require discontinuation of the drug. Therefore, therapists should first optimize a conservative and systematic wound-healing strategy. If these interventions fail, discontinuation of hydroxyurea therapy is advisable.

journal_name

Int J Dermatol

authors

Dissemond J,Hoeft D,Knab J,Franckson T,Kroger K,Goos M

doi

10.1111/j.1365-4632.2004.02450.x

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

158-60

issue

2

eissn

0011-9059

issn

1365-4632

pii

IJD2450

journal_volume

45

pub_type

杂志文章
  • Immunohistochemistry in histoid leprosy.

    abstract:BACKGROUND:Histoid leprosy is a rare form of multibacillary leprosy as the result of secondary or even primary resistance to dapsone. The etiopathogenesis has not been clarified up to now. METHODS:An immunohistochemical study was carried out for the expression of various markers on epidermal and dermal cell population...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1995.tb04396.x

    authors: Kontochristopoulos GJ,Aroni K,Panteleos DN,Tosca AD

    更新日期:1995-11-01 00:00:00

  • Relapsing polychondritis, an underestimated dermatological urgency: case report and literature review.

    abstract:BACKGROUND:Relapsing polychondritis is an autoimmune multisystemic disease with primary chondral involvement. Its high mortality and morbidity make it a real clinical challenge. CASE DESCRIPTION:A 32-year-old woman with a history of relapsing polychondritis, refractory to multiple treatments, with multisystem compromi...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.13755

    authors: Cuestas D,Peñaranda E,Mora S,Cortes C,Galvis I,Patiño M,Velasquez O

    更新日期:2017-12-01 00:00:00

  • Clinical and histological results in the treatment of atrophic and hypertrophic scars using a combined method of radiofrequency, ultrasound, and transepidermal drug delivery.

    abstract::Scars are problematic for thousands of patients. Scarring is a natural part of the healing process after an injury. However, the appearance of a scar and its treatment depend on multiple factors and on the experience of the therapist and the options available. Despite a plethora of rapidly evolving treatment options a...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.13253

    authors: Trelles MA,Martínez-Carpio PA

    更新日期:2016-08-01 00:00:00

  • Transdermal delivery of salicylic acid in the treatment of viral papillomas.

    abstract::Healthy adult (New Zealand, Dutch Belt, and Wild) rabbits were infected with rabbit papilloma virus (Shope variety). The resultant papillomas were treated with salicylic acid in a new transdermal drug delivery system utilizing a karaya gum glycol matrix. Biopsy samples of treated papillomas were taken at 1, 2, and 3 w...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1988.tb02414.x

    authors: Mottaz JH,McKeever PJ,Neveaux JL,Zelickson AS

    更新日期:1988-10-01 00:00:00

  • Skin manifestations in patients hospitalized with confirmed COVID-19 disease: a cross-sectional study in a tertiary hospital.

    abstract:BACKGROUND:COVID-19 cutaneous manifestations have been recently described and classified in five different clinical patterns, including acral erythema-edema (pseudo-chilblain), maculopapular exanthemas, vesicular eruptions, urticarial lesions, and livedo or necrosis. OBJECTIVES:The objective of this study was to exami...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.15180

    authors: Méndez Maestro I,Peña Merino L,Udondo González Del Tánago B,Aramburu González A,Orbea Sopeña A,Sánchez De Vicente J,Ratón Nieto JA,Acebo Mariñas E,Gardeazabal García J

    更新日期:2020-09-24 00:00:00

  • Immunohistochemical analysis of FOXP3+ regulatory T cells in healthy human skin and autoimmune dermatoses.

    abstract:BACKGROUND:Regulatory T cells (Tregs) play an important role in autoimmune diseases. In skin, the presence of Tregs is thought to be mandatory for suppression of autoreactive T cells. Here, we assess the number of Tregs in skin of healthy subjects and patients with an autoimmune dermatosis. METHODS:Immunohistochemical...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2012.05808.x

    authors: Terras S,Gambichler T,Moritz RK,Altmeyer P,Lambert J

    更新日期:2014-03-01 00:00:00

  • Role of diffusion-weighted magnetic resonance imaging in the evaluation of scalp dermatofibrosarcoma protuberans.

    abstract:BACKGROUND:Dermatofibrosarcoma protuberans (DFSP) is a rare tumor that grows with tentacle-like projections. In particular, on the scalp this could explain the frequent incomplete resections and the high rate of multiple local recurrences. Adequate pre- and postoperative imaging methods to visualize these prolongations...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.13050

    authors: Van Steenkiste E,Van Laethem A,Biesemans G,Pans S

    更新日期:2016-02-01 00:00:00

  • Primary cutaneous coccidiodomycosis: case report and review of the literature.

    abstract:BACKGROUND:Coccidiodomycosis is a systemic infection caused by Coccidioides immitis, a dimorphic fungus endemic in the south of the USA and the north of Mexico. The disease usually affects the lungs. Primary cutaneous infection is extremely rare. We present a report of a patient with primary cutaneous infection located...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-4632.2004.02446.x

    authors: Gildardo JM,Leobardo VA,Nora MO,Jorge OC

    更新日期:2006-02-01 00:00:00

  • Azelaic acid (15% gel) in the treatment of acne rosacea.

    abstract::In December of 2002, the FDA approved azelaic acid 15% gel for the topical treatment of inflammatory papules and pustules of mild to moderate rosacea. Azelaic acid is a saturated dicarboxylic acid, which is naturally occurring and has been used in the treatment of rosacea, acne, and melasma. The 15% gel has a high eff...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-4632.2005.02769.x

    authors: Gupta AK,Gover MD

    更新日期:2007-05-01 00:00:00

  • Prurigo pigmentosa: a clinicopathological study and analysis of associated factors.

    abstract:BACKGROUND:Prurigo pigmentosa (PP), a rare inflammatory disease of the skin, is mostly reported in the ethnic Japanese population. Its pathogenesis remains unclear. The chronic and recurrent nature of PP implies a possible role of viral infection in the pathogenesis. The anti-inflammatory mechanism of doxycycline, whic...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2010.04625.x

    authors: Lu PH,Hui RC,Yang LC,Yang CH,Chung WH

    更新日期:2011-01-01 00:00:00

  • The epidemiology of scabies in Turkey.

    abstract::The epidemiology of scabies for the last twelve years has been studied in Turkey. Information was obtained from three regions (Istanbul, Ankara and Erzurum) having different climates. There has been an increase in scabies in the years following 1969 in Ankara and Erzurum and from 1967 on in Istanbul. It reached its ma...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1980.tb01993.x

    authors: Tüzün Y,Kotoğyan A,Cenesizoğlu E,Baransü O,Ozarmağan G,Ural A,Cilara A,Gürler A,Tat AL

    更新日期:1980-01-01 00:00:00

  • Senile erythroderma with serum hyper IgE.

    abstract::Eight patients with senile erythroderma with serum hyper IgE were studied. Characteristic laboratory findings were persistently elevated IgE levels, high peripheral-blood eosinophils, and high lactic dehydrogenase (LDH). Immunologic analysis using immunoglobulin antibodies showed frozen sections of inguinal lymph node...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1989.tb04815.x

    authors: Asai T,Horiuchi Y

    更新日期:1989-05-01 00:00:00

  • Nail pigmentation due to hydroxycarbamide.

    abstract::A 47-year-old male developed both longitudinal melanonychia and periungual hyperpigmentation 6 months after initiation of hydroxycarbamide (synonym: hydroxyurea) therapy for chronic myeloproliferative disease. Based on the clinical symptoms observed in this patient, the broad differential diagnostic spectrum of hyperp...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2007.03502.x

    authors: Ceulen RP,Frank J,Poblete-Gutiérrez P

    更新日期:2007-11-01 00:00:00

  • Effect of topical paromomycin on cell-mediated immunity during cutaneous leishmaniasis.

    abstract:BACKGROUND:The aim of this study was to evaluate the effect of topical paromomycin treatment on the development of immunity during cutaneous leishmaniasis. METHODS:Three parameters of immunity were measured in the course of the disease: leishmanicidal effector activity, lymphocyte proliferation (cell-mediated immunity...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-4362.1993.tb00975.x

    authors: Frankenburg S,Gross A,Jonas F,Klaus S

    更新日期:1993-01-01 00:00:00

  • Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis.

    abstract:BACKGROUND:The aim of this study was to investigate possible associations of the five DNA polymorphic genotypes in the HLA region (transporter associated with antigen processing [TAP1; TAP1 333 a/b, TAP1 637 c/d], the HLA-DRB1*1501-rs3135388, tumor necrosis factor [TNF]α [-238 G/A] and NcoI TNFβ) with characteristics o...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.12213

    authors: Vasku A,Bienertova-Vasku J,Izakovicova-Holla L,Pavkova Goldbergova M,Kozacikova Z,Splichal Z,Vasku V

    更新日期:2013-08-01 00:00:00

  • Dextranomer in dermatologic conditions.

    abstract::Dextranomer, a high molecular weight dextran derivative, was evaluated in 43 patients, and found to be the treatment of choice for decubitus ulcers. It is useful in most leg ulcers and cutaneous wounds, and can aid in the nursing care of terminal patients with gangrene or uclerating carcinoma. Dextranomer hastens the ...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-4362.1979.tb01954.x

    authors: Parish LC,Witkowski JA

    更新日期:1979-07-01 00:00:00

  • Onchocerciasis: clinical presentation and host parasite interactions in patients of southern Sudan.

    abstract:BACKGROUND:Onchocerciasis, an infection by the filarial nematode Onchoverca volvulus, is widely distributed in tropical Africa and of great dermatologic interest. This study analyses the dermatologic presentation and tries to determine the correlations between clinical disease and host parasite interactions in onchocer...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-4362.1997.00007.x

    authors: Stingl P

    更新日期:1997-01-01 00:00:00

  • Characterization of circulating lymphocytes by monoclonal antibodies in childhood and adult leprosy.

    abstract::Peripheral blood lymphocyte assays using monoclonal antibodies were done in 66 patients with leprosy, consisting of 25 children and 41 adults. The results were statistically analyzed for correlations, if any, among the different age groups and matched controls. The results, however, failed to show any significant corr...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1991.tb04786.x

    authors: Sehgal VN,Chaudhry A,Sharma VK,Gupta CK

    更新日期:1991-11-01 00:00:00

  • Nine cases of Japan spotted fever diagnosed at our hospital in 2008.

    abstract:BACKGROUND:The diagnosis of Japan spotted fever (JSF) is very difficult in some cases. The initial diagnosis of JSF is very important to treat. METHODS:We report nine cases of Japan spotted fever (JSF) with variable clinical features diagnosed at our hospital in 2008. RESULTS:Concerning clinical symptom, the most fre...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2010.04359.x

    authors: Kondo M,Nishii M,Gabazza EC,Kurokawa I,Akachi S

    更新日期:2010-04-01 00:00:00

  • International recommendations for an effective control of head louse infestations.

    abstract::Head louse infestations continue to be a concern of public health in most countries, including the most developed ones. The present recommendations are intended to inform and stress the role and impact of the different authorities, institutions, industry, and the public in the control of head lice in order to reduce t...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.15096

    authors: Mumcuoglu KY,Pollack RJ,Reed DL,Barker SC,Gordon S,Toloza AC,Picollo MI,Taylan-Ozkan A,Chosidow O,Habedank B,Ibarra J,Meinking TL,Vander Stichele RH

    更新日期:2020-08-07 00:00:00

  • Cutaneous adverse events in patients receiving anticancer therapy in a tertiary hospital setting: the old and the new.

    abstract:BACKGROUND:Targeted therapies and immunotherapies are increasingly prescribed, but classic chemotherapy agents are still highly used in cancer treatment. Both therapies, the old and the new, are associated with cutaneous adverse events (CAEs) that can cause treatment interruptions or reduce the quality of life of patie...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.15081

    authors: Suh HJ,Flórez Á,Sacristán V,Rodríguez Martinez Á,Fernández F,Vilanova-Trillo L,Constenla M,Pereiro M

    更新日期:2021-02-01 00:00:00

  • A calcipotriene/betamethasone dipropionate two-compound scalp formulation in the treatment of scalp psoriasis in Hispanic/Latino and Black/African American patients: results of the randomized, 8-week, double-blind phase of a clinical trial.

    abstract::The calcipotriene/betamethasone dipropionate two-compound scalp formulation has been shown to be safe and effective in the treatment of scalp psoriasis over 8 weeks, but the patients studied were mainly White and non-Hispanic. The aim of this study was to evaluate the efficacy and safety of the two-compound scalp form...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-4632.2010.04598.x

    authors: Tyring S,Mendoza N,Appell M,Bibby A,Foster R,Hamilton T,Lee M

    更新日期:2010-11-01 00:00:00

  • A comparison of botanical and synthetic substances commonly used to prevent head lice (Pediculus humanus var. capitis) infestation.

    abstract:BACKGROUND:Pediculosis, caused by head lice (Pediculidae: Pediculus humanus var. capitis), is experiencing a global resurgence, with the prevalence in primary schools averaging as high as 40% in some areas regardless of socioeconomic factors. Control efforts using chemical treatments are becoming increasingly ineffecti...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2007.03132.x

    authors: Canyon DV,Speare R

    更新日期:2007-04-01 00:00:00

  • Treatment of histoid leprosy: a lack of consensus.

    abstract::Histoid leprosy is a rare variant of leprosy with a unique clinical presentation and bacilli rich histology. These patients are large reservoirs for disease and vectors for spread, making prompt diagnosis and treatment crucial. To date, no consensus on treatment and duration exists. This paper aims to investigate the ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.14962

    authors: Bartos G,Sheuring R,Combs A,Rivlin D

    更新日期:2020-10-01 00:00:00

  • A comparison of stigma among patients with leprosy in rural Tanzania and urban United States: a role for public health in dermatology.

    abstract:BACKGROUND:  Leprosy is a chronic infection of the skin and peripheral nerves caused by the bacterium Mycobacterium leprae, which causes peripheral insensitivity and disfigurements of the skin, limbs, and digits. Social stigma is a common consequence of leprosy and may differ according to level of physical disfiguremen...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2011.05226.x

    authors: Roosta N,Black DS,Rea TH

    更新日期:2013-04-01 00:00:00

  • Evidence that thalidomide modifies the immune response of patients suffering from actinic prurigo.

    abstract:BACKGROUND:Actinic prurigo (AP) is a photodermatosis with a restricted ethnic distribution, mainly affecting Mestizo women (mixed Indian and European). The lesions are polymorphic and include macules, papules, crusts, hyperpigmentation and lichenification. Thalidomide, an effective immunomodulatory drug, was first used...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2004.02274.x

    authors: Estrada-G I,Garibay-Escobar A,Núñez-Vázquez A,Hojyo-Tomoka T,Vega-Memije E,Cortés-Franco R,Pérez-Uribe A,Flores-Romo L,Santos-Argumedo L,Estrada-Parra S,Domínguez-Soto L

    更新日期:2004-12-01 00:00:00

  • Gender-specific risk factors for androgenetic alopecia in the Korean general population: Associations with medical comorbidities and general health behaviors.

    abstract:BACKGROUND:The relationships between androgenetic alopecia (AGA) and various factors related to metabolic syndrome have been demonstrated in previous studies. However, it remains unclear because of inconsistent results. We investigated the associations between AGA and various risk factors related to metabolic syndrome ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.13843

    authors: Kim BK,Choe SJ,Chung HC,Oh SS,Lee WS

    更新日期:2018-02-01 00:00:00

  • Discordance of skin and muscle involvement in dermatomyositis.

    abstract::The skin manifestations of dermatomyositis infrequently occur without the myositis. A 24-year-old woman presented with concordance of the skin and muscle components of dermatomyositis, followed by a remission of the myositis with a persistence of significant rash for 17 years, finally presenting with a flare of both s...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1985.tb05834.x

    authors: Gertner E,Urowitz MB

    更新日期:1985-10-01 00:00:00

  • Milia in regressing plaques of mycosis fungoides: provoked by topical nitrogen mustard or not?

    abstract:OBJECTIVE:To report three cases of mycosis fungoides with milia formation in the regressing lesions. PATIENTS AND SETTING:Dermatology clinic of a university hospital (referral center). Three patients with mycosis fungoides with body surface involvement of 10% in one case (stage IIb) and exceeding 30% in two cases (sta...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2004.01944.x

    authors: Kalayciyan A,Oguz O,Demirkesen C,Serdaroglu S,Kotogyan A

    更新日期:2004-12-01 00:00:00

  • A retrospective review of the dermatologic manifestations of chronic arsenic poisoning in the Philippines.

    abstract:BACKGROUND:The Section of Dermatology of the University of the Philippines, Philippine General Hospital, reported a case of chronic arsenic poisoning from a community in Luzon island to the Department of Health resulting in the conduct of two health and environmental assessment missions in December 2014. OBJECTIVE:To ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.13615

    authors: Sy SMT,Salud-Gnilo CM,Yap-Silva C,Tababa EJL

    更新日期:2017-07-01 00:00:00