Abstract：
BACKGROUND:Few studies have been published on the histopathology of cutaneous adverse drug reactions (CADR), and most of these lack information on skin allergological tests. The histopathology of drug reaction with eosinophilia and systemic symptoms (DRESS) is also seldom described. The purpose of our study was to examine six types of well-documented CADR (maculopapular exanthema, DRESS, fixed drug eruption, Stevens-Johnson syndrome, toxic epidermal necrolysis [TEN], and acute generalized exanthematous pustulosis) using histopathology and immunohistochemistry to evaluate the expression of granulysin, a key molecule in TEN. METHODS:We retrospectively included 106 skin biopsies performed in proven cases of CADR (by chronological investigation, single attributable drug, or/and skin tests). All slides were reviewed, and microscopic changes were analyzed using a standardized form. Granulysin expression was studied by immunohistochemistry. RESULTS:In DRESS, we observed spongiosis, edema, and basal vacuolization, with rare necrotic keratinocytes and constant lymphocytic infiltrate in the superficial dermis. Eosinophils were often present, and pustules were found in 15% of cases. Necrotic keratinocytes are often absent in maculopapular exanthema. Granulysin was expressed in six types of CADR with a trend toward more intense expression in DRESS and TEN. CONCLUSION:We detailed further about the histopathology of DRESS. Granulysin expression was observed in all CADR with a marked overlap of expression pattern between the six types.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Weinborn M,Barbaud A,Truchetet F,Beurey P,Germain L,Cribier Bdoi
10.1111/ijd.13350subject
Has Abstractpub_date
2016-11-01 00:00:00pages
1225-1233issue
11eissn
0011-9059issn
1365-4632journal_volume
55pub_type
杂志文章abstract：:A male fetus which was the product of full-term pregnancy and normal delivery with no family history is presented. The skin was hard and thick, waxy, yellowish in color, and was crossed by horizontal and or perpendicular red fissures. The eyelids were semiclosed, hard, and stiff resulting in ectropion and the conjunct...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1982.tb03144.x
更新日期：1982-07-01 00:00:00
abstract：BACKGROUND:The use of lasers is very common in dermatology; however, many patients fear it and have various misconceptions about it. A literature search failed to show any studies on this topic. OBJECTIVE:To explore the various misconceptions of patients about lasers in dermatology. METHODS:A self-administered questi...
journal_title：International journal of dermatology
pub_type： 杂志文章
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abstract：BACKGROUND:Dithranol is a potent reducing substance and is thought to achieve its effect on psoriasis by reduction of cell turnover. It was shown to be efficacious in adults, but its efficacy has not been documented in children. METHODS:The efficacy of short-contact therapy, a dithranol cream preparation, was retrospe...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1994.tb01005.x
更新日期：1994-11-01 00:00:00
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journal_title：International journal of dermatology
pub_type： 杂志文章
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更新日期：1976-01-01 00:00:00
abstract：BACKGROUND:Ayurvedic medicines are known to contain arsenic and concentrations up to toxic levels have been reported in certain formulations. However, clinical disease due to arsenic containing ayurvedic medicines has rarely been reported. We seek to highlight the existence of toxic levels of arsenic in certain ayurved...
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abstract：BACKGROUND:In Sri Lanka, cutaneous leishmaniasis is a well-established disease caused by Leishmania donovani. Only a few cases of visceral disease and mucosal localization have been reported to date. CASE REPORT:A 52-year-old man presented with severe local destruction of his upper and lower lip and total destruction ...
journal_title：International journal of dermatology
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journal_title：International journal of dermatology
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abstract：BACKGROUND:Alopecia areata (AA) is a non-scarring, autoimmune, inflammatory hair loss disease. Zinc is a trace element involved in important functional activities of hair follicles. PURPOSE:To evaluate serum zinc levels in patients with newly diagnosed and resistant lesions of AA in comparison to age- and sex-matched ...
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journal_title：International journal of dermatology
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journal_title：International journal of dermatology
pub_type： 杂志文章
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journal_title：International journal of dermatology
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更新日期：2015-04-01 00:00:00
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journal_title：International journal of dermatology
pub_type： 杂志文章
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journal_title：International journal of dermatology
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journal_title：International journal of dermatology
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更新日期：1995-11-01 00:00:00
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journal_title：International journal of dermatology
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2018-09-01 00:00:00
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journal_title：International journal of dermatology
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更新日期：2019-03-01 00:00:00
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journal_title：International journal of dermatology
pub_type： 杂志文章
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abstract：BACKGROUND:Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), infective dermatitis associated with HTLV-1 (IDH), and various other clinical conditions. Several of these diseases can occur i...
journal_title：International journal of dermatology
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更新日期：2013-01-01 00:00:00
abstract：:A Chinese baby girl was born after an uncomplicated pregnancy and a normal spontaneous vaginal delivery to a gravida 2, para 1, 32-year-old mother at 37 weeks' gestation. Neither parent had a history of alcohol or drug ingestion. There was no history of consanguinity. The Apgar scores were 7 at 1 min and 9 at 5 min. H...
journal_title：International journal of dermatology
pub_type： 杂志文章
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更新日期：2001-04-01 00:00:00
