Chronic arsenic toxicity from Ayurvedic medicines.


BACKGROUND:Ayurvedic medicines are known to contain arsenic and concentrations up to toxic levels have been reported in certain formulations. However, clinical disease due to arsenic containing ayurvedic medicines has rarely been reported. We seek to highlight the existence of toxic levels of arsenic in certain ayurvedic preparations that can produce serious systemic manifestations. METHODS:An 11-year-old girl developed manifestations of arsenical keratosis (punctuate palmoplantar keratoderma and leucomelanoderma) and non-cirrhotic portal hypertension, 6 months and 18 months respectively after intake of ayurvedic medications, prescribed for epilepsy. The eight ayurvedic preparations consumed by the patient and her serum levels were analyzed for arsenic content. RESULTS:Arsenic content of ayurvedic medicines ranged from 5 mg/L to 248 mg/L. The serum arsenic level was 202.20 microg/L (normal < 60 microg/L). Skin manifestations improved after the discontinuation of ayurvedic medications. CONCLUSIONS:Ayurvedic medications should be consumed under strict guidance and supervision of qualified practitioners to prevent such catastrophies.


Int J Dermatol


Khandpur S,Malhotra AK,Bhatia V,Gupta S,Sharma VK,Mishra R,Arora NK




Has Abstract


2008-06-01 00:00:00














  • Tick bites in Korea.

    abstract:BACKGROUND:Tick bites are dermatoses not commonly encountered in Korea. Recognizing their clinical signs as well as their histopathologic findings is important in making a diagnosis of tick-related dermatoses. The incidence and causative species are different depending on the geographic areas. The histopathologic findi...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Cho BK,Kang H,Bang D,Kim SN,Hwang S,Song ES

    更新日期:1994-08-01 00:00:00

  • Effect of topical paromomycin on cell-mediated immunity during cutaneous leishmaniasis.

    abstract:BACKGROUND:The aim of this study was to evaluate the effect of topical paromomycin treatment on the development of immunity during cutaneous leishmaniasis. METHODS:Three parameters of immunity were measured in the course of the disease: leishmanicidal effector activity, lymphocyte proliferation (cell-mediated immunity...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Frankenburg S,Gross A,Jonas F,Klaus S

    更新日期:1993-01-01 00:00:00

  • Oxymatrine inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth factor-β1/Smad signaling pathway.

    abstract:BACKGROUND:Keloids are benign dermal tumors characterized by fibroblastic proliferation and excessive accumulation of collagen. Oxymatrine (OMT) is an alkaloid extracted from the Chinese herb Sophora japonica with capacities of anti-fibrosis. OBJECTIVE:To evaluate the effects of OMT on collagen production and to explo...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Fan DL,Zhao WJ,Wang YX,Han SY,Guo S

    更新日期:2012-04-01 00:00:00

  • The risk of malignancy or progression of existing malignancy in patients with psoriasis treated with biologics: case report and review of the literature.

    abstract::There is some debate regarding the risk of developing malignancy and progression of malignancy in patients with psoriasis treated with biologics. The lack of extensive, long-term, and large studies, including patients with psoriasis, to assess these aforementioned risks makes it difficult to ascertain the safety profi...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Patel S,Patel T,Kerdel FA

    更新日期:2016-05-01 00:00:00

  • Acyclovir-induced neuropsychosis successfully recovered after immediate hemodialysis in an end-stage renal disease patient.

    abstract::A 70-year-old man developed herpes zoster over the right L5-S2 region for 3 days and was admitted for acyclovir therapy. He had a medical history of rectal cancer status post-colostomy and end-stage renal disease undergoing thrice weekly hemodialysis. Without a prior loading dose, acyclovir 500 mg (7.7 mg/kg) daily wa...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Yang HH,Hsiao YP,Shih HC,Yang JH

    更新日期:2007-08-01 00:00:00

  • Erosive pustular dermatosis of the scalp: causes and treatments.

    abstract::Erosive pustular dermatosis of the scalp is a rare condition which primarily affects older women after local trauma and has historically been treated with topical steroids. As it is a rare entity and resembles other dermatologic conditions, it may easily be misdiagnosed. Identifying the causes and evaluating the effic...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Karanfilian KM,Wassef C

    更新日期:2021-01-01 00:00:00

  • Features of dermatofibroma in reflectance confocal microscopy.

    abstract:BACKGROUND:Dermatofibroma (DF) is a common benign skin lesion in a majority of cases located on the legs or upper limbs. The etiology of DF is still unclear. OBJECTIVES:Reflectance confocal microscopy features of DF were described. METHODS:Forty patients with DF diagnosis confirmed by dermoscopy were examined using r...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Pogorzelska-Antkowiak A,Wcisło-Dziadecka D,Brzezińska-Wcisło L,Pawlicki K,Antkowiak R,Corneli P

    更新日期:2020-08-01 00:00:00

  • Antihistamines are superior to topical steroids in managing human immunodeficiency virus (HIV)-associated papular pruritic eruption.

    abstract::Papular pruritic eruption (PPE) is a frequent HIV-comorbidity in tropical countries. Because of constant itching and social stigma, effective treatment is highly valued. In our HIV cohort in rural Tanzania with 12% prevalence of PPE, we have retrospectively analyzed responses to available treatments. Oral promethazine...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Navarini AA,Stoeckle M,Navarini S,Mossdorf E,Jullu BS,Mchomvu R,Mbata M,Kibatala P,Tanner M,Hatz C,Schmid-Grendelmeier P

    更新日期:2010-01-01 00:00:00

  • Bazex-Dupré-Christol syndrome: review of clinical and molecular aspects.

    abstract::Bazex-Dupré-Christol syndrome is a rare genodermatosis that manifests with the classical triad of basal cell carcinoma, follicular atrophoderma, and hypotrichosis; yet it may be accompanied by milia, ichthyosis, neurological symptoms, and visceral malignancies. Symptom onset is nonsimultaneous, and hence the diagnosis...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: AlSabbagh MM,Baqi MA

    更新日期:2018-09-01 00:00:00

  • Antibiogram testing of pediatric skin infections in the era of methicillin-resistant Staphylococci aureus: an Egyptian University Hospital-based study.

    abstract:BACKGROUND:Community-associated methicillin-resistant Staphylococci aureus (CA-MRSA) pediatric skin infections have been reported worldwide. However, little is known about pathogens' implications in Egyptian children, and beta-lactams are still the empiric antimicrobials prescribed. This warrants Egyptian studies on an...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Abdel Fattah NS,Darwish YW

    更新日期:2012-12-01 00:00:00

  • Etanercept therapy allows the tapering of methotrexate and sustained clinical responses in patients with moderate to severe psoriasis.

    abstract::Methotrexate, the most common systemic small molecule used in the treatment of moderate to severe psoriasis, is associated with significant toxicities and adverse events. Long-term continuous usage is not recommended due to potential liver toxicity, myelosuppression, and other side effects. Abrupt cessation of methotr...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Yamauchi PS,Lowe NJ

    更新日期:2008-02-01 00:00:00

  • Autologous epidermal grafting with PUVA-irradiated donor skin for the treatment of vitiligo.

    abstract:BACKGROUND:Epidermal autografting has been used to treat vitiligo. The pigmentation achieved at the recipient site can be variegated and incomplete compared with that of the surrounding normal skin, and sometimes remains that way for a fairly long time. OBJECTIVE:We investigated whether the clinical results from epide...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Lee AY,Jang JH

    更新日期:1998-07-01 00:00:00

  • Evidence that thalidomide modifies the immune response of patients suffering from actinic prurigo.

    abstract:BACKGROUND:Actinic prurigo (AP) is a photodermatosis with a restricted ethnic distribution, mainly affecting Mestizo women (mixed Indian and European). The lesions are polymorphic and include macules, papules, crusts, hyperpigmentation and lichenification. Thalidomide, an effective immunomodulatory drug, was first used...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Estrada-G I,Garibay-Escobar A,Núñez-Vázquez A,Hojyo-Tomoka T,Vega-Memije E,Cortés-Franco R,Pérez-Uribe A,Flores-Romo L,Santos-Argumedo L,Estrada-Parra S,Domínguez-Soto L

    更新日期:2004-12-01 00:00:00

  • Amelanotic melanomas presenting as red skin lesions: a diagnostic challenge with potentially lethal consequences.

    abstract:OBJECTIVE:To characterize epidemiologic and clinical features of red primary amelanotic melanomas, an atypical presentation of melanoma that is underemphasized in patient and physician education. PATIENTS AND METHODS:Review of a prospectively collected melanoma database identified 46 patients with red amelanotic melan...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: McClain SE,Mayo KB,Shada AL,Smolkin ME,Patterson JW,Slingluff CL Jr

    更新日期:2012-04-01 00:00:00

  • Scleromyxedema revisited.

    abstract::Scleromyxedema is a rare disease characterized by papular mucinous deposits, dermal fibroblast proliferation, and a monoclonal paraproteinemia. Its chronic course tends to be complicated by gastrointestinal, muscular, pulmonary, and neurologic disorders. We review the literature to identify the common systemic manifes...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Pomann JJ,Rudner EJ

    更新日期:2003-01-01 00:00:00

  • Skin diseases in the Peruvian Amazonia.

    abstract:BACKGROUND:Dermatologic diseases vary widely as a result of geographic location and may be influenced by environmental factors. Aim To determine the epidemiology of dermatological diseases in the Peruvian Amazonia. METHODS:Transversal and multicentric study, which were carried out during February of 2006, 2007, and 20...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,多中心研究


    authors: Gutierrez EL,Galarza C,Ramos W,Tello M,Jiménez G,Ronceros G,Chía H,Hurtado J,Ortega-Loayza AG

    更新日期:2010-07-01 00:00:00

  • Comparison of PTCH1, COX-2, p53, and Ki-67 protein expression in basal cell carcinomas of nodular and superficial subtypes arising on the head and trunk.

    abstract:BACKGROUND:There is some evidence that basal cell carcinomas (BCCs) arising on different anatomic sites and developing to different histological subtypes differ in their pathophysiology. The expression of a number of proteins, including PTCH1, COX-2, p53, and Ki-67, is frequently altered in BCC development. OBJECTIVES...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Khalesi M,Waterhouse M,Whiteman DC,Johns R,Rosendahl C,Hackett T,Pollak T,Kimlin MG,Hacker E,Neale RE,NHMRC Centre of Research Excellence in Sun and Health (CRESH).

    更新日期:2016-10-01 00:00:00

  • Ossification of the auricle.

    abstract::The auricle is a flexible structure because it is formed by elastic cartilage. In the rare occurrence of ectopic auricular ossification, however, the cartilage is replaced by lamellar bone and becomes petrified. Such unphysiological replacement has been reported in association with local trauma, inflammation, systemic...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Sterneberg-Vos H,Winnepenninckx V,Frank J,Kelleners-Smeets NW

    更新日期:2007-11-01 00:00:00

  • Venous ulcer: epidemiology, physiopathology, diagnosis and treatment.

    abstract::This review discusses the epidemiology, pathogenesis, diagnosis and current therapeutic options for venous ulcer. Venous ulcer is a severe clinical manifestation of chronic venous insufficiency (CVI). It is responsible for about 70% of chronic ulcers of the lower limbs. The high prevalence of venous ulcer has a signif...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Abbade LP,Lastória S

    更新日期:2005-06-01 00:00:00

  • Cutaneous porphyrias part II: treatment strategies.

    abstract::The porphyrias are diverse in pathophysiology, clinical presentation, severity, and prognosis, presenting a diagnostic and therapeutic challenge. Although not easily curable, the dermatological manifestations of these diseases, photosensitivity and associated cutaneous pathology, can be effectively prevented and manag...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Tintle S,Alikhan A,Horner ME,Hand JL,Davis DM

    更新日期:2014-01-01 00:00:00

  • Demodex infestation in a child with leukaemia: treatment with ivermectin and permethrin.

    abstract:BACKGROUND:Demodex mites are almost ubiquitous on older adult skin but are infrequent in young children. In immunocompromised patients, demodicosis may be more frequent and severe, and systemic therapy may be needed to achieve clinical resolution. CASE REPORT:A six-year-old boy having maintenance chemotherapy for acut...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Damian D,Rogers M

    更新日期:2003-09-01 00:00:00

  • Exacerbations of oral lichen planus and elevated levels of aminotransferases.

    abstract:BACKGROUND:Liver enzymes appear to be involved in oral lichen planus (OLP), but it is not known whether the elevation develops concomitantly with exacerbations of disease. We compared the levels of serum hepatic aspartate (AST) and alanine (ALT) aminotransferases as markers of OLP exacerbation in patients with chronic ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Bombeccari GP,Tettamanti M,Pallotti F,Spadari F,Giannì AB

    更新日期:2017-08-01 00:00:00

  • Main pigmentary features and melanocortin 1 receptor (MC1R) gene polymorphisms in the population of the Canary Islands.

    abstract:BACKGROUND:Sun exposure, light skin pigmentation, and melanocortin 1 receptor (MC1R) gene variants are independent risk factors for skin cancer. The Canary Islands have a sunny and temperate climate, but data regarding the phenotypic and genotypic risk factors among the population are lacking. METHODS:The main phenoty...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: de-Misa RF,Pérez-Méndez LI,Hernández-Jiménez JG,Rodríguez Mdel C,Vilar MC,Suárez J,Claveríe-Martín F

    更新日期:2008-08-01 00:00:00

  • Satellite repigmentation after punch grafting.

    abstract::Punch grafting is an established treatment modality for management of localized, nonprogressive vitiligo resistant to conventional therapies.(1) In our set up, punch grafting is routinely carried out in focal vitiligo, segmental vitiligo and even in few cases of generalized vitiligo, especially when it is a serious co...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Agarwal US,Gulati R,Shukla SR,Mathur N

    更新日期:2004-04-01 00:00:00

  • Onychomycosis in Hong Kong.

    abstract:BACKGROUND:Onychomycosis in temperate countries has been studied extensively, but few data are available on its epidemiology in tropical countries. We performed a survey of patients seen in Hong Kong for the 8-year period from January 1987 to December 1994. METHODS:A retrospective study of the mycology laboratory reco...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Kam KM,Au WF,Wong PY,Cheung MM

    更新日期:1997-10-01 00:00:00

  • Topical cannabinoid receptor 1 agonist attenuates the cutaneous inflammatory responses in oxazolone-induced atopic dermatitis model.

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    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Kim HJ,Kim B,Park BM,Jeon JE,Lee SH,Mann S,Ahn SK,Hong SP,Jeong SK

    更新日期:2015-10-01 00:00:00

  • Naftifine treatment of resistant dermatophytosis.

    abstract::Despite an array of topical and systemic antifungal agents, cases of resistant dermatophytosis still exist. Use of naftifine, the first commercially available allylamine derivative, proved successful in the management of four such cases. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Rosen T,Fischer M,Orengo I,Abuabara F

    更新日期:1991-08-01 00:00:00

  • Pemphigus vegetans of the oral cavity.

    abstract:BACKGROUND:Pemphigus vegetans, a variant of pemphigus vulgaris, constitutes a rare form of all pemphigus cases, and oral involvement is common. Two clinical subtypes of pemphigus vegetans exist, characterized initially by flaccid bullae and erosions (Neumann) or pustules (Hallopeau). Both subtypes subsequently develop ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Markopoulos AK,Antoniades DZ,Zaraboukas T

    更新日期:2006-04-01 00:00:00

  • Staging of necrotizing fasciitis based on the evolving cutaneous features.

    abstract:BACKGROUND:Necrotizing fasciitis is a severe soft-tissue infection characterized by a fulminant course and high mortality. Early recognition is difficult as the disease is often clinically indistinguishable from cellulitis and other soft-tissue infections early in its evolution. Our aim was to study the manifestations ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Wang YS,Wong CH,Tay YK

    更新日期:2007-10-01 00:00:00

  • Efficacy of lipectomy and liposuction in the treatment of multiple symmetric lipomatosis.

    abstract:BACKGROUND:Multiple symmetric lipomatosis (MSL) is a rare disease characterized by enlarging, symmetric, nonencapsulated, fat deposits mainly on the neck and upper trunk. Liposuction and lipectomy, although palliative, are the treatments of choice, especially indicated when vital structures are compromised. OBJECTIVE:...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Martínez-Escribano JA,Gonzalez R,Quecedo E,Febrer I

    更新日期:1999-07-01 00:00:00