Chronic arsenic toxicity from Ayurvedic medicines.

Abstract:

BACKGROUND:Ayurvedic medicines are known to contain arsenic and concentrations up to toxic levels have been reported in certain formulations. However, clinical disease due to arsenic containing ayurvedic medicines has rarely been reported. We seek to highlight the existence of toxic levels of arsenic in certain ayurvedic preparations that can produce serious systemic manifestations. METHODS:An 11-year-old girl developed manifestations of arsenical keratosis (punctuate palmoplantar keratoderma and leucomelanoderma) and non-cirrhotic portal hypertension, 6 months and 18 months respectively after intake of ayurvedic medications, prescribed for epilepsy. The eight ayurvedic preparations consumed by the patient and her serum levels were analyzed for arsenic content. RESULTS:Arsenic content of ayurvedic medicines ranged from 5 mg/L to 248 mg/L. The serum arsenic level was 202.20 microg/L (normal < 60 microg/L). Skin manifestations improved after the discontinuation of ayurvedic medications. CONCLUSIONS:Ayurvedic medications should be consumed under strict guidance and supervision of qualified practitioners to prevent such catastrophies.

journal_name

Int J Dermatol

authors

Khandpur S,Malhotra AK,Bhatia V,Gupta S,Sharma VK,Mishra R,Arora NK

doi

10.1111/j.1365-4632.2008.03475.x

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

618-21

issue

6

eissn

0011-9059

issn

1365-4632

pii

IJD3475

journal_volume

47

pub_type

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