Abstract：
BACKGROUND:Regulatory T cells (Tregs) play an important role in autoimmune diseases. In skin, the presence of Tregs is thought to be mandatory for suppression of autoreactive T cells. Here, we assess the number of Tregs in skin of healthy subjects and patients with an autoimmune dermatosis. METHODS:Immunohistochemical stainings for CD3 and FOXP3 on skin biopsies of healthy subjects and subjects with psoriasis, vitiligo, pemphigus vulgaris, bullous pemphigoid, and halo nevus to assess the number of T and regulatory T cells, respectively. RESULTS:Low numbers of CD3+ and FOXP3+ cells were seen in the skin of healthy controls (median = 0.5%). A significantly higher frequency of Tregs was seen in lesional skin of patients with psoriasis (median = 12.4%) and patients with bullous pemphigoid (median = 10.1%) as compared to controls. In vitiligo (median = 0.0%), pemphigus vulgaris (median = 5.2%), and halo nevi (median = 5.4%), no significant difference in number of FOXP3+ cells was observed when compared to controls. CONCLUSIONS:As confirmed in the literature, few Tregs were seen in healthy skin. A high number of Tregs were present in lesional skin from patients with psoriasis and bullous pemphigoid. These results support the hypothesis that not a decrease in number but rather a decrease in function of Tregs would be at the basis of autoimmune skin diseases, which could result in unrestrained activation autoreactive T cells in skin of patients with autoimmune dermatoses.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Terras S,Gambichler T,Moritz RK,Altmeyer P,Lambert Jdoi
10.1111/j.1365-4632.2012.05808.xsubject
Has Abstractpub_date
2014-03-01 00:00:00pages
294-9issue
3eissn
0011-9059issn
1365-4632journal_volume
53pub_type
杂志文章abstract：:An 11-year-old girl presented from Villa Azueta, Veracruz, a poor and small town on the Tesechoacan riverside. The Tesechoacan riverside is a tropical area in the south-east of Mexico, between 18 degrees, 04',32" latitude and 95 degrees, 42',23" longitude. Her family consisted of both parents and 12 brothers, all appa...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1997.tb03307.x
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Sporotrichosis is a chronic granulomatous infection caused by Sporothrichum schenckii. The disease has worldwide distribution. Majority of cases from India are reported from North-eastern states. METHODS:The demographic, clinico-investigative profile and therapeutic results of nine patients with cutaneous s...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2008.03538.x
更新日期：2008-04-01 00:00:00
abstract：:The effects of prednisone, oral acyclovir, and radiotherapy were compared with placebo in the prevention of post-herpetic neuralgia. No treatment used was able to prevent, with statistical significance, post-herpetic neuralgia, although prednisone and acyclovir showed some pain reduction in the acute phase. Radiothera...
journal_title：International journal of dermatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-4362.1991.tb04642.x
更新日期：1991-04-01 00:00:00
abstract：:A 30-year-old woman presented with an orange-yellow discoloration of the skin, most noticeable on the palms and soles and nasolabial folds; sclera appeared normal. The patient had observed the abnormal pigmentation of her skin 3 months earlier and noticed that it had become more evident after a sauna she had taken 2 d...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1992.tb03521.x
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Tinea pedis is an infrequent disease in children before the age of puberty. There are few epidemiologic and clinical data regarding cases of tinea pedis observed in children. Materials and methods We prospectively collected all cases of tinea pedis in children diagnosed during the years 1995-1997. Only those...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.2000.00861.x
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Tattoos have reached broadening mainstream acceptance. Medical professional societies have noted that tattoos may co-occur with high risk behaviors. METHODS:Using a variety of statistical models applied to a sample of 2,008 adults residing in the United States via Amazon's Mechanical Turk, we estimate the a...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.14372
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Dithranol is a potent reducing substance and is thought to achieve its effect on psoriasis by reduction of cell turnover. It was shown to be efficacious in adults, but its efficacy has not been documented in children. METHODS:The efficacy of short-contact therapy, a dithranol cream preparation, was retrospe...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1994.tb01005.x
更新日期：1994-11-01 00:00:00
abstract：INTRODUCTION:Diffuse dermal angiomatosis is an entity in the spectrum of reactive angiomatoses characterized by erythematous plaques that mainly affect the lower extremities of patients with a personal history of peripheral vascular disease. Involvement of the breast is a rare event that has only been described as sing...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2012.05812.x
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:Climatologic factors may affect atopic dermatitis (AD), and there have been few explorations into this topic. Because of its size, the United States (US) has a broad range of climates. The objective of this study is to assess the relationship between ambulatory office visits physicians for AD with temperatur...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.14289
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Even with the widespread clinical use of cannabinoid receptor (CBR) stimulating compounds, such as palmitoylethanolamine, the role of CBR agonists on inflammatory skin diseases is not yet fully understood. This study was performed to investigate the effects of CBR agonists on skin inflammation, using acute a...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.12841
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Plantar hyperhidrosis is a common illness with significant impact on quality of life. Oxybutynin presents good short-term results, but longer follow-up results are lacking. We evaluated oxybutynin effectiveness in patients who were not surgically treated and who had at least six months of follow-up. METHODS...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.12729
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Photodynamic therapy (PDT) is a non-surgical method for treating non-melanoma skin cancer and precancerous lesions which involves the activation of a photosensitizer by visible light to produce activated oxygen species within target cells, resulting in the destruction of the latter. The present study evaluat...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2010.04700.x
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:Edema commonly accompanies surgical procedures and when excessive, can adversely affect surgical outcomes. The skin extracellular matrix, including one of its primary components, hyaluronan (HA), is a significant barrier to effective drainage of accumulated edematous fluid. Recombinant human hyaluronidase (r...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.12304
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:The Section of Dermatology of the University of the Philippines, Philippine General Hospital, reported a case of chronic arsenic poisoning from a community in Luzon island to the Department of Health resulting in the conduct of two health and environmental assessment missions in December 2014. OBJECTIVE:To ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.13615
更新日期：2017-07-01 00:00:00
abstract：:Acquired facial hyperpigmentation is a common problem among African patients, particularly women, where the causes of the dermatoses are identified largely from circumstantial evidence of exposure to known agents. These include hydroquinone-induced exogenous ochronosis from skin-bleaching creams, mercury deposits from...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-4362.1991.tb03848.x
更新日期：1991-03-01 00:00:00
abstract：:Fifty-seven patients with primary localized cutaneous amyloidosis (PLCA) were clinically and histopathologically reviewed. Two-thirds of patients had macular amyloidosis (MA). Intermediate cases having macular lesions with micropapules and/or lichens were identified. A spectrum for the disease is proposed, in which th...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1992.tb03245.x
更新日期：1992-02-01 00:00:00
abstract：BACKGROUND:Histoid leprosy (HL) is a highly bacilliferous form of leprosy which requires early diagnosis and management. Dermoscopy is a noninvasive diagnostic method for various malignant and nonmalignant disorders. The aim of this study was to describe the dermoscopic patterns of various types of HL lesions over diff...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.14731
更新日期：2020-03-01 00:00:00
abstract：:Papular pruritic eruption (PPE) is a frequent HIV-comorbidity in tropical countries. Because of constant itching and social stigma, effective treatment is highly valued. In our HIV cohort in rural Tanzania with 12% prevalence of PPE, we have retrospectively analyzed responses to available treatments. Oral promethazine...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2009.04279.x
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Twenty-nail dystrophy (TND) is an idiopathic and non-congenital nail dystrophy that is characterized by excess longitudinal ridges and loss of luster in multiple nail plates. There are a few studies on TND. MATERIALS AND METHODS:In order to investigate the demographic and clinical characteristics of patient...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2011.05118.x
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Though melasma is a common skin condition in India, epidemiological studies are few and geographically confined. The present study was designed to gain insights into factors involved in causation and aggravation of melasma, demographic distribution, clinical presentations, and treatment patterns. METHODS:A ...
journal_title：International journal of dermatology
pub_type： 杂志文章,多中心研究
doi：10.1111/ijd.14541
更新日期：2019-11-01 00:00:00
abstract：:Hydroxyurea is a hydroxylated derivate of urea commonly used in the treatment of various hematologic disorders. Cutaneous side-effects such as alopecia, diffuse hyperpigmentation, scaling, poikiloderma, atrophy of the skin and subcutaneous tissues or nail changes can develop after long-term treatment with hydroxyurea....
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2004.02450.x
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:Isotretinoin, for acne treatment, is associated with high rates of permanent remission. However, at recommended doses of 0.5-1.0 mg/kg/day for 5-6 months [average cumulative dose: 120-150 mg/kg], more than 20% of patients experience a relapse within two years that requires further medical management. OBJECT...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2011.05409.x
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:Sun exposure, light skin pigmentation, and melanocortin 1 receptor (MC1R) gene variants are independent risk factors for skin cancer. The Canary Islands have a sunny and temperate climate, but data regarding the phenotypic and genotypic risk factors among the population are lacking. METHODS:The main phenoty...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2008.03680.x
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:Intralesional bleomycin is effective for the treatment of various dermatologic conditions. However, the efficacy of intralesional bleomycin for the treatment of corns has not been established. METHODS:A total of 50 patients with plantar corns were recruited and equally divided between groups A and B. Groups...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.12586
更新日期：2014-12-01 00:00:00
abstract：:A 5-year study of 668 patients with genital lesions revealed that teenagers and those in the age group of 20 to 40 are most vunerable. The poor, the uneducated and unmarried persons are at high risk. Chancroid and syphilis are the majority of cases. Inguinal bubo, herpes pregenitalis, condylomata acuminata, erosive ba...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：
更新日期：1976-10-01 00:00:00
abstract：BACKGROUND:Phenytoin (5,5 diphenylhydantoin), a widely-used anticonvulsant, has been employed both topically and systemically in the treatment of some dermatological disorders. Immunological and non-immunological defects suggests that phenytoin could be therapeutically effective for vitiligo repigmentation. AIM OF STU...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2012.05551.x
更新日期：2012-11-01 00:00:00
abstract：:Although tamoxifen (TAM) is routinely used in advanced melanoma, it is still uncertain whether evidence exists to support this practice. This review assesses the benefits and harms of systemic therapy with TAM vs. without TAM on response and mortality in patients with advanced melanoma. MEDLINE, The Cochrane Database ...
journal_title：International journal of dermatology
pub_type： 杂志文章,meta分析,评审
doi：10.1111/j.1365-4632.2010.04529.x
更新日期：2010-10-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the effect of topical paromomycin treatment on the development of immunity during cutaneous leishmaniasis. METHODS:Three parameters of immunity were measured in the course of the disease: leishmanicidal effector activity, lymphocyte proliferation (cell-mediated immunity...
journal_title：International journal of dermatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-4362.1993.tb00975.x
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:Epidemiological data have established an association between cardiovascular disease and psoriasis. Only one general population study has so far compared prevalences of cardiovascular risk factors among subjects with psoriasis and control subjects. We aimed to determine the prevalence of cardiovascular risk f...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2011.05408.x
更新日期：2013-06-01 00:00:00
abstract：:The epidemiology of scabies for the last twelve years has been studied in Turkey. Information was obtained from three regions (Istanbul, Ankara and Erzurum) having different climates. There has been an increase in scabies in the years following 1969 in Ankara and Erzurum and from 1967 on in Istanbul. It reached its ma...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1980.tb01993.x
更新日期：1980-01-01 00:00:00
