Abstract：
:A 31-year-old man, an intravenous drug user and in an advanced stage of acquired immune deficiency syndrome (AIDS), was admitted in our Department for the treatment of skin lesions that had been diagnosed as molluscum contagiosum (MC). The clinical examination revealed the presence of multiple nodular lesions, some of which were notably large and whose color resembled that of normal skin. These lesions were localized mainly to the face, and in particular on the forehead, glabellar, malar, beard, submandibular, and neck regions (Fig. 1). Smaller, crateriform lesions were detected on the hands and the upper limbs. The lymphocyte subsets ratio was 0.02, with a CD4+ T cell count of 13 cells per mm3 (1%) and a CD8+ T cell count of 624 per mm3 (48%). The patient also had leukopenia (1690 WBC per mm3), moderate macrocytic anemia, elevation of transaminases (SGOT 105 U/L, SGPT 114 U/L) and of immunoglobulins (IgG 2660 mg/dL), and a decrease of C3 (44.2 mg/dL) and C4 (16.6 mg/dL). Histologic examination revealed the presence of typical MC lesions. In addition to an important acanthosis, it was possible to detect pyriform lobules of perfectly delineated epidermal cells, radially separated by fibrous septa that merge towards the central crater. The characteristic MC eosinophil bodies were observed in infected cells (Fig. 2). The lesions were treated with cryosurgery by spray. Many courses of therapy were given with intervals of 2-3 weeks. Every session consisted of two cycles of rapid freezing followed by a slow thaw. Many lesions disappeared with this treatment, and others were reduced in size, but total destruction of all lesions was not achieved (Fig. 3).
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Vozmediano JM,Manrique A,Petraglia S,Romero MA,Nieto Idoi
10.1111/j.1365-4362.1996.tb01616.xsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
45-7issue
1eissn
0011-9059issn
1365-4632journal_volume
35pub_type
杂志文章abstract：BACKGROUND:Glutathione (GSH) is a naturally occurring thiol that has been reported to cause skin lightening in a manner for which several mechanisms have been proposed. Highest plasma concentrations are achieved with IV administration but are accompanied by greater levels of risk. Oral administration has been less succ...
journal_title：International journal of dermatology
pub_type： 临床试验,杂志文章
doi：10.1111/ijd.12999
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Psoriasis is a common Th1-mediated skin disease whose etiology remains obscure. Loss of sweating caused by retention hyperkeratosis is seen in psoriasis plaques, which is likely to have resulted from autonomic dysfunction. OBJECTIVE:In the present study, we aimed to evaluate autonomic nervous system (ANS) f...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2011.05111.x
更新日期：2012-05-01 00:00:00
abstract：:Pruritus is among the most common complaints in the field of dermatology. It is also a disturbing symptom of many systemic disorders. Chronic pruritus (CP) refers to the cases of the symptom which last longer than 6 weeks. We conducted a prospective analysis of patients with generalized pruritus without primary skin l...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.14125
更新日期：2019-03-01 00:00:00
abstract：UNLABELLED:BACKGROUND> An unchecked proliferation of fibrous tissue after an injury to the skin is the basic mechanism for keloid formation. Recent studies have shown the inhibitory effect of interferons on dermal fibroblast growth and/or collagen production. Various therapeutic modalities have been used for the treatm...
journal_title：International journal of dermatology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1365-4362.1996.tb01671.x
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND:Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin disease. Angiopoietin is an intrinsic mediator induced by T helper 2 cytokines and has been reported it to play a critical role in the pathogenesis of AD. OBJECTIVES:To determine the relationship between circulating angiopoietin-2 (Ang-2) in AD...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.14620
更新日期：2019-11-04 00:00:00
abstract：:Squamous cell carcinoma (scc) of the skin was studied in two similar populations, one living in the temperate zone of Australia, the other living in the tropics. In the tropics, the patients were significantly younger, the man to woman ratio approached unity, and women had significantly more sccs on the legs. In the t...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1992.tb02697.x
更新日期：1992-07-01 00:00:00
abstract：:Young white men (1176 men, mean age 20 years, age range from 18 to 26 years) were examined for dysplastic nevi. In 78 patients (6.63%), 107 clinically dysplastic nevi were observed, demonstrating all three NIH criteria (diameter greater than 5mm, irregularities of border, irregularities of color) suggestive for clinic...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1992.tb03947.x
更新日期：1992-05-01 00:00:00
abstract：:The effects of prednisone, oral acyclovir, and radiotherapy were compared with placebo in the prevention of post-herpetic neuralgia. No treatment used was able to prevent, with statistical significance, post-herpetic neuralgia, although prednisone and acyclovir showed some pain reduction in the acute phase. Radiothera...
journal_title：International journal of dermatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-4362.1991.tb04642.x
更新日期：1991-04-01 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate possible associations of the five DNA polymorphic genotypes in the HLA region (transporter associated with antigen processing [TAP1; TAP1 333 a/b, TAP1 637 c/d], the HLA-DRB1*1501-rs3135388, tumor necrosis factor [TNF]α [-238 G/A] and NcoI TNFβ) with characteristics o...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.12213
更新日期：2013-08-01 00:00:00
abstract：:An 11-month-old male infant was referred to our clinic because of a painful ulcer of approximately 5 months' duration on the ventral surface of the tongue (Fig. 1). On physical examination, the lesion was circular (3 cm x 2 cm) with erythematous, raised, and indurated borders. No pathologic findings emerged from the l...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2004.02554.x
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND:Erythroderma is a generalized erythema of the skin accompanied by a variable degree of scaling. However, most of the published series originate from Western countries. There is only one report from Africa, conducted in Dakar in 1979. The aim of our study was to provide information about this condition in our...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2004.02100.x
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Chronic idiopathic urticaria (CIU) is defined by the almost daily presence of urticaria for at least 6 weeks without an identifiable cause. Symptoms include short-lived wheals, itching, and erythema. CIU impedes significantly a patient's quality of life (QoL). Levocetirizine is an antihistamine from the late...
journal_title：International journal of dermatology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1365-4632.2005.02609.x
更新日期：2006-04-01 00:00:00
abstract：:Necrolytic acral erythema is a relatively recently described psoriasis-like skin eruption seen in people infected with hepatitis C virus. Hepatitis C virus infection is endemic in many parts of the world with a steady increase of incidence in Pakistan. Recognition of this disorder is crucial to an early treatment of t...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2008.03710.x
更新日期：2008-10-01 00:00:00
abstract：:A 65-year-old retired man with hand eczema presented to the Dermatology clinic in October of 2001. He complained of scaly, fissured plaque-type lesions over the radial margin of his right index finger and thumb (Fig. 1). He first noticed these changes 2 years ago. There was no history of irritation from his occupation...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.2002.01533.x
更新日期：2002-11-01 00:00:00
abstract：BACKGROUND:Prompt management of acute graft-versus-host disease (GVHD) may prevent its morbidity and mortality. Maculopapular (MP) eruption is a presenting sign of acute GVHD, but differentiation from other causes of MP rash is challenging. METHODS:A retrospective study was conducted among patients developing MP erupt...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.15186
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:People with albinism (PWA) are targets of prejudice and social exclusion and have limited access to specialized medical care and resources. Our study aimed to describe the epidemiological and dermatological profile of PWA in Togo. METHOD:We carried out a cross-sectional study of 294 medical records of PWA s...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.15069
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:This study sought to gain a better understanding of the patient population in Kampala and was further designed to elucidate barriers that may delay individuals from receiving proper dermatologic care. METHODS:The study took place at the dermatovenereology clinic of a tertiary care hospital in Kampala. New a...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.13435
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Needle biopsy is a rapid, reliable, and reproducible procedure for histological confirmation of metastatic melanoma localization. Nonetheless, this procedure presents a theoretical risk of a mechanical weakening of the lymph node capsule with perinodal tumor seeding. The objective of the study was to evaluat...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.13936
更新日期：2018-04-01 00:00:00
abstract：:A 60-year-old man presented to the Emergency Department (ED) with large, painful, indurated plaques on the right thigh, left abdomen, left chest, and right chest, which began without any preceding trauma on the right thigh 3 weeks prior to presentation in the ED. He was initially treated with cefazolin 1 g three times...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2006.03067.x
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:Phototherapy is already established as an effective mode of therapy in vitiligo. An evidence-based study was carried out of the effect of narrow-band (311 nm) ultraviolet-B (NB-UV-B) radiation in 66 surgically treated patients with recalcitrant vitiligo in whom autologous mini-punch grafting was deployed. M...
journal_title：International journal of dermatology
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1365-4632.2005.02697.x
更新日期：2006-06-01 00:00:00
abstract：:Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy. The disease typically affects older individuals aged 60-80 years and is seen most frequently in postmenopausal Caucasian women and Asian men. EMPD exhibits a predilection for the genital and perianal regions and may be associated with an underlying ca...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/ijd.14328
更新日期：2019-08-01 00:00:00
abstract：:Skin cancers are the most common malignancies and, historically, ionizing radiation has played an important role in their treatment. However, less experienced dermatologists generally consider radiation last in the line of therapeutic options. The authors sought to evaluate the effectiveness and safety of office-based...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2006.03108.x
更新日期：2007-05-01 00:00:00
abstract：:Comparative studies were performed on clinical and laboratory features of four patients with different types of T-cell lymphoma of the skin; adult T-cell leukemia/lymphoma (ATLL), Sézary syndrome, mycosis fungoides, and Ki-1-positive lymphoma. All neoplastic cells studied showed a helper-inducer T-cell phenotype. A Ki...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1989.tb01329.x
更新日期：1989-03-01 00:00:00
abstract：BACKGROUND:Diffuse cutaneous leishmaniasis (DCL) is a rare manifestation of human leishmaniasis, characterized by multiple, slowly progressive nodules or plaques without ulceration, involving almost the entire body. It has been suggested, that DCL results from a lack of cell-mediated immunity to leishmanial antigen, le...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1995.tb00613.x
更新日期：1995-07-01 00:00:00
abstract：BACKGROUND:The aim of this study is to reveal demographic and clinical features of Behçet's disease (BD) in a Turkish population. METHODS:We retrospectively evaluated the clinical findings of 521 patients with BD. RESULTS:A total of 521 patients (287 female and 234 male) were included in this study. Onset signs: oral...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2012.05756.x
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:Alopecia areata (AA) is a non-scarring, autoimmune, inflammatory hair loss disease. Zinc is a trace element involved in important functional activities of hair follicles. PURPOSE:To evaluate serum zinc levels in patients with newly diagnosed and resistant lesions of AA in comparison to age- and sex-matched ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.12769
更新日期：2016-01-01 00:00:00
abstract：:Hyperbaric oxygen therapy (HBOT) appears to enhance wound healing, increase bactericidal activity, and act synergistically with a number of antibiotics. The aim of this study was to evaluate the efficacy of HBOT as an adjunctive therapy in patients with hidradenitis suppurativa (HS) treated with a combination of syste...
journal_title：International journal of dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/ijd.12936
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) is an important nosocomial pathogen. It can also cause community-acquired infections. Indian reports about MRSA in community-acquired infections are rare. AIM:To evaluate the rate of MRSA in community-acquired pyoderma and the nasal colonisation with S. aur...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2004.02138.x
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Until now mortality trends of melanoma and nonmelanoma skin cancer (NMSC) in Germany have been studied only in West Germany. We were interested in comparing mortality trends of melanoma and NMSC in West and East Germany before and after the post-communist transition. By analyses of health care...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2009.03892.x
更新日期：2009-04-01 00:00:00
abstract：:Biopsy specimens of cutaneous discoid lesions of 71 patients with cutaneous lupus erythematosus (CLE) were studied. The material was examined by direct immunofluorescence (DIF) to establish positivity and morphologic patterns of immunoglobulins and complement deposits in the basement membrane zone (BMZ). A correlation...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1992.tb03567.x
更新日期：1992-04-01 00:00:00
