Abstract:
:Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy. The disease typically affects older individuals aged 60-80 years and is seen most frequently in postmenopausal Caucasian women and Asian men. EMPD exhibits a predilection for the genital and perianal regions and may be associated with an underlying carcinoma in adjacent organs. EMPD presents a challenge in both diagnosis and management. Often treated empirically as various dermatitides, the correct diagnosis is frequently delayed by many years. Following diagnosis, an extensive search for an associated malignancy should be initiated. If invasive disease is present on biopsy, a sentinel lymph node biopsy may guide further treatment. Mohs micrographic surgery appears to be superior to wide local excision when considering tissue sparing ability and disease recurrence. Nonsurgical interventions have also been investigated with varied results. Regardless of treatment method, long-term follow-up is recommended to monitor for local disease recurrence, development of internal malignancy, regional lymphadenopathy, or distant metastasis.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Simonds RM,Segal RJ,Sharma Adoi
10.1111/ijd.14328subject
Has Abstractpub_date
2019-08-01 00:00:00pages
871-879issue
8eissn
0011-9059issn
1365-4632journal_volume
58pub_type
杂志文章,评审abstract::Idiopathic palmar and plantar hyperhidrosis is a relatively common disorder of eccrine sweat gland function. Treatment with glutaraldehyde of formaldehyde, although successful, may cause undesirable side effects. Methenamine is a polycyclic organic compound which release ammonia and formaldehyde at acid pH. Five per c...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-4362.1976.tb00240.x
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:Tumor necrosis factor alpha (TNFα) gene -238G/A polymorphism (rs361525) is associated with psoriasis in several populations worldwide. To the best of our knowledge, there is no information about this polymorphism in Indian psoriatic patients. This study was undertaken to fill the gap in knowledge. METHODS:T...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13482
更新日期:2017-03-01 00:00:00
abstract::During a 10-year period (1976-1985), eight Chinese patients from a population of 2.5 million fulfilled the criteria for dermatitis herpetiformis and linear IgA bullous dermatosis (LABD). These rare diseases among Asians presented during the third decade of life with homogenous linear IgA deposits along the dermoepider...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1988.tb02328.x
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Lichen planus pigmentosus inversus (LPPI) is a rare variant of LP. Only 31 cases have been reported in the literature. METHODS:Here we report a series of 10 patients with LPPI from North Africa. RESULTS:Ten cases of LPPI, clinically suspected and histologically confirmed, were seen over 3 years (2013-2015)...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13295
更新日期:2016-10-01 00:00:00
abstract::Cutaneous calcium deposition can occur in long-term inflammation. The deposition of calcium in long-standing acne may produce either small pigmented nodules or no visible lesions. The former type is or no visible lesions. The former type is much less common, with the nodules containing particulate spheres of mineral w...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1977.tb01897.x
更新日期:1977-11-01 00:00:00
abstract::A 21-year-old student of sports science presented with a 12-month history of a painful nodule on the sole of her left foot, which severely constrained her sporting activities. She was otherwise well. On examination there was a bluish pink 7-mm nodule on the arch of her left foot (Fig. 1). It was firm, exquisitely tend...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.01964.x
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Reed's nevi are distinguished from Sptiz tumors by their significant melanogenesis and growth pattern. They may be confused with melanoma on clinical and histologic grounds. CASE REPORT:An unusual case in which multiple agminated Reed's nevi mimicked acral lentiginous malignant melanoma in an African-Americ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1993.tb04268.x
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Mycosis fungoides is a lymphoma of cutaneous origin characterized by a proliferation of cells with a T phenotype. METHODS:In this pilot study, 13 men with mycosis fungoides in various stages were treated with alpha-2b interferon and etretinate. RESULTS:In ten of them, such a therapy proved to be effective ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1993.tb01458.x
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:This study reports the comorbidity of lifetime psychiatric disorders in children and adolescents with alopecia areata (AA) in a child and adolescent psychiatry clinical sample. METHODS:Fourteen patients with AA were interviewed using the Diagnostic and Statistical Manual of Mental Disorders-Fourth edition (...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.03743.x
更新日期:2008-11-01 00:00:00
abstract::The authors collected data from the literature and from experts on the subject of vaccination of patients with dermatologic disorders. They assembled these data into categories of specific skin conditions and vaccinations. These data may be used in deciding whether or not to vaccinate, and at which stage of the dermat...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1975.tb01431.x
更新日期:1975-03-01 00:00:00
abstract::Ten healthy volunteers were studied to find out whether tachyphylaxis occurs on repeated application of topical steroids. The Singh and Singh modification of the Reddy and Singh (1976) technique was used. Fluocinolone acetonide cream (0.1%) under occlusion was applied daily for 14 days on the flexor aspect of the fore...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-4362.1986.tb02258.x
更新日期:1986-06-01 00:00:00
abstract::The authors describe ten cases of cutis marmorata telangiectatica congenita (CMTC). All of these cases were sporadic. The incidence of associated anomalies was relatively low, and three patients had skin manifestations (cutaneous atrophy and nevus telangiectaticus). In two patients, the right leg was shorter and thinn...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1992.tb03564.x
更新日期:1992-04-01 00:00:00
abstract::A 10-year-old immunocompetent boy presented with multiple, verrucous, disseminated pheohyphomycotic lesions caused by Exophiala spinifera. The patient was not responsive to combination antifungal therapy (itraconazole, terbinafine, fluconazole) and cryotherapy. As antifungal susceptibility is known to be variable for ...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2007.03430.x
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Vitiligo is an acquired progressive disorder characterized by destruction of melanocytes in the lesion and the lesional hair follicles. A number of new therapeutic options for vitiligo have become available over the last decade or so both on the medical as well as surgical side. One among them is the smash...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05513.x
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Necrotizing fasciitis is a severe soft-tissue infection characterized by a fulminant course and high mortality. Early recognition is difficult as the disease is often clinically indistinguishable from cellulitis and other soft-tissue infections early in its evolution. Our aim was to study the manifestations ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2007.03201.x
更新日期:2007-10-01 00:00:00
abstract::Eccrine poroma (EP) is a benign tumor of the eccrine duct. Multiple EPs are defined as eccrine poromatosis (EPS), an uncommon phenomenon. To date there are only eight reported cases of EPS. This review exemplifies the epidemiology, pathogenesis, differential diagnosis, and histology of EP, while reviewing the eight ca...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2012.05831.x
更新日期:2014-05-01 00:00:00
abstract::Atypical presentations of cutaneous tuberculosis are not so uncommon and are frequently overlooked in clinical practice, leading to late diagnosis and increased morbidity. We report three cases of lupus vulgaris with atypical presentations. The cases mimicked other chronic skin lesions like actinomycosis, mycetoma, an...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2009.03863.x
更新日期:2009-02-01 00:00:00
abstract::A 32-year-old Thai woman developed acquired hypertrichosis lanuginosa with generalized lanugo hair, deeply furrowed tongue, and keratosis pilaris. She had metastatic adenocarcinoma of the liver. A review of world literature reveals 24 cases of which 22 were associated with proven malignancies. Acquired hypertrichosis ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1982.tb02043.x
更新日期:1982-12-01 00:00:00
abstract::Overproduction of sweat, sweaty skin, and body malodors are felt unpleasant by many people in diverse social groups. This review summarizes the functional aspects of the eccrine, apocrine, and apoeccrine sweat glands as encountered in health and disease. A series of measuring methods are conveniently used to explore a...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2011.05307.x
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Though any drug can be a potential cause of such hypersensitivity reactions, paracetamol, an over-the-counter drug used extensively as an analgesic and antipyretic agent, is considered to be relatively safe, with hepatotoxicity as a major adverse effect only in large doses. MATERIALS AND METHODS:We report a...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12355
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:It is known that malignant melanoma (MM) survivors are at increased risk of future primary MM. However, the risk for noncutaneous second primary malignancies (SPMs) is not as well-understood. METHODS:An observational study utilizing data from the Surveillance, Epidemiology, and End Results (SEER) database w...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.14781
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Biologic therapies are more effective than conventional therapies in the treatment of psoriasis, but they are also more costly. OBJECTIVES:The aim of this study was to compare the cost-efficacy of etanercept, adalimumab, and ustekinumab therapies in the treatment of moderate to severe psoriasis in a Taiwane...
journal_title:International journal of dermatology
pub_type: 杂志文章,meta分析,评审
doi:10.1111/ijd.12462
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Targeted therapies and immunotherapies are increasingly prescribed, but classic chemotherapy agents are still highly used in cancer treatment. Both therapies, the old and the new, are associated with cutaneous adverse events (CAEs) that can cause treatment interruptions or reduce the quality of life of patie...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.15081
更新日期:2021-02-01 00:00:00
abstract::Necrolytic acral erythema is a relatively recently described psoriasis-like skin eruption seen in people infected with hepatitis C virus. Hepatitis C virus infection is endemic in many parts of the world with a steady increase of incidence in Pakistan. Recognition of this disorder is crucial to an early treatment of t...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.03710.x
更新日期:2008-10-01 00:00:00
abstract::A 59-year-old man presented with a 10-cm x 8-cm tumoral plaque with a superficial nodule in the interscapular region of the back (Fig. 1). The lesion had been growing for 25 years. As a cystic lesion was suspected, the superficial nodule was biopsied. The histopathologic diagnosis was low-grade sarcoma with sclerosis....
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02340.x
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Associations between vitamin D deficiency and a broad variety of independent diseases, including several bone diseases, various types of cancer, autoimmune diseases, hypertension, and cardiovascular disease, have been suggested. It is therefore important to detect and treat vitamin D deficiency in high-risk ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13119
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:With the increasing incidence of human immunodeficiency virus (HIV) infection and immunosuppressive therapy, the incidence of syphilis has been increasing. Given the fact that the above conditions may mask or obscure the usual clinical signs and symptoms of syphilis, a means of enhanced detection is essentia...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2000.00029.x
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND:Self-reported complaints in people having tattoos, including swelling, itch, and photosensitivity, are frequent. Tattooists are usually heavily tattooed with multiple extended colored tattoos and constitute a specific population of interest. OBJECTIVES:To assess the prevalence of cutaneous complications on ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13030
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Prompt management of acute graft-versus-host disease (GVHD) may prevent its morbidity and mortality. Maculopapular (MP) eruption is a presenting sign of acute GVHD, but differentiation from other causes of MP rash is challenging. METHODS:A retrospective study was conducted among patients developing MP erupt...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.15186
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:The hair cycle is regulated by various molecules, among which FGF-5 has been shown to promote the transition from anagen to catagen. The FGFR-1, a trans-membrane receptor of FGF-5 with tyrosine kinase activity, is localized in the follicular papilla of hair follicles. OBJECTIVES:In order to apply the antise...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2007.03018.x
更新日期:2007-03-01 00:00:00