Extramammary Paget's disease: a review of the literature.


:Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy. The disease typically affects older individuals aged 60-80 years and is seen most frequently in postmenopausal Caucasian women and Asian men. EMPD exhibits a predilection for the genital and perianal regions and may be associated with an underlying carcinoma in adjacent organs. EMPD presents a challenge in both diagnosis and management. Often treated empirically as various dermatitides, the correct diagnosis is frequently delayed by many years. Following diagnosis, an extensive search for an associated malignancy should be initiated. If invasive disease is present on biopsy, a sentinel lymph node biopsy may guide further treatment. Mohs micrographic surgery appears to be superior to wide local excision when considering tissue sparing ability and disease recurrence. Nonsurgical interventions have also been investigated with varied results. Regardless of treatment method, long-term follow-up is recommended to monitor for local disease recurrence, development of internal malignancy, regional lymphadenopathy, or distant metastasis.


Int J Dermatol


Simonds RM,Segal RJ,Sharma A




Has Abstract


2019-08-01 00:00:00












  • Telangiectasia macularis eruptiva perstans with an associated myeloproliferative disorder.

    abstract::Telangiectasia macularis eruptiva perstans (TMEP) is a cutaneous form of mastocytosis. It has been rarely associated with an underlying myeloproliferative disorder. We report the case of a patient, while receiving treatment for thrombocytosis, with both platelet production and function inhibitors presented with TMEP. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Martin LK,Romanelli P,Ahn YS,Kirsner RS

    更新日期:2004-12-01 00:00:00

  • WhatsApp platforms in tropical public health resource-poor settings.

    abstract::In order to deliver equal healthcare access to resource-poor settings, sustainable, cost-effective systems of communication should be used. As mobile phone use increases, remote care can be delivered via teledermatology using Apps. This commentary covers how WhatsApp could be used by dermatologists seeking to deliver ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Hogan SC,van Hees C,Asiedu KB,Fuller LC

    更新日期:2019-02-01 00:00:00

  • Current therapies for actinic keratosis.

    abstract::Actinic keratosis (AK) is a very common skin disease caused by chronic sun damage, which in 75% of cases arises on chronically sun-exposed areas, such as face, scalp, neck, hands, and forearms. AKs must be considered an early squamous cell carcinoma (SCC) for their probable progression into invasive SCC. For this reas...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Dianzani C,Conforti C,Giuffrida R,Corneli P,di Meo N,Farinazzo E,Moret A,Magaton Rizzi G,Zalaudek I

    更新日期:2020-06-01 00:00:00

  • Prevention of post-herpetic neuralgia. Evaluation of treatment with oral prednisone, oral acyclovir, and radiotherapy.

    abstract::The effects of prednisone, oral acyclovir, and radiotherapy were compared with placebo in the prevention of post-herpetic neuralgia. No treatment used was able to prevent, with statistical significance, post-herpetic neuralgia, although prednisone and acyclovir showed some pain reduction in the acute phase. Radiothera...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Benoldi D,Mirizzi S,Zucchi A,Allegra F

    更新日期:1991-04-01 00:00:00

  • Beta defensin-1 gene (DEFB1) polymorphisms are not associated with atopic dermatitis in children and adolescents from northeast Brazil (Recife, Pernambuco).

    abstract:BACKGROUND:Atopic dermatitis (AD) is a common inflammatory skin disease resulting from the interplay between environmental, immunological and genetic factors. In our study, we investigated the role of three single nucleotide polymorphisms (SNPs) at 5'-UTR of DEFB1 gene, encoding for the human beta defensin-1, on the su...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Segat L,Guimarães RL,Brandão LA,Rocha CR,Zanin V,Trevisiol C,de Lima Filho JL,Crovella S

    更新日期:2010-06-01 00:00:00

  • A comparison of botanical and synthetic substances commonly used to prevent head lice (Pediculus humanus var. capitis) infestation.

    abstract:BACKGROUND:Pediculosis, caused by head lice (Pediculidae: Pediculus humanus var. capitis), is experiencing a global resurgence, with the prevalence in primary schools averaging as high as 40% in some areas regardless of socioeconomic factors. Control efforts using chemical treatments are becoming increasingly ineffecti...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Canyon DV,Speare R

    更新日期:2007-04-01 00:00:00

  • Is narrowband ultraviolet B monotherapy effective in the treatment of pityriasis lichenoides?

    abstract:BACKGROUND:Pityriasis lichenoides (PL) is a self-limiting papulosquamous disease that may persist for years and is associated with a high relapse rate. To date, few comparative studies have investigated the efficacy of narrowband ultraviolet B (NB-UVB) phototherapy and other therapies in the treatment of PL. OBJECTIVE...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Park JM,Jwa SW,Song M,Kim HS,Chin HW,Ko HC,Kim MB,Kim BS

    更新日期:2013-08-01 00:00:00

  • Suicidal ideation in psoriasis.

    abstract:BACKGROUND:Psoriasis has been associated with depressive disease and case reports of completed suicide. METHODS:217 consenting psoriasis patients completed the Carroll Rating Scale for Depression (CRSD), a 52-item self-rated scale, with four of the items directly addressing wishes to be dead and suicidal ideation. The...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Gupta MA,Schork NJ,Gupta AK,Kirkby S,Ellis CN

    更新日期:1993-03-01 00:00:00

  • Efficacy of intralesional bleomycin for the treatment of plantar hard corns.

    abstract:BACKGROUND:Intralesional bleomycin is effective for the treatment of various dermatologic conditions. However, the efficacy of intralesional bleomycin for the treatment of corns has not been established. METHODS:A total of 50 patients with plantar corns were recruited and equally divided between groups A and B. Groups...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Lee WJ,Lee SM,Won CH,Chang SE,Lee MW,Choi JH,Moon KC

    更新日期:2014-12-01 00:00:00

  • Sequence variants in nine different genes underlying rare skin disorders in 10 consanguineous families.

    abstract:BACKGROUND:Genodermatoses represent genetic anomalies of skin tissues including hair follicles, sebaceous glands, eccrine glands, nails, and teeth. Ten consanguineous families segregating various genodermatosis phenotypes were investigated in the present study. METHODS:Homozygosity mapping, exome, and Sanger sequencin...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Shah K,Mehmood S,Jan A,Abbe I,Hussain Ali R,Khan A,Chishti MS,Lee K,Ahmad F,Ansar M,University of Washington Center for Mendelian Genomics.,Shahzad S,Nickerson DA,Bamshad MJ,Coucke PJ,Santos-Cortez RLP,Spritz RA,Leal SM

    更新日期:2017-12-01 00:00:00

  • Seasonal variations in the severity of acne vulgaris.

    abstract:BACKGROUND AND OBJECTIVE:The improvement of acne in summertime or the aggravation of acne in winter is a traditional dermatologic opinion. Ultraviolet rays are thought to be beneficial in the treatment of acne. In the existing literature there is no proof of this. The purpose of this study was to find out whether or no...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Gfesser M,Worret WI

    更新日期:1996-02-01 00:00:00

  • Epidemiological studies on head lice infestation in Israel. I. Parasitological examination of children.

    abstract::Of 3,079 children in a medium-sized community near Jerusalem, 11.2% were found to be infested with living lice and eggs and another 23.4% had only nits. Boys and girls were equally infested. The incidence of infestation was highest among children 4-11 years of age. About 78% of the infested children had from one to te...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Mumcuoglu KY,Miller J,Gofin R,Adler B,Ben-Ishai F,Almog R,Kafka D,Klaus S

    更新日期:1990-09-01 00:00:00

  • Linear basal cell epithelioma.

    abstract::A 73-year-old Celtic man presented with a linear pigmented 20-mm lesion on the left infraorbital cheek (Fig. 1). Clinical impression was pigmented basal cell epithelioma. Removal was accomplished by linear excision under local anesthesia. The wound was closed with a running 5-0 nylon subcuticular suture, which was rem...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Lewis JE

    更新日期:1985-03-01 00:00:00

  • Characteristics of superficial mycoses in Malta.

    abstract:BACKGROUND:A study was conducted to determine the chief agents of superficial mycoses in Malta. Data were collected over a 5-year period from mycologic investigations carried out on all dermatologic specimens sent to the Mycology Laboratory at St. Luke's Hospital in Malta. METHODS:In the period between January 1995 an...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Vella Zahra L,Gatt P,Boffa MJ,Borg E,Mifsud E,Scerri L,Vella Briffa D,Pace JL

    更新日期:2003-04-01 00:00:00

  • Outbreak of cercarial dermatitis in Thailand.

    abstract:BACKGROUND:An epidemic of cercarial dermatitis caused by Schistosoma spindale cercaria occurred in November 1988 in a district called Chaiya, Surajthani province, in Southern Thailand. CASE REPORTS:Fifty-eight Thai farmers in Chaiya, Surajthani gave a history of itch following immersion in water while planting rice. T...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Kullavanijaya P,Wongwaisayawan H

    更新日期:1993-02-01 00:00:00

  • Primary Merkel cell tumor: a clinical analysis of eight cases.

    abstract:BACKGROUND:In recent years, an unusual biologic behavior of Merkel cell tumor (MCT) has been noted. In some patients, the tumor was indolent and well controlled by therapy, while in others it was lethal in a few months. Even though the majority of the reported cases are between these two biologic extremes, it seems evi...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Micali G,Ferraú F,Innocenzi D

    更新日期:1993-05-01 00:00:00

  • Mycosis fungoides with oral involvement.

    abstract::Oral mucous membrane involvement occurs uncommonly in mycosis fungoides and reports of it are scarce. We present two patients with severe involvement of the oral mucous membranes. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Vicente A,Martí RM,Martín E,Estrach T,Herrero C,Mascaró JM

    更新日期:1991-12-01 00:00:00

  • Risks for noncutaneous second primary malignancy in cutaneous malignant melanoma survivors: an analysis of data from the Surveillance, Epidemiology, and End Results (SEER) program.

    abstract:BACKGROUND:It is known that malignant melanoma (MM) survivors are at increased risk of future primary MM. However, the risk for noncutaneous second primary malignancies (SPMs) is not as well-understood. METHODS:An observational study utilizing data from the Surveillance, Epidemiology, and End Results (SEER) database w...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Vakharia PP,Kelm RC,Orrell KA,Patel KR,Singam V,Ali Y,Rastogi S,Yousif R,Rangel SM,West DP,Nardone B

    更新日期:2020-04-01 00:00:00

  • The frequency of scarring after genital ulcers in Behçet's syndrome: a prospective study.

    abstract:BACKGROUND:Although genital ulceration with or without scar formation is an important manifestation of Behçet's syndrome, formal data on the rate of genital scarring are lacking. OBJECTIVE:To study prospectively the frequency of genital scar formation after genital ulcers in patients with Behçet's syndrome. Methods On...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Mat MC,Goksugur N,Engin B,Yurdakul S,Yazici H

    更新日期:2006-05-01 00:00:00

  • Assessment of thyroid function and lipid profile in patients with postadolescent acne in a Mediterranean population from Turkey.

    abstract:BACKGROUND:Postadolescent acne is defined as acne that is seen even after the age of 25 years, regardless of the age at onset. The causes of postadolescent acne have not been completely clarified up to now. Androgens are considered to be the major factor involved in pathogenesis. OBJECTIVE:We aimed to investigate the ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Ekiz O,Balta I,Unlu E,Bulbul Sen B,Rifaioğlu EN,Dogramaci AC

    更新日期:2015-12-01 00:00:00

  • Longitudinal progress of transepidermal water loss, color, and sensory elements in split-thickness skin graft donor sites in East Asians.

    abstract:BACKGROUND:There is little research available that describes the natural progression of split-thickness skin graft (STSG) donor site wounds after re-epithelialization. The purpose of this study was to evaluate the longitudinal clinical progress of transepidermal water loss (TEWL), color, and sensory elements in STSG do...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Kim J,Kim R,Jeong W,Choi J,Park SW

    更新日期:2019-05-01 00:00:00

  • Alopecia in congenital hidrotic ectodermal dysplasia responding to treatment with a combination of topical minoxidil and tretinoin.

    abstract::Clouston's syndrome is an ectodermal dysplasia characterized by dystrophic nails, alopecia, and palmoplantar hyperkeratosis. Alopecia is due to decrease in number and degree of maturation of the hair follicles. Tretinoin is a mitogen by itself and also enhances the absorption of minoxidil which acts by enlarging the m...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Melkote S,Dhurat RS,Palav A,Jerajani HR

    更新日期:2009-02-01 00:00:00

  • A comparison of neuropeptide expression in skin with allergic contact dermatitis in human and mouse.

    abstract:BACKGROUND:Allergic contact dermatitis (ACD) is a manifestation of a cell-mediated immune response, but its mechanism remains unknown. Recently, we investigated whether ACD involves various neuropeptides. Substance P (SP) is a neuropeptide that is known to act as a neurokinin receptor when the immune response is initia...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Lim YY,Kim HM,Lee HI,Mun SK,Kim CW,Kim MN,Kim BJ

    更新日期:2012-08-01 00:00:00

  • A surgical approach for dermatosis papulosa nigra.

    abstract::Dermatosis papulosa nigra (DPN) is a disorder commonly encountered in the adult black population. We describe 20 cases of clinicopathologically confirmed DPN cases treated with light abrasive curettage without local anesthesia. We found this procedure to be an effective therapy, which did not cause postoperative scarr...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Kauh YC,McDonald JW,Rapaport JA,Ruschak PJ,Luscombe HA

    更新日期:1983-12-01 00:00:00

  • Is season important for the diagnosis of cutaneous melanoma in southern Brazil? A 10-year hospital-based study.

    abstract:BACKGROUND:Exposure to sunlight is an important etiologic factor in cutaneous melanoma (CM). In several countries, more cases of CM are diagnosed in summer than in winter. AIM:To analyze whether there is seasonal variation in the diagnosis of CM in southern Brazil. METHODS:Data were collected from a hospital-based re...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Bakos L,Masiero NC,Burttet RM,Moreira LM,Santos KO,Brunetto LT,Benzano D

    更新日期:2010-01-01 00:00:00

  • Oxymatrine inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth factor-β1/Smad signaling pathway.

    abstract:BACKGROUND:Keloids are benign dermal tumors characterized by fibroblastic proliferation and excessive accumulation of collagen. Oxymatrine (OMT) is an alkaloid extracted from the Chinese herb Sophora japonica with capacities of anti-fibrosis. OBJECTIVE:To evaluate the effects of OMT on collagen production and to explo...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Fan DL,Zhao WJ,Wang YX,Han SY,Guo S

    更新日期:2012-04-01 00:00:00

  • A retrospective review of cutaneous lymphoma in Botswana.

    abstract:BACKGROUND:Primary cutaneous lymphoma (PCL) represents a heterogeneous collection of non-Hodgkin lymphomas originating in the skin. Our study describes the clinical and histological findings of cutaneous lymphoma within Botswana to expand the paucity of data on this rare disease in sub-Saharan Africa. METHODS:We condu...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Rodriguez O,Sowash M,Mosojane KI,Ralefala T,Grover S,Haun P,Kovarik C,Williams VL

    更新日期:2020-03-01 00:00:00

  • Buschke-Ollendorff syndrome.

    abstract:BACKGROUND:Buschke-Ollendorff syndrome is a rare autosomal dominant disease featuring osteopoikilosis and skin lesions. It is caused by genetic mutations in a protein deeply involved in bone and connective tissue morphogenesis. METHODS:We describe a 39-year-old woman with Buschke-Ollendorff syndrome. RESULTS:After a ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Schena D,Germi L,Zamperetti MR,Colato C,Girolomoni G

    更新日期:2008-11-01 00:00:00

  • Basal cell carcinoma treated with Mohs micrographic surgery in young Ibero-American patients.

    abstract:BACKGROUND:The incidence of basal cell carcinoma (BCC) in younger individuals has increased in recent decades. However, the characteristics of BCCs in this population, especially in Ibero-Latin American countries, have not been completely defined. OBJECTIVE:To describe the demographic, clinical, and histopathological ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,多中心研究


    authors: Aluma-Tenorio MS,Ávila-Álvarez A,Jaimes N,Caballero-Uribe N,González A,Terzian LR,Ocampo-Candiani J,Zuluaga MA,Garza-Rodríguez V,Tamayo-Betancur MC,Cuesta-Castro DP,Garcés JR,Ruiz-Salas V,Goldberg L,Kimyai-Asadi A

    更新日期:2018-12-01 00:00:00

  • Pheohyphomycosis caused by Exophiala spinifera: a rare occurrence.

    abstract::A 10-year-old immunocompetent boy presented with multiple, verrucous, disseminated pheohyphomycotic lesions caused by Exophiala spinifera. The patient was not responsive to combination antifungal therapy (itraconazole, terbinafine, fluconazole) and cryotherapy. As antifungal susceptibility is known to be variable for ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Singal A,Pandhi D,Bhattacharya SN,Das S,Aggarwal S,Mishra K

    更新日期:2008-01-01 00:00:00